Detailed information for compound 1415519

Basic information

Technical information
  • TDR Targets ID: 1415519
  • Name: N-acenaphthen-5-yl-2-[1-(4-fluorophenyl)-6-hy droxy-5-methyl-4-oxopyrimidin-2-yl]sulfanylac etamide
  • MW: 461.508 | Formula: C25H20FN3O3S
  • H donors: 2 H acceptors: 3 LogP: 4.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c3c1cccc3CC2)CSc1nc(=O)c(c(n1c1ccc(cc1)F)O)C
  • InChi: 1S/C25H20FN3O3S/c1-14-23(31)28-25(29(24(14)32)18-10-8-17(26)9-11-18)33-13-21(30)27-20-12-7-16-6-5-15-3-2-4-19(20)22(15)16/h2-4,7-12,32H,5-6,13H2,1H3,(H,27,30)
  • InChiKey: JFSYWNJNKGRFON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-acenaphthen-5-yl-2-[1-(4-fluorophenyl)-6-hydroxy-5-methyl-4-oxo-pyrimidin-2-yl]sulfanyl-acetamide
  • N-(5-acenaphthenyl)-2-[[1-(4-fluorophenyl)-6-hydroxy-5-methyl-4-oxo-2-pyrimidinyl]thio]acetamide
  • N-acenaphthen-5-yl-2-[[1-(4-fluorophenyl)-6-hydroxy-4-keto-5-methyl-pyrimidin-2-yl]thio]acetamide
  • N-acenaphthen-5-yl-2-[1-(4-fluorophenyl)-6-hydroxy-5-methyl-4-oxo-pyrimidin-2-yl]sulfanyl-ethanamide
  • N-(1,2-dihydro-5-acenaphthylenyl)-2-{[1-(4-fluorophenyl)-4-hydroxy-5-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl]sulfanyl}acetamide
  • SMR000226482
  • AH-487/40669531
  • MLS000698897

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Plasmodium falciparum M17 leucyl aminopeptidase Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Trypanosoma congolense metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania mexicana cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum M17 leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae Probable cytosol aminopeptidase PepB Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis leucine aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative leucine aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania infantum cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense cytosolic leucyl aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Cryptosporidium parvum putative leucine aminopeptidase; of possible plant or bacterial origin Get druggable targets OG5_127293 All targets in OG5_127293
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani cytosolic leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus leucine aminopeptidase protein Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aminopeptidase PepB Get druggable targets OG5_127293 All targets in OG5_127293
Babesia bovis leucine aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis leucine aminopeptidase protein Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva leucine aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Neospora caninum Probable cytosol aminopeptidase, related Get druggable targets OG5_127293 All targets in OG5_127293
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii leucyl aminopeptidase LAP Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis cytosol aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni intermediate filament proteins 0.0033 0.0945 0.0869
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0361 0.0061
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0333 0.0333
Brugia malayi Protein kinase domain containing protein 0.0016 0.0266 0.0185
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0333 0.0552
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0333 0.0552
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0333 0.0552
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.113 0.2198
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0476 1
Echinococcus granulosus geminin 0.0205 0.8128 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0476 0.272
Trypanosoma cruzi cytochrome P450, putative 0.0103 0.3896 0.7913
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.1825 0.3262
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0085 0.0002
Leishmania major cytochrome p450-like protein 0.0103 0.3896 0.7913
Loa Loa (eye worm) hypothetical protein 0.0016 0.0266 0.0266
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.113 0.2198
Leishmania major cytochrome p450-like protein 0.0093 0.3481 0.7056
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.4695 0.6804
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.5265 1
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0361 0.061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0085 0.0085
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0266 0.0228
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.0645 0.0645
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0093 0.3481 0.6865
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.0645 0.0699
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0093 0.3481 0.6382
Loa Loa (eye worm) hypothetical protein 0.0016 0.0241 0.0241
Plasmodium falciparum glutathione reductase 0.0019 0.0361 0.0574
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.3073 0.3718
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0093 0.3481 0.6865
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0361 0.1385
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0093 0.3481 0.7056
Loa Loa (eye worm) hypothetical protein 0.0148 0.5762 0.5762
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0127 0.4905 1
Plasmodium falciparum M17 leucyl aminopeptidase 0.0127 0.4905 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.4695 0.8844
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0645 0.0567
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0093 0.3481 0.6382
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0645 0.0699
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0093 0.3481 0.6382
Echinococcus granulosus intermediate filament protein 0.0033 0.0945 0.1071
Brugia malayi hypothetical protein 0.0148 0.5762 0.5726
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0645 0.0699
