Detailed information for compound 1414571

Basic information

Technical information
  • TDR Targets ID: 1414571
  • Name: 4-methyl-N-pyridin-3-yl-3-pyrrolidin-1-ylsulf onylbenzamide
  • MW: 345.416 | Formula: C17H19N3O3S
  • H donors: 1 H acceptors: 4 LogP: 1.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)S(=O)(=O)N1CCCC1)C)Nc1cccnc1
  • InChi: 1S/C17H19N3O3S/c1-13-6-7-14(17(21)19-15-5-4-8-18-12-15)11-16(13)24(22,23)20-9-2-3-10-20/h4-8,11-12H,2-3,9-10H2,1H3,(H,19,21)
  • InChiKey: JJPGKHQVSUDTNE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-N-(3-pyridyl)-3-pyrrolidin-1-ylsulfonyl-benzamide
  • 4-methyl-N-(3-pyridyl)-3-1-pyrrolidinylsulfonylbenzamide
  • 4-methyl-N-pyridin-3-yl-3-pyrrolidin-1-ylsulfonyl-benzamide
  • STK242953
  • Oprea1_132889

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.3877 0.3877
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0449 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Onchocerca volvulus 0.0022 0.0146 0.0252
Schistosoma mansoni intermediate filament proteins 0.0058 0.0714 0.0691
Loa Loa (eye worm) hypothetical protein 0.0048 0.0549 0.0546
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.3088 0.3086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0449 0.1078
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1509 0.2063
Loa Loa (eye worm) RecQ helicase 0.0022 0.0146 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Trypanosoma brucei trypanothione reductase 0.0048 0.0555 0.0506
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0449 0.437
Echinococcus granulosus twitchin 0.0056 0.0685 0.0682
Schistosoma mansoni cell adhesion molecule 0.0018 0.0093 0.0069
Brugia malayi tailless protein 0.0014 0.0024 0.0024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0982 0.0951
Echinococcus multilocularis roundabout 2 0.0066 0.0843 0.0841
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0263 0.0263
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0068 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0415 0.0412
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0486 0.0483
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0656 1 1
Brugia malayi steroid hormone receptor 0.0029 0.0263 0.0263
Echinococcus multilocularis cysteine protease 0.0022 0.0146 0.0143
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0093 0.009
Echinococcus granulosus geminin 0.0365 0.5487 0.5486
Echinococcus multilocularis lachesin 0.0018 0.0093 0.009
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0943 0.0897
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0146 0.0288
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0943 0.1253
Echinococcus granulosus bloom syndrome protein 0.0022 0.0146 0.0144
Brugia malayi nuclear receptor NHR-88 0.0029 0.0263 0.0263
Echinococcus granulosus Immunoglobulin 0.0048 0.0561 0.0558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Brugia malayi hypothetical protein 0.0043 0.0486 0.0486
Loa Loa (eye worm) inositol-1 0.0041 0.0449 0.0446
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.005 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Schistosoma mansoni hypothetical protein 0.0059 0.0731 0.0708
Mycobacterium tuberculosis Conserved protein 0.0073 0.0943 0.1253
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0144 0.0142
Toxoplasma gondii ABC1 family protein 0.0073 0.0943 0.0912
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0943 1
Schistosoma mansoni roundabout 0.0018 0.0093 0.0069
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0146 0.0143
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0035 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0943 0.0912
Loa Loa (eye worm) hypothetical protein 0.0048 0.0561 0.0558
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0024 0.0021
Plasmodium falciparum glutathione reductase 0.0048 0.0555 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0263 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Loa Loa (eye worm) hypothetical protein 0.0073 0.0943 0.0941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Trichomonas vaginalis esterase, putative 0.0073 0.0943 0.2365
Brugia malayi ecdysteroid receptor 0.0029 0.0263 0.0263
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0146 0.0143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0024 0.0021
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0146 0.1169
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0043 0.0486 0.4758
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0024 0.0024
Onchocerca volvulus 0.0312 0.4664 0.9602
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0263 0.0495
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0034
Loa Loa (eye worm) hypothetical protein 0.0073 0.0943 0.0941
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1509 0.2063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0943 0.2365
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0263 0.024
Mycobacterium tuberculosis Conserved protein 0.0073 0.0943 0.1253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0034
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0263 0.0261
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0146 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0263 0.0261
Loa Loa (eye worm) hypothetical protein 0.0073 0.0943 0.0941
Echinococcus granulosus intermediate filament protein 0.0058 0.0714 0.0711
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0656 1 1
Echinococcus multilocularis cysteine protease 0.0022 0.0146 0.0143
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0943 1
Brugia malayi hypothetical protein 0.0015 0.005 0.005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0982 0.0936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1288 0.1267
Onchocerca volvulus 0.0022 0.0146 0.0252
Schistosoma mansoni cell adhesion molecule 0.0058 0.0719 0.0697
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0449 0.0415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0263 0.024
