Detailed information for compound 1417642

Basic information

Technical information
  • TDR Targets ID: 1417642
  • Name: 5-[(4-ethylphenoxy)methyl]furan-2-carboxylic acid
  • MW: 246.259 | Formula: C14H14O4
  • H donors: 1 H acceptors: 2 LogP: 3.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)OCc1ccc(o1)C(=O)O
  • InChi: 1S/C14H14O4/c1-2-10-3-5-11(6-4-10)17-9-12-7-8-13(18-12)14(15)16/h3-8H,2,9H2,1H3,(H,15,16)
  • InChiKey: AODZZHSIEMSDEZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[(4-ethylphenoxy)methyl]-2-furancarboxylic acid
  • 5-[(4-ethylphenoxy)methyl]-2-furoic acid
  • Oprea1_359959
  • SBB000856
  • Oprea1_799813

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0085 0.0578 0.1049
Echinococcus multilocularis protein dispatched 1 0.0058 0.0362 0.0431
Schistosoma mansoni cpg binding protein 0.0035 0.0171 0.0276
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0084 0.0112
Brugia malayi jmjC domain containing protein 0.0071 0.0466 0.0466
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0122 0.0234
Echinococcus multilocularis protein patched 0.0051 0.0303 0.0356
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0074 0.0062
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.129 0.4528
Loa Loa (eye worm) TAR-binding protein 0.0666 0.5294 0.5294
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0043 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0561 0.0685
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0083 0.0561 0.2907
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0074 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0666 0.5294 0.6746
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.034 0.2649 0.9623
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0186 0.0654
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0676
Schistosoma mansoni Smad4 0.0038 0.0197 0.0326
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0265 0.0265
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1288 0.6852
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0238 0.1824 1
Loa Loa (eye worm) nuclear factor I 0.0047 0.027 0.027
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0238 0.1824 1
Giardia lamblia DNA repair protein RAD52 0.034 0.2649 0.9613
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0043 0.0033
Brugia malayi jmjC domain containing protein 0.0019 0.0043 0.0043
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0258 0.1987 0.3722
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0258 0.1987 0.2511
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0556 0.288
Onchocerca volvulus 0.0095 0.0663 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0229 0.1749 0.3272
Onchocerca volvulus 0.0035 0.0171 0.2578
Echinococcus granulosus GPCR family 2 0.0229 0.1749 0.3272
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0043 0.0033
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0869 0.1601
Brugia malayi mothers against decapentaplegic homolog 3 0.0038 0.0197 0.0197
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0085 0.0578 0.1049
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0074 0.0074
Brugia malayi plexin A 0.0048 0.0275 0.0275
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1227 0.1227
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0699 0.2538
Brugia malayi CHE-14 protein 0.0051 0.0303 0.0303
Brugia malayi Sema domain containing protein 0.0017 0.0026 0.0026
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1227 0.1538
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0122 0.0442
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0043 0.0152
Schistosoma mansoni hypothetical protein 0.0229 0.1749 0.3272
Onchocerca volvulus 0.004 0.0215 0.3248
Brugia malayi TAR-binding protein 0.0666 0.5294 0.5294
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0043 0.0033
Loa Loa (eye worm) glutaminase 0.033 0.2568 0.2568
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.1824 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0397 0.1392
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0303 0.1102
Echinococcus multilocularis mothers against decapentaplegic 5 0.0085 0.0578 0.0708
Echinococcus multilocularis GPCR, family 2 0.0229 0.1749 0.2207
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0303 0.0527
Loa Loa (eye worm) MH2 domain-containing protein 0.1246 1 1
Echinococcus granulosus plexin a4 0.0048 0.0275 0.0473
Entamoeba histolytica hypothetical protein 0.0258 0.1987 0.7215
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0043 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0043 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0122 0.0122
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0122 0.0442
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2753 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0238 0.1824 0.3414
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0074 0.0268
Schistosoma mansoni tar DNA-binding protein 0.0666 0.5294 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.0324
Brugia malayi MH1 domain containing protein 0.0085 0.0578 0.0578
Brugia malayi latrophilin 2 splice variant baaae 0.0495 0.3907 0.3907
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0122 0.0234
Echinococcus multilocularis expressed conserved protein 0.0112 0.0796 0.0986
Echinococcus granulosus peptidase Clp S14 family 0.0156 0.1158 0.2149
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0306 0.1073
Schistosoma mansoni hypothetical protein 0.0024 0.0084 0.0112
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0561 0.1969
Schistosoma mansoni cpg binding protein 0.0037 0.0187 0.0306
Schistosoma mansoni alpha glucosidase 0.0037 0.0186 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0265 0.0454
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0063 0.0112
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0043 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0265 0.0454
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.3685 0.4686
