Detailed information for compound 1415720

Basic information

Technical information
  • TDR Targets ID: 1415720
  • Name: 3-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxo ethyl]-4-[(4-phenylphenyl)methyl]piperazin-2- one
  • MW: 436.547 | Formula: C25H32N4O3
  • H donors: 2 H acceptors: 3 LogP: 1.1 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)C(=O)CC1C(=O)NCCN1Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C25H32N4O3/c30-17-16-27-12-14-28(15-13-27)24(31)18-23-25(32)26-10-11-29(23)19-20-6-8-22(9-7-20)21-4-2-1-3-5-21/h1-9,23,30H,10-19H2,(H,26,32)
  • InChiKey: VCRANFZOSQDHQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxo-ethyl]-4-[(4-phenylphenyl)methyl]piperazin-2-one
  • 3-[2-[4-(2-hydroxyethyl)-1-piperazinyl]-2-oxoethyl]-4-[(4-phenylphenyl)methyl]-2-piperazinone
  • 3-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-keto-ethyl]-4-(4-phenylbenzyl)piperazin-2-one
  • 4-(biphenyl-4-ylmethyl)-3-{2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethyl}piperazin-2-one
  • MLS000773262
  • SMR000318974

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0082 0.0338
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0108 0.1482 0.2366
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0588 0.2416
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0171 0.0274
Schistosoma mansoni DNA helicase recq1 0.0043 0.0499 0.0499
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0096 0.0136
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.1187 0.1187
Schistosoma mansoni uridine phosphorylase 0.0088 0.1178 0.1178
Onchocerca volvulus 0.0541 0.8037 1
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0087 0.116 0.1853
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0088 0.1178 0.1465
Entamoeba histolytica recQ family DNA helicase 0.0022 0.0181 0.1535
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0066 0.0271
Schistosoma mansoni ets-related 0.001 0.0004 0.0004
Mycobacterium tuberculosis Hypothetical protein 0.0088 0.1178 0.1881
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0066 0.0556
Schistosoma mansoni microtubule-associated protein tau 0.0671 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0082 0.0338
Plasmodium falciparum glutathione reductase 0.0037 0.0415 0.1705
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0038 0.0054
Echinococcus granulosus bloom syndrome protein 0.0071 0.0931 0.0931
Schistosoma mansoni gabp alpha 0.007 0.0915 0.0915
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0891 0.0891
Trichomonas vaginalis DNA helicase recq, putative 0.0071 0.0931 0.1159
Brugia malayi Ets-domain containing protein 0.007 0.0915 0.1299
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0004 0.0004
Echinococcus multilocularis purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0004 0.0004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1187 0.1895
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0088 0.1178 0.1465
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1187 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0066 0.0271
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.001 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0415 0.1705
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.1187 0.1187
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0171 0.2436 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0929 0.0929
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0096 0.0096
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0054 0.0674 0.0674
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0341 0.0484
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0494 0.0701
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0171 0.0243
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0849 0.0849
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Treponema pallidum uridine phosphorylase (udp) 0.0088 0.1178 0.9923
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0043 0.0499 0.0709
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0043 0.0499 0.0499
Plasmodium falciparum purine nucleoside phosphorylase 0.0088 0.1178 0.4835
Brugia malayi Fli-1 protein 0.0214 0.3084 0.4378
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0415 0.1705
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0171 0.0213
Brugia malayi Intermediate filament tail domain containing protein 0.0089 0.119 0.169
Echinococcus granulosus Ankyrin 0.0016 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0022 0.0181 0.0257
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0049 0.0599 0.0956
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0088 0.1178 0.1881
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0171 0.0171
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0494 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0724 0.0901
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0194 0.0311
Loa Loa (eye worm) hypothetical protein 0.0043 0.0494 0.0701
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0006
Treponema pallidum pfs protein (pfs) 0.0088 0.1178 0.9923
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0021 0.0168 0.0691
Echinococcus multilocularis musashi 0.0089 0.119 0.119
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0066 0.0082
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0066 0.0271
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0082 0.0082
Entamoeba histolytica recQ family helicase, putative 0.0049 0.0588 0.4998
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0849 0.1205
