Detailed information for compound 1415169

Basic information

Technical information
  • TDR Targets ID: 1415169
  • Name: 2-[(1,1-dioxo-1,2-benzothiazol-3-yl)sulfanyl] -N-phenylacetamide
  • MW: 332.397 | Formula: C15H12N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 2.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)CSC1=NS(=O)(=O)c2c1cccc2
  • InChi: 1S/C15H12N2O3S2/c18-14(16-11-6-2-1-3-7-11)10-21-15-12-8-4-5-9-13(12)22(19,20)17-15/h1-9H,10H2,(H,16,18)
  • InChiKey: AGHRALKGLMEALT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(1,1-dioxo-1,2-benzothiazol-3-yl)sulfanyl]-N-phenyl-acetamide
  • 2-[(1,1-dioxo-1,2-benzothiazol-3-yl)thio]-N-phenylacetamide
  • 2-[(1,1-diketo-1,2-benzothiazol-3-yl)thio]-N-phenyl-acetamide
  • 2-[(1,1-dioxo-1,2-benzothiazol-3-yl)sulfanyl]-N-phenyl-ethanamide
  • ChemDiv2_006792
  • IDI1_005507
  • SMR000095170
  • MLS000118226

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Simian virus 40 Large T antigen Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Saccharomyces cerevisiae ribosomal 60S subunit protein L19B Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Plasmodium falciparum 60S ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum LSU ribosomal protein L19E, related Get druggable targets OG5_126940 All targets in OG5_126940
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma japonicum IPR009041,Proteinase inhibitor, PMP and SGCI,domain-containing Get druggable targets OG5_126940 All targets in OG5_126940
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Echinococcus multilocularis ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) DnaJ domain-containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Trypanosoma brucei 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09536 DnaJ homolog, subfamily C, member 16, putative Get druggable targets OG5_132364 All targets in OG5_132364
Leishmania braziliensis 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Leishmania mexicana 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi 60S ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_132364 All targets in OG5_132364
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Echinococcus granulosus dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii 60S ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Trichomonas vaginalis 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Entamoeba histolytica 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Trypanosoma cruzi 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni 60S ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium vivax 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Plasmodium berghei 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis 60S ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Trypanosoma congolense 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis protein kinase inhibitor, putative Get druggable targets OG5_132364 All targets in OG5_132364
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania donovani 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K02885 large subunit ribosomal protein L19e, putative Get druggable targets OG5_126940 All targets in OG5_126940
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Trypanosoma brucei 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi DnaJ domain containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Echinococcus multilocularis dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium knowlesi 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ribosomal protein RPL19 Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum 60S ribosomal protein L19 Get druggable targets OG5_126940 All targets in OG5_126940
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Leishmania braziliensis 60S ribosomal protein L19, putative Get druggable targets OG5_126940 All targets in OG5_126940
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0173 0.0231
Brugia malayi hypothetical protein 0.0024 0.0154 0.0205
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0536 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3072 0.324
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0536 0.0536
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0536 0.064
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3072 0.3072
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.031 0.035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0173 0.0173
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0536 0.086
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8631 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0297 0.1303
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0154 0.0297
Schistosoma mansoni loxhd1 0.0024 0.0154 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3072 0.324
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0536 1
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0173 0.0231
Mycobacterium ulcerans hypothetical protein 0.0029 0.031 0.1377
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0536 0.0157
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0173 0.0231
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0536 0.0713
Plasmodium falciparum glutathione reductase 0.0036 0.0536 0.1748
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.031 0.1377
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3072 0.3442
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0173 0.0435
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0173 0.0435
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0173 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3072 0.324
Brugia malayi AMP-binding enzyme family protein 0.0029 0.031 0.0413
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.031 0.1377
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0536 0.1343
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.1776 0.2365
Brugia malayi DnaJ domain containing protein 0.0074 0.1776 0.2365
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0173 0.0173
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0536 0.1748
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0101
Plasmodium vivax 60S ribosomal protein L19, putative 0.0032 0.0407 0.1258
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1755 0.5253
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0173 0.0435
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1755 0.9883
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.1774 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0536 0.099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.055 0.1378
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.0484
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3072 0.7702
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0101
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0154 0.0386
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.0484
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0173 0.0435
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3072 0.7702
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0536 0.2707
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3072 0.324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0173 0.0231
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1755 0.2209
Entamoeba histolytica hypothetical protein 0.0043 0.0789 0.1772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.0484
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.7809 1
Plasmodium falciparum 60S ribosomal protein L19 0.0032 0.0407 0.1258
