Detailed information for compound 1414106

Basic information

Technical information
  • TDR Targets ID: 1414106
  • Name: MLS000098779
  • MW: 270.323 | Formula: C12H15FN2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.25 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)S(=O)(=O)NC1N2CCCCC1
  • InChi: 1S/C12H15FN2O2S/c13-9-5-6-10-11(8-9)18(16,17)14-12-4-2-1-3-7-15(10)12/h5-6,8,12,14H,1-4,7H2
  • InChiKey: YUXMECOUFJYJTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • T0507-8454
  • SMR000061116

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0321 0.0536
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0019
Onchocerca volvulus 0.0045 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0019
Echinococcus granulosus geminin 0.0502 0.5994 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0039
Brugia malayi pregnancy-associated plasma protein-A 0.0045 0.0414 0.1425
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1607 0.1607
Brugia malayi RNA binding protein 0.0249 0.2908 1
Brugia malayi Sushi domain 0.0045 0.0414 0.1425
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.038 0.8618
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0321 0.1104
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0249 0.2908 0.4852
Onchocerca volvulus 0.0026 0.0185 0.4313
Echinococcus multilocularis transmembrane protease serine 3 0.0012 0.0011 0.0011
Plasmodium falciparum thrombospondin-related anonymous protein 0.0026 0.0185 0.0722
Schistosoma mansoni tar DNA-binding protein 0.0249 0.2908 0.4852
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0291 0.5434
Echinococcus granulosus voltage dependent calcium channel subunit 0.0026 0.0185 0.0309
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0026 0.0185 0.0637
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0012 0.0011 0.0019
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Onchocerca volvulus 0.0045 0.0414 1
Onchocerca volvulus 0.0026 0.0185 0.4313
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0898
Plasmodium vivax apical sushi protein, putative 0.0045 0.0414 1
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0026 0.0185 0.0722
Brugia malayi Trypsin family protein 0.0012 0.0011 0.0039
Onchocerca volvulus 0.0045 0.0414 1
Brugia malayi Trypsin family protein 0.0012 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0098 0.1065 0.3661
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1065 0.3661
Brugia malayi Trypsin-like protease protein 5 0.0012 0.0011 0.0039
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0026 0.0185 0.0637
Brugia malayi hypothetical protein 0.0045 0.0414 0.1425
Brugia malayi RNA recognition motif domain containing protein 0.0249 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Onchocerca volvulus 0.0045 0.0414 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0544 0.0907
Brugia malayi hypothetical protein 0.0045 0.0414 0.1425
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Schistosoma mansoni tar DNA-binding protein 0.0249 0.2908 0.4852
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0281 0.4579
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1559 0.2601
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0247 0.0851
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.038 0.0634
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0012 0.0011 0.0039
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0321 0.0321
Loa Loa (eye worm) RNA binding protein 0.0249 0.2908 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Echinococcus granulosus c4b binding protein beta chain 0.0045 0.0414 0.0691
Echinococcus multilocularis geminin 0.0502 0.5994 0.5994
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0039
Brugia malayi hypothetical protein 0.0045 0.0414 0.1425
Schistosoma mansoni hypothetical protein 0.0035 0.0295 0.0492
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0039
Onchocerca volvulus 0.0045 0.0414 1
Onchocerca volvulus 0.0045 0.0414 1
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.7193
Brugia malayi hypothetical protein 0.0045 0.0414 0.1425
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0362 0.0605
Brugia malayi Zona pellucida-like domain containing protein 0.0026 0.0185 0.0637
Treponema pallidum 76K protein 0.0026 0.0185 0.5
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0026 0.0185 0.0722
Schistosoma mansoni c4b-binding protein beta chain 0.0045 0.0414 0.0691
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Echinococcus granulosus GPCR family 2 0.0031 0.0247 0.0413
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0026 0.0185 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0544 0.0907
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0295 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0249 0.2908 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0338 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0045 0.0414 0.1425
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0291 0.5434
Loa Loa (eye worm) trypsin family protein 0.0012 0.0011 0.0039
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0026 0.0185 0.0722
Onchocerca volvulus 0.0026 0.0185 0.4313
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Brugia malayi hypothetical protein 0.0035 0.0295 0.1014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0247 0.0851
Echinococcus granulosus collagen alpha 1VII chain 0.0026 0.0185 0.0309
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0026 0.0185 0.0722
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0011 0.0019
Plasmodium falciparum apical sushi protein 0.0045 0.0414 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0362 0.0605
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0295 0.0492
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0185 0.0637
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0544 0.1869
Brugia malayi hypothetical protein 0.0012 0.0011 0.0039
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.7193
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.038 1
Schistosoma mansoni hypothetical protein 0.0031 0.0247 0.0413
Echinococcus granulosus C type lectin domian containing protein 0.0045 0.0414 0.0691
Brugia malayi hypothetical protein 0.0026 0.0185 0.0637
Brugia malayi GCC2 and GCC3 family protein 0.0045 0.0414 0.1425
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0019
Echinococcus multilocularis enteropeptidase 0.0012 0.0011 0.0011
Onchocerca volvulus 0.0045 0.0414 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0338 1
Loa Loa (eye worm) TAR-binding protein 0.0249 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0039
Echinococcus multilocularis C type lectin domian containing protein 0.0045 0.0414 0.0414
Brugia malayi hypothetical protein 0.0016 0.0062 0.0212