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0415 0.35
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0415 0.35
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0265 0.0377
Toxoplasma gondii phosphorylase family protein 0.0088 0.1178 0.4835
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0066 0.0082
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0004 0.0004
Leishmania major nucleoside phosphorylase-like protein 0.0088 0.1178 0.4835
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0004 0.0004
Brugia malayi uridine phosphorylase family protein 0.0088 0.1178 0.1672
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0096 0.0096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.001 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0891 0.0891
Treponema pallidum ATP-dependent DNA helicase 0.0022 0.0181 0.1523
Brugia malayi Pre-SET motif family protein 0.0069 0.0891 0.1265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Onchocerca volvulus 0.0014 0.0066 0.0082
Mycobacterium ulcerans thymidylate synthase 0.0121 0.1687 0.2694
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0424 0.6261 0.779
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0171 0.2436 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1187 0.4872
Brugia malayi PAS domain containing protein 0.0055 0.0681 0.0968
Brugia malayi Ets-domain containing protein 0.001 0.0004 0.0006
Schistosoma mansoni single-minded 0.0055 0.0681 0.0681
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0066 0.0066
Trypanosoma cruzi trypanothione reductase, putative 0.0108 0.1482 0.6084
Mycobacterium leprae probable uridine phosphorylase 0.0088 0.1178 0.1881
Loa Loa (eye worm) hypothetical protein 0.0087 0.116 0.1647
Onchocerca volvulus 0.0182 0.2612 0.325
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0494 0.0494
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0171 0.1444
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0088 0.1178 0.4835
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0415 0.0663
Schistosoma mansoni hypothetical protein 0.0356 0.5239 0.5239
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0088 0.1178 0.1465
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0194 0.0276
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0088 0.1178 0.4835
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0082 0.0082
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0088 0.1178 1
Mycobacterium ulcerans epimerase 0.0023 0.0194 0.0311
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.1178 0.1465
Echinococcus multilocularis ets variant gene 4 0.001 0.0004 0.0004
Schistosoma mansoni netrin receptor unc5 0.0016 0.0096 0.0096
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0171 0.0704
Echinococcus multilocularis geminin 0.0356 0.5239 0.5239
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0171 0.1444
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0044 0.0511 0.2099
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0082 0.0117
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0494 0.0494
Brugia malayi hypothetical protein 0.0058 0.0724 0.1028
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0194 0.0311
Schistosoma mansoni dihydrofolate reductase 0.0049 0.0599 0.0599
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0171 0.0243
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Schistosoma mansoni methylthioadenosine phosphorylase 0.0088 0.1178 0.1178
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0066 0.0271
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0246 0.3572 0.5705
Echinococcus multilocularis purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0066 0.0082
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0087 0.116 0.1853
Schistosoma mansoni cpg binding protein 0.0034 0.0369 0.0369
Brugia malayi thymidylate synthase 0.0121 0.1687 0.2395
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0088 0.1178 0.1881
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0066 0.0082
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0066 0.0066
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0494 0.4195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Echinococcus multilocularis purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Toxoplasma gondii endonuclease IV APN 0.0087 0.116 0.4763
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0494 0.2028
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.1187 0.1895
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0494 0.0494
Giardia lamblia UPL-1 0.0088 0.1178 0.1881
Echinococcus multilocularis microtubule associated protein 2 0.0671 1 1
Brugia malayi isocitrate dehydrogenase 0.0015 0.0082 0.0117
Brugia malayi intermediate filament protein 0.0089 0.119 0.169
Brugia malayi Protein kinase domain containing protein 0.0016 0.0096 0.0136
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0415 0.1705
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0082 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0891 0.0891
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0066 0.0271
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0415 0.1705
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0568 0.0806
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.1187 0.1187
Echinococcus multilocularis thymidylate synthase 0.0121 0.1687 0.1687
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0004 0.0004
Chlamydia trachomatis endonuclease IV 0.0087 0.116 0.9776
Trypanosoma brucei uridine phosphorylase 0.0088 0.1178 0.4835
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0004 0.0004
