Detailed information for compound 1415604

Basic information

Technical information
  • TDR Targets ID: 1415604
  • Name: 7-(morpholin-4-ylmethyl)-5-(phenylmethoxymeth yl)quinolin-8-ol
  • MW: 364.438 | Formula: C22H24N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(CN2CCOCC2)cc(c2c1nccc2)COCc1ccccc1
  • InChi: 1S/C22H24N2O3/c25-22-18(14-24-9-11-26-12-10-24)13-19(20-7-4-8-23-21(20)22)16-27-15-17-5-2-1-3-6-17/h1-8,13,25H,9-12,14-16H2
  • InChiKey: ZPJRWICTQQZYDM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 7-(morpholinomethyl)-5-(phenylmethoxymethyl)quinolin-8-ol
  • 7-(morpholinomethyl)-5-(phenylmethoxymethyl)-8-quinolinol
  • 5-(benzyloxymethyl)-7-(morpholinomethyl)quinolin-8-ol
  • Oprea1_635626
  • SMR000030494
  • EU-0045348
  • MLS000094940

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0079 0.0089
Brugia malayi flavodoxin family protein 0.0775 0.7878 1
Schistosoma mansoni opsin-like receptor 0.0023 0.0079 0.0089
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0021 0.0059 0.0075
Schistosoma mansoni multiple pdz domain protein 0.0021 0.0059 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.0021 0.0059 0.0059
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0775 0.7878 0.7878
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0021 0.0059 0.0066
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0088 0.0751 0.1458
Loa Loa (eye worm) hypothetical protein 0.0286 0.2801 0.3555
Schistosoma mansoni survival motor neuron protein 0.0058 0.0441 0.0516
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0775 0.7878 0.9284
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0296 0.2913 0.3694
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0775 0.7878 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2806 0.3558
Loa Loa (eye worm) guanylate kinase 0.0021 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0057 0.0425 0.0539
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0021 0.0059 0.007
Loa Loa (eye worm) PAR-6 protein 0.0021 0.0059 0.0075
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0021 0.0059 0.0059
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0021 0.0059 0.007
Brugia malayi diaphorase 0.0088 0.0751 0.0949
Echinococcus granulosus pdz domain containing protein 0.0021 0.0059 0.007
Schistosoma mansoni pdz domain containing protein 0.0021 0.0059 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0021 0.0059 0.0059
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0079 0.01
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0244 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0079 0.0093
Echinococcus multilocularis protein lin 7 B 0.0021 0.0059 0.0059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0035 0.0039
Plasmodium vivax SET domain protein, putative 0.0036 0.0211 0.0263
Loa Loa (eye worm) flavodoxin family protein 0.0296 0.2913 0.3697
Schistosoma mansoni hypothetical protein 0.0205 0.1961 0.2307
Echinococcus granulosus geminin 0.0205 0.1961 0.2311
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0035 0.0039
Brugia malayi hypothetical protein 0.0021 0.0059 0.0071
Plasmodium falciparum ferredoxin--NADP reductase 0.0088 0.0751 0.0949
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0035 0.0039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0175 0.0222
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0585 0.0585
Brugia malayi AKH receptor 0.0023 0.0079 0.0096
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis ligand of numb protein x 2 0.0021 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni amine GPCR 0.0023 0.0079 0.0089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0664 0.227
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8486 0.8486
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Echinococcus granulosus Rho GTPase activating protein 21 0.0021 0.0059 0.007
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0079 0.0096
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0664 0.0779
Brugia malayi Endoplasmin precursor 0.0039 0.0244 0.0305
Echinococcus multilocularis heat shock protein 0.0039 0.0244 0.0244
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0079 0.0089
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0079 0.0089
Giardia lamblia Hypothetical protein 0.0687 0.6964 1
Echinococcus granulosus hypothetical protein 0.0023 0.0079 0.0093
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0585 0.069
Echinococcus granulosus segment polarity protein dishevelled 0.0021 0.0059 0.007
Brugia malayi neuropeptide F receptor 0.0023 0.0079 0.0096
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Brugia malayi rho guanine nucleotide exchange factor 12 0.0021 0.0059 0.0071
Echinococcus multilocularis methionine synthase reductase 0.0478 0.4802 0.4802
Schistosoma mansoni opsin-like receptor 0.0023 0.0079 0.0089
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0664 0.0839
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0088 0.0751 0.0764
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0079 0.0079
Brugia malayi PDZ-domain protein scribble 0.0021 0.0059 0.0071
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0079 0.0079
Brugia malayi hypothetical protein 0.0286 0.2801 0.3552
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0079 0.0079
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0687 0.6964 0.8839
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Onchocerca volvulus 0.0023 0.0079 0.0269
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0059 0.0066
Leishmania major nitrate reductase, putative 0.0088 0.0751 0.0949
Brugia malayi RasGEF domain containing protein 0.0021 0.0059 0.0071
Onchocerca volvulus 0.0088 0.0751 0.2667
Echinococcus granulosus disks large 1 0.0021 0.0059 0.007
Brugia malayi PDZ domain containing protein 0.0021 0.0059 0.0071
Echinococcus granulosus lamin 0.0033 0.0175 0.0206
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0244 0.0827
Schistosoma mansoni hypothetical protein 0.0018 0.0029 0.0029
Schistosoma mansoni tight junction protein 0.0021 0.0059 0.0066
