TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 353.438 | Formula: C19H19N3O2S
H donors: 2 H acceptors: 2 LogP: 5.66 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(C)c2c(c1)c(N=NC(=O)c1cc3c(s1)CCCC3)c([nH]2)O
InChi: 1S/C19H19N3O2S/c1-10-7-11(2)16-13(8-10)17(19(24)20-16)21-22-18(23)15-9-12-5-3-4-6-14(12)25-15/h7-9,20,24H,3-6H2,1-2H3
InChiKey: QHSIUVMJKJGVLP-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	Get druggable targets OG5_129301	All targets in OG5_129301
Cryptosporidium parvum	phosphopantetheinyl transferase	Get druggable targets OG5_129301	All targets in OG5_129301
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129301	All targets in OG5_129301
Echinococcus multilocularis	L aminoadipate semialdehyde	Get druggable targets OG5_129301	All targets in OG5_129301
Cryptosporidium hominis	proteinx0005	Get druggable targets OG5_129301	All targets in OG5_129301
Echinococcus granulosus	L aminoadipate semialdehyde	Get druggable targets OG5_129301	All targets in OG5_129301
Schistosoma japonicum	expressed protein	Get druggable targets OG5_129301	All targets in OG5_129301
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Get druggable targets OG5_129301	All targets in OG5_129301
Onchocerca volvulus		Get druggable targets OG5_129301	All targets in OG5_129301
Schistosoma japonicum	ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative	Get druggable targets OG5_129301	All targets in OG5_129301

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	aminoadipate-semialdehyde dehydrogenase small subunit	4'-phosphopantetheinyl transferase ffp	224 aa	183 aa	27.3 %
Onchocerca volvulus		4'-phosphopantetheinyl transferase ffp	224 aa	186 aa	26.3 %
Entamoeba histolytica	hypothetical protein	4'-phosphopantetheinyl transferase ffp	224 aa	198 aa	28.3 %
Trichomonas vaginalis	conserved hypothetical protein	4'-phosphopantetheinyl transferase ffp	224 aa	197 aa	22.3 %
Candida albicans	aminoadipate-semialdehyde dehydrogenase small subunit	4'-phosphopantetheinyl transferase ffp	224 aa	183 aa	27.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Echinococcus granulosus	L aminoadipate semialdehyde	0.01	0.193	0.2397
Schistosoma mansoni	ubiquitin-specific peptidase 46 (C19 family)	0.0012	0.0065	0.0081
Giardia lamblia	Hypothetical protein	0.0012	0.0065	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0028	0.0406	0.5
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0017	0.0163	0.0163
Schistosoma mansoni	hypothetical protein	0.0052	0.0897	0.1114
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 20	0.0012	0.0065	0.0081
Echinococcus multilocularis	smad	0.0033	0.0504	0.0625
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0158	0.0484
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0065	0.0081
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.02	0.4031	0.4031
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0504	0.0625
Schistosoma mansoni	hypothetical protein	0.0111	0.216	0.2682
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0158	0.0484
Schistosoma mansoni	smad	0.0033	0.0504	0.0625
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0017	0.0163	0.0163
Loa Loa (eye worm)	MH1 domain-containing protein	0.0015	0.012	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.039	0.8052	1
Schistosoma mansoni	ubiquitin-specific peptidase 14 (C19 family)	0.0012	0.0065	0.0081
Schistosoma mansoni	tar DNA-binding protein	0.02	0.4031	0.5005
Brugia malayi	hypothetical protein	0.0017	0.0163	0.0163
Loa Loa (eye worm)	G protein alpha subunit 3	0.0017	0.0163	0.0163
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0012	0.0065	0.0081
Onchocerca volvulus		0.01	0.193	0.5236
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0158	0.0484
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0028	0.0406	0.2052
Schistosoma mansoni	ubiquitin-specific peptidase 48 (C19 family)	0.0012	0.0065	0.0081
Echinococcus multilocularis	GPCR, family 2	0.0052	0.0897	0.1114
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0017	0.0163	0.0203
Trypanosoma brucei	hypothetical protein, conserved	0.0028	0.0406	0.178
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0017	0.0163	0.0203
Echinococcus multilocularis	expressed protein	0.0012	0.0065	0.0081
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0163	0.3248	0.3248
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0046	0.0782	0.0971
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0017	0.0163	0.0203
Loa Loa (eye worm)	Smad1	0.0033	0.0504	0.0504
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Echinococcus granulosus	smad	0.0033	0.0504	0.0625
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0017	0.0163	1
Brugia malayi	hypothetical protein	0.0103	0.1977	0.1977
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.0012	0.0065	0.0065
Trypanosoma cruzi	PAB1-binding protein , putative	0.0103	0.1977	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Entamoeba histolytica	hypothetical protein	0.0028	0.0406	1
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0017	0.0163	1
Schistosoma mansoni	ubiquitin-specific peptidase 10 (C19 family)	0.0012	0.0065	0.0081
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Toxoplasma gondii	ubiquitin-specific protease USP4	0.0012	0.0065	0.033
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0017	0.0163	0.0163
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.039	0.8052	1
Brugia malayi	G-protein alpha subunit	0.0017	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0012	0.0065	0.0081
Schistosoma mansoni	calpain-7 (C02 family)	0.0012	0.0065	0.0081
Echinococcus granulosus	GPCR family 2	0.0052	0.0897	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0193