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0063
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0306 0.1073
Brugia malayi Probable ClpP-like protease 0.0238 0.1824 0.1824
Brugia malayi Smad1 0.0085 0.0578 0.0578
Brugia malayi Sema domain containing protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) MH1 domain-containing protein 0.0085 0.0578 0.0578
Loa Loa (eye worm) MH1 domain-containing protein 0.0038 0.0197 0.0197
Leishmania major hypothetical protein, conserved 0.0054 0.0324 0.1138
Loa Loa (eye worm) hypothetical protein 0.0119 0.0854 0.0854
Echinococcus granulosus TGF beta signal transducer SmadC 0.0085 0.0578 0.1049
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0074 0.0091
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0043 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0265 0.0454
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0122 0.0234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0063
Brugia malayi jmjC domain containing protein 0.0019 0.0043 0.0043
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1268 0.1591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0265 0.0454
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0122 0.0428
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0063
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0238 0.1824 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0074 0.0259
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0229 0.1749 0.2207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0265 0.0454
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0043 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0699 0.0699
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0084 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0063
Schistosoma mansoni alpha-glucosidase 0.0142 0.104 0.1926
Trichomonas vaginalis glutaminase, putative 0.033 0.2568 0.9327
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0265 0.0306
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0854 0.1573
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0186 0.0676
Schistosoma mansoni hypothetical protein 0.0023 0.0079 0.0102
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0265 0.0265
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0074 0.0268
Loa Loa (eye worm) isocitrate dehydrogenase 0.0083 0.0561 0.0561
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2753 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0466 0.0835
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0043
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0324 0.1577
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0324 0.1577
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0561 0.2907
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0676
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0186 0.0305
Echinococcus granulosus phd:f box containing protein 0.0019 0.0043 0.0033
Trypanosoma brucei glucosidase, putative 0.0037 0.0186 0.0654
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0043 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0229 0.1749 0.2207
Echinococcus multilocularis mothers against decapentaplegic 6 0.0038 0.0197 0.022
Schistosoma mansoni hypothetical protein 0.0049 0.0289 0.0499
Entamoeba histolytica hypothetical protein 0.0258 0.1987 0.7215
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0083 0.0561 0.1016
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0043 0.0022
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0122 0.0489
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1227 0.1227
Brugia malayi Plexin repeat family protein 0.004 0.0215 0.0215
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0074 0.0145
Brugia malayi jmjC domain containing protein 0.0019 0.0043 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0324 0.1138
Echinococcus granulosus neuropeptide s receptor 0.0468 0.3685 0.6945
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0561 0.1969
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0122 0.0234
Schistosoma mansoni smad 0.0038 0.0197 0.0326
Loa Loa (eye worm) hypothetical protein 0.0238 0.1824 0.1824
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1227 0.1538
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0258 0.1987 0.7215
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0171 0.0171
Brugia malayi RNA recognition motif domain containing protein 0.0666 0.5294 0.5294
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0561 0.1969
Brugia malayi CXXC zinc finger family protein 0.0035 0.0171 0.0171
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2753 1
Schistosoma mansoni smad 0.0085 0.0578 0.1049
Loa Loa (eye worm) Smad1 0.0085 0.0578 0.0578
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0676
Entamoeba histolytica hypothetical protein 0.0258 0.1987 0.7215
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0122 0.0234
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0043 0.0033
Schistosoma mansoni hypothetical protein 0.0049 0.0289 0.0499
Loa Loa (eye worm) hypothetical protein 0.0724 0.5767 0.5767
Schistosoma mansoni tar DNA-binding protein 0.0666 0.5294 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Echinococcus granulosus tar DNA binding protein 0.0666 0.5294 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0561 0.0685
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0324 0.1577
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0303 0.0356
Echinococcus granulosus cpg binding protein 0.0037 0.0187 0.0306
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0122 0.0489
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.0079
Schistosoma mansoni glutaminase 0.033 0.2568 0.4826
Brugia malayi jmjC domain containing protein 0.0019 0.0043 0.0043
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0074 0.0074
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.0675 0.2451
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.2849 1