Brugia malayi hypothetical protein 0.0021 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Loa Loa (eye worm) syntrophin-1 0.0021 0.0059 0.0075
Echinococcus multilocularis lamin dm0 0.0033 0.0175 0.0175
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0119 0.0136
Loa Loa (eye worm) hypothetical protein 0.006 0.0457 0.058
Echinococcus granulosus segment polarity protein dishevelled 0.0021 0.0059 0.007
Brugia malayi intermediate filament protein 0.0033 0.0175 0.0217
Echinococcus granulosus partitioning defective 3 0.0021 0.0059 0.007
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0244 0.0305
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0088 0.0751 0.0867
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0079 0.0079
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0079 0.0093
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8486 1
Brugia malayi Bromodomain containing protein 0.0046 0.0317 0.0398
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0087 0.0105
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Echinococcus granulosus pdz domain containing protein 0.0021 0.0059 0.007
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0079 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Brugia malayi Ferm domain 0.0021 0.0059 0.0071
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0021 0.0059 0.0059
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0222 0.0277
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0775 0.7878 1
Onchocerca volvulus 0.0023 0.0079 0.0269
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0264 0.033
Brugia malayi Patj homolog 0.0021 0.0059 0.0071
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Onchocerca volvulus 0.0033 0.0175 0.0611
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0342 0.3383 0.3985
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0079 0.0093
Onchocerca volvulus 0.0021 0.0059 0.0199
Echinococcus multilocularis pdz domain containing protein 0.0021 0.0059 0.0059
Trypanosoma brucei nitrate reductase, putative 0.0088 0.0751 0.0949
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0088 0.0751 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0775 0.7878 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0249 0.0311
Schistosoma mansoni leucine-rich repeat protein 0.0021 0.0059 0.0066
Brugia malayi Bromodomain containing protein 0.0091 0.0777 0.0982
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0211 0.0244
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0079 0.0079
Echinococcus multilocularis disks large 3 0.0021 0.0059 0.0059
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0079 0.0079
Schistosoma mansoni dishevelled 0.0021 0.0059 0.0066
Echinococcus multilocularis beta 1 syntrophin 0.0021 0.0059 0.0059
Brugia malayi gamma-syntrophin-like protein SYN2 0.0021 0.0059 0.0071
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0775 0.7878 1
Echinococcus granulosus g protein coupled receptor 0.0023 0.0079 0.0093
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Schistosoma mansoni hypothetical protein 0.0041 0.0264 0.0307
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0079 0.0093
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Schistosoma mansoni amine GPCR 0.038 0.378 0.4452
Leishmania major NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) 9ORF binding protein 1 0.0021 0.0059 0.0075
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0079 0.0079
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0035 0.0035
Onchocerca volvulus Huntingtin homolog 0.0148 0.1372 0.4884
Onchocerca volvulus 0.0021 0.0059 0.0199
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Trypanosoma brucei ISWI complex protein 0.0018 0.0029 0.0032
Loa Loa (eye worm) diaphorase 0.0088 0.0751 0.0953
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0249 0.0293
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0021 0.0059 0.0059
Schistosoma mansoni sap-97 0.0021 0.0059 0.0066
Onchocerca volvulus 0.0023 0.0079 0.0269
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2801 0.2801
Schistosoma mansoni hypothetical protein 0.0023 0.0079 0.0089
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0462 0.0581
Brugia malayi putative neuropeptide receptor 0.0023 0.0079 0.0096
Brugia malayi Neurabin protein 1 0.0021 0.0059 0.0071
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Echinococcus multilocularis GPCR, family 2 0.0019 0.0035 0.0035
Onchocerca volvulus Huntingtin homolog 0.0148 0.1372 0.4884
Echinococcus granulosus cell polarity protein 0.0021 0.0059 0.007
Schistosoma mansoni pdz domain containing protein 0.0021 0.0059 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0079 0.0093
Schistosoma mansoni diflavin oxidoreductase 0.0384 0.3827 0.4508
Leishmania major hypothetical protein, conserved 0.0296 0.2913 0.3694
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0088 0.0751 0.0881
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0035 0.0081
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0244 0.0629
Onchocerca volvulus 0.0023 0.0079 0.0269
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0079 0.0079
Onchocerca volvulus 0.0021 0.0059 0.0199
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0161 0.02
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1333 0.1692
Echinococcus granulosus PRKCA binding protein 0.0021 0.0059 0.007
Schistosoma mansoni endoplasmin 0.0039 0.0244 0.0283
Schistosoma mansoni discs lost-related 0.0021 0.0059 0.0066
Brugia malayi C2 domain containing protein 0.0021 0.0059 0.0071
Leishmania major NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Echinococcus granulosus somatostatin receptor 0.0023 0.0079 0.0093
Echinococcus granulosus zinc finger protein 0.0024 0.0082 0.0097
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0079 0.0079
Echinococcus multilocularis serotonin receptor 0.0023 0.0079 0.0079
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0021 0.0059 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Loa Loa (eye worm) guanylate kinase 0.0021 0.0059 0.0075
Brugia malayi Pre-SET motif family protein 0.0251 0.2445 0.3101
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0079 0.0093
