Detailed information for compound 1416716

Basic information

Technical information
  • TDR Targets ID: 1416716
  • Name: MLS000040065
  • MW: 347.432 | Formula: C17H21N3O3S
  • H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc2c(c1N)c1CCCc1c(n2)N1CCOCC1
  • InChi: 1S/C17H21N3O3S/c1-2-23-17(21)14-13(18)12-10-4-3-5-11(10)15(19-16(12)24-14)20-6-8-22-9-7-20/h2-9,18H2,1H3
  • InChiKey: ZOOLZEWFARNRQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • SMR000042703
  • STOCK3S-92791

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0178 0.0125
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0567 0.0608
Brugia malayi glutathione reductase 0.0057 0.0441 0.0592
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.03 0.0291
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0063 0.0504 0.3917
Brugia malayi MH1 domain containing protein 0.0028 0.0136 0.0182
Schistosoma mansoni hypothetical protein 0.0067 0.0544 0.0595
Echinococcus multilocularis muscleblind protein 0.018 0.1719 0.1674
Leishmania major DNA topoisomerase 1A 0.0041 0.0275 0.2016
Loa Loa (eye worm) hypothetical protein 0.0131 0.1203 0.1543
Brugia malayi hypothetical protein 0.0084 0.0723 0.0971
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0054 0.0009
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0649 0.0598
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0178 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0567 0.8627
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.197 0.6328
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0178 0.1184
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0597 0.0545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Echinococcus multilocularis GPCR, family 2 0.0067 0.0544 0.0492
Loa Loa (eye worm) TAR-binding protein 0.0259 0.2531 0.3341
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0178 0.0125
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0374 0.0321
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0367 0.0315
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2085 0.6706
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0178 0.1184
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0081 0.0031
Echinococcus multilocularis zinc finger protein 0.0024 0.0094 0.004
Schistosoma mansoni Smad4 0.0022 0.0081 0.0047
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0081 0.0031
Schistosoma mansoni smad1 5 8 and 0.005 0.0367 0.0386
Entamoeba histolytica hypothetical protein 0.0043 0.03 1
Brugia malayi hypothetical protein 0.0043 0.03 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2531 0.2949
Brugia malayi follicle stimulating hormone receptor 0.028 0.2749 0.3689
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0299 0.029
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0649 0.9092
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0178 0.1079
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0054 0.0117
Plasmodium falciparum glutathione reductase 0.0057 0.0441 0.3367
Trypanosoma brucei DNA topoisomerase IA, putative 0.0041 0.0275 0.2016
Loa Loa (eye worm) hypothetical protein 0.0196 0.1878 0.2457
Brugia malayi Bromodomain containing protein 0.0091 0.0788 0.1058
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0125 0.1077
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.2044 0.2743
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.2801 0.2762
Leishmania major DNA topoisomerase III, putative 0.0021 0.0071 0.0261
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0367 0.0315
Brugia malayi DNA topoisomerase III beta-1 0.0021 0.0071 0.0096
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0649 0.9092
Loa Loa (eye worm) hypothetical protein 0.018 0.1719 0.2242
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.1203 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0374 0.2469
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Loa Loa (eye worm) nuclear factor I 0.0028 0.0136 0.0099
Toxoplasma gondii DNA topoisomerase family protein 0.0041 0.0275 0.1922
Brugia malayi MH2 domain containing protein 0.0733 0.7451 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.2801 0.3268
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.2044 0.2743
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3082 1
Toxoplasma gondii SWI2/SNF2-containing protein 0.0042 0.0283 0.1986
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0374 0.2029
Plasmodium falciparum DNA topoisomerase 3, putative 0.0041 0.0275 0.1922
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Echinococcus multilocularis muscleblind protein 1 0.018 0.1719 0.1674
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0081 0.0108
Loa Loa (eye worm) hypothetical protein 0.0067 0.0544 0.0651
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0441 0.3445
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0441 0.2991
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0441 0.0389
Treponema pallidum DNA topoisomerase I (topA) 0.0083 0.0708 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3082 1
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0041 0.0275 0.2016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0054 0.0117
Brugia malayi MH2 domain containing protein 0.005 0.0367 0.0493
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0441 0.3367
Trypanosoma cruzi DNA topoisomerase III, putative 0.0021 0.0071 0.0261
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.03 0.0247
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0178 0.0125
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.2044 0.2681
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.135 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0649 0.5176
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.1203 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0178 0.0163
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0132 0.0078
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0021 0.0071 0.0011
Schistosoma mansoni Smad4 0.0022 0.0081 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3082 1
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.197 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.1203 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0063 0.0026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0544 0.058
Brugia malayi Muscleblind-like protein 0.018 0.1719 0.2307
Schistosoma mansoni Smad4 0.005 0.0367 0.0386
Brugia malayi N-terminal motif family protein 0.0196 0.1878 0.2521
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0041 0.0275 0.0729
