Detailed information for compound 1417764

Basic information

Technical information
  • TDR Targets ID: 1417764
  • Name: N-(2-furan-2-yl-3H-benzimidazol-5-yl)acetamid e
  • MW: 241.245 | Formula: C13H11N3O2
  • H donors: 2 H acceptors: 2 LogP: 1.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc2c(c1)nc([nH]2)c1ccco1
  • InChi: 1S/C13H11N3O2/c1-8(17)14-9-4-5-10-11(7-9)16-13(15-10)12-3-2-6-18-12/h2-7H,1H3,(H,14,17)(H,15,16)
  • InChiKey: GDUWMPAQQXMMFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(2-furyl)-3H-benzimidazol-5-yl]acetamide
  • N-(2-furan-2-yl-3H-benzimidazol-5-yl)ethanamide
  • ZINC00469051
  • N-(2-Furan-2-yl-1H-benzoimidazol-5-yl)-acetamide
  • BAS 07310619
  • MLS000765199
  • SMR000288604

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.01 0.0175
Brugia malayi Bromodomain containing protein 0.0077 0.0816 0.238
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0038 0.0084
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.01 0.0175
Loa Loa (eye worm) hypothetical protein 0.004 0.0356 0.0952
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0052 0.008
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0305 0.3674 0.3672
Toxoplasma gondii exonuclease III APE 0.002 0.0107 0.1635
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0038 0.0058
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.0052 0.0128
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0451 0.0811
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0215 0.3338
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.01 0.0159
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.01 0.062
Trichomonas vaginalis esterase, putative 0.004 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0261
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.012 0.0193
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0038 0.0063
Schistosoma mansoni hypothetical protein 0.0182 0.213 0.3852
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.0052 0.1015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.01 0.0159
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.01 0.0175
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.012 0.3314
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0051 0.0086
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0038 0.0732
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0356 0.0638
Schistosoma mansoni hypothetical protein 0.0033 0.0271 0.0484
Schistosoma mansoni cpg binding protein 0.0036 0.0299 0.0536
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0159 0.0283
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0583 0.1565
Onchocerca volvulus 0.0015 0.0038 0.0224
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0052 0.0305
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.0052 0.0128
Schistosoma mansoni jumonji domain containing protein 0.0059 0.059 0.1063
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0003 0.0009
Trypanosoma cruzi ISWI complex protein 0.0015 0.0046 0.1212
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0038 0.0084
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.0052 0.0128
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.0052 0.1015
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.0052 0.0128
Echinococcus multilocularis zinc finger protein 0.0021 0.0122 0.0119
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0356 0.1127
Loa Loa (eye worm) hypothetical protein 0.005 0.048 0.1287
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.01 0.0175
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.0052 0.1015
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0356 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.0052 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.01 0.0291
Schistosoma mansoni cpg binding protein 0.0036 0.0299 0.0536
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0038 0.099
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0038 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.01 0.0291
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.3706 1
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0003 0.00000034793
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0076 0.0195
Mycobacterium ulcerans hypothetical protein 0.005 0.048 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.01 0.0159
Brugia malayi beta-lactamase family protein 0.004 0.0356 0.1038
Mycobacterium ulcerans lipase LipD 0.004 0.0356 0.7396
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0637 0.1046
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0261
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.01 0.0097
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.012 0.0315
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0147 0.408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0489 0.0879
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.048 1
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0148
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0147 0.408
Schistosoma mansoni bromodomain containing protein 0.0065 0.0669 0.1206
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.01 0.0291
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.0052 0.1015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.059 0.0969
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0003 0.0000098667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.01 0.0261
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0107 0.0104
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0038 0.0549
Onchocerca volvulus 0.004 0.0356 0.2264
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0261
Schistosoma mansoni hypothetical protein 0.0058 0.0583 0.105
Brugia malayi ecdysteroid receptor 0.002 0.01 0.0291
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0215 0.0212
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0052 0.1372
Loa Loa (eye worm) hypothetical protein 0.0071 0.0739 0.1988
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0271 0.079
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0356 1
Echinococcus multilocularis dnaJ subfamily B 0.0453 0.5525 0.5524
Trypanosoma cruzi ISWI complex protein 0.0015 0.0046 0.1212
Onchocerca volvulus Huntingtin homolog 0.0136 0.156 1
Echinococcus granulosus GPCR family 2 0.0033 0.0271 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0296 0.0932
Mycobacterium tuberculosis Conserved protein 0.004 0.0356 0.1127
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0038 0.0084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.01 0.0097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.01 0.0175
Leishmania major hypothetical protein, conserved 0.0016 0.0051 0.0286