Brugia malayi Bromodomain containing protein 0.0076 0.0991 0.0991
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0244 0.36 0.3577
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.1793 0.1791
Echinococcus multilocularis roundabout 2 0.0018 0.0093 0.009
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Plasmodium vivax SET domain protein, putative 0.003 0.0281 0.2681
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0486 0.0483
Brugia malayi Thioredoxin reductase 0.0048 0.0555 0.0555
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0018 0.0093 0.0069
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0024 0.0024
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0034
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0144 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0263 0.0261
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0263 0.0495
Brugia malayi Peroxidasin 0.0018 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0146 0.0111
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0146 0.0143
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0376 0.0374
Echinococcus multilocularis hemicentin 1 0.0018 0.0093 0.009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0144 0.1994
Echinococcus multilocularis Immunoglobulin 0.0048 0.0561 0.0558
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0263 0.0261
Brugia malayi Inositol-1 0.0041 0.0449 0.0449
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0244 0.36 0.3577
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0144 0.1178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0263 0.0263
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0549 0.0546
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0449 0.4347
Echinococcus granulosus roundabout 2 0.0018 0.0093 0.009
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0943 0.4265
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0024 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0068 0.0088
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0263 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3877 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0135 0.0133
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0092 0.004
Brugia malayi Cathepsin L-like precursor 0.0022 0.0146 0.0146
Onchocerca volvulus 0.0073 0.0943 0.1903
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0263 0.0261
Echinococcus multilocularis Immunoglobulin 0.0048 0.0561 0.0558
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0018 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Echinococcus multilocularis roundabout 2 0.0018 0.0093 0.009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0943 0.0941
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2479 0.636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1288 0.1285
Loa Loa (eye worm) ctsf protein 0.0022 0.0146 0.0143
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2479 0.636
Schistosoma mansoni tyrosine kinase 0.0023 0.0161 0.0137
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1509 0.2063
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0146 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0068 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0034
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0092 0.0092
Echinococcus granulosus lachesin 0.0018 0.0093 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2479 0.636
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0146 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0263 0.0263
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0068 0.0034
Leishmania major hypothetical protein, conserved 0.0073 0.0943 0.0897
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0146 0.0252
Loa Loa (eye worm) hypothetical protein 0.0048 0.0561 0.0558
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1509 0.2063
Onchocerca volvulus Tyrosine kinase homolog 0.0325 0.4857 1
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0092 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0032
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0146 0.1586
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0486 0.0463
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1698 0.2335
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0144 0.0285
Mycobacterium leprae Probable lipase LipE 0.0073 0.0943 0.4265
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0263 0.0261
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0263 0.0261
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0943 0.0941
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0024 0.0021
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0058 0.0719 0.0716
Brugia malayi isocitrate dehydrogenase 0.0018 0.0092 0.0092
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0263 0.0261
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0092 0.0057
Onchocerca volvulus 0.0173 0.2499 0.5121
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0263 0.0263
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0144 0.0109
Loa Loa (eye worm) DR-78 0.0014 0.0024 0.0021
Brugia malayi PHD-finger family protein 0.0025 0.0203 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0263 0.0261
Loa Loa (eye worm) hypothetical protein 0.0066 0.0843 0.0841
Onchocerca volvulus 0.0022 0.0146 0.0252
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0943 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0003 0.0003
Schistosoma mansoni neuroglian 0.0018 0.0093 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0263 0.0261
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0024 0.0021
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0294 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0263 0.0263
Onchocerca volvulus 0.003 0.0281 0.0531
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0073 0.0943 0.0941
Plasmodium vivax vivapain-2 0.0022 0.0146 0.1192
Loa Loa (eye worm) hypothetical protein 0.0072 0.0924 0.0922