Brugia malayi G-protein coupled receptor 0.0023 0.0079 0.0096
Echinococcus multilocularis 0.0021 0.0059 0.0059
Schistosoma mansoni intermediate filament proteins 0.0033 0.0175 0.0202
Schistosoma mansoni myosin xvIII 0.0023 0.0079 0.0089
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Entamoeba histolytica type A flavoprotein, putative 0.0296 0.2913 1
Leishmania major hypothetical protein, conserved 0.0018 0.0029 0.0032
Brugia malayi Shank2E 0.0021 0.0059 0.0071
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0079 0.0089
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.0021 0.0059 0.007
Onchocerca volvulus 0.0023 0.0079 0.0269
Schistosoma mansoni heat shock protein 0.0039 0.0244 0.0283
Mycobacterium ulcerans monooxygenase 0.0088 0.0751 0.0764
Loa Loa (eye worm) hypothetical protein 0.0032 0.0169 0.0214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Brugia malayi hypothetical protein 0.0148 0.1372 0.1738
Trypanosoma cruzi p450 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0316 0.0316
Brugia malayi isocitrate dehydrogenase 0.0019 0.0035 0.0039
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0059 0.0066
Onchocerca volvulus Arc homolog 0.0021 0.0059 0.0199
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0244 0.0827
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0161 0.5
Echinococcus granulosus protein lin 7 B 0.0021 0.0059 0.007
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0079 0.0079
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.0021 0.0059 0.0071
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.0021 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0148 0.1372 0.1742
Onchocerca volvulus 0.0023 0.0079 0.0269
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Brugia malayi gopc protein 0.0021 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus multilocularis multiple pdz domain protein 0.0021 0.0059 0.0059
Schistosoma mansoni cell polarity protein 0.0021 0.0059 0.0066
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Echinococcus multilocularis heat shock protein 90 0.0039 0.0244 0.0244
Brugia malayi G-protein coupled receptor 0.0023 0.0079 0.0096
Schistosoma mansoni neuropeptide receptor 0.0023 0.0079 0.0089
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0079 0.0093
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0079 0.0093
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0287 0.0338
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0775 0.7878 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0775 0.7878 0.9284
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0079 0.01
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0035 0.0044
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0079 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Brugia malayi hypothetical protein 0.0021 0.0059 0.0071
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Echinococcus granulosus tumor protein p63 0.0408 0.4072 0.4798
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0079 0.0093
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0079 0.01
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0775 0.7878 1
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0021 0.0059 0.0066
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0664 0.0839
Brugia malayi PDZ domain 0.0021 0.0059 0.0071
Mycobacterium tuberculosis Probable monooxygenase 0.0088 0.0751 1
Schistosoma mansoni multiple pdz domain protein 0.0021 0.0059 0.0066
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0079 0.0079
Schistosoma mansoni amine GPCR 0.0023 0.0079 0.0089
Loa Loa (eye worm) X11 protein 0.0021 0.0059 0.0075
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0021 0.0059 0.0059
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0296 0.2913 0.3694
Leishmania major NADH-dependent fumarate reductase-like protein 0.0088 0.0751 0.0949
Echinococcus multilocularis protein piccolo 0.0021 0.0059 0.0059
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0244 0.0305
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0079 0.0096
Onchocerca volvulus 0.0286 0.2806 1
Brugia malayi MH2 domain containing protein 0.0144 0.1333 0.1688
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0079 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Schistosoma mansoni leucine-rich repeat protein 0.0021 0.0059 0.0066
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0079 0.0079
Brugia malayi neuropeptide F receptor 0.0023 0.0079 0.0096
Echinococcus granulosus endoplasmin 0.0031 0.0161 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0088 0.0751 0.0949
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0021 0.0059 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0425 0.0496
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0021 0.0059 0.007
Echinococcus multilocularis sex peptide receptor 0.0023 0.0079 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0079 0.0093
Echinococcus granulosus heat shock protein 90 0.0039 0.0244 0.0288
Echinococcus granulosus orexin receptor type 2 0.0023 0.0079 0.0093
Entamoeba histolytica type A flavoprotein, putative 0.0296 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.0335
Echinococcus granulosus g protein coupled receptor 0.0023 0.0079 0.0093
Brugia malayi Partitioning defective-6 homolog alpha 0.0021 0.0059 0.0071
Loa Loa (eye worm) cell junction protein LIN-7 0.0021 0.0059 0.0075
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0469 0.4705 0.5972
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0457 0.0534
Loa Loa (eye worm) endoplasmin 0.0039 0.0244 0.031
Echinococcus multilocularis amyloid beta A4 protein 0.0021 0.0059 0.0059
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0095 0.0121
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0079 0.0089
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0021 0.0059 0.007
Leishmania major cytochrome-b5 reductase, putative 0.0088 0.0751 0.0949
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0035 0.0081
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0079 0.0093
Schistosoma mansoni Patj homolog 0.0021 0.0059 0.0066
