Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2234 | 0.2234 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3306 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3306 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.1752 | 0.1752 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3306 | 0.3306 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1318 | 0.1318 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.1752 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.1752 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2234 | 0.2234 |
Brugia malayi | Inositol-1 | 0.0045 | 0.1752 | 0.1752 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.3306 | 0.3306 |
Brugia malayi | TAR-binding protein | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0197 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0256 | 0.0256 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.1752 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0256 | 0.0256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0256 | 0.0256 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0256 | 0.0256 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.1752 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0256 | 0.0256 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.1752 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0256 | 0.0256 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3306 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0256 | 0.0256 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2234 | 0.2234 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.3306 | 0.3306 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.1752 | 0.1752 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.1752 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0256 | 0.0256 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.1499 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0256 | 0.0256 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.1752 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.1752 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.3306 | 0.3306 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2234 | 0.2234 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0256 | 0.0256 |
Echinococcus granulosus | tar DNA binding protein | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0256 | 0.0256 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.1752 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.1752 | 0.1752 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0256 | 0.0256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1318 | 0.1318 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0256 | 0.0256 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.3306 | 0.3306 |
Loa Loa (eye worm) | RNA binding protein | 0.0197 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.1752 | 0.1752 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3306 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.1752 | 0.1752 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.1499 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.1752 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1318 | 0.1318 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0256 | 0.0256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.