Schistosoma mansoni hypothetical protein 0.0049 0.0289 0.0499
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0724 0.5767 0.5767
Loa Loa (eye worm) hypothetical protein 0.004 0.0215 0.0215
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0229 0.1749 0.3272
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0074 0.0268
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1288 0.8854
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0186 0.0676
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Loa Loa (eye worm) sema domain-containing protein 0.0017 0.0026 0.0026
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.1824 0.7031
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0186 0.0676
Brugia malayi Latrophilin receptor protein 2 0.0229 0.1749 0.1749
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0324 0.1138
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0186 0.0803
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0083 0.0561 0.1016
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0059 0.0043
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1227 0.228
Loa Loa (eye worm) hypothetical protein 0.0229 0.1749 0.1749
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0122 0.0122
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.129 0.4528
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Brugia malayi MH1 domain containing protein 0.0047 0.027 0.027
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2753 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0085 0.0578 0.0578
Echinococcus multilocularis mothers against decapentaplegic 2 0.0038 0.0197 0.022
Onchocerca volvulus 0.0017 0.0026 0.0387
Schistosoma mansoni ap endonuclease 0.0023 0.0074 0.0091
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.1824 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0556 0.288
Brugia malayi hypothetical protein 0.0035 0.017 0.017
Brugia malayi isocitrate dehydrogenase 0.0083 0.0561 0.0561
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0186 0.0186
Schistosoma mansoni Smad4 0.0085 0.0578 0.1049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0229 0.1749 0.1749
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0482 0.0866
Mycobacterium ulcerans hypothetical protein 0.0192 0.1448 0.553
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0186 0.0676
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0306 0.1073
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0083 0.0561 0.2907
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1268 0.2358
Brugia malayi RNA binding protein 0.0666 0.5294 0.5294
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0466 0.0835
Brugia malayi MH1 domain containing protein 0.0085 0.0578 0.0578
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus Smad4 0.0085 0.0578 0.1049
Echinococcus granulosus mothers against decapentaplegic 2 0.0038 0.0197 0.0326
Loa Loa (eye worm) sema domain-containing protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) glutaminase 2 0.033 0.2568 0.2568
Brugia malayi MH2 domain containing protein 0.0085 0.0578 0.0578
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0561 0.2907
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0122 0.0428
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0063 0.0112
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0306 0.1073
Loa Loa (eye worm) hypothetical protein 0.0495 0.3907 0.3907
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0724 0.5767 0.5767
Schistosoma mansoni cpg binding protein 0.0037 0.0187 0.0306
Brugia malayi hypothetical protein 0.0258 0.1987 0.1987
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0466 0.0564
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0238 0.1824 1
Schistosoma mansoni tar DNA-binding protein 0.0666 0.5294 1
Schistosoma mansoni hypothetical protein 0.0258 0.1987 0.3722
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0303 0.0527
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0083 0.0561 0.1969
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0229 0.1749 0.3272
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0063
Brugia malayi MH2 domain containing protein 0.0038 0.0197 0.0197
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0186 0.0676
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0043 0.0152
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0854 0.0854
Brugia malayi glutaminase DH11.1 0.033 0.2568 0.2568
Schistosoma mansoni patched 1 0.0051 0.0303 0.0527
Echinococcus multilocularis plexin a4 0.0048 0.0275 0.0319
Schistosoma mansoni transcription factor LCR-F1 0.0258 0.1987 0.3722
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0043
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.3685 0.6945
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0186 0.0676
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0043 0.0033
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0043 0.0022
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0083 0.0561 0.3638
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0122 0.0234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.1824 0.7031
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.1824 1
Brugia malayi MH2 domain containing protein 0.0085 0.0578 0.0578
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0082 0.0556 0.2551
Onchocerca volvulus 0.0029 0.0122 0.1837
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0156 0.1158 0.7917
Echinococcus multilocularis cpg binding protein 0.0037 0.0187 0.0207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0486 0.0875
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0854 0.1061
Brugia malayi jmjC domain containing protein 0.0073 0.0482 0.0482
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.3685 0.4686
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0186 0.0654
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0466 0.0564
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0074 0.0259
