Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0697 | 0.0536 | 0.056 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.8994 | 1 | 1 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0388 | 0.0183 | 0.0183 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0378 | 0.0172 | 0.0172 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8994 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8628 | 0.9583 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.8628 | 0.9583 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.4105 | 0.4423 | 0.4398 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.8994 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0378 | 0.0172 | 0.0179 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.4824 | 0.5243 | 0.5388 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4105 | 0.4423 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0378 | 0.0172 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0378 | 0.0172 | 0.0292 |
Schistosoma mansoni | hypothetical protein | 0.0378 | 0.0172 | 0.0179 |
Onchocerca volvulus | 0.8628 | 0.9583 | 1 | |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0378 | 0.0172 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0378 | 0.0172 | 0.0292 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0378 | 0.0172 | 0.0172 |
Schistosoma mansoni | thymidylate kinase | 0.0378 | 0.0172 | 0.0179 |
Loa Loa (eye worm) | thymidylate synthase | 0.8628 | 0.9583 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.8628 | 0.9583 | 1 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.4824 | 0.5243 | 0.5388 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0388 | 0.0183 | 0.014 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0388 | 0.0183 | 0.014 |
Echinococcus granulosus | dihydrofolate reductase | 0.0697 | 0.0536 | 0.0387 |
Brugia malayi | dihydrofolate reductase family protein | 0.0697 | 0.0536 | 0.0387 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.4824 | 0.5243 | 0.5388 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0378 | 0.0172 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0697 | 0.0536 | 0.0387 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.8628 | 0.9583 | 1 |
Leishmania major | thymidylate kinase-like protein | 0.0378 | 0.0172 | 0.0128 |
Echinococcus multilocularis | thymidylate synthase | 0.8628 | 0.9583 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0697 | 0.0536 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.8994 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.4105 | 0.4423 | 0.4517 |
Giardia lamblia | CDC8 | 0.0378 | 0.0172 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0378 | 0.0172 | 0.0128 |
Brugia malayi | hypothetical protein | 0.4105 | 0.4423 | 0.4517 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0697 | 0.0536 | 0.0387 |
Brugia malayi | thymidylate synthase | 0.8628 | 0.9583 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0697 | 0.0536 | 0.0387 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0388 | 0.0183 | 0.014 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0697 | 0.0536 | 0.0387 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0378 | 0.0172 | 0.0128 |
Mycobacterium ulcerans | thymidylate synthase | 0.8628 | 0.9583 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8994 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0697 | 0.0536 | 0.0387 |
Brugia malayi | Dihydrofolate reductase | 0.0697 | 0.0536 | 0.0387 |
Trypanosoma brucei | thymidine kinase | 0.0266 | 0.0044 | 0.0044 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2 mg kg-1 | Inhibition of apomorphine induced emesis in dogs following p.o. administration. | ChEMBL. | 6147414 |
ED50 (functional) | > 50 mg kg-1 | Inhibition of apomorphine induced climbing in mice following p.o. administration. | ChEMBL. | 6147414 |
ED50 (functional) | > 50 mg kg-1 | Inhibition of apomorphine induced climbing in mice following p.o. administration. | ChEMBL. | 6147414 |
LD50 (ADMET) | > 500 mg kg-1 | Toxicity in mice following p.o. administration. | ChEMBL. | 6147414 |
LD50 (ADMET) | > 500 mg kg-1 | Toxicity in mice following p.o. administration. | ChEMBL. | 6147414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.