Detailed information for compound 1416358

Basic information

Technical information
  • TDR Targets ID: 1416358
  • Name: N-(5-chloro-2-methoxyphenyl)-5-(4-methoxyphen yl)-1,2-oxazole-3-carboxamide
  • MW: 358.776 | Formula: C18H15ClN2O4
  • H donors: 1 H acceptors: 2 LogP: 3.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1onc(c1)C(=O)Nc1cc(Cl)ccc1OC
  • InChi: 1S/C18H15ClN2O4/c1-23-13-6-3-11(4-7-13)17-10-15(21-25-17)18(22)20-14-9-12(19)5-8-16(14)24-2/h3-10H,1-2H3,(H,20,22)
  • InChiKey: ULHGUDSVAGCOSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-chloro-2-methoxy-phenyl)-5-(4-methoxyphenyl)isoxazole-3-carboxamide
  • N-(5-chloro-2-methoxyphenyl)-5-(4-methoxyphenyl)-3-isoxazolecarboxamide
  • N-(5-chloro-2-methoxy-phenyl)-5-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide
  • EU-0023672

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0089 0.0909 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0024
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0024 0.0054 0.0054
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0783 1 1
Brugia malayi RasGEF domain containing protein 0.0024 0.0054 0.0054
Schistosoma mansoni tight junction protein 0.0024 0.0054 0.0054
Echinococcus multilocularis Partitioning defective 3 protein B 0.0024 0.0054 0.0054
Loa Loa (eye worm) guanylate kinase 0.0024 0.0054 0.0054
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0109 0.1167 0.1167
Entamoeba histolytica type A flavoprotein, putative 0.03 0.3666 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.0716 0.0716
Schistosoma mansoni regulator of G protein signaling 0.0024 0.0054 0.0054
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0783 1 1
Brugia malayi flavodoxin family protein 0.03 0.3666 0.3666
Schistosoma mansoni MAGUK homolog 0.0024 0.0054 0.0054
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0024 0.0054 0.0054
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis cytochrome b5 reductase 4 0.0089 0.0909 0.0909
Schistosoma mansoni diflavin oxidoreductase 0.0389 0.4832 0.4832
Onchocerca volvulus 0.0024 0.0054 0.0593
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Brugia malayi FAD binding domain containing protein 0.0783 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus granulosus pdz domain containing protein 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0783 1 1
Echinococcus granulosus ligand of numb protein x 2 0.0024 0.0054 0.0054
Schistosoma mansoni discs lost-related 0.0024 0.0054 0.0054
Schistosoma mansoni cell polarity protein 0.0024 0.0054 0.0054
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.0024 0.0054 0.0054
Brugia malayi protein kinase C-binding protein PICK1 0.0024 0.0054 0.0054
Brugia malayi PDZ domain 0.0024 0.0054 0.0054
Echinococcus multilocularis protein piccolo 0.0024 0.0054 0.0054
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0694 0.8834 0.8753
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0024 0.0024
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0024 0.0054 0.0054
Echinococcus multilocularis pdz domain containing protein 0.0024 0.0054 0.0054
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0054 0.0054
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.0024 0.0054 0.0054
Echinococcus granulosus pdz domain containing protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) DIX domain-containing protein 0.0024 0.0054 0.0054
Echinococcus granulosus disks large 3 0.0024 0.0054 0.0054
Echinococcus granulosus disks large 1 0.0024 0.0054 0.0054
Schistosoma mansoni MAGUK homolog 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0024 0.0054 0.0054
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0024 0.0054 0.0054
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0783 1 1
Schistosoma mansoni ATP-dependent RNA Helicase 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0064 0.0587 0.0587
Loa Loa (eye worm) flavodoxin family protein 0.03 0.3666 0.3666
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0783 1 1
Brugia malayi PDZ-domain protein scribble 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni maguk P55 subfamily member 35 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0325 0.4005 0.4005
Schistosoma mansoni multiple pdz domain protein 0.0024 0.0054 0.0054
Schistosoma mansoni dock 0.0109 0.1167 0.1167
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0089 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis beta 1 syntrophin 0.0024 0.0054 0.0054
Trichomonas vaginalis NADPH cytochrome P450, putative 0.03 0.3666 0.3225
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.03 0.3666 0.3033
Echinococcus granulosus segment polarity protein dishevelled 0.0024 0.0054 0.0054
Loa Loa (eye worm) diaphorase 0.0089 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0805 0.0805
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) syntrophin-1 0.0024 0.0054 0.0054
Brugia malayi PDZ domain containing protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) gopc protein 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni multiple pdz domain protein 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Echinococcus multilocularis methionine synthase reductase 0.0484 0.6076 0.6076