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0032 0.0407 0.0395
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.031 0.1377
Schistosoma mansoni hypothetical protein 0.0074 0.1776 0.1776
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.031 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.031 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0173 0.0231
Brugia malayi 60S ribosomal protein L19 0.0032 0.0407 0.0542
Brugia malayi AMP-binding enzyme family protein 0.0029 0.031 0.0413
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.031 0.0046
Mycobacterium tuberculosis Probable reductase 0.0234 0.6963 0.8912
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0297 0.1303
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2727 0.6836
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.055 0.1048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.031 0.035
Echinococcus multilocularis RUN 0.0024 0.0154 0.0386
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.1776 0.4452
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.7809 1
Echinococcus granulosus ribosomal protein L19 0.0032 0.0407 0.102
Giardia lamblia Kinase, PLK 0.0114 0.3072 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0173 0.0023
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.6963 0.8912
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3072 0.324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.031 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1755 0.1755
Echinococcus multilocularis ribosomal protein L19 0.0032 0.0407 0.102
Echinococcus granulosus RUN 0.0024 0.0154 0.0386
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.086
Loa Loa (eye worm) hypothetical protein 0.0032 0.0407 0.0542
Brugia malayi hypothetical protein 0.0043 0.0789 0.105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.055 0.055
Schistosoma mansoni hypothetical protein 0.0043 0.0789 0.0789
Brugia malayi steroid hormone receptor 0.0024 0.0173 0.0231
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0173 0.0173
Leishmania major 60S ribosomal protein L19, putative 0.0032 0.0407 0.0395
Loa Loa (eye worm) hypothetical protein 0.0024 0.0154 0.0205
Echinococcus granulosus ribosomal protein L19 0.0032 0.0407 0.102
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.1774 0.2363
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.031 0.1377
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1755 0.6048
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.055 0.1378
Loa Loa (eye worm) hypothetical protein 0.0041 0.0715 0.0952
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.133 0.1772
Plasmodium vivax SET domain protein, putative 0.0036 0.055 0.1801
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0173 0.0173
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0297 0.4813
Trypanosoma brucei trypanothione reductase 0.0103 0.2707 0.8685
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0536 0.099
Schistosoma mansoni polycystin 1-related 0.0024 0.0154 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0173 0.0231
Trypanosoma brucei polo-like protein kinase 0.0114 0.3072 1
Entamoeba histolytica hypothetical protein 0.0043 0.0789 0.1772
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Schistosoma mansoni kinase 0.0058 0.1258 0.1258
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0154 0.0386
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.7809 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0173 0.0231
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.1473 0.1962
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0173 0.0435
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.1774 0.5325
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2707 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0154 0.0386
Entamoeba histolytica hypothetical protein 0.0043 0.0789 0.1772
Schistosoma mansoni hypothetical protein 0.0024 0.0154 0.0154
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3072 0.4091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.055 0.1378
Plasmodium falciparum thioredoxin reductase 0.0103 0.2707 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Leishmania major trypanothione reductase 0.0103 0.2707 0.8685
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0173 0.0435
Brugia malayi nuclear receptor NHR-88 0.0024 0.0173 0.0231
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0536 0.086
Loa Loa (eye worm) glutathione reductase 0.0103 0.2707 0.3605
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0173 0.0435
Schistosoma mansoni 60S ribosomal protein L19 0.0032 0.0407 0.0407
Schistosoma mansoni rab6-interacting 0.0024 0.0154 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3072 0.324
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0173 0.0231
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.1776 0.4452
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.6963 0.8912
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1755 0.4399
Brugia malayi AMP-binding enzyme family protein 0.0029 0.031 0.0413
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0154 0.0386
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1755 0.9883
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0536 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0173 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0173 0.0231
Echinococcus multilocularis ribosomal protein L19 0.0032 0.0407 0.102
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0536 0.0157
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2707 0.3605
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.263 0.3502
Schistosoma mansoni coup transcription factor 0.0024 0.0173 0.0173
Brugia malayi Pre-SET motif family protein 0.0251 0.7509 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3072 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0173 0.0231
Leishmania major 60S ribosomal protein L19, putative 0.0032 0.0407 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0173 0.0231
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.121 0.0976
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0173 0.0435
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.086
Brugia malayi Pre-SET motif family protein 0.0036 0.055 0.0732
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0789 0.1978
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.031 0.1377
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.6963 0.8912
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0154 0.0386
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.031 0.1377
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2727 0.6836
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0032 0.0407 0.0395
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0173 0.0023
Treponema pallidum NADH oxidase 0.0036 0.0536 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3072 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0173 0.0231
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0536 0.086
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0173 0.0435
Brugia malayi Thioredoxin reductase 0.0103 0.2707 0.3605
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0536 0.1748
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0173 0.0231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.133 0.1772
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.1774 0.1774
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0173 0.0231