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0079 0.01
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0021 0.0059 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0161 0.02
Echinococcus granulosus methionine synthase reductase 0.0478 0.4802 0.5659
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni adenoreceptor 0.0023 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Brugia malayi Melatonin receptor type 1A 0.0023 0.0079 0.0096
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.0021 0.0059 0.0059
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0079 0.01
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0079 0.0079
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8486 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0287 0.0334
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1333 0.1692
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0342 0.3383 0.4295
Plasmodium vivax hypothetical protein, conserved 0.0296 0.2913 0.3694
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0079 0.0093
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0077 0.0093
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.0021 0.0059 0.0059
Brugia malayi FAD binding domain containing protein 0.0775 0.7878 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0079 0.0093
Loa Loa (eye worm) gopc protein 0.0021 0.0059 0.0075
Brugia malayi DIX domain containing protein 0.0021 0.0059 0.0071
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0079 0.0079
Echinococcus multilocularis geminin 0.0205 0.1961 0.1961
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0079 0.0096
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0021 0.0059 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus granulosus fmrfamide receptor 0.0023 0.0079 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0035 0.0035
Echinococcus granulosus MAGUK p55 subfamily 0.0021 0.0059 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0079 0.01
Schistosoma mansoni syntrophin 0.0021 0.0059 0.0066
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0035 0.0041
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0079 0.0089
Schistosoma mansoni MAGUK homolog 0.0021 0.0059 0.0066
Echinococcus multilocularis segment polarity protein dishevelled 0.0021 0.0059 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0244 0.0305
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0161 0.019
Schistosoma mansoni discs large 0.0021 0.0059 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus multilocularis MAGUK p55 subfamily 0.0021 0.0059 0.0059
Brugia malayi G protein-coupled receptor 0.0023 0.0079 0.0096
Echinococcus multilocularis syndecan binding protein (syntenin) 0.0021 0.0059 0.0059
Trypanosoma cruzi p450 reductase, putative 0.0775 0.7878 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis disks large 1 0.0021 0.0059 0.0059
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0316 0.0372
Loa Loa (eye worm) DIX domain-containing protein 0.0021 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Entamoeba histolytica type A flavoprotein, putative 0.0296 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0161 0.1765
Entamoeba histolytica type A flavoprotein, putative 0.0296 0.2913 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0079 0.0093
Onchocerca volvulus 0.0023 0.0079 0.0269
Echinococcus granulosus neurabin 1 0.0021 0.0059 0.007
Schistosoma mansoni cell polarity protein 0.0021 0.0059 0.0066
Echinococcus granulosus pdz domain containing protein 0.0021 0.0059 0.007
Echinococcus multilocularis serotonin receptor 0.0023 0.0079 0.0079
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0775 0.7878 1
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.0021 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0287 0.0334
Echinococcus granulosus lamin dm0 0.0033 0.0175 0.0206
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.0021 0.0059 0.007
Brugia malayi protein kinase C-binding protein PICK1 0.0021 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni pdz and lim domain protein 0.0021 0.0059 0.0066
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0441 0.0556
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0222
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0044
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0249 0.0249
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0088 0.0751 0.1955
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0079 0.0093
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0088 0.0751 0.2143
Echinococcus multilocularis MAGUK p55 subfamily 0.0021 0.0059 0.0059
Brugia malayi heat shock protein 90 0.0039 0.0244 0.0305
Echinococcus multilocularis MAGUK p55 subfamily 0.0021 0.0059 0.0059
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0051 0.0055
Trypanosoma brucei oxidoreductase-protein, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) hypothetical protein 0.0148 0.1372 0.1742
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.0021 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0034 0.0195 0.0247
Echinococcus multilocularis Partitioning defective 3 protein B 0.0021 0.0059 0.0059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2445 0.3104
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0079 0.0089
Echinococcus multilocularis lamin 0.0033 0.0175 0.0175
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0079 0.0079
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Brugia malayi Serotonin receptor 0.0023 0.0079 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0664 0.0839
Brugia malayi PX domain containing protein 0.0021 0.0059 0.0071
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0296 0.2913 0.3694
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Schistosoma mansoni endoplasmin 0.0039 0.0244 0.0283
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus granulosus tight junction protein ZO 3 0.0021 0.0059 0.007
Plasmodium vivax flavodoxin domain containing protein 0.0687 0.6964 0.8839
Echinococcus multilocularis neurabin 1 0.0021 0.0059 0.0059
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0021 0.0059 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0425 0.0496
