Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0103 | 0.2806 | 0.3099 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0209 | 0.6244 | 0.6244 |
Schistosoma mansoni | tar DNA-binding protein | 0.0209 | 0.6244 | 0.9211 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0103 | 0.2806 | 0.3099 |
Schistosoma mansoni | tar DNA-binding protein | 0.0209 | 0.6244 | 0.9211 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1263 | 0.1263 |
Schistosoma mansoni | tar DNA-binding protein | 0.0209 | 0.6244 | 0.9211 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.667 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0222 | 0.667 | 0.667 |
Loa Loa (eye worm) | RNA binding protein | 0.0209 | 0.6244 | 0.6133 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0287 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0103 | 0.2806 | 0.3099 |
Schistosoma mansoni | tar DNA-binding protein | 0.0209 | 0.6244 | 0.9211 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.2806 | 0.2854 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2806 | 0.2594 |
Echinococcus granulosus | tar DNA binding protein | 0.0209 | 0.6244 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0103 | 0.2806 | 0.3099 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0287 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0103 | 0.2806 | 0.2594 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0287 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0325 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0209 | 0.6244 | 0.9211 |
Brugia malayi | TAR-binding protein | 0.0209 | 0.6244 | 0.6244 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0287 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0325 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1263 | 0.1004 |
Echinococcus multilocularis | tar DNA binding protein | 0.0209 | 0.6244 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0209 | 0.6244 | 0.6133 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0287 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0287 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.2806 | 0.2854 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.2806 | 0.2854 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0103 | 0.2806 | 0.3099 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0103 | 0.2806 | 0.2806 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0103 | 0.2806 | 0.2806 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.2806 | 0.2854 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0287 | 0.5 |
Brugia malayi | RNA binding protein | 0.0209 | 0.6244 | 0.6244 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.667 | 0.6572 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0287 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | TAR-binding protein | 0.0209 | 0.6244 | 0.6133 |
Echinococcus granulosus | GPCR family 2 | 0.0103 | 0.2806 | 0.3099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.