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0146 0.1586
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0751 0.0748
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0943 0.2365
Mycobacterium ulcerans hypothetical protein 0.0073 0.0943 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0943 0.0922
Brugia malayi Cathepsin L-like precursor 0.0022 0.0146 0.0146
Brugia malayi beta-lactamase family protein 0.0073 0.0943 0.0943
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0017
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0982 0.0982
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0048 0.0561 0.0538
Loa Loa (eye worm) hypothetical protein 0.0048 0.0561 0.0558
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0449 0.0446
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0092 0.0089
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0146 0.1586
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0263 0.0263
Schistosoma mansoni septate junction protein 0.0018 0.0093 0.0069
Echinococcus multilocularis hemicentin 1 0.0018 0.0093 0.009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0263 0.0263
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0246 0.0244
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.005 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0656 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0719 0.0716
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0656 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0943 0.2365
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0449 0.1078
Echinococcus multilocularis thyroid hormone receptor alpha 0.0157 0.2246 0.2244
Echinococcus multilocularis lamin 0.0058 0.0714 0.0711
Schistosoma mansoni inositol monophosphatase 0.0041 0.0449 0.0426
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0144 0.0142
Echinococcus multilocularis lamin dm0 0.0058 0.0714 0.0711
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Brugia malayi Cathepsin L-like precursor 0.0022 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0076 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1288 0.1267
Onchocerca volvulus 0.0022 0.0146 0.0252
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi nuclear receptor NHR-88 0.0014 0.0024 0.0024
Onchocerca volvulus 0.0014 0.0035 0.0022
Loa Loa (eye worm) hypothetical protein 0.0173 0.2499 0.2497
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0017
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0943 0.1253
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0092 0.0057
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0024 0.0021
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0048 0.0561 0.0558
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0068 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0263 0.024
Schistosoma mansoni nephrin 0.0056 0.0685 0.0662
Loa Loa (eye worm) hypothetical protein 0.0066 0.0843 0.0841
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0263 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2479 0.636
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0943 0.0943
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0263 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0263 0.0263
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0018 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0057 0.0697 0.0695
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0144 0.0093
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0068 0.034
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0263 0.0495
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0376 0.0374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Onchocerca volvulus 0.0058 0.0714 0.1427
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0943 0.1253
Schistosoma mansoni lamin 0.0058 0.0714 0.0691
Echinococcus granulosus lamin dm0 0.0058 0.0714 0.0711
Mycobacterium ulcerans beta-lactamase 0.0073 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0561 0.0558
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0089 0.0086
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0263 0.0261
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.7049 1
Schistosoma mansoni ap endonuclease 0.0021 0.0144 0.0121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0263 0.024
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0093 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0146 0.0122
Schistosoma mansoni titin 0.0018 0.0093 0.0069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0144 0.011
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0982 0.0936
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0146 0.0122
Brugia malayi beta-lactamase family protein 0.0073 0.0943 0.0943
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0982 0.098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1288 0.1285
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0035 0.0035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.3537 0.3535
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0263 0.0261
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0144 0.1156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0048 0.0561 0.0558
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0092 0.0057
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0982 0.0961
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0041 0.0452 0.0449
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0449 0.04
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0146 0.0143
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1698 0.2335
Plasmodium vivax glutathione reductase, putative 0.0048 0.0555 0.5711
Schistosoma mansoni inositol monophosphatase 0.0041 0.0449 0.0426
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0092 0.0474
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0165 0.0142
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0263 0.024
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0093 0.009