Loa Loa (eye worm) CUTiclin-Like family member 0.0026 0.0185 0.0637
Schistosoma mansoni hypothetical protein 0.0026 0.0185 0.0309
Echinococcus granulosus tar DNA binding protein 0.0249 0.2908 0.4852
Onchocerca volvulus 0.0026 0.0185 0.4313
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0687 0.2361
Echinococcus multilocularis tar DNA binding protein 0.0249 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0012 0.0011 0.0019
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0281 0.0468
Brugia malayi hypothetical protein 0.0045 0.0414 0.1425
Echinococcus granulosus transmembrane protease serine 3 0.0012 0.0011 0.0019
Brugia malayi Trypsin family protein 0.0012 0.0011 0.0039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1065 0.3661
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1065 0.3661
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0544 0.0907
Loa Loa (eye worm) hypothetical protein 0.0024 0.0167 0.0576
Onchocerca volvulus 0.0026 0.0185 0.4313
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Brugia malayi hypothetical protein 0.0024 0.0167 0.0576
Onchocerca volvulus 0.0026 0.0185 0.4313
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.7193
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0321 0.1104
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0281 0.0965
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0247 0.0247
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0247 0.0413
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Schistosoma mansoni hypothetical protein 0.0031 0.0247 0.0413
Schistosoma mansoni hypothetical protein 0.0067 0.0687 0.1145
Brugia malayi hypothetical protein 0.0045 0.0414 0.1425
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.038 0.8618
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.038 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Echinococcus multilocularis GPCR, family 2 0.0031 0.0247 0.0247
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.038 0.8618
Echinococcus granulosus enteropeptidase 0.0012 0.0011 0.0019
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0281 0.0281
Brugia malayi Trypsin family protein 0.0012 0.0011 0.0039
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1607 0.5527
Brugia malayi TAR-binding protein 0.0249 0.2908 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0544 0.0907
Schistosoma mansoni tar DNA-binding protein 0.0249 0.2908 0.4852
Toxoplasma gondii rhoptry neck protein RON1 0.0045 0.0414 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Echinococcus multilocularis glycoprotein Antigen 5 0.0012 0.0011 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0247 0.0247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Schistosoma mansoni hypothetical protein 0.0031 0.0247 0.0413
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0185 0.0722
Schistosoma mansoni hypothetical protein 0.0502 0.5994 1
Toxoplasma gondii microneme protein MIC2 0.0026 0.0185 0.0722
Loa Loa (eye worm) CUTiclin family member 0.0026 0.0185 0.0637
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Brugia malayi Zona pellucida-like domain containing protein 0.0026 0.0185 0.0637
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.7193
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0281 0.4579
Echinococcus multilocularis c4b binding protein beta chain 0.0045 0.0414 0.0414
Schistosoma mansoni tar DNA-binding protein 0.0249 0.2908 0.4852
Treponema pallidum hypothetical protein 0.0026 0.0185 0.5
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0026 0.0185 0.0185
Onchocerca volvulus 0.0026 0.0185 0.4313
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Onchocerca volvulus 0.0045 0.0414 1
Plasmodium vivax thrombospondin-related anonymous protein 0.0026 0.0185 0.0722
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0544 0.0907
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0281 1
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0026 0.0185 0.0722
Loa Loa (eye worm) hypothetical protein 0.0067 0.0687 0.2361
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0295 0.0492
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0026 0.0185 0.0309
Echinococcus granulosus Mastin 0.0012 0.0011 0.0019
Toxoplasma gondii rhoptry neck protein RON9 0.0045 0.0414 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0019
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0338 0.6894
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Brugia malayi hypothetical protein 0.0045 0.0414 0.1425
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0045 0.0414 0.1425
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Brugia malayi von Willebrand Factor 0.0026 0.0185 0.0637
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0026 0.0185 0.0722
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0019
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0185 0.0637
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0281 0.4579
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Echinococcus multilocularis Mastin 0.0012 0.0011 0.0011
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0012 0.0011 0.0011
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0281 0.4579
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0019
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0011 0.0019
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1607 0.2682
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Schistosoma mansoni hypothetical protein 0.0031 0.0247 0.0413
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0026 0.0185 0.0637
Onchocerca volvulus 0.0045 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0247 0.0851
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0039
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0281 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0544 0.1869
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0003 0.0005
Echinococcus granulosus glycoprotein Antigen 5 0.0012 0.0011 0.0019
Loa Loa (eye worm) acetyltransferase 0.0142 0.1607 0.5527
Mycobacterium ulcerans hypothetical protein 0.0012 0.0011 0.5
Brugia malayi Augmenter of liver regeneration 0.0034 0.0281 0.0965
Schistosoma mansoni hypothetical protein 0.0502 0.5994 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0247 0.0413
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0034 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0247 0.0851
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0637
Onchocerca volvulus 0.0045 0.0414 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0281 1
Schistosoma mansoni hypothetical protein 0.0026 0.0185 0.0309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0039

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.