Echinococcus multilocularis	ubiquitin specific protease 41	0.0012	0.0065	0.0081
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0163	0.3248	0.3248
Schistosoma mansoni	ubiquitin-specific peptidase 16 (C19 family)	0.0012	0.0065	0.0081
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.0012	0.0065	0.0081
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0033	0.0504	0.0625
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.039	0.8052	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.216	0.216
Schistosoma mansoni	tar DNA-binding protein	0.02	0.4031	0.5005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.0158	0.0484
Brugia malayi	ubiquitin carboxyl-terminal hydrolase 46	0.0012	0.0065	0.0065
Schistosoma mansoni	hypothetical protein	0.0052	0.0897	0.1114
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0012	0.0065	0.5
Toxoplasma gondii	hypothetical protein	0.0012	0.0065	0.033
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0504	0.0625
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0012	0.0065	0.0081
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0017	0.0163	0.0203
Schistosoma mansoni	ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold	0.0012	0.0065	0.0081
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase family 2 protein	0.0012	0.0065	0.033
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.0012	0.0065	0.0081
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0028	0.0406	0.5
Brugia malayi	MH1 domain containing protein	0.0033	0.0504	0.0504
Brugia malayi	latrophilin 2 splice variant baaae	0.0111	0.216	0.216
Schistosoma mansoni	hypothetical protein	0.0046	0.0782	0.0971
Echinococcus multilocularis	L aminoadipate semialdehyde	0.01	0.193	0.2397
Loa Loa (eye worm)	MH1 domain-containing protein	0.0033	0.0504	0.0504
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0033	0.0504	0.0625
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0065	0.0081
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0017	0.0163	0.0203
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0504	0.0625
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0017	0.0163	0.0203
Brugia malayi	TAR-binding protein	0.02	0.4031	0.4031
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0015	0.012	0.0324
Brugia malayi	hypothetical protein	0.0012	0.0065	0.0065
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0017	0.0163	0.0203
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 23	0.0012	0.0065	0.0081
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 12	0.0012	0.0065	0.0081
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 47	0.0012	0.0065	0.0081
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 24	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0163	0.0163
Echinococcus multilocularis	Smad4	0.0033	0.0504	0.0625
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0158	0.0196
Echinococcus granulosus	ubiquitin specific peptidase c family	0.0012	0.0065	0.0081
Plasmodium falciparum	ataxin-2 like protein, putative	0.0103	0.1977	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0052	0.0897	0.1114
Loa Loa (eye worm)	RNA binding protein	0.02	0.4031	0.4031
Schistosoma mansoni	hypothetical protein	0.0052	0.0897	0.1114
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0017	0.0163	0.0163
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.0012	0.0065	0.0081
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0158	0.0196
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0065	0.0081
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065
Schistosoma mansoni	ubiquitin-specific peptidase 42 (C19 family)	0.0012	0.0065	0.0081
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0065	0.0081
Schistosoma mansoni	smad	0.0015	0.012	0.0148
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0017	0.0163	0.0163
Echinococcus granulosus	5'partial\|Ubiquitin carboxyl terminal hydrolase 48	0.0012	0.0065	0.0081
Onchocerca volvulus		0.0012	0.0065	0.0177
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.0012	0.0065	0.0081
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0017	0.0163	0.0203
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase	0.0012	0.0065	0.0081
Schistosoma mansoni	tar DNA-binding protein	0.02	0.4031	0.5005
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.0012	0.0065	0.0081
Trypanosoma brucei	PAB1-binding protein , putative	0.0103	0.1977	1
Toxoplasma gondii	ubiquitin specific protease 39 isoform 2, putative	0.0012	0.0065	0.033
Brugia malayi	ubiquitin specific protease 14	0.0012	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.012	0.012
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0017	0.0163	0.0163
Brugia malayi	MH2 domain containing protein	0.0033	0.0504	0.0504
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 5	0.0012	0.0065	0.0081
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0017	0.0163	0.0203
Echinococcus granulosus	ubiquitin specific peptidase 30 (C19 family)	0.0012	0.0065	0.0081
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0052	0.0897	0.0897
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.0012	0.0065	0.0081
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0017	0.0163	0.0203
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.0012	0.0065	0.0081
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Loa Loa (eye worm)	MH2 domain-containing protein	0.0482	1	1
Schistosoma mansoni	tar DNA-binding protein	0.02	0.4031	0.5005
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0028	0.0406	0.178
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0158	0.0484
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0065	0.0081
