Detailed information for compound 1416877

Basic information

Technical information
  • TDR Targets ID: 1416877
  • Name: 1-(2,5-diethoxyphenyl)sulfonyl-2-methylpiperi dine
  • MW: 327.439 | Formula: C16H25NO4S
  • H donors: 0 H acceptors: 2 LogP: 3.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1S(=O)(=O)N1CCCCC1C)OCC
  • InChi: 1S/C16H25NO4S/c1-4-20-14-9-10-15(21-5-2)16(12-14)22(18,19)17-11-7-6-8-13(17)3/h9-10,12-13H,4-8,11H2,1-3H3
  • InChiKey: WEOIARJVTJPTGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,5-diethoxyphenyl)sulfonyl-2-methyl-piperidine
  • BAS 01178052
  • 1-(2,5-Diethoxy-benzenesulfonyl)-2-methyl-piperidine
  • MLS000073788
  • SMR000010141
  • A2156/0090585
  • Oprea1_693241
  • Oprea1_725628

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.1897 0.4508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Schistosoma mansoni biogenic amine receptor 0.003 0.1897 0.4508
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.1897 0.4508
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0202 0.048
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi Cathepsin L-like precursor 0.002 0.0202 0.0285
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0202 0.048
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.8847 0.8824
Leishmania major cathepsin L-like protease 0.0077 1 1
Schistosoma mansoni biogenic amine receptor 0.003 0.1897 0.4508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.1897 0.2673
Onchocerca volvulus 0.003 0.1897 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus neuropeptide Y receptor 0.003 0.1897 0.4508
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.1897 0.4508
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.1897 0.4508
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.1897 0.4508
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.4207 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Echinococcus multilocularis sex peptide receptor 0.003 0.1897 0.4508
Brugia malayi GnHR receptor homolog 0.003 0.1897 0.2673
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0202 0.0285
Entamoeba histolytica hypothetical protein 0.0043 0.4207 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.1897 0.4508
Echinococcus granulosus neuropeptide receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.1897 0.4508
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0202 0.048
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0202 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.1897 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni amine GPCR 0.003 0.1897 0.4508
Onchocerca volvulus 0.003 0.1897 1
Brugia malayi Melatonin receptor type 1A 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.1897 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0202 0.048
Brugia malayi Serotonin receptor 0.003 0.1897 0.2673
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.1897 0.2673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1897 0.4508
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0202 0.048
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.1897 0.4508
Onchocerca volvulus 0.003 0.1897 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0202 0.048
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.1897 0.4508
Brugia malayi larval opioid receptor 0.003 0.1897 0.2673
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.1897 0.4508
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Brugia malayi G protein-coupled receptor 0.003 0.1897 0.2673
Echinococcus granulosus neuropeptides capa receptor 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus granulosus G protein coupled receptor 139 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi Cathepsin L-like precursor 0.002 0.0202 0.0285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Schistosoma mansoni neuropeptide receptor 0.003 0.1897 0.4508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Echinococcus multilocularis fmrfamide receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.7096 1
Onchocerca volvulus 0.003 0.1897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus multilocularis cysteine protease 0.002 0.0202 0.048
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1897 0.4508
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0202 0.048
Brugia malayi AKH receptor 0.003 0.1897 0.2673
Schistosoma mansoni hypothetical protein 0.0043 0.4207 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Brugia malayi Cathepsin L-like precursor 0.002 0.0202 0.0285
Schistosoma mansoni adenoreceptor 0.003 0.1897 0.4508
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.1897 0.4508
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.1897 0.4508
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.1897 0.2673
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.1897 0.4508
Echinococcus multilocularis fmrfamide receptor 0.003 0.1897 0.4508
Schistosoma mansoni biogenic amine receptor 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.1897 0.2673
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.1897 0.2673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni amine GPCR 0.003 0.1897 0.4508
Brugia malayi G-protein coupled receptor 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Onchocerca volvulus 0.003 0.1897 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1897 0.4508
Echinococcus granulosus sex peptide receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni hypothetical protein 0.003 0.1897 0.4508
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) fibroinase 0.002 0.0202 0.0285
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.1897 0.4508
Onchocerca volvulus 0.003 0.1897 1
Brugia malayi RE15519p 0.003 0.1897 0.2673
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.1897 0.4508
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Onchocerca volvulus 0.003 0.1897 1
Echinococcus granulosus fmrfamide receptor 0.003 0.1897 0.4508
Schistosoma mansoni hypothetical protein 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus multilocularis neuropeptide s receptor 0.003 0.1897 0.4508
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.1897 0.4508
Plasmodium vivax vivapain-2 0.002 0.0202 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.1897 0.2673
Schistosoma mansoni hypothetical protein 0.003 0.1897 0.4508
Schistosoma mansoni hypothetical protein 0.003 0.1897 0.4508
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.1897 0.4508
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0202 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.1897 0.4508
Echinococcus granulosus serotonin receptor 0.003 0.1897 0.4508
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.1897 0.4508
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.1897 0.2673
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.1897 0.2673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.1897 0.4508
Schistosoma mansoni amine GPCR 0.003 0.1897 0.4508
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.1897 0.4508
Schistosoma mansoni neuropeptide receptor 0.003 0.1897 0.4508
Echinococcus multilocularis neuropeptide receptor 0.003 0.1897 0.4508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Schistosoma mansoni opsin-like receptor 0.003 0.1897 0.4508
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.1897 0.4508
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.1897 0.2673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus multilocularis serotonin receptor 0.003 0.1897 0.4508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Toxoplasma gondii cathepsin CPL 0.002 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni hypothetical protein 0.0041 0.3812 0.906
Onchocerca volvulus 0.003 0.1897 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.1897 0.2673