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.059 0.0587
Brugia malayi hypothetical protein 0.0012 0.0003 0.0009
Plasmodium falciparum importin beta, putative 0.0029 0.0215 0.6657
Brugia malayi beta-lactamase 0.004 0.0356 0.1038
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.048 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0068 0.0117
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0271 0.0722
Echinococcus multilocularis geminin 0.0182 0.213 0.2128
Trichomonas vaginalis ran, putative 0.0021 0.012 0.3314
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0356 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0051 0.0748
Loa Loa (eye worm) hypothetical protein 0.0048 0.0451 0.121
Entamoeba histolytica Ran family GTPase 0.0021 0.012 0.2451
Brugia malayi jmjC domain containing protein 0.0063 0.0637 0.1859
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0003 0.0000054752
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0107 0.2947
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0107 0.031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0356 0.1127
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.0052 0.0128
Plasmodium vivax hypothetical protein, conserved 0.004 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0356 0.0952
Brugia malayi nuclear hormone receptor 0.002 0.01 0.0291
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.012 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.0052 0.1015
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.0052 0.1015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.01 0.0159
Echinococcus granulosus zinc finger protein 0.0021 0.0122 0.0196
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.048 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.01 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.01 0.0291
Echinococcus multilocularis snurportin 1 0.0308 0.3706 0.3704
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0583 0.1702
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.0052 0.0128
Brugia malayi cytochrome P450 0.0016 0.0052 0.015
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0038 0.0732
Schistosoma mansoni ran 0.0021 0.012 0.0212
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0097 0.0094
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0624 0.0621
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0051 0.1492
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0261
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0356 0.0952
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0038 0.0732
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0038 0.099
Brugia malayi DKFZp564C0469 protein 0.0012 0.0003 0.0009
Mycobacterium ulcerans hypothetical protein 0.004 0.0356 0.7396
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0052 0.1372
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0304 0.0301
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0356 0.1127
Leishmania major GTP-binding protein, putative 0.0021 0.012 0.1854
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0051 0.0048
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0107 0.0171
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0094
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.3057 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.0052 0.1015
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0003 0.0009
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0038 0.0732
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0038 0.0084
Brugia malayi jmjC domain containing protein 0.0059 0.059 0.1723
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0038 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0107 0.2179
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0051 0.0086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0038 0.0111
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0051 0.0748
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0038 0.0549
Onchocerca volvulus 0.005 0.048 0.3062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.01 0.0159
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1169 0.3413
Mycobacterium leprae Probable lipase LipE 0.004 0.0356 0.7396
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0753 0.2199
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.012 0.1839
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.0052 0.1015
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0322 0.9036
Trypanosoma brucei ISWI complex protein 0.0015 0.0046 0.1212
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.0052 0.0128
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0038 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0356 1
Leishmania major cytochrome p450-like protein 0.0016 0.0052 0.0305
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0261
Loa Loa (eye worm) beta-lactamase 0.004 0.0356 0.0952
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0038 0.099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.086
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.01 0.0261
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0637 0.1148
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0038 0.099
Loa Loa (eye worm) hypothetical protein 0.0136 0.156 0.4205
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.0052 0.1015
Echinococcus multilocularis neuropeptide s receptor 0.0497 0.6065 0.6063
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.0052 0.1015
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0003 0.0000098667
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Brugia malayi Cytochrome P450 family protein 0.0016 0.0052 0.015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.086
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0534 0.0876
Loa Loa (eye worm) hypothetical protein 0.004 0.0356 0.0952
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0038 0.0084
Plasmodium vivax JmjC domain containing protein 0.0016 0.0051 0.1348
Mycobacterium tuberculosis Conserved protein 0.004 0.0356 0.1127
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0296 0.0932
Schistosoma mansoni thyroid hormone receptor 0.002 0.01 0.0175
Loa Loa (eye worm) hypothetical protein 0.0136 0.156 0.4205
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0097 0.0155
Loa Loa (eye worm) hypothetical protein 0.004 0.0356 0.0952
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0356 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.01 0.0097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.01 0.0159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0489 0.0801