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0054 0.0054
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0024 0.0054 0.0054
Brugia malayi Neurabin protein 1 0.0024 0.0054 0.0054
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.0024 0.0054 0.0054
Echinococcus multilocularis pdz domain containing protein 0.0024 0.0054 0.0054
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0024 0.0054 0.0054
Schistosoma mansoni Patj homolog 0.0024 0.0054 0.0054
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.03 0.3666 0.3033
Brugia malayi Ferm domain 0.0024 0.0054 0.0054
Brugia malayi Protein-tyrosine phosphatase 1 0.0024 0.0054 0.0054
Mycobacterium tuberculosis Possible oxygenase 0.0089 0.0909 0.5
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0024 0.0054 0.0054
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0024 0.0024
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0024 0.0054 0.0054
Schistosoma mansoni pdz and lim domain protein 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Plasmodium vivax flavodoxin domain containing protein 0.0694 0.8834 0.8717
Onchocerca volvulus 0.0024 0.0054 0.0593
Mycobacterium tuberculosis Probable monooxygenase 0.0089 0.0909 0.5
Brugia malayi PDZ domain 0.0024 0.0054 0.0054
Echinococcus granulosus protein lin 7 B 0.0024 0.0054 0.0054
Echinococcus multilocularis 0.0024 0.0054 0.0054
Leishmania major hypothetical protein, conserved 0.03 0.3666 0.3033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus granulosus cell polarity protein 0.0024 0.0054 0.0054
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0024 0.0054 0.0054
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0783 1 1
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0054 0.0054
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0325 0.4005 0.4005
Echinococcus multilocularis partitioning defective 3 0.0024 0.0054 0.0054
Onchocerca volvulus Arc homolog 0.0024 0.0054 0.0593
Trichomonas vaginalis NADPH cytochrome P450, putative 0.03 0.3666 0.3225
Brugia malayi Partitioning defective-6 homolog alpha 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0024 0.0024
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0024 0.0054 0.0054
Schistosoma mansoni dishevelled 0.0024 0.0054 0.0054
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0054 0.0054
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0325 0.4005 0.4005
Schistosoma mansoni cytochrome P450 reductase 0.0783 1 1
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0024 0.0054 0.0054
Trichomonas vaginalis sulfite reductase, putative 0.0783 1 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0783 1 1
Entamoeba histolytica type A flavoprotein, putative 0.03 0.3666 0.5
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.0024 0.0054 0.0054
Brugia malayi PDZ domain containing protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) RasGEF domain-containing protein 0.0024 0.0054 0.0054
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Echinococcus multilocularis ligand of numb protein x 2 0.0024 0.0054 0.0054
Schistosoma mansoni cell polarity protein 0.0024 0.0054 0.0054
Schistosoma mansoni cell polarity protein 0.0024 0.0054 0.0054
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0024 0.0024
Echinococcus granulosus multiple pdz domain protein 0.0024 0.0054 0.0054
Echinococcus granulosus amyloid beta A4 protein 0.0024 0.0054 0.0054
Echinococcus granulosus segment polarity protein dishevelled 0.0024 0.0054 0.0054
Schistosoma mansoni pdz domain containing protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0805 0.0805
Onchocerca volvulus 0.0089 0.0909 1
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0024 0.0054 0.0054
Echinococcus granulosus neurabin 1 0.0024 0.0054 0.0054
Toxoplasma gondii flavodoxin domain-containing protein 0.0389 0.4832 1
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Echinococcus granulosus PRKCA binding protein 0.0024 0.0054 0.0054
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0024 0.0054 0.0593
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus granulosus partitioning defective 3 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Schistosoma mansoni cell polarity protein 0.0024 0.0054 0.0054
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.03 0.3666 0.3033
Brugia malayi gopc protein 0.0024 0.0054 0.0054
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0024 0.0054 0.0054
Echinococcus multilocularis multiple pdz domain protein 0.0024 0.0054 0.0054
Toxoplasma gondii flavodoxin domain-containing protein 0.0389 0.4832 1
Echinococcus multilocularis disks large 3 0.0024 0.0054 0.0054
Schistosoma mansoni protein kinase C alpha binding protein 0.0024 0.0054 0.0054
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0024 0.0054 0.0054
Brugia malayi C2 domain containing protein 0.0024 0.0054 0.0054
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.0716 0.0716
Echinococcus multilocularis partitioning defective 3 0.0024 0.0054 0.0054
Schistosoma mansoni maguk P55 subfamily member 26 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Plasmodium falciparum nitric oxide synthase, putative 0.0783 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) PX domain-containing protein 0.0024 0.0054 0.0054
