Detailed information for compound 1414631

Basic information

Technical information
  • TDR Targets ID: 1414631
  • Name: 2,3-di(furan-2-yl)-N-methylquinoxaline-6-carb oxamide
  • MW: 319.314 | Formula: C18H13N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1ccc2c(c1)nc(c(n2)c1ccco1)c1ccco1
  • InChi: 1S/C18H13N3O3/c1-19-18(22)11-6-7-12-13(10-11)21-17(15-5-3-9-24-15)16(20-12)14-4-2-8-23-14/h2-10H,1H3,(H,19,22)
  • InChiKey: VVPPIFAGOAUIGZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2,3-bis(2-furyl)-N-methyl-quinoxaline-6-carboxamide
  • 2,3-bis(2-furyl)-N-methyl-6-quinoxalinecarboxamide
  • 2,3-di(furan-2-yl)-N-methyl-quinoxaline-6-carboxamide
  • STK249926

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.1714 0.4099
Brugia malayi chromobox protein homolog 3 0.0047 0.1984 0.3289
Echinococcus multilocularis dna polymerase eta 0.0041 0.1605 0.266
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.3918 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0383 0.1488
Loa Loa (eye worm) ACC-1 protein 0.0026 0.071 0.17
Echinococcus multilocularis chromobox protein 1 0.0084 0.418 0.693
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.071 0.1178
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0026 0.071 0.1178
Leishmania major cathepsin L-like protease 0.002 0.0383 0.0072
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0357 0.0855
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1984 0.9031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Brugia malayi Cation transporter family protein 0.0026 0.071 0.1178
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0383 0.0635
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.1605 0.4096
Loa Loa (eye worm) hypothetical protein 0.0037 0.1378 0.3297
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0383 0.1488
Schistosoma mansoni nAChR subunit 0.0026 0.071 0.071
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0026 0.071 0.1178
Echinococcus granulosus cathepsin l1 0.002 0.0383 0.0635
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1714 0.1714
Schistosoma mansoni nAChR subunit 0.0026 0.071 0.071
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.7783 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0005 0.0009
Brugia malayi Heterochromatin protein 1 0.0084 0.418 0.693
Schistosoma mansoni nAChR subunit 0.0026 0.071 0.071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.071 0.1178
Schistosoma mansoni nAChR subunit 0.0026 0.071 0.071
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0026 0.071 0.1178
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.3918 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0026 0.071 0.1178
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0026 0.071 0.071
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0005 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.1842 0.4169
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.3918 1
Trypanosoma brucei unspecified product 0.0028 0.0853 0.1391
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.1923 0.3188
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0026 0.071 0.071
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.105 0.2512
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0357 0.1389
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.1605 0.3504
Onchocerca volvulus Cathepsin L homolog 0.002 0.0383 0.1744
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0045 0.0075
Entamoeba histolytica hypothetical protein 0.0014 0.0005 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3759 0.9553
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.1605 0.1605
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.3918 0.6495
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1984 0.4746
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Onchocerca volvulus 0.0026 0.071 0.3235
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.2574 1
Treponema pallidum NADH oxidase 0.002 0.0357 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0383 0.0635
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0357 0.1389
Loa Loa (eye worm) hypothetical protein 0.0041 0.1605 0.3839
Leishmania major cathepsin L-like protease 0.002 0.0383 0.0072
Onchocerca volvulus Putative nachr subunit 0.0026 0.071 0.3235
Toxoplasma gondii thioredoxin reductase 0.0057 0.2574 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.35 0.8374
Plasmodium falciparum glutathione reductase 0.0057 0.2574 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0383 0.0635
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.3918 0.6495
Leishmania major cathepsin L-like protease 0.002 0.0383 0.0072
Leishmania major DNA polymerase eta, putative 0.0041 0.1605 0.3504
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.1714 0.2841
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0026 0.071 0.1178
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.071 0.1178
Echinococcus multilocularis cysteine protease 0.002 0.0383 0.0635
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.105 0.1946
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0026 0.071 0.1178
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.2574 0.4267
Echinococcus multilocularis dna polymerase kappa 0.0073 0.3512 0.5823
Trypanosoma brucei unspecified product 0.0028 0.0853 0.1391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Entamoeba histolytica Flap nuclease, putative 0.0031 0.105 0.2681
Plasmodium vivax vivapain-2 0.002 0.0383 0.1488