Brugia malayi MH1 domain containing protein 0.0047 0.027 0.027
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0186 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0666 0.5294 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0038 0.0197 0.0326
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0074 0.0172
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0038 0.0197 0.2978
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0074 0.0043
Loa Loa (eye worm) transcription factor SMAD2 0.1246 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0854 0.3102
Schistosoma mansoni Smad4 0.0038 0.0197 0.0326
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis Smad4 0.0085 0.0578 0.0708
Mycobacterium ulcerans hypothetical protein 0.0029 0.0122 0.0234
Loa Loa (eye worm) MH2 domain-containing protein 0.0038 0.0197 0.0197
Echinococcus multilocularis peptidase Clp (S14 family) 0.0156 0.1158 0.145
Schistosoma mansoni ap endonuclease 0.0023 0.0074 0.0091
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0423 0.213
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0122 0.0428
Echinococcus granulosus mothers against decapentaplegic 5 0.0085 0.0578 0.1049
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0122 0.0122
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0059 0.0064
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0049 0.0289 0.0499
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0122 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0666 0.5294 1
Brugia malayi hypothetical protein 0.0054 0.0324 0.0324
Echinococcus granulosus expressed conserved protein 0.0112 0.0796 0.1462
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0156 0.1158 0.6085
Echinococcus granulosus smad 0.0085 0.0578 0.1049
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.2849 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0083 0.0561 0.0685
Echinococcus multilocularis isocitrate dehydrogenase 0.0083 0.0561 0.0685
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0186 0.0654
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.0122
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1288 0.4892
Schistosoma mansoni alpha-glucosidase 0.0142 0.104 0.1926
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1448 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0074 0.0259
Brugia malayi Calcitonin receptor-like protein seb-1 0.0724 0.5767 0.5767
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0238 0.1824 0.3414
Loa Loa (eye worm) hypothetical protein 0.0047 0.027 0.027
Echinococcus multilocularis smad 0.0085 0.0578 0.0708
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0324 0.1138
Mycobacterium ulcerans glutaminase 0.033 0.2568 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0303 0.0303
Loa Loa (eye worm) RNA binding protein 0.0666 0.5294 0.5294
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0074 0.0259
Toxoplasma gondii hypothetical protein 0.0059 0.0367 0.1817
Schistosoma mansoni plexin 0.0023 0.0079 0.0102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0561 0.0685
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0324 0.1577
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0238 0.1824 0.6533
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.2849 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0666 0.5294 0.5294
Schistosoma mansoni hypothetical protein 0.0495 0.3907 0.7368
Brugia malayi Isocitrate dehydrogenase 0.0083 0.0561 0.0561
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0265 0.0306
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0482 0.0866
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.1824 1
Toxoplasma gondii hypothetical protein 0.0082 0.0556 0.288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Toxoplasma gondii exonuclease III APE 0.0023 0.0074 0.0172
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7835 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0556 0.18
Schistosoma mansoni smad1 5 8 and 0.0085 0.0578 0.1049
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.129 0.4528
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0083 0.0561 0.1969
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0482 0.0482
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0122 0.0442
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0482 0.0866
Loa Loa (eye worm) hypothetical protein 0.0062 0.0397 0.0397
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0043 0.0152
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.0122
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0085 0.0578 0.0708
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0699 0.2538
Schistosoma mansoni smad1 5 8 and 0.0085 0.0578 0.1049
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0186 0.0186
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0238 0.1824 0.2303
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0676
Schistosoma mansoni hypothetical protein 0.0229 0.1749 0.3272
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0229 0.1749 0.1749
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0063 0.0068
Schistosoma mansoni hypothetical protein 0.0229 0.1749 0.3272
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0676
Leishmania major hypothetical protein, conserved 0.0019 0.0043 0.0152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Entamoeba histolytica hypothetical protein 0.0097 0.0675 0.2451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2753 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0156 0.1158 0.7917
Loa Loa (eye worm) plexin A 0.0048 0.0275 0.0275
Schistosoma mansoni plexin 0.004 0.0215 0.036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0053 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2908 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3661 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.1331 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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