Brugia malayi Doublecortin family protein 0.0024 0.0154 0.0205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0789 0.1978
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0173 0.0435
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.055 0.0732
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.1774 1
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0173 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0173 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.055 0.055
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0536 0.1343
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.031 0.0046
Schistosoma mansoni lipoxygenase 0.01 0.2603 0.2603
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0173 0.0435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.0484
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0536 0.086
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.023 0.0306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.031 0.0046
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.6963 0.8912
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0032 0.0407 0.0395
Toxoplasma gondii thioredoxin reductase 0.0103 0.2707 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.7809 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.3988 1
Brugia malayi nuclear hormone receptor 0.0024 0.0173 0.0231
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0101
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.263 0.263
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0536 0.086
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.1774 0.4449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0173 0.0231
Schistosoma mansoni rab6-interacting 0.0024 0.0154 0.0154
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0507 0.127
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2707 0.3434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0173 0.0231
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0032 0.0407 0.0395
Schistosoma mansoni lipoxygenase 0.0142 0.3988 0.3988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0154 0.0205
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.0484
Loa Loa (eye worm) hypothetical protein 0.01 0.263 0.3502
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0173 0.0231
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.006 0.133 0.1772
Loa Loa (eye worm) hypothetical protein 0.0029 0.031 0.0413
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3072 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0173 0.0231
Plasmodium falciparum thioredoxin reductase 0.0036 0.0536 0.1748
Loa Loa (eye worm) hypothetical protein 0.0029 0.031 0.0413
Loa Loa (eye worm) hypothetical protein 0.0029 0.031 0.0413
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3072 0.324
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0173 0.0173
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0173 0.0435
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0173 0.0435
Toxoplasma gondii ribosomal protein RPL19 0.0032 0.0407 0.0455
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0173 0.0173
Onchocerca volvulus 0.0036 0.055 0.0467
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.133 0.1772
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0173 0.0231
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0715 0.0952
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0173 0.0231
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0536 0.0484
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0154 0.0386
Schistosoma mansoni hypothetical protein 0.0041 0.0715 0.0715
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0536 0.2707
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.031 0.0017
Onchocerca volvulus 0.01 0.263 0.2921
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.263 0.6594
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0154 0.0205
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1755 0.9883
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0536 0.0484
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0154 0.0297
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0173 0.0435
Plasmodium falciparum glutathione reductase 0.0103 0.2707 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.6963 0.8912
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.1776 0.1664
Onchocerca volvulus 0.0024 0.0173 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2707 0.8631
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1755 0.1755
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0789 0.0789
Brugia malayi ecdysteroid receptor 0.0024 0.0173 0.0231
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.031 0.1377
Onchocerca volvulus 0.0029 0.031 0.0184
Brugia malayi hypothetical protein 0.0024 0.0154 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.055 0.055
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0536 0.1748
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0536 0.0484
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7509 1
Entamoeba histolytica hypothetical protein 0.0043 0.0789 0.1772
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0297 0.0841
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0173 0.0435
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0536 0.0484
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0173 0.0173
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3072 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0173 0.0231
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.1774 0.2234
Plasmodium vivax glutathione reductase, putative 0.0103 0.2707 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0076 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0173 0.0231
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0536 0.086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0173 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.055 0.055
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3072 0.4091
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0536 0.2707
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0297 0.0333
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.6963 0.8874
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.263 0.6594
Onchocerca volvulus 0.0286 0.8631 1
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0173 0.0435
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.023 0.0306
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.121 0.0976
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.3988 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0173 0.0435
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1755 0.4399
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0101
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0297 0.0841
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0536 0.1748
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.031 0.0017
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.1774 0.4449
Brugia malayi glutathione reductase 0.0103 0.2707 0.3605

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.501 uM PUBCHEM_BIOASSAY: Dose Response of TOR pathway GFP-fusion proteins in Saccharomyces cerevisiae specifically RPL19A based on MLPCN hits. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1908, AID488814, AID488818] ChEMBL. No reference
IC50 (functional) 12.2 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.6213 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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