Detailed information for compound 1415600

Basic information

Technical information
  • TDR Targets ID: 1415600
  • Name: 2-methyl-N-[4-(4-morpholin-4-ylsulfonylphenyl )-1,3-thiazol-2-yl]propanamide
  • MW: 395.496 | Formula: C17H21N3O4S2
  • H donors: 1 H acceptors: 4 LogP: 1.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(=O)Nc1scc(n1)c1ccc(cc1)S(=O)(=O)N1CCOCC1)C
  • InChi: 1S/C17H21N3O4S2/c1-12(2)16(21)19-17-18-15(11-25-17)13-3-5-14(6-4-13)26(22,23)20-7-9-24-10-8-20/h3-6,11-12H,7-10H2,1-2H3,(H,18,19,21)
  • InChiKey: GQVLBTXOVGKXTG-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methyl-N-[4-(4-morpholinosulfonylphenyl)thiazol-2-yl]propanamide
  • 2-methyl-N-[4-(4-morpholinosulfonylphenyl)-2-thiazolyl]propanamide
  • 2-methyl-N-[4-(4-morpholinosulfonylphenyl)thiazol-2-yl]propionamide
  • ZINC01020412

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens fatty acid synthase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.2595 0.6016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.2595 0.2595
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.9412 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.1195 0.0807
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.3912 0.5131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.2544 0.3255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.4721 0.481
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.4328 0.5702
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0589 0.0589
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.4721 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.4721 0.481
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.4328 0.4065
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.3174 0.4119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0589 0.1365
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.3272 0.2064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0885 0.1025
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.2595 0.6016
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.4721 0.481
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.2595 0.3006
Loa Loa (eye worm) hypothetical protein 0.0026 0.3429 0.3971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Brugia malayi AMP-binding enzyme family protein 0.0028 0.3912 0.3912
Loa Loa (eye worm) fatty acid synthase 0.003 0.4244 0.4915
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.4314 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Giardia lamblia GTOR 0.0022 0.2595 0.5
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.7461 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.4328 0.4328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0885 0.2052
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.2595 0.4987
Entamoeba histolytica hypothetical protein 0.003 0.4314 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.2595 0.4987
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.4314 0.4314
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.4314 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.7461 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.3272 0.4254
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.2595 0.5386
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.4328 0.4065
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.4134 0.5436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.3429 0.7623
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.4721 0.481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0589 0.1365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0555 0.0527
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.2103 0.3174
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.2595 0.3006
Echinococcus multilocularis serine protein kinase ATM 0.003 0.4314 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.2595 0.4987
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.3912 0.453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.2595 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0589 0.1365
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.4134 0.5436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.2595 0.5386
Mycobacterium ulcerans polyketide synthase 0.0032 0.4721 0.481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.4314 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.2595 0.5386
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.2595 0.5386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.2595 0.2595
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.4328 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.309 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.2604 0.541
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.2595 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Toxoplasma gondii FATC domain-containing protein 0.003 0.4314 0.8938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0589 0.1365
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0906 0.105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.4721 0.6242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0589 0.1365
Loa Loa (eye worm) hypothetical protein 0.0017 0.1543 0.1786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.2595 0.6016
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.2595 0.6016
Mycobacterium ulcerans polyketide synthase 0.003 0.4328 0.4065
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.4328 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0589 0.1365
Mycobacterium ulcerans thioesterase 0.0025 0.3272 0.2064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0589 0.1365
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0589 0.1365
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.4721 0.481
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.4314 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.2595 0.5386
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.7461 1
Mycobacterium ulcerans thioesterase TesA 0.0025 0.3272 0.2064
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.2595 0.5386
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.309 0.172
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.4328 0.5702
Echinococcus granulosus serine protein kinase ATM 0.003 0.4314 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.8635 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0589 0.1365
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.2604 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0885 0.2052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0589 0.1365
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.309 0.172
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.4721 0.6242
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.1595 0.1953
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.4328 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.4328 0.4065
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.7461 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.2595 0.4458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.2503 0.4216
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.2595 0.4987
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.4328 0.5702
Onchocerca volvulus 0.0052 0.9019 0.9285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.4721 0.6242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2595 0.6016
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.2595 0.6016

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0.53 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 0.614 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 0.874 uM PubChem BioAssay. SAR confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.