Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | topbp1 | 0.0041 | 0.0017 | 0.0017 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.021 | 0.0531 | 0.0531 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.021 | 0.0531 | 0.0531 |
Brugia malayi | MH2 domain containing protein | 0.0094 | 0.0178 | 0.0191 |
Loa Loa (eye worm) | RNA binding protein | 0.2468 | 0.7403 | 0.7979 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0497 | 0.0536 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0909 | 0.2658 | 0.2865 |
Onchocerca volvulus | 0.0199 | 0.0497 | 0.1793 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0909 | 0.2658 | 0.2658 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0041 | 0.0017 | 0.0019 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0228 | 0.0584 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.021 | 0.0531 | 0.0531 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0199 | 0.0497 | 0.0536 |
Brugia malayi | DKFZp564C0469 protein | 0.0041 | 0.0017 | 0.0019 |
Echinococcus granulosus | nibrin | 0.0041 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0094 | 0.0178 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0497 | 0.0536 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0909 | 0.2658 | 0.2658 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0228 | 0.0584 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.3321 | 1 | 1 |
Echinococcus multilocularis | nibrin | 0.0041 | 0.0017 | 0.0017 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0514 | 0.0514 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0571 | 0.163 | 0.603 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.0047 | 0.2643 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0088 | 0.0159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.092 | 0.2691 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.1964 | 0.5869 | 0.5869 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0093 | 0.0175 | 0.0175 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0101 | 0.0198 | 0.0198 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.0128 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.2468 | 0.7403 | 0.7403 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0088 | 0.0159 | 1 |
Onchocerca volvulus | 0.092 | 0.2691 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.163 | 0.1757 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0228 | 0.0584 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0514 | 0.0514 |
Schistosoma mansoni | tar DNA-binding protein | 0.2468 | 0.7403 | 0.7403 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.013 | 0.0288 | 0.4777 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.2873 | 0.8635 | 0.9307 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0041 | 0.0017 | 0.0017 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0094 | 0.0178 | 0.0178 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0228 | 0.0584 | 1 |
Brugia malayi | Smad1 | 0.021 | 0.0531 | 0.0573 |
Schistosoma mansoni | smad | 0.0094 | 0.0178 | 0.0178 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0094 | 0.0178 | 0.0599 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0128 | 0.1954 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0288 | 0.0311 |
Schistosoma mansoni | smad1 5 8 and | 0.021 | 0.0531 | 0.0531 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0094 | 0.0178 | 0.0191 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.013 | 0.0288 | 0.4777 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1964 | 0.5869 | 0.6325 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0041 | 0.0017 | 0.0017 |
Echinococcus multilocularis | serotonin transporter | 0.0199 | 0.0497 | 0.0497 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0094 | 0.0178 | 0.0178 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0514 | 0.0514 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.021 | 0.0531 | 0.0573 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0093 | 0.0175 | 0.0189 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.0584 |
Echinococcus granulosus | GPCR family 2 | 0.0909 | 0.2658 | 0.2658 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.0128 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0909 | 0.2658 | 0.2658 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.007 | 0.007 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.013 | 0.0288 | 0.4777 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.3321 | 1 | 1 |
Schistosoma mansoni | Smad4 | 0.0094 | 0.0178 | 0.0178 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0228 | 0.0584 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.0047 | 0.0047 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0093 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0128 | 0.0138 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0199 | 0.0497 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0497 | 0.0536 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0199 | 0.0497 | 1 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0041 | 0.0017 | 0.5 |
Schistosoma mansoni | smad | 0.021 | 0.0531 | 0.0531 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0199 | 0.0497 | 0.0497 |
Schistosoma mansoni | Smad4 | 0.021 | 0.0531 | 0.0531 |
Echinococcus granulosus | geminin | 0.0205 | 0.0514 | 0.0514 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.013 | 0.0288 | 0.4777 |
Brugia malayi | RNA recognition motif domain containing protein | 0.2468 | 0.7403 | 0.7979 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0228 | 0.0584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.2468 | 0.7403 | 0.7403 |
Brugia malayi | Isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0106 | 0.0114 |
Schistosoma mansoni | P2X receptor subunit | 0.3321 | 1 | 1 |
Brugia malayi | topoisomerase | 0.0041 | 0.0017 | 0.0019 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0094 | 0.0178 | 0.0178 |
Echinococcus granulosus | smad | 0.021 | 0.0531 | 0.0531 |
Brugia malayi | MH1 domain containing protein | 0.021 | 0.0531 | 0.0573 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0148 | 0.0159 |
Echinococcus multilocularis | GPCR, family 2 | 0.0909 | 0.2658 | 0.2658 |