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0079 0.0079
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0035 0.0035
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0119 0.0119
Brugia malayi PDZ domain containing protein 0.0021 0.0059 0.0071
Schistosoma mansoni hypothetical protein 0.0025 0.0095 0.0108
Echinococcus granulosus beta 1 syntrophin 0.0021 0.0059 0.007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0318 0.0403
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Schistosoma mansoni heat shock protein 0.0039 0.0244 0.0283
Leishmania major reductase, putative 0.0088 0.0751 0.0949
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0021 0.0059 0.007
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0087 0.0105
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0088 0.0751 0.0953
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0088 0.0751 0.0751
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0175 0.0217
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0079 0.0079
Onchocerca volvulus 0.0021 0.0059 0.0199
Echinococcus granulosus glutamate receptor interacting protein 1 0.0021 0.0059 0.007
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0244 0.0305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0088 0.0751 0.1955
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Loa Loa (eye worm) FAD binding domain-containing protein 0.0478 0.4802 0.6096
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0088 0.0751 0.0885
Brugia malayi FAD binding domain containing protein 0.0478 0.4802 0.6094
Brugia malayi Pre-SET motif family protein 0.0036 0.0211 0.0263
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni hypothetical protein 0.0205 0.1961 0.2307
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0211 0.0211
Mycobacterium tuberculosis Possible oxygenase 0.0088 0.0751 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0079 0.0093
Leishmania major oxidoreductase-like protein 0.0088 0.0751 0.0949
Brugia malayi PDZ domain 0.0021 0.0059 0.0071
Onchocerca volvulus 0.0023 0.0079 0.0269
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0161 0.5
Giardia lamblia Nitric oxide synthase, inducible 0.0687 0.6964 1
Echinococcus granulosus partitioning defective 3 0.0021 0.0059 0.007
Onchocerca volvulus 0.0058 0.0441 0.1562
Schistosoma mansoni bromodomain containing protein 0.0076 0.063 0.0738
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0021 0.0059 0.0059
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0088 0.0751 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0664 0.0839
Schistosoma mansoni multiple pdz domain protein 0.0021 0.0059 0.0066
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0296 0.2913 0.3694
Onchocerca volvulus 0.0023 0.0079 0.0269
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0161 0.02
Brugia malayi Serotonin receptor 0.0023 0.0079 0.0096
Loa Loa (eye worm) hypothetical protein 0.006 0.0462 0.0586
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0021 0.0059 0.007
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0058 0.0074
Onchocerca volvulus 0.0023 0.0079 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Schistosoma mansoni neuropeptide receptor 0.0023 0.0079 0.0089
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0664 0.0664
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0161 0.02
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) PX domain-containing protein 0.0021 0.0059 0.0075
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Schistosoma mansoni biogenic amine receptor 0.0023 0.0079 0.0089
Loa Loa (eye worm) PDZ domain-containing protein 0.0021 0.0059 0.0075
Echinococcus granulosus MAGUK p55 subfamily 0.0021 0.0059 0.007
Brugia malayi Protein-tyrosine phosphatase 1 0.0021 0.0059 0.0071
Echinococcus multilocularis musashi 0.0033 0.0175 0.0175
Entamoeba histolytica type A flavoprotein, putative 0.0296 0.2913 1
Echinococcus granulosus cytochrome b5 reductase 4 0.0088 0.0751 0.0885
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0079 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0079 0.0093
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0079 0.0096
Schistosoma mansoni ATP-dependent RNA Helicase 0.0021 0.0059 0.0066
Brugia malayi hypothetical protein 0.0021 0.0059 0.0071
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0021 0.0059 0.0071
Loa Loa (eye worm) FAD binding domain-containing protein 0.0775 0.7878 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0425 0.0501
Echinococcus multilocularis partitioning defective 3 0.0021 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0023 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0079 0.0079
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0079 0.0079
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0244 0.0305
Schistosoma mansoni PDZ domain protein 0.0021 0.0059 0.0066
Trypanosoma cruzi ISWI complex protein 0.0018 0.0029 0.0032
Onchocerca volvulus 0.0033 0.0175 0.0611
Schistosoma mansoni maguk P55 subfamily member 35 0.0021 0.0059 0.0066
Onchocerca volvulus 0.0023 0.0079 0.0269
Trypanosoma brucei NADH-dependent fumarate reductase 0.0088 0.0751 0.0949
Mycobacterium ulcerans oxygenase 0.0088 0.0751 0.0764
Schistosoma mansoni multiple pdz domain protein 0.0021 0.0059 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0079 0.0089
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0079 0.0269
Echinococcus granulosus serotonin receptor 0.0023 0.0079 0.0093
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Echinococcus granulosus amyloid beta A4 protein 0.0021 0.0059 0.007
Onchocerca volvulus 0.0021 0.0059 0.0199
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0775 0.7878 1
Echinococcus multilocularis Rho GTPase activating protein 21 0.0021 0.0059 0.0059
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0079 0.0096
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0079 0.0096
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0296 0.2913 0.3694
Schistosoma mansoni hypothetical protein 0.0023 0.0079 0.0089