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0077 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0107 0.2947
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1169 0.315
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1169 0.315
Schistosoma mansoni ran 0.0021 0.012 0.0212
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0451 0.0811
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.01 0.0097
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0356 0.1127
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0038 0.0084
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0088
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.01 0.0097
Brugia malayi mbt repeat family protein 0.0048 0.0451 0.1317
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.048 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0107 0.0312
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0356 0.0582
Leishmania major importin beta-1 subunit, putative 0.0023 0.0147 0.2466
Schistosoma mansoni hypothetical protein 0.0033 0.0271 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.01 0.0291
Leishmania major cytochrome p450-like protein 0.0016 0.0052 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.01 0.0291
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0271 0.0267
Onchocerca volvulus Huntingtin homolog 0.0136 0.156 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0051 0.0078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0147 0.408
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.0052 0.1015
Brugia malayi photoreceptor-specific nuclear receptor 0.0281 0.3372 0.9844
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0107 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.0052 0.0128
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0038 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.0052 0.0128
Brugia malayi mbt repeat family protein 0.0048 0.0451 0.1317
Toxoplasma gondii ABC1 family protein 0.004 0.0356 0.5549
Onchocerca volvulus 0.0015 0.0038 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.01 0.0261
Echinococcus granulosus importin subunit beta 1 0.0029 0.0215 0.035
Mycobacterium leprae putative cytochrome p450 0.0016 0.0052 0.1015
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0052 0.1372
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0038 0.099
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0052 0.0131
Schistosoma mansoni hypothetical protein 0.0033 0.0271 0.0484
Loa Loa (eye worm) hypothetical protein 0.0281 0.3372 0.91
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0038 0.099
Mycobacterium tuberculosis Conserved protein 0.004 0.0356 0.1127
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.1433
Schistosoma mansoni ap endonuclease 0.002 0.0107 0.0188
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0003 0.0000098667
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0038 0.0732
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0148
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0107 0.1561
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0038 0.0732
Loa Loa (eye worm) hypothetical protein 0.0038 0.0335 0.0895
Onchocerca volvulus 0.002 0.01 0.062
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0128
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0304 0.0496
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0038 0.0732
Brugia malayi steroid hormone receptor 0.002 0.01 0.0291
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.0052 0.0128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.01 0.0175
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0534 0.0876
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0271 0.0722
Loa Loa (eye worm) hypothetical protein 0.0041 0.0364 0.0975
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.2257 0.2255
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.01 0.0291
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0147 0.408
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0051 0.0086
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.0052 0.1015
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0003 0.0000072976
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0068 0.0117
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0038 0.0732
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0052 0.1372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0489 0.0879
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0198
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3426 0.5647
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0051 0.0048
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0534 0.0531
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0052 0.1372
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0637 0.1712
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0038 0.0094
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.048 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0253 0.0674
Echinococcus granulosus neuropeptide receptor A26 0.0497 0.6065 1
Schistosoma mansoni cytochrome P450 0.0016 0.0052 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.0052 0.0128
Brugia malayi hypothetical protein 0.0012 0.0003 0.0009
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0038 0.1096
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0051 0.1348
Brugia malayi topoisomerase 0.0012 0.0003 0.0009
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.0052 0.1015
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.059 0.0587
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.086
Brugia malayi beta-lactamase family protein 0.004 0.0356 0.1038
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.0052 0.0128
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0107 0.8892
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0489 0.0879
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0038 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.002 0.01 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.0052 0.0128
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.048 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0451 0.0739
Schistosoma mansoni importin beta-1 0.0029 0.0215 0.0384
Mycobacterium leprae conserved hypothetical protein 0.004 0.0356 0.7396
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.048 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0215 0.0628
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.01 0.0261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0296 0.0932
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0051 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.01 0.0291