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0093 0.3481 0.6382
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0361 0.0281
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0266 0.0266
Brugia malayi Cytochrome P450 family protein 0.0103 0.3896 0.3845
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0083 0.0083
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0093 0.3481 0.6865
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0361 0.061
Echinococcus granulosus death domain containing protein 0.0016 0.0266 0.0228
Loa Loa (eye worm) RecQ helicase 0.0029 0.0795 0.0795
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0093 0.3481 0.6865
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0093 0.3481 0.7056
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0093 0.3481 0.7056
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.0645 0.0645
Echinococcus multilocularis Ankyrin 0.0016 0.0272 0.0235
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0645 0.1197
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0333 0.0552
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0093 0.3481 0.6865
Schistosoma mansoni lamin 0.0033 0.0945 0.0869
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0093 0.3481 0.6382
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0093 0.3481 0.6865
Brugia malayi isocitrate dehydrogenase 0.0018 0.0333 0.0253
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0127 0.4905 1
Echinococcus multilocularis 0.0093 0.3481 0.4224
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0266 0.0228
Echinococcus granulosus expressed protein 0.0038 0.1167 0.1348
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.5265 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0361 0.061
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0313 0.0233
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0085 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0945 0.0869
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0093 0.3481 0.7056
Loa Loa (eye worm) hypothetical protein 0.007 0.2518 0.2518
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0333 0.0312
Toxoplasma gondii cytochrome p450 superfamily protein 0.0093 0.3481 0.7056
Schistosoma mansoni DNA helicase recq5 0.0012 0.0085 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0361 0.0574
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0085 0.0038
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.113 1
Loa Loa (eye worm) fli-1 protein 0.0249 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0266 0.0185
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0333 0.0312
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0085 0.0085
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0361 0.0346
Plasmodium falciparum thioredoxin reductase 0.0054 0.1825 0.361
Echinococcus multilocularis leucine aminopeptidase protein 0.0127 0.4905 0.5995
Schistosoma mansoni ap endonuclease 0.0021 0.0476 0.0397
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0083
Brugia malayi glutathione reductase 0.0054 0.1825 0.1757
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0476 0.0476
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0361 0.061
Loa Loa (eye worm) hypothetical protein 0.0033 0.0945 0.0945
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0232 0.0342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0476 0.0489
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0093 0.3481 0.6382
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0795 0.0886
Loa Loa (eye worm) CYP4Cod1 0.0103 0.3896 0.3896
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0266 0.0228
Schistosoma mansoni netrin receptor unc5 0.0016 0.0266 0.0185
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0127 0.4905 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0216 0.0216
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0025 0.0645 0.0567
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0945 0.0945
Brugia malayi Cytochrome P450 family protein 0.0103 0.3896 0.3845
Brugia malayi Ets-domain containing protein 0.0082 0.3015 0.2957
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0085 0.0002
Toxoplasma gondii exonuclease III APE 0.0021 0.0476 0.0847
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0361 0.061
Loa Loa (eye worm) cytochrome P450 family protein 0.0093 0.3481 0.3481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0645 0.0699
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0645 0.1197
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0795 0.6024
Plasmodium falciparum thioredoxin reductase 0.0019 0.0361 0.0574
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0127 0.4905 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0093 0.3481 0.6865
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0266 0.0228
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0093 0.3481 0.6382
Brugia malayi intermediate filament protein 0.0033 0.0945 0.0869
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0476 0.0847
Brugia malayi cytochrome P450 0.0093 0.3481 0.3426
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0361 0.061
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0093 0.3481 0.6382
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0313 0.0313
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0093 0.3481 0.6382
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0476 0.0847
Brugia malayi Uncoordinated protein 44 0.0016 0.0266 0.0185
Echinococcus multilocularis expressed protein 0.0038 0.1167 0.1348
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0645 0.0699
Echinococcus granulosus leucine aminopeptidase protein 0.0127 0.4905 0.5995
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0093 0.3481 0.6382
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0155 0.0073
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0333 0.0312