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0024 0.0024
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.061 0.9288 0.9288
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1288 0.1288
Brugia malayi nuclear receptor RXR 0.0015 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0128 0.1793 0.1773
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0079 0.0055
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0068 0.034
Onchocerca volvulus 0.0073 0.0943 0.1903
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0024 0.0021
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0068 0.0034
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0024 0.0021
Toxoplasma gondii thioredoxin reductase 0.0048 0.0555 0.0522
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3877 1
Brugia malayi cathepsin L-like precursor 0.0014 0.0035 0.0035
Brugia malayi nuclear hormone receptor 0.0029 0.0263 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2622 0.6734
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1509 0.856
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Toxoplasma gondii cathepsin CPL 0.0022 0.0146 0.0111
Loa Loa (eye worm) hypothetical protein 0.0027 0.023 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0146 0.0144
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0092 0.0089
Loa Loa (eye worm) beta-lactamase 0.0073 0.0943 0.0941
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0263 0.024
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0045
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0092 0.0089
Echinococcus granulosus peroxidasin 0.0018 0.0093 0.009
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0943 0.1253
Schistosoma mansoni hypothetical protein 0.0021 0.0135 0.0112
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0263 0.0261
Brugia malayi beta-lactamase 0.0073 0.0943 0.0943
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.005 0.005
Leishmania major trypanothione reductase 0.0048 0.0555 0.0506
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0018 0.0093 0.009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0375 0.5641 0.5641
Brugia malayi Cathepsin L-like precursor 0.0022 0.0146 0.0146
Entamoeba histolytica hypothetical protein 0.0043 0.0486 0.4758
Brugia malayi Cathepsin L-like precursor 0.0014 0.0035 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0146 0.0111
Toxoplasma gondii fructose-bisphospatase I 0.0244 0.36 0.3577
Brugia malayi Cytochrome P450 family protein 0.0024 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3877 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1288 0.1285
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0092 0.0033
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0092 0.004
Schistosoma mansoni zinc finger protein 0.002 0.0119 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Brugia malayi glutathione reductase 0.0048 0.0555 0.0555
Schistosoma mansoni hypothetical protein 0.0365 0.5487 0.5476
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0489 0.0486
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0043 0.0482 0.0479
Mycobacterium tuberculosis Probable reductase 0.0109 0.1509 0.2063
Brugia malayi hypothetical protein 0.0014 0.0024 0.0024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0382 0.0449
Echinococcus granulosus roundabout 2 0.0066 0.0843 0.0841
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0024 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0177 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0263 0.0261
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0656 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0144 0.011
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0018 0.0093 0.009
Brugia malayi conserved hypotetical protein 0.0014 0.0024 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0263 0.0261
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0092 0.0595
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Echinococcus granulosus hemicentin 1 0.0018 0.0093 0.009
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0263 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Schistosoma mansoni bromodomain containing protein 0.0064 0.0807 0.0785
Echinococcus multilocularis neuroglian 0.0018 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0561 0.0558
Loa Loa (eye worm) hypothetical protein 0.0073 0.0943 0.0941
Schistosoma mansoni hypothetical protein 0.0365 0.5487 0.5476
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Onchocerca volvulus 0.0058 0.0714 0.1427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0943 0.0922
Schistosoma mansoni septate junction protein 0.0018 0.0093 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0263 0.024
Trypanosoma cruzi ISWI complex protein 0.0016 0.0051 0.0017
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0024 0.0024
Echinococcus multilocularis neuroglian 0.0056 0.0685 0.0682
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0263 0.0261
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0017
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0146 0.0291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0146 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1288 0.1285
Trypanosoma cruzi ISWI complex protein 0.0016 0.0051 0.0017
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0068 0.0017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0092 0.0089
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0982 0.098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3877 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0375 0.5641 0.564
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0263 0.0263
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0068 0.0017
Leishmania major 0.0656 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0092 0.0089
Echinococcus granulosus lamin 0.0058 0.0714 0.0711
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0244 0.36 0.3567
Schistosoma mansoni nephrin 0.0018 0.0093 0.0069