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0079 0.0093
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0079 0.0089
Trichomonas vaginalis sulfite reductase, putative 0.0775 0.7878 1
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0036
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0079 0.0079
Schistosoma mansoni lim domain 0.0021 0.0059 0.0066
Echinococcus granulosus g protein coupled receptor 0.0023 0.0079 0.0093
Echinococcus granulosus heat shock protein 0.0039 0.0244 0.0288
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0035 0.0037
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Onchocerca volvulus 0.0021 0.0059 0.0199
Schistosoma mansoni afadin (af-6 protein) 0.0021 0.0059 0.0066
Echinococcus multilocularis pdz domain containing protein 0.0021 0.0059 0.0059
Echinococcus multilocularis partitioning defective 3 0.0021 0.0059 0.0059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0462 0.0586
Echinococcus multilocularis PRKCA binding protein 0.0021 0.0059 0.0059
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.0021 0.0059 0.007
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0085 0.0723 0.0918
Brugia malayi RE15519p 0.0023 0.0079 0.0096
Schistosoma mansoni biogenic amine receptor 0.0023 0.0079 0.0089
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0079 0.0089
Schistosoma mansoni neuropeptide receptor 0.0023 0.0079 0.0089
Brugia malayi Dopamine receptor protein 1 0.0023 0.0079 0.0096
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.0021 0.0059 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0211 0.0244
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus multilocularis microtubule associated serine:threonine protein 0.0021 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Treponema pallidum flavodoxin 0.0296 0.2913 1
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Brugia malayi 9ORF binding protein 1 0.0021 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Echinococcus granulosus GPCR family 2 0.0019 0.0035 0.0041
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0018 0.0023
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0021 0.0059 0.007
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0244 0.0305
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0021 0.0059 0.0066
Schistosoma mansoni histamine h1 receptor 0.0023 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Brugia malayi flavodoxin family protein 0.0296 0.2913 0.3694
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0775 0.7878 1
Echinococcus multilocularis pdz domain containing protein 0.0021 0.0059 0.0059
Onchocerca volvulus 0.0021 0.0059 0.0199
Schistosoma mansoni opsin-like receptor 0.0023 0.0079 0.0089
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0021 0.0059 0.0199
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0079 0.0093
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0775 0.7878 0.7878
Echinococcus granulosus pdz domain containing protein 0.0021 0.0059 0.007
Echinococcus multilocularis somatostatin receptor 0.0023 0.0079 0.0079
Leishmania major cytochrome P450 reductase, putative 0.0687 0.6964 0.8839
Echinococcus multilocularis multiple pdz domain protein 0.0021 0.0059 0.0059
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0079 0.0079
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0342 0.3383 0.4292
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0051 0.006
Schistosoma mansoni lamin 0.0033 0.0175 0.0202
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0021 0.0059 0.0059
Brugia malayi Guanylate kinase family protein 0.0021 0.0059 0.0071
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0004 0.0004
Schistosoma mansoni biogenic amine receptor 0.0023 0.0079 0.0089
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0664 0.0839
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0021 0.0059 0.0059
Brugia malayi GnHR receptor homolog 0.0023 0.0079 0.0096
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Trypanosoma cruzi reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0079 0.0093
Brugia malayi interleukin-16 0.0021 0.0059 0.0071
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0088 0.0751 0.0949
Echinococcus multilocularis partitioning defective protein 6 0.0021 0.0059 0.0059
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0079 0.0096
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni syntenin 0.0021 0.0059 0.0066
Brugia malayi Dopamine receptor protein 2 0.0023 0.0079 0.0096
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0664 0.0783
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0079 0.0093
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis tumor protein p63 0.0408 0.4072 0.4072
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Chlamydia trachomatis sulfite reductase 0.0478 0.4802 1
Onchocerca volvulus 0.0023 0.0079 0.0269
Schistosoma mansoni cytochrome B5 0.0088 0.0751 0.0881
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0079 0.0089
Brugia malayi Syntrophin-1 0.0021 0.0059 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0079 0.0079
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0079 0.0093
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0035 0.0039
Onchocerca volvulus 0.0023 0.0079 0.0269
Echinococcus granulosus disks large 3 0.0021 0.0059 0.007
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0244 0.0305
Schistosoma mansoni cytochrome P450 reductase 0.0775 0.7878 0.9284
Loa Loa (eye worm) hypothetical protein 0.0052 0.0371 0.0471
Onchocerca volvulus 0.0023 0.0079 0.0269
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0035 0.0039
Onchocerca volvulus 0.0023 0.0079 0.0269
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0079 0.0093
Echinococcus multilocularis cytochrome b5 reductase 4 0.0088 0.0751 0.0751
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.0021 0.0059 0.0071
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0079 0.0093
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0079 0.0089
Brugia malayi Guanylate kinase family protein 0.0021 0.0059 0.0071
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0296 0.2913 0.3694