Plasmodium vivax SET domain protein, putative 0.0069 0.0891 0.3657
Echinococcus granulosus methylthioadenosine phosphorylase 0.0088 0.1178 0.1178
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0415 0.0663
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0497 0.0497
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0088 0.1178 1
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0088 0.1178 0.4835
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0494 0.2028
Schistosoma mansoni intermediate filament proteins 0.0089 0.119 0.119
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0267 0.3892 0.5526
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0171 0.2436 1
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0004 0.0004
Leishmania major trypanothione reductase 0.0108 0.1482 0.6084
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0358 0.5273 0.7487
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0494 0.2028
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0066 0.0082
Chlamydia trachomatis dihydrofolate reductase 0.0049 0.0599 0.5047
Loa Loa (eye worm) hypothetical protein 0.0041 0.0472 0.067
Schistosoma mansoni ets 0.001 0.0004 0.0004
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0494 0.0494
Schistosoma mansoni methylthioadenosine phosphorylase 0.0088 0.1178 0.1178
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0415 0.1705
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0194 0.0311
Mycobacterium tuberculosis Conserved hypothetical protein 0.0088 0.1178 0.1881
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0082 0.0338
Onchocerca volvulus 0.0121 0.1687 0.2099
Echinococcus multilocularis dihydrofolate reductase 0.0049 0.0599 0.0599
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0497 0.0497
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0494 0.0494
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0066 0.0842 0.3457
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0088 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0136
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0849 0.0849
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0082 0.0338
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0415 0.1705
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.031 0.0496
Echinococcus multilocularis uridine phosphorylase 1 0.0088 0.1178 0.1178
Echinococcus multilocularis purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0004 0.0006
Toxoplasma gondii exonuclease III APE 0.0021 0.0171 0.0704
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0273 0.3988 0.6369
Loa Loa (eye worm) RecQ helicase 0.0071 0.0931 0.1323
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0088 0.1178 0.1465
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0066 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0088 0.1178 0.1881
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0915 0.1299
Brugia malayi Pre-SET motif family protein 0.0475 0.7043 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0088 0.1178 0.1465
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0726 0.0726
Giardia lamblia Sgs1 DNA helicase, putative 0.0043 0.0499 0.0797
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0681 0.0681
Echinococcus multilocularis Ankyrin 0.0016 0.0098 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0818 0.3358
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0096 0.0136
Echinococcus multilocularis purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Loa Loa (eye worm) hypothetical protein 0.0089 0.119 0.169
Brugia malayi hypothetical protein 0.0182 0.2612 0.3709
Mycobacterium tuberculosis Hypothetical protein 0.0058 0.0724 0.1156
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0043 0.0499 0.0499
Entamoeba histolytica hypothetical protein 0.0088 0.1178 1
Echinococcus granulosus dihydrofolate reductase 0.0049 0.0599 0.0599
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0415 0.1705
Toxoplasma gondii hypothetical protein 0.003 0.031 0.1275
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0849 0.1356
Schistosoma mansoni hypothetical protein 0.0356 0.5239 0.5239
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0171 0.0704
Echinococcus granulosus thioredoxin glutathione reductase 0.0108 0.1482 0.1482
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0726 0.116
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0273 0.3988 0.6369
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0499 0.2049
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0066 0.0271
Mycobacterium leprae Possible regulatory protein 0.0014 0.0066 0.0105
Schistosoma mansoni hypothetical protein 0.0462 0.6842 0.6842
Brugia malayi CXXC zinc finger family protein 0.0032 0.0341 0.0484
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0088 0.1178 0.1672
Brugia malayi hypothetical protein 0.0137 0.1931 0.2741
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0171 0.0213
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0415 0.1705
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0088 0.1178 1
Brugia malayi Probable ClpP-like protease 0.0088 0.1187 0.1685
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0415 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0066 0.0082
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0588 0.2416
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0499 0.0709
Brugia malayi follicle stimulating hormone receptor 0.0266 0.3884 0.5514
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.001 0.001