Echinococcus multilocularis GPCR, family 2 0.0033 0.0271 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0051 0.0128
Echinococcus granulosus snurportin 1 0.0308 0.3706 0.6108
Loa Loa (eye worm) cytochrome P450 0.0016 0.0052 0.0131
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0051 0.0048
Echinococcus multilocularis 0.0016 0.0052 0.0048
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0534 0.1558
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.012 0.3314
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0356 0.7396
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0534 0.0961
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0038 0.0732
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0051 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.048 1
Mycobacterium ulcerans beta-lactamase 0.004 0.0356 0.7396
Loa Loa (eye worm) hypothetical protein 0.0286 0.3426 0.9245
Leishmania major cytochrome p450-like protein 0.0016 0.0052 0.0305
Schistosoma mansoni hypothetical protein 0.0072 0.0753 0.1358
Brugia malayi Cytochrome P450 family protein 0.0016 0.0052 0.015
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0356 0.1127
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0077 0.0121
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.0052 0.0128
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0305 0.3674 0.6057
Brugia malayi hypothetical protein 0.0286 0.3426 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0271 0.0441
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0052 0.1372
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.01 0.0261
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0107 0.0281
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.048 0.1535
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0113 0.0296
Echinococcus granulosus phd:f box containing protein 0.0016 0.0051 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0077 0.0133
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.01 0.0291
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0107 0.2947
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.012 0.3667
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.0052 0.1015
Schistosoma mansoni zinc finger protein 0.0015 0.0046 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0077 0.0133
Brugia malayi RNA, U transporter 1 0.0082 0.088 0.257
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.01 0.0291
Schistosoma mansoni ap endonuclease 0.002 0.0107 0.0188
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0148
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0451 0.0448
Loa Loa (eye worm) oxidoreductase 0.0015 0.0038 0.0094
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0038 0.0084
Brugia malayi nuclear receptor NHR-88 0.002 0.01 0.0291
Entamoeba histolytica hypothetical protein 0.0023 0.0147 0.3018
Loa Loa (eye worm) hypothetical protein 0.0072 0.0753 0.2026
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0322 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0253 0.0737
Schistosoma mansoni survival motor neuron protein 0.0058 0.0583 0.105
Schistosoma mansoni hypothetical protein 0.0021 0.0113 0.0198
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0051 0.1348
Onchocerca volvulus 0.0015 0.0038 0.0224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0271 0.0441
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0356 0.0353
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0451 0.2878
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0038 0.099
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.01 0.0175
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0068 0.0107
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0038 0.099
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0038 0.0732
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.01 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.048 1
Schistosoma mansoni hypothetical protein 0.0015 0.0046 0.0077
Loa Loa (eye worm) MBCTL1 0.0054 0.0534 0.1433
Echinococcus granulosus cpg binding protein 0.0036 0.0299 0.0488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0489 0.0801
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0003 0.00000057381
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0052 0.1015
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0215 0.6016
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0356 0.1127
Brugia malayi AMP-binding enzyme family protein 0.005 0.048 0.14
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.01 0.0159
Onchocerca volvulus 0.0048 0.0451 0.2878
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0638 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.01 0.062
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Schistosoma mansoni cpg binding protein 0.0032 0.0253 0.0452
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0215 0.6016
Echinococcus granulosus geminin 0.0182 0.213 0.3509
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.01 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.01 0.0261
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0052 0.0131
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.048 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.0052 0.0128
Plasmodium vivax importin-beta 2, putative 0.0029 0.0215 0.6016
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3426 0.3424
Brugia malayi AMP-binding enzyme family protein 0.005 0.048 0.14
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0038 0.0084
Leishmania major hypothetical protein, conserved 0.004 0.0356 0.719
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0038 0.0094
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.0052 0.1015
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0356 0.7396
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0637 0.1148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.01 0.0261
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0356 0.0638
Onchocerca volvulus 0.0032 0.0253 0.1602
Schistosoma mansoni hypothetical protein 0.0453 0.5525 1
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0051 0.0086
Echinococcus multilocularis FTZ F1 alpha 0.002 0.01 0.0097
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0271 0.079
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0356 0.1127
Loa Loa (eye worm) hypothetical protein 0.005 0.048 0.1287
Brugia malayi AMP-binding enzyme family protein 0.005 0.048 0.14
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0094
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.01 0.0175
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0159 0.0156
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0051 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0038 0.0732