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Plasmodium vivax endoplasmin, putative 0.0039 0.0244 0.0305
Schistosoma mansoni amine GPCR 0.0023 0.0079 0.0089
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0664 0.0843
Schistosoma mansoni multiple pdz domain protein 0.0021 0.0059 0.0066
Schistosoma mansoni cell polarity protein 0.0021 0.0059 0.0066
Schistosoma mansoni hypothetical protein 0.0058 0.0441 0.0516
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0425 0.0425
Echinococcus multilocularis pdz domain containing protein 0.0021 0.0059 0.0059
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0051 0.0055
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0478 0.4802 0.5657
Onchocerca volvulus 0.0021 0.0059 0.0199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Schistosoma mansoni amine GPCR 0.0023 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0775 0.7878 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0347 0.0441
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Schistosoma mansoni NADPH flavin oxidoreductase 0.039 0.3888 0.458
Onchocerca volvulus 0.0021 0.0059 0.0199
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0079 0.0079
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0035 0.0035
Plasmodium falciparum heat shock protein 90 0.0039 0.0244 0.0305
Echinococcus multilocularis endoplasmin 0.0031 0.0161 0.0161
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0079 0.0093
Trypanosoma cruzi ISWI complex protein 0.0018 0.0029 0.0032
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0021 0.0059 0.007
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0244 0.0629
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0296 0.2913 0.3694
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0004 0.0004
Echinococcus granulosus cytochrome b5 reductase 4 0.0088 0.0751 0.0885
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0021 0.0059 0.007
Brugia malayi sulfakinin receptor protein 0.0023 0.0079 0.0096
Schistosoma mansoni maguk P55 subfamily member 26 0.0021 0.0059 0.0066
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0021 0.0059 0.0071
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0079 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0079 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0197 0.0232
Onchocerca volvulus Big bang homolog 0.0021 0.0059 0.0199
Onchocerca volvulus 0.0021 0.0059 0.0199
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0175 0.0222
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0079 0.0089
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0296 0.2913 0.3694
Echinococcus granulosus neuropeptide receptor 0.0023 0.0079 0.0093
Schistosoma mansoni protein kinase C alpha binding protein 0.0021 0.0059 0.0066
Schistosoma mansoni amyloid beta A4 protein related 0.0021 0.0059 0.0066
Brugia malayi PDZ domain containing protein 0.0021 0.0059 0.0071
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0021 0.0059 0.007
Echinococcus multilocularis heat shock protein 90 0.0031 0.0161 0.0161
Brugia malayi PHD-finger family protein 0.003 0.0149 0.0185
Echinococcus granulosus multiple pdz domain protein 0.0021 0.0059 0.007
Echinococcus granulosus intermediate filament protein 0.0033 0.0175 0.0206
Brugia malayi hypothetical protein 0.0021 0.0059 0.0071
Mycobacterium tuberculosis Probable oxidoreductase 0.0088 0.0751 1
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0035 0.0041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0079 0.01
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0035 0.0039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0035 0.0044
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0079 0.0093
Onchocerca volvulus 0.0023 0.0079 0.0269
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Schistosoma mansoni dishevelled 0.0021 0.0059 0.0066
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0021 0.0059 0.0059
Schistosoma mansoni zinc finger protein 0.0024 0.0082 0.0092
Schistosoma mansoni cell polarity protein 0.0021 0.0059 0.0066
Brugia malayi cell junction protein LIN-7 0.0021 0.0059 0.0071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0035 0.0035
Echinococcus multilocularis tight junction protein ZO 3 0.0021 0.0059 0.0059
Trypanosoma brucei NADH-dependent fumarate reductase 0.0088 0.0751 0.0949
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Onchocerca volvulus 0.0023 0.0079 0.0269
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.0021 0.0059 0.0066
Leishmania major cytochrome-b5 reductase, putative 0.0088 0.0751 0.0949
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Echinococcus granulosus multiple pdz domain protein 0.0021 0.0059 0.007
Echinococcus multilocularis zinc finger protein 0.0024 0.0082 0.0082
Loa Loa (eye worm) RasGEF domain-containing protein 0.0021 0.0059 0.0075
Brugia malayi hypothetical protein 0.0021 0.0059 0.0071
Brugia malayi Peripheral plasma membrane protein CASK 0.0021 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0222 0.0277
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Brugia malayi PDZ domain containing protein 0.0021 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0342 0.3383 0.4295
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0079 0.01
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.0021 0.0059 0.0075
Leishmania major NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Echinococcus granulosus ligand of numb protein x 2 0.0021 0.0059 0.007
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0021 0.0059 0.007
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Echinococcus granulosus allatostatin A receptor 0.0023 0.0079 0.0093
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0296 0.2913 0.3694
Echinococcus granulosus sex peptide receptor 0.0023 0.0079 0.0093
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Brugia malayi ORL1-like opioid receptor 0.0023 0.0079 0.0096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0462 0.0581
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0023 0.0079 0.0089
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0287 0.0287