Schistosoma mansoni cell adhesion molecule 0.0018 0.0093 0.0069
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0165 0.0163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0144 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2622 0.6734
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0106 0.0764
Echinococcus granulosus zinc finger protein 0.002 0.0119 0.0116
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0146 0.0095
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0092 0.0089
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0246 0.0244
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.005 0.0047
Brugia malayi hypothetical protein 0.0015 0.005 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3877 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0943 0.2365
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0018 0.0093 0.0142
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0048 0.0561 0.0538
Brugia malayi nuclear receptor RXR 0.0014 0.0024 0.0024
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0018 0.0093 0.009
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0656 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0017
Echinococcus granulosus neuroglian 0.0018 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0058 0.0714 0.0711
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0982 0.0951
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.3877 0.3875
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0263 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1698 1
Schistosoma mansoni thyroid hormone receptor 0.0157 0.2246 0.2227
Echinococcus multilocularis peroxidasin 0.0018 0.0093 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0024 0.0021
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0146 0.0288
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2479 0.636
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0244 0.36 0.3577
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Echinococcus multilocularis tyrosine protein kinase otk 0.0018 0.0093 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0146 0.0111
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0982 1
Loa Loa (eye worm) fibroinase 0.0022 0.0146 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0281 0.0257
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0144 0.0144
Brugia malayi nuclear hormone receptor 0.0014 0.0024 0.0024
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.005 0.0026
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0656 1 1
Brugia malayi hypothetical protein 0.0048 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0555 0.0552
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0555 0.0552
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0943 0.0912
Brugia malayi Prion-like- 0.0018 0.0093 0.0093
Echinococcus granulosus defective proboscis extension response 0.0048 0.0561 0.0558
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0714 0.0711
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0489 0.0486
Onchocerca volvulus 0.0022 0.0146 0.0252
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0066
Echinococcus multilocularis musashi 0.0058 0.0714 0.0711
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Schistosoma mansoni coup transcription factor 0.0029 0.0263 0.024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0943 0.1253
Plasmodium falciparum thioredoxin reductase 0.0048 0.0555 1
Leishmania major cathepsin L-like protease 0.0022 0.0146 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Onchocerca volvulus 0.0022 0.0146 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3877 1
Schistosoma mansoni hypothetical protein 0.0016 0.0051 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0263 0.0261
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0146 0.0111
Mycobacterium ulcerans lipase LipD 0.0073 0.0943 1
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0943 0.1253
Loa Loa (eye worm) hypothetical protein 0.0022 0.0146 0.0143
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.1793 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0943 0.0941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0714 0.0714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0281 0.0257
Loa Loa (eye worm) cysteine protease 0.0022 0.0146 0.0143
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0024 0.0021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0146 0.0143
Brugia malayi Fibronectin type III domain containing protein 0.0048 0.0561 0.0561
Entamoeba histolytica hypothetical protein 0.0043 0.0486 0.4758
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0032
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0093 0.009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0024 0.0021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Onchocerca volvulus Cathepsin F homolog 0.0022 0.0146 0.0252
Brugia malayi intermediate filament protein 0.0058 0.0714 0.0714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0549 0.0526
Brugia malayi ecdysone receptor 0.0014 0.0024 0.0024
Loa Loa (eye worm) glutathione reductase 0.0048 0.0555 0.0552
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0068 0.0017
Brugia malayi Bromodomain containing protein 0.0039 0.0414 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1288 0.1267
Onchocerca volvulus 0.024 0.354 0.7276
Schistosoma mansoni lamin 0.0058 0.0714 0.0691
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0982 0.098
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0018 0.0093 0.009
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1698 0.2335
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0449 0.0415
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0943 0.2365
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0555 0.0552
Schistosoma mansoni ap endonuclease 0.0021 0.0144 0.0121
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0555 0.0522