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0241 0.0197
Loa Loa (eye worm) cytochrome P450 family protein 0.0103 0.3896 0.3896
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0093 0.3481 0.6865
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0093 0.3481 0.6382
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0093 0.3481 0.6865
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.4695 0.8844
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.1825 0.1825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Plasmodium falciparum glutathione reductase 0.0054 0.1825 0.361
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0093 0.3481 0.6865
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.5265 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0333 0.0552
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0361 0.7069
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0083 0.0083
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0361 0.0281
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0361 0.0346
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0232 0.0342
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0645 0.1197
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.0645 0.0567
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0093 0.3481 0.6382
Trichomonas vaginalis rotamase, putative 0.0037 0.113 0.9602
Brugia malayi Cytochrome P450 family protein 0.0093 0.3481 0.3426
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0232 0.0342
Mycobacterium tuberculosis Probable reductase 0.0122 0.4695 0.8844
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0083 0.0083
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0093 0.3481 0.6382
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0361 0.061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0361 0.0056
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0093 0.3481 0.6865
Trypanosoma brucei cytochrome P450, putative 0.0103 0.3896 0.7913
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0361 0.0061
Brugia malayi cytosol aminopeptidase 0.0025 0.0645 0.0567
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0645 0.0699
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.3015 0.3015
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.1167 0.1167
Brugia malayi Ets-domain containing protein 0.0082 0.3015 0.2957
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0333 0.0552
Echinococcus multilocularis musashi 0.0033 0.0945 0.1071
Echinococcus granulosus bloom syndrome protein 0.0029 0.0795 0.0886
Plasmodium vivax glutathione reductase, putative 0.0054 0.1825 0.3262
Schistosoma mansoni ap endonuclease 0.0021 0.0476 0.0397
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0093 0.3481 0.6382
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.113 0.2198
Chlamydia trachomatis cytosol aminopeptidase 0.0127 0.4905 1
Leishmania major cytochrome p450-like protein 0.0093 0.3481 0.7056
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0333 0.0516
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0127 0.4905 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0333 0.0253
Trichomonas vaginalis rotamase, putative 0.0038 0.1167 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0103 0.3896 0.7778
Schistosoma mansoni hypothetical protein 0.0093 0.3481 0.3426
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0127 0.4905 0.7986
Loa Loa (eye worm) glutathione reductase 0.0054 0.1825 0.1825
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0645 0.1197
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0093 0.3481 0.6382
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.1825 0.3025
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0155 0.0073
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.4695 0.8844
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0083 0.0083
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0361 0.061
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0476 0.2611
Onchocerca volvulus 0.0033 0.0945 0.1235
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0648 0.1169
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0945 0.0945
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0093 0.3481 0.6382
Schistosoma mansoni hypothetical protein 0.0205 0.8128 0.8112
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0795 0.6024
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0093 0.3481 0.6865
Loa Loa (eye worm) hypothetical protein 0.0016 0.0272 0.0272
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0476 0.0252
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0093 0.3481 0.6865
Schistosoma mansoni cytochrome P450 0.0093 0.3481 0.3426
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0083
Echinococcus multilocularis lamin 0.0033 0.0945 0.1071
Echinococcus multilocularis lamin dm0 0.0033 0.0945 0.1071
Loa Loa (eye worm) hypothetical protein 0.0148 0.5762 0.5762
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0476 0.2611
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.4695 0.8844
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1167 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0093 0.3481 0.6865
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0127 0.4905 0.9271
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0093 0.3481 0.7056
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.1825 0.3634
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0093 0.3481 0.6382
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0093 0.3481 0.6865
Trypanosoma cruzi cytochrome P450, putative 0.0103 0.3896 0.7913
Trypanosoma brucei trypanothione reductase 0.0054 0.1825 0.3634
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0361 0.061
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0241 0.0197
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0333 0.0312