Brugia malayi Cytochrome P450 family protein 0.0058 0.0583 0.1701
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0107 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0038 0.0549
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0107 0.2179
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0052 0.1372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0489 0.0486
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0038 0.0035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.01 0.0097
Brugia malayi Cytochrome P450 family protein 0.0016 0.0052 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0051 0.0128
Brugia malayi Steroid receptor seven-up type 2 0.002 0.01 0.0291
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.0052 0.1015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0107 0.2947
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0215 0.0573
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.048 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.01 0.0291
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.012 0.3314
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0051 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.0052 0.0128
Onchocerca volvulus Bile acid receptor homolog 0.002 0.01 0.062
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.048 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0534 0.0531
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0699 0.126
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.0052 0.1015
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.048 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.01 0.0097
Brugia malayi Bromodomain containing protein 0.0038 0.0334 0.0974
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0038 0.0732
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0038 0.0111
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0322 0.1016
Echinococcus granulosus neuropeptide s receptor 0.0497 0.6065 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.0038 0.0732
Schistosoma mansoni coup transcription factor 0.002 0.01 0.0175
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.0052 0.1015
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.048 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0003 0.00000062987
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0261
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0322 0.6683
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.0052 0.1015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0356 0.1038
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.048 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.048 0.1535
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0261
Onchocerca volvulus 0.0058 0.0583 0.3724
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0052 0.0761
Brugia malayi PHD-finger family protein 0.0027 0.0189 0.0551
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0356 1
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0052 0.1015
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.0052 0.0128
Loa Loa (eye worm) hypothetical protein 0.005 0.048 0.1287
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0271 0.0267
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0489 0.1311
Echinococcus granulosus dnaJ subfamily B 0.0453 0.5525 0.911
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0624 0.1024
Schistosoma mansoni hypothetical protein 0.0294 0.3533 0.6393
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0296 0.0932
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0489 0.1426
Onchocerca volvulus 0.004 0.0356 0.2264
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.0052 0.0128
Schistosoma mansoni hypothetical protein 0.0308 0.3706 0.6705
Loa Loa (eye worm) hypothetical protein 0.004 0.0356 0.0952
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.2257 0.3719
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0038 0.099
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.0038 0.0732
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0107 0.2947
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.012 0.3314
Echinococcus multilocularis neuropeptide receptor A26 0.0497 0.6065 0.6063
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0451 0.0448
Schistosoma mansoni hypothetical protein 0.0033 0.0271 0.0484
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0107 0.3261
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0128
Onchocerca volvulus 0.004 0.0356 0.2264
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.012 0.035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0107 0.2946
Echinococcus multilocularis cpg binding protein 0.0036 0.0299 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.01 0.0291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.01 0.0291
Schistosoma mansoni thyroid hormone receptor 0.002 0.01 0.0175
Schistosoma mansoni zinc finger protein 0.0021 0.0122 0.0215
Schistosoma mansoni nuclear hormone receptor 0.002 0.01 0.0175
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0451 0.0811
Loa Loa (eye worm) hypothetical protein 0.0044 0.0411 0.1101
Onchocerca volvulus 0.0015 0.0038 0.0224
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0052 0.0131
Brugia malayi hypothetical protein 0.0136 0.156 0.4553
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0051 0.1348
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0489 0.0486
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0051 0.0048
Loa Loa (eye worm) hypothetical protein 0.004 0.0356 0.0952
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.0052 0.0128
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0451 0.121
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0322 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1169 0.3413
Leishmania major hypothetical protein, conserved 0.0015 0.0046 0.0177
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0451 0.0739
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.086
Schistosoma mansoni hypothetical protein 0.0182 0.213 0.3852
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.0052 0.1015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.01 0.0159
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0038 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0038 0.0111
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.01 0.0097
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0159 0.0257

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 25 uM Cytotoxicity against human HuH7 cells ChEMBL. 21531135
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.