Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.0449 | 0.0575 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3297 | 0.4137 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0159 | 0.3997 | 0.5118 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0276 | 0.781 | 0.781 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.781 | 1 |
Giardia lamblia | Hypothetical protein | 0.0276 | 0.781 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0276 | 0.781 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0276 | 0.781 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0057 | 0.0665 | 0.8123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3297 | 0.4137 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0114 | 0.0114 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.004 | 0.0114 | 0.0114 |
Brugia malayi | PAS domain containing protein | 0.0049 | 0.0419 | 0.0536 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.004 | 0.0114 | 0.0114 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0449 | 0.0449 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0446 | 0.0431 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0819 | 0.0916 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0276 | 0.781 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0449 | 0.0449 |
Plasmodium falciparum | protease, putative | 0.0057 | 0.0665 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0449 | 0.0436 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0159 | 0.3997 | 0.5046 |
Brugia malayi | hypothetical protein | 0.0166 | 0.4213 | 0.5395 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.0449 | 0.0575 |
Onchocerca volvulus | 0.005 | 0.0446 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0176 | 0.4543 | 0.5755 |
Onchocerca volvulus | 0.004 | 0.0114 | 0.2549 | |
Echinococcus granulosus | GPCR family 2 | 0.005 | 0.0449 | 0.0449 |
Echinococcus multilocularis | tumor protein p63 | 0.0344 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.2355 | 0.2912 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0819 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0159 | 0.3997 | 0.5118 |
Brugia malayi | RNA binding protein | 0.0138 | 0.3297 | 0.4222 |
Brugia malayi | Cytochrome P450 family protein | 0.005 | 0.0423 | 0.0542 |
Echinococcus granulosus | tar DNA binding protein | 0.0138 | 0.3297 | 0.3297 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0153 | 0.3795 | 0.4783 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0114 | 0.0114 |
Brugia malayi | Doublecortin family protein | 0.004 | 0.0114 | 0.0145 |
Brugia malayi | hypothetical protein | 0.004 | 0.0114 | 0.0145 |
Onchocerca volvulus | 0.004 | 0.0114 | 0.2549 | |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0276 | 0.781 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.005 | 0.0423 | 0.0402 |
Plasmodium vivax | protease, putative | 0.0057 | 0.0665 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2355 | 0.2912 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3297 | 0.4137 |
Chlamydia trachomatis | hypothetical protein | 0.0057 | 0.0665 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0276 | 0.781 | 0.781 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0449 | 0.0449 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0819 | 0.0819 |
Mycobacterium ulcerans | hypothetical protein | 0.0057 | 0.0665 | 0.8123 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.0419 | 0.0397 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0449 | 0.0436 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0176 | 0.4543 | 0.4543 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0276 | 0.781 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0138 | 0.3297 | 0.4137 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0276 | 0.781 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0449 | 0.0449 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0276 | 0.781 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0276 | 0.781 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0114 | 0.0145 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3297 | 0.4137 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0819 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0114 | 0.0114 |
Brugia malayi | TAR-binding protein | 0.0138 | 0.3297 | 0.4222 |
Echinococcus multilocularis | GPCR, family 2 | 0.005 | 0.0449 | 0.0449 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0819 | 0.0819 |
Loa Loa (eye worm) | RNA binding protein | 0.0138 | 0.3297 | 0.4137 |
Mycobacterium ulcerans | integral membrane protein | 0.0057 | 0.0665 | 0.8123 |
Schistosoma mansoni | single-minded | 0.0049 | 0.0419 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4213 | 0.5327 |
Echinococcus multilocularis | tar DNA binding protein | 0.0138 | 0.3297 | 0.3297 |
Treponema pallidum | hypothetical protein | 0.0057 | 0.0665 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0819 | 0.0916 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0449 | 0.0436 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0819 | 1 |
Echinococcus multilocularis | RUN | 0.004 | 0.0114 | 0.0114 |
Brugia malayi | hypoxia-induced factor 1 | 0.0153 | 0.3795 | 0.4859 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0449 | 0.0436 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.0449 | 0.0436 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0176 | 0.4543 | 0.4543 |
Echinococcus granulosus | RUN | 0.004 | 0.0114 | 0.0114 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.2355 | 0.3015 |
Loa Loa (eye worm) | TAR-binding protein | 0.0138 | 0.3297 | 0.4137 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0446 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0449 | 0.0436 |
Schistosoma mansoni | lipoxygenase | 0.0104 | 0.2192 | 0.27 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0819 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0114 | 0.0114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3297 | 0.4137 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0138 | 0.3297 | 0.4222 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0276 | 0.781 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.3997 | 0.5046 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0819 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.