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.0024 0.0054 0.0054
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0024 0.0054 0.0054
Echinococcus granulosus beta 1 syntrophin 0.0024 0.0054 0.0054
Echinococcus multilocularis multiple pdz domain protein 0.0024 0.0054 0.0054
Echinococcus multilocularis microtubule associated serine:threonine protein 0.0024 0.0054 0.0054
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.03 0.3666 0.3033
Schistosoma mansoni multiple pdz domain protein 0.0024 0.0054 0.0054
Echinococcus granulosus multiple pdz domain protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) FAD binding domain-containing protein 0.0783 1 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0783 1 1
Entamoeba histolytica type A flavoprotein, putative 0.03 0.3666 0.5
Brugia malayi Synapse defective protein 1 0.0024 0.0054 0.0054
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0783 1 1
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0089 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.03 0.3666 0.3033
Echinococcus multilocularis partitioning defective protein 6 0.0024 0.0054 0.0054
Brugia malayi gamma-syntrophin-like protein SYN2 0.0024 0.0054 0.0054
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0024 0.0054 0.0054
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0089 0.0909 0.0909
Schistosoma mansoni afadin (af-6 protein) 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Entamoeba histolytica type A flavoprotein, putative 0.03 0.3666 0.5
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0024 0.0054 0.0054
Brugia malayi Guanylate kinase family protein 0.0024 0.0054 0.0054
Brugia malayi Peripheral plasma membrane protein CASK 0.0024 0.0054 0.0054
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.03 0.3666 0.3033
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0024 0.0024
Brugia malayi cell junction protein LIN-7 0.0024 0.0054 0.0054
Leishmania major cytochrome P450 reductase, putative 0.0694 0.8834 0.8717
Echinococcus multilocularis multiple pdz domain protein 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Brugia malayi Syntrophin-1 0.0024 0.0054 0.0054
Schistosoma mansoni amyloid beta A4 protein related 0.0024 0.0054 0.0054
Plasmodium vivax hypothetical protein, conserved 0.03 0.3666 0.3033
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.0024 0.0054 0.0054
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0484 0.6076 0.6076
Onchocerca volvulus 0.0024 0.0054 0.0593
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0024 0.0054 0.0054
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0054 0.0054
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.0716 0.0716
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0783 1 1
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0109 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0325 0.4005 0.4005
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Brugia malayi diaphorase 0.0089 0.0909 0.0909
Brugia malayi interleukin-16 0.0024 0.0054 0.0054
Brugia malayi 9ORF binding protein 1 0.0024 0.0054 0.0054
Echinococcus multilocularis pdz domain containing protein 0.0024 0.0054 0.0054
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0089 0.0909 0.5
Echinococcus multilocularis segment polarity protein dishevelled 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0024 0.0054 0.0054
Schistosoma mansoni multiple pdz domain protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0448 0.5607 0.5607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0024 0.0054 0.0054
Brugia malayi Guanylate kinase family protein 0.0024 0.0054 0.0054
Echinococcus multilocularis segment polarity protein dishevelled 0.0024 0.0054 0.0054
Schistosoma mansoni amine GPCR 0.0362 0.4485 0.4485
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0024 0.0054 0.0054
Trichomonas vaginalis NADPH cytochrome P450, putative 0.03 0.3666 0.3225
Schistosoma mansoni PDZ domain protein 0.0024 0.0054 0.0054
Brugia malayi PDZ domain containing protein 0.0024 0.0054 0.0054
Echinococcus granulosus Partitioning defective 3 protein B 0.0024 0.0054 0.0054
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0024 0.0054 0.0054
Echinococcus granulosus cytochrome b5 reductase 4 0.0089 0.0909 0.0909
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0054 0.0054
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.0024 0.0054 0.0054
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.0024 0.0054 0.0054
Echinococcus multilocularis pdz domain containing protein 0.0024 0.0054 0.0054
Echinococcus multilocularis amyloid beta A4 protein 0.0024 0.0054 0.0054
Echinococcus granulosus multiple pdz domain protein 0.0024 0.0054 0.0054
Schistosoma mansoni syntenin 0.0024 0.0054 0.0054
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) X11 protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) PDZ domain-containing protein 0.0024 0.0054 0.0054
Entamoeba histolytica type A flavoprotein, putative 0.03 0.3666 0.5
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.0024 0.0054 0.0054
Echinococcus multilocularis tight junction protein ZO 3 0.0024 0.0054 0.0054