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0649 0.9092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0544 0.0492
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0178 0.1079
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0649 0.5176
Schistosoma mansoni hypothetical protein 0.0059 0.0457 0.0492
Toxoplasma gondii hypothetical protein 0.0027 0.0125 0.0613
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0567 0.0516
Loa Loa (eye worm) hypothetical protein 0.0085 0.0735 0.0909
Trypanosoma brucei DNA topoisomerase III, putative 0.0021 0.0071 0.0261
Entamoeba histolytica hypothetical protein 0.0043 0.03 1
Brugia malayi DNA topoisomerase III 0.0041 0.0275 0.0369
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0441 0.0512
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.197 0.6328
Loa Loa (eye worm) hypothetical protein 0.0145 0.1349 0.1741
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.2801 0.3268
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0178 0.1184
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.12 0.877
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0054 0.0117
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8488 0.8479
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0178 0.0239
Echinococcus granulosus muscleblind protein 0.018 0.1719 0.1974
Chlamydia trachomatis DNA topoisomerase I 0.0083 0.0708 1
Loa Loa (eye worm) DNA topoisomerase III 0.0041 0.0275 0.0287
Brugia malayi Probable ClpP-like protease 0.0077 0.0649 0.0871
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0285 0.2801 0.3759
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0054 0.0016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0567 0.8627
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.3082 0.4136
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0041 0.0275 0.0729
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0519 0.0618
Toxoplasma gondii LsmAD domain-containing protein 0.0131 0.1203 1
Echinococcus multilocularis tar DNA binding protein 0.0259 0.2531 0.2491
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0054 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2749 0.3635
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0178 0.1184
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0441 0.0459
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0081 0.0027
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0021 0.0071 0.0017
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0178 0.0147
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0054 0.0117
Trypanosoma cruzi DNA topoisomerase III, putative 0.0041 0.0275 0.2016
Schistosoma mansoni zinc finger protein 0.0024 0.0094 0.0063
Schistosoma mansoni bromodomain containing protein 0.0076 0.0641 0.0711
Brugia malayi MH1 domain containing protein 0.005 0.0367 0.0493
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Echinococcus granulosus GPCR family 2 0.0067 0.0544 0.058
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.1203 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Schistosoma mansoni hypothetical protein 0.0145 0.1349 0.1549
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0178 0.0156
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0081 0.0024
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0081 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.033 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2531 0.2949
Brugia malayi MH1 domain containing protein 0.005 0.0367 0.0493
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0567 0.3964
Brugia malayi RNA binding protein 0.0259 0.2531 0.3397
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0367 0.0412
Schistosoma mansoni hypothetical protein 0.0067 0.0544 0.0595
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0054 0.0117
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0649 0.4278
Brugia malayi Bromodomain containing protein 0.0046 0.0329 0.0441
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0054 0.0117
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0132 0.0091
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.0457 0.0477
Brugia malayi MH1 domain containing protein 0.0028 0.0136 0.0182
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0567 0.0623
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0108 0.0061
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8488 1
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0041 0.0275 0.2016
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0132 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.2801 0.3268
Brugia malayi TAR-binding protein 0.0259 0.2531 0.3397
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0544 0.073
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0567 0.0762
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0649 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.2801 0.2762
Schistosoma mansoni hypothetical protein 0.0043 0.03 0.0306
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0054 0.0117
Brugia malayi PHD-finger family protein 0.003 0.0161 0.0216
Trypanosoma cruzi DNA topoisomerase III, putative 0.0041 0.0275 0.2016
Giardia lamblia DNA topoisomerase III 0.0021 0.0071 0.076
Loa Loa (eye worm) hypothetical protein 0.0077 0.0649 0.0793
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0597 0.0643
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0083 0.0708 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0063 0.0008
Brugia malayi Smad1 0.005 0.0367 0.0493
Toxoplasma gondii thioredoxin reductase 0.0057 0.0441 0.3367
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0081 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.2801 0.3257
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0178 0.0125
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0374 0.2469
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.2531 0.3397
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3082 1
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0374 0.0378
Entamoeba histolytica hypothetical protein 0.0043 0.03 1
Trypanosoma brucei PAB1-binding protein , putative 0.0131 0.1203 1
Entamoeba histolytica hypothetical protein 0.0043 0.03 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3082 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.197 0.6328
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0041 0.0275 0.0262
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0178 0.1184
Loa Loa (eye worm) MH2 domain-containing protein 0.0733 0.7451 1
Plasmodium vivax ataxin-2 like protein, putative 0.0131 0.1203 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.03 0.0306