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0158	0.0484
Brugia malayi	Latrophilin receptor protein 2	0.0052	0.0897	0.0897
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0015	0.012	0.0148
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Brugia malayi	MH1 domain containing protein	0.0033	0.0504	0.0504
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0158	0.0196
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0158	0.0196
Plasmodium vivax	ataxin-2 like protein, putative	0.0103	0.1977	1
Schistosoma mansoni	Smad4	0.0015	0.012	0.0148
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 14	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Loa Loa (eye worm)	nuclear factor I	0.0018	0.0193	0.0193
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0163	0.3248	0.3248
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 16	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0052	0.0897	0.1114
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0017	0.0163	0.0203
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.01	0.193	0.2397
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0015	0.012	0.0148
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0046	0.0782	0.0971
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0017	0.0163	0.0163
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Plasmodium falciparum	ataxin-2 like protein, putative	0.0103	0.1977	1
Brugia malayi	mothers against decapentaplegic homolog 3	0.0015	0.012	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.039	0.8052	1
Onchocerca volvulus		0.0017	0.0163	0.0443
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0163	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0012	0.0065	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0052	0.0897	0.1114
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0158	0.0798
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 36	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Toxoplasma gondii	LsmAD domain-containing protein	0.0103	0.1977	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 20	0.0012	0.0065	0.0081
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0163	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0033	0.0504	0.0504
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0017	0.0163	0.0203
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.039	0.8052	0.8052
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0065	0.0081
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0158	0.0158
Echinococcus granulosus	mothers against decapentaplegic 6	0.0015	0.012	0.0148
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0017	0.0163	0.0203
Schistosoma mansoni	calpain-7 (C02 family)	0.0012	0.0065	0.0081
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0012	0.0065	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0163	0.0163
Echinococcus granulosus	mothers against decapentaplegic 2	0.0015	0.012	0.0148
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Schistosoma mansoni	tar DNA-binding protein	0.02	0.4031	0.5005
Schistosoma mansoni	ubiquitin-specific peptidase 45 (C19 family)	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0897	0.0897
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.0012	0.0065	0.0081
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0033	0.0504	0.0625
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0017	0.0163	0.0203
Leishmania major	hypothetical protein, conserved	0.0103	0.1977	1
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.01	0.193	0.193
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0028	0.0406	0.178
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0017	0.0163	1
Echinococcus multilocularis	expressed protein	0.0017	0.0163	0.0203
Schistosoma mansoni	ubiquitin-specific peptidase 7 (C19 family)	0.0012	0.0065	0.0081
Trypanosoma cruzi	PAB1-binding protein , putative	0.0103	0.1977	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0158	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 47	0.0012	0.0065	0.0081
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0028	0.0406	0.2052
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0158	0.0196
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 16	0.0012	0.0065	0.0081
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0017	0.0163	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0163	0.0163
Echinococcus granulosus	Smad4	0.0033	0.0504	0.0625
Echinococcus granulosus	ubiquitin specific protease 41	0.0012	0.0065	0.0081
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 24	0.0012	0.0065	0.0081
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0065	0.0081
Schistosoma mansoni	ubiquitin-specific peptidase 30 (C19 family)	0.0012	0.0065	0.0081
Schistosoma mansoni	peptidase	0.0012	0.0065	0.0081
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0184	0.3686	1
Brugia malayi	Smad1	0.0033	0.0504	0.0504
Onchocerca volvulus		0.0017	0.0163	0.0443
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0158	0.0158
Brugia malayi	N-terminal motif family protein	0.0184	0.3686	0.3686
Brugia malayi	hypothetical protein	0.0066	0.1209	0.1209
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0163	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1977	0.1977
Brugia malayi	MH2 domain containing protein	0.0015	0.012	0.012
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0017	0.0163	0.0163
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0017	0.0163	0.0163
Schistosoma mansoni	hypothetical protein	0.0012	0.0065	0.0081
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0017	0.0163	0.0163
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0028	0.0406	0.5