Mycobacterium tuberculosis Probable oxidoreductase 0.0089 0.0909 0.5
Schistosoma mansoni dishevelled 0.0024 0.0054 0.0054
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0783 1 1
Echinococcus granulosus Rho GTPase activating protein 21 0.0024 0.0054 0.0054
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.0024 0.0054 0.0054
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0783 1 1
Schistosoma mansoni leucine-rich repeat protein 0.0024 0.0054 0.0054
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0783 1 1
Chlamydia trachomatis sulfite reductase 0.0484 0.6076 1
Echinococcus granulosus cytochrome b5 reductase 4 0.0089 0.0909 0.0909
Echinococcus multilocularis PRKCA binding protein 0.0024 0.0054 0.0054
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Giardia lamblia Hypothetical protein 0.0694 0.8834 1
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0024 0.0054 0.0054
Trypanosoma cruzi p450 reductase, putative 0.0783 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0024 0.0054 0.0054
Schistosoma mansoni multiple pdz domain protein 0.0024 0.0054 0.0054
Echinococcus multilocularis syndecan binding protein (syntenin) 0.0024 0.0054 0.0054
Echinococcus multilocularis protein lin 7 B 0.0024 0.0054 0.0054
Echinococcus multilocularis dedicator of cytokinesis protein 0.0092 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis Rho GTPase activating protein 21 0.0024 0.0054 0.0054
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0024 0.0054 0.0054
Loa Loa (eye worm) PAR-6 protein 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Loa Loa (eye worm) cell junction protein LIN-7 0.0024 0.0054 0.0054
Echinococcus granulosus pdz domain containing protein 0.0024 0.0054 0.0054
Echinococcus granulosus methionine synthase reductase 0.0484 0.6076 0.6076
Echinococcus granulosus pdz domain containing protein 0.0024 0.0054 0.0054
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0089 0.0909 0.1419
Trichomonas vaginalis NADPH cytochrome P450, putative 0.03 0.3666 0.3225
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0089 0.0909 0.0909
Brugia malayi rho guanine nucleotide exchange factor 12 0.0024 0.0054 0.0054
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0024 0.0024
Schistosoma mansoni discs large 0.0024 0.0054 0.0054
Schistosoma mansoni cytochrome B5 0.0089 0.0909 0.0909
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0024 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni sap-97 0.0024 0.0054 0.0054
Loa Loa (eye worm) FAD binding domain-containing protein 0.0484 0.6076 0.6076
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.0024 0.0054 0.0054
Schistosoma mansoni NADPH flavin oxidoreductase 0.0395 0.491 0.491
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0089 0.0909 0.0909
Treponema pallidum flavodoxin 0.03 0.3666 1
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus granulosus tight junction protein ZO 3 0.0024 0.0054 0.0054
Echinococcus multilocularis neurabin 1 0.0024 0.0054 0.0054
Brugia malayi Shank2E 0.0024 0.0054 0.0054
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0448 0.5607 0.5607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Brugia malayi DIX domain containing protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) 9ORF binding protein 1 0.0024 0.0054 0.0054
Giardia lamblia Nitric oxide synthase, inducible 0.0694 0.8834 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Brugia malayi Patj homolog 0.0024 0.0054 0.0054
Schistosoma mansoni lim domain 0.0024 0.0054 0.0054
Echinococcus granulosus glutamate receptor interacting protein 1 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0024 0.0054 0.0054
Schistosoma mansoni leucine-rich repeat protein 0.0024 0.0054 0.0054
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0783 1 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0783 1 1
Loa Loa (eye worm) guanylate kinase 0.0024 0.0054 0.0054
Brugia malayi syntenin 0.0024 0.0054 0.0054
Onchocerca volvulus 0.0024 0.0054 0.0593
Schistosoma mansoni syntrophin 0.0024 0.0054 0.0054
Brugia malayi PX domain containing protein 0.0024 0.0054 0.0054
Brugia malayi PDZ domain containing protein 0.0024 0.0054 0.0054
Echinococcus granulosus partitioning defective 3 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Echinococcus multilocularis disks large 1 0.0024 0.0054 0.0054
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0024 0.0054 0.0054
Schistosoma mansoni pdz domain containing protein 0.0024 0.0054 0.0054
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0024 0.0054 0.0054
Schistosoma mansoni lin-7-like proteins 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0024 0.0054 0.0054
Leishmania major p450 reductase, putative 0.0783 1 1
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.0024 0.0054 0.0054
Echinococcus granulosus syndecan binding protein syntenin 0.0024 0.0054 0.0054
Brugia malayi FAD binding domain containing protein 0.0484 0.6076 0.6076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Onchocerca volvulus Big bang homolog 0.0024 0.0054 0.0593

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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