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0004 0.0004
Echinococcus multilocularis lamin 0.0089 0.119 0.119
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0082 0.0131
Mycobacterium ulcerans hypothetical protein 0.0023 0.0194 0.0311
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0082 0.0082
Schistosoma mansoni purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0415 0.0415
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0088 0.1178 0.4835
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0066 0.0082
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1187 0.4872
Loa Loa (eye worm) hypothetical protein 0.0184 0.264 0.3748
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0045 0.0524 0.215
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0171 0.0704
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0088 0.1178 0.1465
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0415 0.1705
Brugia malayi hypothetical protein 0.0184 0.264 0.3748
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0139
Schistosoma mansoni purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Echinococcus multilocularis dnaJ subfamily B 0.0462 0.6842 0.6842
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0415 0.1705
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0089 0.119 0.169
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0246 0.3572 0.5705
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0066 0.0082
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0265 0.0377
Loa Loa (eye worm) thioredoxin reductase 0.0108 0.1482 0.2104
Echinococcus multilocularis protein C ets 2 0.001 0.0004 0.0004
Trypanosoma brucei trypanothione reductase 0.0108 0.1482 0.6084
Leishmania major protein kinase, putative 0.0014 0.0066 0.0271
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0588 0.0732
Onchocerca volvulus 0.0089 0.119 0.1481
Brugia malayi glutathione reductase 0.0108 0.1482 0.2104
Brugia malayi Uncoordinated protein 44 0.0016 0.0096 0.0136
Loa Loa (eye worm) glutathione reductase 0.0108 0.1482 0.2104
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0088 0.1178 0.1465
Toxoplasma gondii Purine nucleoside phosphorylase 0.0088 0.1178 0.4835
Brugia malayi Bloom's syndrome protein homolog 0.0071 0.0931 0.1323
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1187 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.031 0.1275
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0424 0.6261 1
Echinococcus multilocularis cpg binding protein 0.0034 0.0369 0.0369
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.1109 0.1109
Echinococcus multilocularis lamin dm0 0.0089 0.119 0.119
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0181 0.0742
Onchocerca volvulus 0.0069 0.0891 0.1108
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0915 0.0915
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Loa Loa (eye worm) hypothetical protein 0.0023 0.0194 0.0276
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0181 0.0742
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0066 0.0082
Echinococcus granulosus intermediate filament protein 0.0089 0.119 0.119
Loa Loa (eye worm) hypothetical protein 0.006 0.0761 0.108
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0415 0.1705
Echinococcus granulosus uridine phosphorylase 1 0.0088 0.1178 0.1178
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0098 0.0098
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.116 0.4763
Plasmodium vivax thioredoxin reductase, putative 0.0108 0.1482 0.6084
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0424 0.6261 0.7792
Echinococcus multilocularis bloom syndrome protein 0.0071 0.0931 0.0931
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.1187 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0088 0.1178 0.1881
Schistosoma mansoni elf1 0.001 0.0004 0.0004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0475 0.7043 1
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0082 0.0338
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.3892 0.3892
Loa Loa (eye worm) thymidylate synthase 0.0121 0.1687 0.2395
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0849 0.1356
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0499 0.2049
Onchocerca volvulus 0.0089 0.119 0.1481
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0415 0.0663
Echinococcus granulosus lamin dm0 0.0089 0.119 0.119
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0004 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0891 0.0891
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0915 0.0915
Plasmodium falciparum thioredoxin reductase 0.0108 0.1482 0.6084
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0273 0.3988 0.6369
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0726 0.116
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.001 0.001
Echinococcus multilocularis purine nucleoside phosphorylase 0.0336 0.4934 0.4934
Schistosoma mansoni uridine phosphorylase 0.0088 0.1178 0.1178
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.004 0.004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.3884 0.5514
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0088 0.1178 0.4835
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0121 0.1687 0.2694
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.1187 0.4872
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.004 0.004
Loa Loa (eye worm) histone methyltransferase 0.0013 0.004 0.0056
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Schistosoma mansoni blooms syndrome DNA helicase 0.005 0.0601 0.0601
