Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Echinococcus multilocularis | neuroligin | 0.0384 | 0.1483 | 0.1483 |
Onchocerca volvulus | 0.0384 | 0.1483 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2273 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0384 | 0.1483 | 0.1483 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0384 | 0.1483 | 0.1483 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0384 | 0.1483 | 0.1483 |
Onchocerca volvulus | 0.0384 | 0.1483 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0384 | 0.1483 | 0.1483 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0384 | 0.1483 | 0.1483 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0384 | 0.1483 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | carboxylesterase | 0.0384 | 0.1483 | 0.1483 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0384 | 0.1483 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0384 | 0.1483 | 0.1483 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0384 | 0.1483 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0384 | 0.1483 | 0.1483 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2273 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0384 | 0.1483 | 0.1483 |
Schistosoma mansoni | acetylcholinesterase | 0.0384 | 0.1483 | 0.1483 |
Onchocerca volvulus | 0.0384 | 0.1483 | 0.5 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.4166 | 0.4166 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0384 | 0.1483 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0384 | 0.1483 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Echinococcus granulosus | carboxylesterase 5A | 0.2273 | 1 | 1 |
Onchocerca volvulus | 0.0384 | 0.1483 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Echinococcus multilocularis | acetylcholinesterase | 0.2273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0384 | 0.1483 | 0.1483 |
Brugia malayi | Carboxylesterase family protein | 0.0384 | 0.1483 | 0.1483 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0384 | 0.1483 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0384 | 0.1483 | 0.1483 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | carboxylesterase | 0.2273 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0384 | 0.1483 | 0.1483 |
Brugia malayi | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1483 | 0.1483 |
Onchocerca volvulus | 0.0384 | 0.1483 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.2273 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.2273 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2273 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2273 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0384 | 0.1483 | 0.1483 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2273 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.6513 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.