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0035 0.0035
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0035 0.0039
Echinococcus granulosus Partitioning defective 3 protein B 0.0021 0.0059 0.007
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.0021 0.0059 0.007
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Echinococcus granulosus heat shock protein 90 0.0031 0.0161 0.019
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0079 0.0079
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0079 0.0093
Plasmodium falciparum nitric oxide synthase, putative 0.0775 0.7878 1
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Onchocerca volvulus 0.0036 0.0211 0.074
Trypanosoma cruzi oxidoreductase-protein, putative 0.0088 0.0751 0.0949
Trypanosoma brucei heat shock protein, putative 0.0039 0.0244 0.0305
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0035 0.0039
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0249 0.0316
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0021 0.0059 0.0066
Mycobacterium ulcerans electron transfer protein FdxB 0.0088 0.0751 0.0764
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Brugia malayi Dopamine receptor 0.0023 0.0079 0.0096
Echinococcus granulosus neuropeptide receptor 0.0023 0.0079 0.0093
Schistosoma mansoni lamin 0.0033 0.0175 0.0202
Schistosoma mansoni lin-7-like proteins 0.0021 0.0059 0.0066
Brugia malayi Synapse defective protein 1 0.0021 0.0059 0.0071
Leishmania major p450 reductase, putative 0.0775 0.7878 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0079 0.0079
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis segment polarity protein dishevelled 0.0021 0.0059 0.0059
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0079 0.0079
Brugia malayi larval opioid receptor 0.0023 0.0079 0.0096
Loa Loa (eye worm) hypothetical protein 0.0469 0.4705 0.5972
Onchocerca volvulus 0.0021 0.0059 0.0199
Echinococcus granulosus multiple pdz domain protein 0.0021 0.0059 0.007
Brugia malayi syntenin 0.0021 0.0059 0.0071
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0161 0.02
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Toxoplasma gondii flavodoxin domain-containing protein 0.0384 0.3827 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0244 0.0305
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0079 0.0093
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0088 0.0751 0.0949
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2801 0.33
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0244 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0035 0.0041
Leishmania major heat shock protein 83-1 0.0039 0.0244 0.0305
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0211 0.0542
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0035 0.0035
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0244 0.0305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0021 0.0059 0.0059
Toxoplasma gondii flavodoxin domain-containing protein 0.0384 0.3827 1
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0088 0.0751 0.0949
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0079 0.0079
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0021 0.0059 0.0059
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0088 0.0751 0.0764
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0079 0.0079
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0775 0.7878 1
Brugia malayi hypothetical protein 0.0023 0.0079 0.0096
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0119 0.0141
Echinococcus granulosus MAGUK p55 subfamily 0.0021 0.0059 0.007
Schistosoma mansoni neuropeptide receptor 0.0023 0.0079 0.0089
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0079 0.0089
Echinococcus granulosus syndecan binding protein syntenin 0.0021 0.0059 0.007
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0161 0.02
Onchocerca volvulus 0.006 0.0457 0.1617
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0079 0.0079
Trypanosoma cruzi nitrate reductase, putative 0.0088 0.0751 0.0949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0079 0.0096
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0021 0.0059 0.0075
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0079 0.0079
Plasmodium falciparum endoplasmin, putative 0.0024 0.0087 0.0105
Mycobacterium ulcerans oxidoreductase 0.0088 0.0751 0.0764
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0088 0.0751 0.0949
Echinococcus multilocularis multiple pdz domain protein 0.0021 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0075
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0244 0.0305
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0066
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0079 0.0093
Schistosoma mansoni zinc finger protein 0.0018 0.0029 0.0029
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0035 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.01
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0035 0.0039
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0021 0.0059 0.0059
Schistosoma mansoni MAGUK homolog 0.0021 0.0059 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0079 0.0089
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0079 0.0089
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0079 0.0089
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0296 0.2913 0.3694
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0079 0.0079

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.963 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
EC50 (functional) = 36.339 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
IC50 (functional) 4.948 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
IC50 (binding) = 25.735 um PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays: 1220 ] ChEMBL. No reference
Potency (functional) 0.0041 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (binding) = 18.6982 um PUBCHEM_BIOASSAY: Alpha-synuclein ThS binding assay. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID492947] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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