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.105 0.1946
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.7783 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.1605 0.266
Schistosoma mansoni chromobox protein 0.0084 0.418 0.418
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1273 0.4947
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0026 0.071 0.17
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.1166 0.2789
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.3361 0.8438
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.3918 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.6032 1
Schistosoma mansoni jumonji domain containing protein 0.0092 0.4624 0.4624
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0357 0.0357
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0026 0.071 0.1178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.692 0.8837
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.1326 0.2721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trichomonas vaginalis chromobox protein, putative 0.0051 0.2196 0.5254
Echinococcus granulosus transcription factor Dp 1 0.0046 0.1923 0.3188
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.2574 0.6226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Onchocerca volvulus Cathepsin F homolog 0.002 0.0383 0.1744
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.1273 0.3046
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.105 0.2512
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0026 0.071 0.17
Schistosoma mansoni flap endonuclease-1 0.0028 0.0871 0.0871
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.1273 0.2111
Loa Loa (eye worm) GABA receptor subunit 0.0014 0.0005 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.3039 0.7532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Echinococcus granulosus flap endonuclease 1 0.0031 0.105 0.1741
Echinococcus multilocularis cysteine protease 0.002 0.0383 0.0635
Onchocerca volvulus 0.0026 0.071 0.3235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.3512 0.8403
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.105 0.4026
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.1326 0.2721
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.3759 0.9553
Schistosoma mansoni nAChR subunit 0.0026 0.071 0.071
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0045 0.0075
Trichomonas vaginalis chromobox protein, putative 0.0051 0.2196 0.5254
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0357 0.0593
Leishmania major cathepsin L-like protease 0.0077 0.3759 0.9553
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Echinococcus granulosus peregrin 0.0035 0.1273 0.2111
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0357 0.1389
Leishmania major DNA polymerase kappa, putative 0.0049 0.2078 0.4833
Plasmodium falciparum thioredoxin reductase 0.0057 0.2574 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.071 0.1178
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.071 0.1178
Brugia malayi glutathione reductase 0.0057 0.2574 0.4267
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.2196 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.071 0.1178
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.7783 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.071 0.1178
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.2574 0.2985
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0005 0.0009
Brugia malayi Cathepsin L-like precursor 0.002 0.0383 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0383 0.0635
Echinococcus granulosus nAChR subunit 0.0014 0.0005 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.1605 0.168
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.3918 0.3918
Onchocerca volvulus 0.002 0.0383 0.1744
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0383 0.0917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.071 0.1178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Brugia malayi Flap endonuclease-1 0.0031 0.105 0.1741
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.3918 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0026 0.071 0.1178
Brugia malayi Cathepsin L-like precursor 0.002 0.0383 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Loa Loa (eye worm) ACC-1 protein 0.0026 0.071 0.17
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.071 0.1178
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0357 0.1389
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.1714 0.2841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.071 0.1178
Leishmania major trypanothione reductase 0.0057 0.2574 0.6226
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0383 0.0978
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0026 0.071 0.071
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.1273 0.1273
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.3512 0.8862
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0026 0.071 0.17
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.071 0.1178
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.3512 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.692 0.8837
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0026 0.071 0.1178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Echinococcus granulosus chromobox protein 1 0.0084 0.418 0.693
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.692 0.8837
