Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4263 | 0.4263 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0043 | 0.2335 | 0.5477 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0042 | 0.2288 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.2288 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0042 | 0.2288 | 0.2985 |
Treponema pallidum | NADH oxidase | 0.0015 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0066 | 0.4263 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0043 | 0.2335 | 0.5477 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.4263 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.4263 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.4263 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4263 | 0.4263 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.2288 | 0.5367 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.2288 | 1 |
Brugia malayi | glutathione reductase | 0.0042 | 0.2288 | 0.5367 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0015 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0042 | 0.2288 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.4263 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0107 | 0.7665 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.4263 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4263 | 0.4263 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.2288 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4263 | 0.4263 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.2288 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.4263 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0015 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0042 | 0.2288 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4263 | 0.4263 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0015 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.2288 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0107 | 0.7665 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0096 | 0.6774 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0015 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.4263 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0015 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0096 | 0.6774 | 0.8837 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0015 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0107 | 0.7665 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0096 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0096 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0096 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0096 | 0.6774 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0015 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0107 | 0.7665 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.