Brugia malayi	RNA binding protein	0.02	0.4031	0.4031
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0033	0.0504	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0163	0.0163
Echinococcus multilocularis	ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase	0.0012	0.0065	0.0081
Schistosoma mansoni	ubiquitin-specific peptidase 22 (C19 family)	0.0012	0.0065	0.0081
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 36	0.0012	0.0065	0.0081
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.039	0.8052	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0012	0.0065	0.0081
Echinococcus granulosus	tar DNA binding protein	0.02	0.4031	0.5005
Onchocerca volvulus		0.0012	0.0065	0.0177
Schistosoma mansoni	Smad4	0.0033	0.0504	0.0625
Schistosoma mansoni	Smad4	0.0015	0.012	0.0148
Entamoeba histolytica	G protein alpha subunit, putative	0.0017	0.0163	0.2879
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0017	0.0163	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0015	0.012	0.012
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0017	0.0163	0.0163
Echinococcus granulosus	expressed protein	0.0017	0.0163	0.0203
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0017	0.0163	0.0203
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0158	0.0798
Giardia lamblia	DUB-1	0.0012	0.0065	0.5
Toxoplasma gondii	UBA/TS-N domain-containing protein	0.0012	0.0065	0.033
Schistosoma mansoni	hypothetical protein	0.0052	0.0897	0.1114
Onchocerca volvulus		0.0017	0.0163	0.0443
Echinococcus multilocularis	Ubiquitin carboxyl terminal hydrolase 48	0.0012	0.0065	0.0081
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 12	0.0012	0.0065	0.0081
Leishmania major	phosphopantetheinyl transferase-like protein	0.0028	0.0406	0.178
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0163	0.3248	0.3248
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0158	0.0158
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.033
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0158	0.0196
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0017	0.0163	0.0203
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0012	0.0065	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 4 (C19 family)	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Echinococcus granulosus	mothers against decapentaplegic 5	0.0033	0.0504	0.0625
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase	0.0012	0.0065	0.0081
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0065	0.0081
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0012	0.0065	0.0081
Schistosoma mansoni	family C19 unassigned peptidase (C19 family)	0.0012	0.0065	0.0081
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.01	0.193	0.193
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.039	0.8052	1
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0017	0.0163	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0163	0.0163
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0017	0.0163	0.0203
Echinococcus granulosus	Ubiquitin carboxyl terminal hydrolase 48	0.0012	0.0065	0.0081
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0052	0.0897	0.1114
Brugia malayi	MH1 domain containing protein	0.0018	0.0193	0.0193
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0012	0.0065	0.0081
Brugia malayi	MH2 domain containing protein	0.0033	0.0504	0.0504
Brugia malayi	RNA recognition motif domain containing protein	0.02	0.4031	0.4031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.039	0.8052	0.8052
Schistosoma mansoni	ubiquitin-specific peptidase 24 (C19 family)	0.0012	0.0065	0.0081
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0065	0.0081
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0017	0.0163	0.0163
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 14	0.0012	0.0065	0.0081
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0052	0.0897	0.0897
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0017	0.0163	0.0203
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.039	0.8052	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0158	0.0196
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0028	0.0406	0.5
Onchocerca volvulus		0.0012	0.0065	0.0177
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0028	0.0406	1
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0017	0.0163	0.0203
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0163	1
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0065
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0017	0.0163	0.0163
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase 46	0.0012	0.0065	0.0065
Mycobacterium leprae	conserved hypothetical protein	0.0028	0.0406	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0482	1	1
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0028	0.0406	0.5
Brugia malayi	MH1 domain containing protein	0.0018	0.0193	0.0193
Loa Loa (eye worm)	TAR-binding protein	0.02	0.4031	0.4031
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0065	0.0065
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0017	0.0163	0.0203
Echinococcus multilocularis	tar DNA binding protein	0.02	0.4031	0.5005
Echinococcus multilocularis	ubiquitin specific peptidase 42 (C19 family)	0.0012	0.0065	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0184	0.3686	0.3686
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0017	0.0163	0.0203
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0065	0.0081
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0065	0.0065

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.0787 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1571159

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1417058