Echinococcus multilocularis nAChR subunit 0.0014 0.0005 0.0009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0357 0.0593
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Brugia malayi PHD-finger family protein 0.0035 0.1273 0.2111
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.105 0.408
Onchocerca volvulus 0.002 0.0383 0.1744
Loa Loa (eye worm) hypothetical protein 0.0035 0.1273 0.3046
Onchocerca volvulus 0.0014 0.0005 0.0025
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0005 0.0005
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0026 0.071 0.1178
Giardia lamblia DINP protein human, muc B family 0.0049 0.2078 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.418 0.693
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0026 0.071 0.1178
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.1605 0.266
Onchocerca volvulus 0.0014 0.0005 0.0025
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.105 0.408
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0026 0.071 0.17
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.2574 0.6158
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.1273 0.4947
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3759 0.9553
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.071 0.1178
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.071 0.1178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Schistosoma mansoni nAChR subunit 0.0026 0.071 0.071
Brugia malayi jmjC domain containing protein 0.0043 0.1714 0.2841
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0383 0.0635
Loa Loa (eye worm) hypothetical protein 0.0045 0.1842 0.4405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.1605 0.1605
Onchocerca volvulus 0.002 0.0383 0.1744
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.071 0.071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0383 0.0917
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3759 0.9553
Brugia malayi Cathepsin L-like precursor 0.002 0.0383 0.0635
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0357 0.0855
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Trypanosoma brucei trypanothione reductase 0.0057 0.2574 0.6226
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.2093 0.3469
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.071 0.1178
Onchocerca volvulus 0.002 0.0383 0.1744
Leishmania major cathepsin L-like protease 0.002 0.0383 0.0072
Entamoeba histolytica cysteine protease, putative 0.002 0.0383 0.0978
Loa Loa (eye worm) cysteine protease 0.002 0.0383 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0357 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0026 0.071 0.1178
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Brugia malayi polk-prov protein 0.0045 0.1842 0.3053
Plasmodium falciparum phd finger protein, putative 0.0035 0.1273 0.4947
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.1605 0.266
Echinococcus granulosus nAChR subunit 0.0026 0.071 0.1178
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0005 0.0009
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.1605 0.3839
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.3512 0.8862
Mycobacterium tuberculosis Probable reductase 0.013 0.692 0.8837
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.418 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.1166 0.2789
Brugia malayi jmjC domain containing protein 0.0115 0.6032 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.071 0.1178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Brugia malayi Cation transporter family protein 0.0026 0.071 0.1178
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0383 0.1488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0026 0.071 0.1178
Brugia malayi Bromodomain containing protein 0.0035 0.1273 0.2111
Echinococcus granulosus dna polymerase eta 0.0041 0.1605 0.266
Leishmania major cathepsin L-like protease 0.0077 0.3759 0.9553
Leishmania major cysteine peptidase A (CPA) 0.002 0.0383 0.0072
Trichomonas vaginalis chromobox protein, putative 0.0084 0.418 1
Onchocerca volvulus 0.002 0.0383 0.1744
Plasmodium falciparum flap endonuclease 1 0.0031 0.105 0.408
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.2078 0.2317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Echinococcus multilocularis peregrin 0.0035 0.1273 0.2111
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0026 0.071 0.1178
Loa Loa (eye worm) fibroinase 0.002 0.0383 0.0917
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.3918 0.6495
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Onchocerca volvulus 0.0026 0.071 0.3235
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1984 0.4746
Plasmodium falciparum glutathione reductase 0.002 0.0357 0.1389
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0383 0.0917
Plasmodium vivax vivapain-2 0.002 0.0383 0.1488
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.1273 0.2111
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0383 0.0635
Schistosoma mansoni nAChR subunit 0.0026 0.071 0.071
Plasmodium vivax glutathione reductase, putative 0.0057 0.2574 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0383 0.0917
Loa Loa (eye worm) LGC-31 protein 0.0026 0.071 0.17
Echinococcus granulosus dna polymerase kappa 0.0073 0.3512 0.5823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Onchocerca volvulus 0.0026 0.071 0.3235
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.105 0.1946
Echinococcus multilocularis nAChR subunit 0.0026 0.071 0.1178