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.1897 0.4508
Brugia malayi Dopamine receptor 0.003 0.1897 0.2673
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.4207 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Onchocerca volvulus 0.003 0.1897 1
Onchocerca volvulus 0.003 0.1897 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.1897 0.4508
Onchocerca volvulus 0.003 0.1897 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus neuropeptide receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus g protein coupled receptor 0.003 0.1897 0.4508
Echinococcus multilocularis neuropeptide receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) ctsf protein 0.002 0.0202 0.0285
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.1897 0.4508
Echinococcus multilocularis somatostatin receptor 0.003 0.1897 0.4508
Echinococcus granulosus orexin receptor type 2 0.003 0.1897 0.4508
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.1897 0.4508
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.1897 0.4508
Echinococcus granulosus neuropeptide receptor A26 0.003 0.1897 0.4508
Brugia malayi hypothetical protein 0.0043 0.4207 0.5929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Echinococcus multilocularis g protein coupled receptor 0.003 0.1897 0.4508
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.7096 1
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Brugia malayi G-protein coupled receptor 0.003 0.1897 0.2673
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1897 0.4508
Leishmania major cathepsin L-like protease 0.0077 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.1897 0.4508
Schistosoma mansoni amine GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.1897 0.4508
Echinococcus multilocularis cysteine protease 0.002 0.0202 0.048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Schistosoma mansoni neuropeptide receptor 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus multilocularis allatostatin A receptor 0.003 0.1897 0.4508
Brugia malayi Cathepsin L-like precursor 0.002 0.0202 0.0285
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.1897 0.4508
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0202 0.0285
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.1897 0.4508
Echinococcus multilocularis g protein coupled receptor 0.003 0.1897 0.4508
Echinococcus granulosus g-protein coupled receptor 0.003 0.1897 0.4508
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.7157 0.7098
Echinococcus granulosus cathepsin l1 0.002 0.0202 0.048
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Brugia malayi neuropeptide F receptor 0.003 0.1897 0.2673
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0202 0.0285
Onchocerca volvulus 0.003 0.1897 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 1 1
Echinococcus granulosus g protein coupled receptor 0.003 0.1897 0.4508
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.006 0.7096 1
Onchocerca volvulus 0.003 0.1897 1
Echinococcus multilocularis g-protein coupled receptor 0.003 0.1897 0.4508
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.4207 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.1897 0.4508
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0202 0.5
Brugia malayi hypothetical protein 0.003 0.1897 0.2673
Brugia malayi putative neuropeptide receptor 0.003 0.1897 0.2673
Schistosoma mansoni myosin xvIII 0.003 0.1897 0.4508
Brugia malayi Cathepsin L-like precursor 0.002 0.0202 0.0285
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.1897 0.4508
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.1897 0.4508
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.1897 0.4508
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.1897 0.4508
Entamoeba histolytica hypothetical protein 0.0043 0.4207 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1897 0.4508
Echinococcus granulosus somatostatin receptor 0.003 0.1897 0.4508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.1897 0.2673
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.0041 0.3812 0.5371
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.1897 0.4508
Onchocerca volvulus 0.003 0.1897 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.1897 0.4508
Schistosoma mansoni opsin-like receptor 0.003 0.1897 0.4508
Echinococcus granulosus neuropeptide Y receptor 0.003 0.1897 0.4508
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi follicle stimulating hormone receptor 0.003 0.1897 0.2673
Schistosoma mansoni amine GPCR 0.003 0.1897 0.4508
Entamoeba histolytica hypothetical protein 0.0043 0.4207 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.1897 0.4508
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.1897 0.4508
Brugia malayi Cathepsin L-like precursor 0.002 0.0202 0.0285
Onchocerca volvulus 0.003 0.1897 1
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.1897 0.2673
Brugia malayi sulfakinin receptor protein 0.003 0.1897 0.2673
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.1897 0.4508
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.1897 0.4508
Echinococcus multilocularis serotonin receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi Dopamine receptor protein 2 0.003 0.1897 0.2673
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.1897 0.2673
Schistosoma mansoni opsin-like receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.1897 0.2673
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.7096 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.1897 0.4508
Loa Loa (eye worm) TYRA-2 protein 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.1897 0.4508
Echinococcus multilocularis g protein coupled receptor 0.003 0.1897 0.4508
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.1897 0.4508
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0202 0.048
Brugia malayi Serotonin receptor 0.003 0.1897 0.2673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0202 0.5
Echinococcus granulosus g protein coupled receptor 0.003 0.1897 0.4508
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.3812 0.5371
Brugia malayi ORL1-like opioid receptor 0.003 0.1897 0.2673
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.1897 0.4508
Schistosoma mansoni neuropeptide receptor 0.003 0.1897 0.4508
Echinococcus granulosus neuropeptides capa receptor 0.003 0.1897 0.4508
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.1897 0.4508
Plasmodium vivax vivapain-2 0.002 0.0202 0.5
Echinococcus multilocularis orexin receptor type 2 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus hypothetical protein 0.003 0.1897 0.4508
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) cysteine protease 0.002 0.0202 0.0285
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.1897 0.2673
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.1897 0.4508
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.1897 0.4508
Schistosoma mansoni histamine h1 receptor 0.003 0.1897 0.4508
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1897 0.4508
Echinococcus granulosus neuropeptide s receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.1897 0.2673
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0202 0.0285
Onchocerca volvulus 0.003 0.1897 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.4207 1
Echinococcus granulosus allatostatin A receptor 0.003 0.1897 0.4508
Onchocerca volvulus 0.003 0.1897 1
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1897 0.4508
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673
Brugia malayi neuropeptide F receptor 0.003 0.1897 0.2673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 0.5
Brugia malayi Dopamine receptor protein 1 0.003 0.1897 0.2673
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1897 0.2673

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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