Schistosoma mansoni | hypothetical protein | 0.0909 | 0.2658 | 0.2658 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0094 | 0.0178 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.2873 | 0.8635 | 0.9307 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.063 |
Loa Loa (eye worm) | nuclear factor I | 0.0116 | 0.0245 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0245 | 0.0264 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.013 | 0.0288 | 0.4777 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.2873 | 0.8635 | 0.9307 |
Brugia malayi | MH2 domain containing protein | 0.3084 | 0.9278 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.2468 | 0.7403 | 0.7403 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.021 | 0.0531 | 0.0531 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.3321 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.3084 | 0.9278 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0228 | 0.0584 | 1 |
Brugia malayi | hypothetical protein | 0.092 | 0.2691 | 0.29 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.021 | 0.0531 | 0.0573 |
Schistosoma mansoni | P2X receptor subunit | 0.3321 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0909 | 0.2658 | 0.2865 |
Brugia malayi | N-terminal motif family protein | 0.0571 | 0.163 | 0.1757 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.013 | 0.0288 | 0.4777 |
Brugia malayi | isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.063 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0909 | 0.2658 | 0.2865 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 0.231 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0228 | 0.0584 | 0.0584 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0058 | 0.007 | 0.007 |
Brugia malayi | MH1 domain containing protein | 0.021 | 0.0531 | 0.0573 |
Loa Loa (eye worm) | hypothetical protein | 0.0909 | 0.2658 | 0.2865 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0128 | 0.1954 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0094 | 0.0178 | 0.0178 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.021 | 0.0531 | 0.0531 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.2873 | 0.8635 | 0.9307 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 0.0128 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0909 | 0.2658 | 0.2658 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.0047 | 0.0047 |
Schistosoma mansoni | DNA ligase IV | 0.0041 | 0.0017 | 0.0017 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.0584 |
Brugia malayi | MH2 domain containing protein | 0.021 | 0.0531 | 0.0573 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0041 | 0.0017 | 0.0017 |
Schistosoma mansoni | tar DNA-binding protein | 0.2468 | 0.7403 | 0.7403 |
Brugia malayi | hypothetical protein | 0.013 | 0.0288 | 0.0311 |
Echinococcus multilocularis | tar DNA binding protein | 0.2468 | 0.7403 | 0.7403 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.0584 |
Schistosoma mansoni | topbp1 | 0.0041 | 0.0017 | 0.0017 |
Echinococcus granulosus | Smad4 | 0.021 | 0.0531 | 0.0531 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0909 | 0.2658 | 0.2658 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.0584 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0041 | 0.0017 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.0128 | 0.1954 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.0584 |
Schistosoma mansoni | tar DNA-binding protein | 0.2468 | 0.7403 | 0.7403 |
Schistosoma mansoni | hypothetical protein | 0.0909 | 0.2658 | 0.2658 |
Schistosoma mansoni | smad1 5 8 and | 0.021 | 0.0531 | 0.0531 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0017 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.021 | 0.0531 | 0.0531 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 1 |
Brugia malayi | MH2 domain containing protein | 0.021 | 0.0531 | 0.0573 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0228 | 0.0584 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0199 | 0.0497 | 0.0536 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0228 | 0.0584 | 0.0584 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.3084 | 0.9278 | 1 |
Loa Loa (eye worm) | Smad1 | 0.021 | 0.0531 | 0.0573 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0199 | 0.0497 | 0.0536 |
Schistosoma mansoni | smad1 5 8 and | 0.021 | 0.0531 | 0.0531 |
Brugia malayi | TAR-binding protein | 0.2468 | 0.7403 | 0.7979 |
Echinococcus granulosus | serotonin transporter | 0.0199 | 0.0497 | 0.0497 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0017 | 0.0019 |
Schistosoma mansoni | Smad4 | 0.0094 | 0.0178 | 0.0178 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0101 | 0.0198 | 0.0198 |
Schistosoma mansoni | P2X receptor subunit | 0.3321 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.3321 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.3321 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.3321 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0228 | 0.0584 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0058 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0178 | 0.0191 |
Brugia malayi | RNA binding protein | 0.2468 | 0.7403 | 0.7979 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.1964 | 0.5869 | 0.6325 |
Echinococcus multilocularis | smad | 0.021 | 0.0531 | 0.0531 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0041 | 0.0017 | 0.0019 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0199 | 0.0497 | 0.0497 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.2468 | 0.7403 | 0.7979 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.013 | 0.0288 | 0.4777 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0228 | 0.0584 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0128 | 0.1954 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0093 | 0.0175 | 0.0189 |
Loa Loa (eye worm) | TAR-binding protein | 0.2468 | 0.7403 | 0.7979 |
Schistosoma mansoni | hypothetical protein | 0.0909 | 0.2658 | 0.2658 |
Brugia malayi | MH1 domain containing protein | 0.0116 | 0.0245 | 0.0264 |
Brugia malayi | MH1 domain containing protein | 0.0116 | 0.0245 | 0.0264 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.