Echinococcus granulosus cpg binding protein 0.0034 0.0369 0.0369
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0088 0.1178 0.4835
Schistosoma mansoni lamin 0.0089 0.119 0.119
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0171 0.1455
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0415 0.1705
Echinococcus multilocularis purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0087 0.116 0.1647
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0088 0.1178 0.9923
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0568 0.0806
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0171 0.2436 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1187 0.1895
Mycobacterium ulcerans endonuclease IV 0.0087 0.116 0.1853
Brugia malayi hypothetical protein 0.0267 0.3892 0.5526
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0849 0.0849
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1187 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.1187 0.1685
Brugia malayi hypoxia-induced factor 1 0.017 0.2424 0.3441
Trichomonas vaginalis set domain proteins, putative 0.0541 0.8035 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0066 0.0094
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0494 0.0789
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0082 0.0338
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0494 0.0494
Schistosoma mansoni methylthioadenosine phosphorylase 0.0088 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0087 0.1165 0.1655
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0415 0.0663
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.031 0.2616
Loa Loa (eye worm) dihydrofolate reductase 0.0049 0.0599 0.085
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0171 0.0171
Schistosoma mansoni ap endonuclease 0.0021 0.0171 0.0171
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0088 0.1178 1
Loa Loa (eye worm) intermediate filament protein 0.0089 0.119 0.169
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.3892 0.3892
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0121 0.1687 0.2694
Echinococcus multilocularis purine nucleoside phosphorylase 0.0336 0.4934 0.4934
Loa Loa (eye worm) hypothetical protein 0.0041 0.0472 0.067
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.0891 0.0891
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0336 0.4934 0.4934
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0494 0.0615
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0066 0.0066
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0171 0.0704
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0415 0.059
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0096 0.0096
Trichomonas vaginalis DNA helicase recq1, putative 0.0071 0.0931 0.1159
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0726 0.116
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0082 0.0082
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0004 0.0006
Brugia malayi Dihydrofolate reductase 0.0049 0.0599 0.085
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0082 0.0082
Schistosoma mansoni survival motor neuron protein 0.0054 0.0674 0.0674
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0043 0.0499 0.0499
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0842 0.0842
Mycobacterium tuberculosis Probable reductase 0.0246 0.3572 0.5705
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0499 0.0709
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0494 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.1178 0.1465
Echinococcus granulosus death domain containing protein 0.0016 0.0096 0.0096
Brugia malayi transcription factor E74 isoform 0.001 0.0004 0.0006
Schistosoma mansoni ets-related 0.0214 0.3084 0.3084
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0096 0.0096
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0171 0.0704
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0726 0.0726
Echinococcus granulosus protein C ets 2 0.001 0.0004 0.0004
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0088 0.1178 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0004 0.0006
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0066 0.0094
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0004 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0849 0.1356
Schistosoma mansoni lamin 0.0089 0.119 0.119
Brugia malayi Death domain containing protein 0.0016 0.0096 0.0136
Onchocerca volvulus 0.0041 0.0465 0.0579
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0096 0.0119
Mycobacterium ulcerans putative regulatory protein 0.0041 0.0465 0.0743
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0415 0.35
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0849 0.3486
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0246 0.3572 0.5705
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0424 0.6261 0.889
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0181 0.0181
Mycobacterium tuberculosis Probable oxidoreductase 0.0273 0.3988 0.6369
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0082 0.0117
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0082 0.0338
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0171 0.2436 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0415 0.1705
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0058 0.0724 0.2971
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.116 0.4763
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0066 0.0082
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0424 0.6261 1