Loa Loa (eye worm) glutathione reductase 0.0057 0.0441 0.0512
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0299 0.0246
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0367 0.0386
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0054 0.0117
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0367 0.0371
Schistosoma mansoni smad 0.005 0.0367 0.0386
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0649 1
Schistosoma mansoni hypothetical protein 0.0067 0.0544 0.0595
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8488 1
Schistosoma mansoni smad1 5 8 and 0.005 0.0367 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0367 0.0412
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.135 1
Echinococcus multilocularis smad 0.005 0.0367 0.0315
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0178 0.1079
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0649 0.0705
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0178 0.0964
Loa Loa (eye worm) RNA binding protein 0.0259 0.2531 0.3341
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2531 0.2949
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0544 0.0651
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0063 0.0008
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.12 0.8838
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0063 0.0026
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.135 1
Mycobacterium tuberculosis Probable reductase 0.013 0.12 0.8838
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.12 0.8838
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0063 0.0026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0544 0.0492
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0544 0.058
Schistosoma mansoni hypothetical protein 0.0067 0.0544 0.0595
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2531 0.2949
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0117
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0544 0.073
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.2531 0.3341
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.197 0.6328
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0021 0.0071 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0024
Schistosoma mansoni smad 0.0022 0.0081 0.0047
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.12 0.8838
Loa Loa (eye worm) hypothetical protein 0.0212 0.2044 0.2681
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.1349 0.1811
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0649 0.5176
Brugia malayi MH2 domain containing protein 0.0022 0.0081 0.0108
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0178 0.1079
Leishmania major DNA topoisomerase III, putative 0.0083 0.0708 0.5744
Trypanosoma brucei DNA topoisomerase III, putative 0.0041 0.0275 0.2016
Loa Loa (eye worm) transcription factor SMAD2 0.0733 0.7451 1
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2085 0.6706
Trypanosoma brucei trypanothione reductase 0.0057 0.0441 0.3445
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0125 0.0613
Echinococcus granulosus tar DNA binding protein 0.0259 0.2531 0.2937
Brugia malayi isocitrate dehydrogenase 0.0032 0.0178 0.0239
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0054 0.0117
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0649 0.072
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.12 0.8838
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0649 0.9092
Plasmodium vivax glutathione reductase, putative 0.0057 0.0441 0.3367
Plasmodium vivax DNA topoisomerase 3, putative 0.0041 0.0275 0.1922
Schistosoma mansoni hypothetical protein 0.0025 0.0108 0.0079
Loa Loa (eye worm) Smad1 0.005 0.0367 0.0412
Leishmania major hypothetical protein, conserved 0.0131 0.1203 1
Plasmodium falciparum thioredoxin reductase 0.0057 0.0441 0.3367
Echinococcus granulosus zinc finger protein 0.0024 0.0094 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0063 0.0026
Echinococcus granulosus smad 0.005 0.0367 0.0371
Echinococcus multilocularis Smad4 0.005 0.0367 0.0315
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.135 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0136 0.0099
Brugia malayi Thioredoxin reductase 0.0057 0.0441 0.0592
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.0457 0.0404
Schistosoma mansoni smad1 5 8 and 0.005 0.0367 0.0386
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0649 0.5176
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.2801 0.3257
Giardia lamblia DNA topoisomerase III 0.0041 0.0275 1
Brugia malayi MH2 domain containing protein 0.005 0.0367 0.0493
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0083 0.0708 0.079
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0063 0.001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.1878 0.9514
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.007 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0285 0.2801 0.3706
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3082 1
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0041 0.0275 0.1227
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0367 0.0371
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0063 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.197 0.6328
Leishmania major trypanothione reductase 0.0057 0.0441 0.3445
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0125 0.0613
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.12 0.8838
Loa Loa (eye worm) hypothetical protein 0.0052 0.0383 0.0434
Mycobacterium ulcerans DNA topoisomerase I 0.0041 0.0275 0.3713
Loa Loa (eye worm) hypothetical protein 0.018 0.1719 0.2242
Brugia malayi hypothetical protein 0.0131 0.1203 0.1615
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.3082 0.4086
Loa Loa (eye worm) hypothetical protein 0.0049 0.0359 0.0401
Echinococcus granulosus Smad4 0.005 0.0367 0.0371
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0021 0.0071 0.002
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2531 0.2949
Echinococcus multilocularis rho GTPase activating protein 20 0.0041 0.0275 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.197 0.6328
Entamoeba histolytica DNA topoisomerase III, putative 0.0041 0.0275 0.8929
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0022 0.0081 0.0051
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0567 0.4531
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.197 0.6328

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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