Onchocerca volvulus 0.0026 0.071 0.3235
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0383 0.0383
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.071 0.1178
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0026 0.071 0.1178
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.3918 0.9372
Schistosoma mansoni DNA polymerase eta 0.0041 0.1605 0.1605
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0026 0.071 0.1178
Echinococcus granulosus jumonji domain containing protein 0.0049 0.2093 0.3469
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Onchocerca volvulus 0.0037 0.1378 0.6276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.2078 0.4833
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0026 0.071 0.17
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.1842 0.4169
Onchocerca volvulus 0.0026 0.071 0.3235
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0357 0.5
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.2574 0.4267
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0383 0.0917
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.1605 0.266
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.2779 0.6802
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0383 0.0072
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.3512 0.8403
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.3512 1
Echinococcus multilocularis flap endonuclease 1 0.0031 0.105 0.1741
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.2078 0.4833
Trypanosoma brucei unspecified product 0.0065 0.3039 0.7532
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0357 0.1389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.071 0.071
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0026 0.071 0.1178
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.071 0.1178
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0407 0.1582
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.692 0.8837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Loa Loa (eye worm) glutathione reductase 0.0057 0.2574 0.6158
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.692 0.8837
Toxoplasma gondii cathepsin CPL 0.002 0.0383 0.1488
Schistosoma mansoni hypothetical protein 0.0035 0.1273 0.1273
Giardia lamblia PHD finger protein 15 0.0035 0.1273 0.5324
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0357 0.0593
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0383 0.0917
Brugia malayi Cathepsin L-like precursor 0.002 0.0383 0.0635
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.071 0.1178
Loa Loa (eye worm) ctsf protein 0.002 0.0383 0.0917
Onchocerca volvulus Alhambra homolog 0.0035 0.1273 0.5798
Brugia malayi Cation transporter family protein 0.0026 0.071 0.1178
Onchocerca volvulus 0.002 0.0383 0.1744
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0383 0.0978
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0013
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0357 0.1389
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0026 0.071 0.1178
Echinococcus granulosus chromobox protein 1 0.0084 0.418 0.693
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.071 0.1178
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.071 0.071
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.1273 0.4947
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.071 0.1178
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0383 0.0635
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0383 0.0635
Schistosoma mansoni chromobox protein 0.0084 0.418 0.418
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0357 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1714 0.1714
Loa Loa (eye worm) hypothetical protein 0.0047 0.1984 0.4746
Loa Loa (eye worm) hypothetical protein 0.0026 0.071 0.17
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.6032 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.1605 0.3504
Leishmania major cathepsin L-like protease 0.0077 0.3759 0.9553
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Plasmodium falciparum thioredoxin reductase 0.002 0.0357 0.1389
Leishmania major cathepsin L-like protease 0.002 0.0383 0.0072
Onchocerca volvulus 0.002 0.0383 0.1744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.7783 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.071 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0026 0.071 0.17
Brugia malayi Thioredoxin reductase 0.0057 0.2574 0.4267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3759 0.9553
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0014 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.3512 0.8862
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.071 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.1326 0.2721
Brugia malayi excitatory GABA receptor EXP-1A 0.0026 0.071 0.1178
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.071 0.1178
Trichomonas vaginalis chromobox protein, putative 0.0084 0.418 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0383 0.0917
Onchocerca volvulus Cathepsin L homolog 0.002 0.0383 0.1744
Brugia malayi Cathepsin L-like precursor 0.002 0.0383 0.0635
Loa Loa (eye worm) hypothetical protein 0.006 0.2768 0.6621

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay. (Class of assay: confirmatory) [Related pubchem assays: 1476 (Cruzain without detergent), 1478 (Cruzain with detergent)] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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