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0476 0.0289
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.113 0.2198
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0272 0.0191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0205 0.8128 0.8112
Leishmania major trypanothione reductase 0.0054 0.1825 0.3634
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0476 0.0847
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0093 0.3481 0.6865
Brugia malayi Thioredoxin reductase 0.0054 0.1825 0.1757
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.0645 0.0567
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0093 0.3481 0.6865
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.3015 0.3645
Brugia malayi Cytochrome P450 family protein 0.0093 0.3481 0.3426
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0085 0.0038
Schistosoma mansoni rotamase 0.0038 0.1167 0.1094
Echinococcus granulosus cytochrome P450 2K1 0.0093 0.3481 0.4224
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0093 0.3481 0.6382
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0333 0.0552
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.5265 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.5762 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0127 0.4905 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.5677 0.5677
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0476 0.0847
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0476 0.0489
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0361 0.061
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0476 0.0397
Echinococcus granulosus lamin dm0 0.0033 0.0945 0.1071
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0093 0.3481 0.6865
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0476 0.0812
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.1167 0.1094
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0361 0.061
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0403 0.0153
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.113 0.2198
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0645 0.1197
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0266 0.0185
Mycobacterium ulcerans leucyl aminopeptidase 0.0127 0.4905 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.3073 0.3718
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0093 0.3481 0.6865
Schistosoma mansoni ets-related 0.0249 1 1
Toxoplasma gondii thioredoxin reductase 0.0054 0.1825 0.3634
Schistosoma mansoni gabp alpha 0.0082 0.3015 0.2957
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0361 0.1385
Schistosoma mansoni lamin 0.0033 0.0945 0.0869
Echinococcus granulosus Ankyrin 0.0016 0.0272 0.0235
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0085 0.0002
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0795 0.0719
Loa Loa (eye worm) cytochrome P450 0.0093 0.3481 0.3481
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0127 0.4905 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0093 0.3481 0.6382
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0476 0.0312
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0645 0.1197
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0361 0.061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0333 0.0312
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0361 0.0574
Onchocerca volvulus Huntingtin homolog 0.0148 0.5762 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0085 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.092 0.092
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0541 0.0462
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.1825 0.2166
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.3015 0.3645
Brugia malayi Death domain containing protein 0.0016 0.0266 0.0185
Loa Loa (eye worm) cytochrome P450 family protein 0.0103 0.3896 0.3896
Schistosoma mansoni DNA helicase recq1 0.0012 0.0085 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0093 0.3481 0.6382
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0361 0.061
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0361 0.061
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0476 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0645 0.1197
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.1825 0.2166
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0645 0.1197
Echinococcus multilocularis geminin 0.0205 0.8128 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0333 0.0312
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0266 0.0185
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0476 0.0847
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0093 0.3481 0.6865
Echinococcus granulosus lamin 0.0033 0.0945 0.1071
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.4695 0.8844
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0394 0.0677
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0333 0.0253
Schistosoma mansoni leucine aminopeptidase 0.0025 0.0645 0.0567
Onchocerca volvulus 0.0033 0.0945 0.1235
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0085 0.0002

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6.36 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 59.642 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). (Class of assay: confirmatory) [Related pubchem assays: 1619 (Screening assay (M17LAP inhibitors).), 1445 (Screening Assay (M1AAP inhibitors).)] ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 73.456 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). (Class of assay: confirmatory) [Related PubChem assays: 1619 (Screening assay (M17LAP inhibitors).), 1445 (Screening assay (M1AAP inhibitors).)] ChEMBL. No reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.636 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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