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.1929 0.2739
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0171 0.0274
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0415 0.0517
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.1929 0.2739
Brugia malayi MH2 domain containing protein 0.0137 0.1929 0.2739
Toxoplasma gondii phosphorylase family protein 0.0088 0.1178 0.4835
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0088 0.1178 0.1178
Onchocerca volvulus 0.0032 0.0341 0.0424
Loa Loa (eye worm) fli-1 protein 0.0214 0.3084 0.4378
Echinococcus granulosus geminin 0.0356 0.5239 0.5239
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0194 0.0242
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0465 0.0465
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0494 0.0494
Schistosoma mansoni ap endonuclease 0.0021 0.0171 0.0171
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0415 0.0517
Onchocerca volvulus 0.0054 0.0674 0.0839
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.031 0.1275
Schistosoma mansoni DNA helicase recq5 0.0043 0.0499 0.0499
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0782 0.111
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0415 0.0415
Echinococcus granulosus lamin 0.0089 0.119 0.119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0891 0.0891
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0246 0.3572 0.5705
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0066 0.0082
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0004 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0415 0.1705
Loa Loa (eye worm) hypothetical protein 0.0043 0.0499 0.0709
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0088 0.1178 0.4835
Toxoplasma gondii thioredoxin reductase 0.0108 0.1482 0.6084
Loa Loa (eye worm) hypothetical protein 0.0336 0.4934 0.7005
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0043 0.0499 0.2049
Loa Loa (eye worm) hypothetical protein 0.005 0.0613 0.0871
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0674 0.0958
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0415 0.1705
Brugia malayi dihydrofolate reductase family protein 0.0049 0.0599 0.085
Echinococcus granulosus dnaJ subfamily B 0.0462 0.6842 0.6842
Brugia malayi Thioredoxin reductase 0.0108 0.1482 0.2104
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0181 0.0742
Brugia malayi Ets-domain containing protein 0.007 0.0915 0.1299
Echinococcus granulosus single minded 2 0.0041 0.0465 0.0465
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0082 0.0082
Mycobacterium tuberculosis Probable dehydrogenase 0.0246 0.3572 0.5705
Plasmodium falciparum thioredoxin reductase 0.0037 0.0415 0.1705
Echinococcus granulosus thymidylate synthase 0.0121 0.1687 0.1687
Loa Loa (eye worm) uridine phosphorylase 0.0088 0.1178 0.1672
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0494 0.0615
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0082 0.0082
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0246 0.3572 0.5705
Loa Loa (eye worm) hypothetical protein 0.0069 0.0891 0.1265
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0168 0.1428
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0004 0.0004
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0043 0.0499 0.0499
Leishmania major methylthioadenosine phosphorylase, putative 0.0088 0.1178 0.4835
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0171 0.0704
Loa Loa (eye worm) hypothetical protein 0.0043 0.0497 0.0705
Schistosoma mansoni cpg binding protein 0.0032 0.0341 0.0341
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0088 0.1178 0.1881
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0415 0.1705
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.001 0.001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0082 0.0338
Echinococcus granulosus purine nucleoside phosphorylase 0.0424 0.6261 0.6261
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0424 0.6261 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.017 0.2424 0.3441
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0171 0.2436 1
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0465 0.0661
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.0891 0.3657
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1187 0.4872
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0049 0.0599 0.0956
Leishmania major protein kinase, putative 0.0014 0.0066 0.0271
Loa Loa (eye worm) hypothetical protein 0.0182 0.2612 0.3709
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0588 0.2416
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0121 0.1687 0.1687
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0424 0.6261 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0494 0.0615
Plasmodium falciparum glutathione reductase 0.0108 0.1482 0.6084
Schistosoma mansoni cpg binding protein 0.0034 0.0369 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0891 0.0891
Treponema pallidum NADH oxidase 0.0037 0.0415 0.35
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0171 0.0274
Echinococcus multilocularis thioredoxin glutathione reductase 0.0108 0.1482 0.1482
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0004 0.0004
Brugia malayi MTAP 0.0088 0.1178 0.1672
Chlamydia trachomatis AMP nucleosidase 0.0088 0.1178 0.9923
Plasmodium vivax glutathione reductase, putative 0.0108 0.1482 0.6084
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0049 0.0599 0.0956

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

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