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2479 0.5079
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0068 0.0088
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0068 0.0068
Entamoeba histolytica cysteine protease, putative 0.0022 0.0146 0.1169
Brugia malayi Pre-SET motif family protein 0.003 0.0281 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0032
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0751 0.0748
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0246 0.0244
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0146 0.0252
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0263 0.0261
Echinococcus granulosus cathepsin l1 0.0014 0.0035 0.0032
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0449 0.04
Brugia malayi hypothetical protein 0.0173 0.2499 0.2499
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1288 0.1285
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0281 0.0246
Brugia malayi follicle stimulating hormone receptor 0.024 0.3537 0.3537
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0263 0.024
Echinococcus multilocularis geminin 0.0365 0.5487 0.5486
Loa Loa (eye worm) hypothetical protein 0.0027 0.023 0.0227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Onchocerca volvulus 0.0073 0.0943 0.1903
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0092 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0146 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2479 0.636
Schistosoma mansoni thyroid hormone receptor 0.0157 0.2246 0.2227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0263 0.0261
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0263 0.0261
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0144 0.0867
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0146 0.0288
Brugia malayi Cathepsin L-like precursor 0.0022 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Echinococcus granulosus roundabout 2 0.0018 0.0093 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0144 0.0093
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0079 0.0076
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1509 0.2063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0078 0.0076
Onchocerca volvulus 0.0029 0.0263 0.0495
Echinococcus granulosus neuroglian 0.0056 0.0685 0.0682
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0549 0.0546
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0555 0.5711
Brugia malayi nuclear receptor NHR-67 0.0014 0.0024 0.0024
Brugia malayi hypothetical protein 0.0014 0.0024 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0092 0.0089
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0943 0.0941
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0449 0.0446
Plasmodium vivax vivapain-2 0.0022 0.0146 0.1192
Brugia malayi Pre-SET motif family protein 0.0211 0.3088 0.3088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0549 0.0526
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0555 0.0697
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0092 0.004
Toxoplasma gondii exonuclease III APE 0.0021 0.0144 0.011
Entamoeba histolytica hypothetical protein 0.0043 0.0486 0.4758
Brugia malayi Cathepsin L-like precursor 0.0022 0.0146 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0263 0.0263
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0144 0.0285
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0068 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0018 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Trichomonas vaginalis set domain proteins, putative 0.024 0.354 0.9124
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0146 0.0143
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0024 0.0024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0449 0.1078
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0281 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.009
Echinococcus granulosus contactin 0.0018 0.0093 0.009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0263 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0146 0.0288
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0024 0.0021
Echinococcus granulosus tyrosine protein kinase otk 0.0018 0.0093 0.009
Brugia malayi Cathepsin L-like precursor 0.0014 0.0035 0.0035
Mycobacterium tuberculosis Conserved protein 0.0073 0.0943 0.1253
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0263 0.0263
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.005 0.0047
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0943 0.1253
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0263 0.0261
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0079 0.0076
Schistosoma mansoni cell adhesion molecule 0.0018 0.0093 0.0069
Echinococcus granulosus cathepsin l1 0.0022 0.0146 0.0143
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0144 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0263 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0146 0.0095
Schistosoma mansoni hypothetical protein 0.0043 0.0486 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2479 0.636
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0021
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0294 0.0292
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0068 0.0017
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0165 0.0163
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0714 0.0711
Onchocerca volvulus 0.0022 0.0146 0.0252
Echinococcus multilocularis zinc finger protein 0.002 0.0119 0.0116
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0263 0.0263
Toxoplasma gondii fructose-bisphospatase II 0.0656 1 1
Schistosoma mansoni zinc finger protein 0.0016 0.0051 0.0027
Schistosoma mansoni vesicular amine transporter 0.0048 0.0561 0.0538
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0144 0.1559
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0146 0.0291

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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