Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0194 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.1042 | 0.0977 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0194 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.1255 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0152 | 0.4137 | 0.5908 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.5748 | 0.5717 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0152 | 0.4137 | 0.4094 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.1042 | 0.0977 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0155 | 0.4224 | 0.6035 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0152 | 0.4137 | 0.4094 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1042 | 0.0977 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0194 | 0.1546 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0152 | 0.4137 | 0.4094 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.1042 | 0.141 |
Brugia malayi | TAR-binding protein | 0.0206 | 0.5748 | 0.825 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1042 | 0.0977 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0056 | 0.1255 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0194 | 0.1546 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0194 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0194 | 0.0177 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0155 | 0.4224 | 0.6035 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Echinococcus multilocularis | tar DNA binding protein | 0.0206 | 0.5748 | 0.5717 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0025 | 0.0325 | 0.0255 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0194 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.1042 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1255 | 0.1719 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0152 | 0.4137 | 0.4094 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.5748 | 0.5717 |
Loa Loa (eye worm) | RNA binding protein | 0.0206 | 0.5748 | 0.825 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.5748 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4224 | 0.6035 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0194 | 0.0177 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.5748 | 0.5717 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0152 | 0.4137 | 0.4094 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0194 | 0.0123 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0056 | 0.1255 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0056 | 0.1255 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1042 | 0.0977 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0152 | 0.4137 | 0.4094 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0194 | 0.0123 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Brugia malayi | MH2 domain containing protein | 0.0246 | 0.6952 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0025 | 0.0325 | 0.0255 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.1042 | 0.0977 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0056 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2751 | 0.3894 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.1042 | 0.0977 |
Echinococcus multilocularis | geminin | 0.0347 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0194 | 0.0177 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.1042 | 0.0977 |
Brugia malayi | hypothetical protein | 0.0056 | 0.1255 | 0.1719 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1042 | 0.0977 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0194 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0152 | 0.4137 | 0.5908 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0155 | 0.4224 | 0.6035 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0194 | 0.0177 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0194 | 0.0123 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.0194 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0194 | 0.1546 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0325 | 0.0255 |
Echinococcus granulosus | tar DNA binding protein | 0.0206 | 0.5748 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.5706 | 0.8189 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0194 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0206 | 0.5748 | 0.825 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0657 | 0.085 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0194 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0194 | 0.0123 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0056 | 0.1255 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0056 | 0.1255 | 0.5 |
Brugia malayi | N-terminal motif family protein | 0.0204 | 0.5706 | 0.8189 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.2751 | 0.2698 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0194 | 0.0123 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0194 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0152 | 0.4137 | 0.4094 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0194 | 0.0123 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0194 | 0.1546 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0194 | 0.0123 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0194 | 0.0123 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0206 | 0.5748 | 0.825 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0056 | 0.1255 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.1042 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1042 | 0.141 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0194 | 0.1546 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0194 | 0.1546 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0204 | 0.5706 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0106 | 0.2751 | 0.3894 |
Schistosoma mansoni | tar DNA-binding protein | 0.0206 | 0.5748 | 0.5717 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0206 | 0.5748 | 0.825 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0246 | 0.6952 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0246 | 0.6952 | 1 |
Brugia malayi | RNA binding protein | 0.0206 | 0.5748 | 0.825 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.1042 | 0.0977 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.