Detailed information for compound 1417783

Basic information

Technical information
  • TDR Targets ID: 1417783
  • Name: N,N-di(phenyl)imidazole-1-carboxamide
  • MW: 263.294 | Formula: C16H13N3O
  • H donors: 0 H acceptors: 2 LogP: 3.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(c1ccccc1)c1ccccc1)n1cncc1
  • InChi: 1S/C16H13N3O/c20-16(18-12-11-17-13-18)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H
  • InChiKey: FYSIBSOBMCDYHZ-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-di(phenyl)-1-imidazolecarboxamide
  • STOCK3S-46326
  • MLS000036460
  • SMR000035730
  • ZINC00102851

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0027 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0073 0.1545 0.483
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0119 0.2752 0.86
Schistosoma mansoni smad1 5 8 and 0.0027 0.0327 0.1021
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0119 0.2752 0.86
Loa Loa (eye worm) hypothetical protein 0.0107 0.2437 0.2437
Brugia malayi MH2 domain containing protein 0.0027 0.0327 0.0327
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0119 0.2752 1
Schistosoma mansoni tar DNA-binding protein 0.0136 0.32 1
Loa Loa (eye worm) RNA binding protein 0.0136 0.32 0.32
Echinococcus multilocularis tar DNA binding protein 0.0136 0.32 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0511 0.1597
Entamoeba histolytica tartrate dehydrogenase, putative 0.0014 0 0.5
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0014 0 0.5
Brugia malayi hypothetical protein 0.0016 0.0054 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0136 0.32 1
Schistosoma mansoni Smad4 0.0027 0.0327 0.1021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0119 0.2752 0.86
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0119 0.2752 1
Echinococcus granulosus GPCR family 2 0.0034 0.0511 0.1597
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0327 0.1021
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0119 0.2752 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0327 0.1021
Brugia malayi MH1 domain containing protein 0.0015 0.0011 0.0011
Echinococcus granulosus smad 0.0027 0.0327 0.1021
Schistosoma mansoni hypothetical protein 0.0034 0.0511 0.1597
Leishmania major hypothetical protein, conserved 0.0026 0.0292 0.1061
Schistosoma mansoni hypothetical protein 0.0034 0.0511 0.1597
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Brugia malayi RNA binding protein 0.0136 0.32 0.32
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0119 0.2752 0.86
Brugia malayi Smad1 0.0027 0.0327 0.0327
Brugia malayi MH1 domain containing protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0073 0.1545 0.1545
Echinococcus granulosus Smad4 0.0027 0.0327 0.1021
Echinococcus multilocularis isocitrate dehydrogenase 0.0119 0.2752 0.86
Toxoplasma gondii isocitrate dehydrogenase 0.0119 0.2752 1
Echinococcus granulosus tar DNA binding protein 0.0136 0.32 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.32 0.32
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0119 0.2752 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0327 0.1021
Schistosoma mansoni tar DNA-binding protein 0.0136 0.32 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0394 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0327 0.1021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0119 0.2752 0.86
Echinococcus multilocularis smad 0.0027 0.0327 0.1021
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0014 0 0.5
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0119 0.2752 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0119 0.2752 0.86
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1545 0.1545
Schistosoma mansoni hypothetical protein 0.0034 0.0511 0.1597
Schistosoma mansoni tar DNA-binding protein 0.0136 0.32 1
Echinococcus multilocularis Smad4 0.0027 0.0327 0.1021
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0327 0.0327
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0327 0.1021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.2437 0.2437
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0014 0 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.32 0.32
Toxoplasma gondii isocitrate dehydrogenase 0.0119 0.2752 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0327 0.1021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0511 0.1597
Loa Loa (eye worm) hypothetical protein 0.0026 0.0292 0.0292
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.2437 0.2437
Brugia malayi isocitrate dehydrogenase 0.0119 0.2752 0.2752
Brugia malayi hypothetical protein 0.0026 0.0292 0.0292
Schistosoma mansoni smad 0.0027 0.0327 0.1021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0119 0.2752 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0511 0.1597
Loa Loa (eye worm) hypothetical protein 0.0034 0.0511 0.0511
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0511 0.0511
Brugia malayi Isocitrate dehydrogenase 0.0119 0.2752 0.2752
Loa Loa (eye worm) nuclear factor I 0.0015 0.0011 0.0011
Loa Loa (eye worm) Smad1 0.0027 0.0327 0.0327
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0119 0.2752 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0327 0.1021
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0119 0.2752 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0119 0.2752 0.2752
Brugia malayi MH2 domain containing protein 0.0027 0.0327 0.0327
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0511 0.1597
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0327 0.0327
Schistosoma mansoni tar DNA-binding protein 0.0136 0.32 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.2437 0.2437
Echinococcus multilocularis GPCR, family 2 0.0034 0.0511 0.1597
Brugia malayi MH1 domain containing protein 0.0027 0.0327 0.0327
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0014 0 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0511 0.1597
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0511 0.0511
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0511 0.0511
Loa Loa (eye worm) TAR-binding protein 0.0136 0.32 0.32
Brugia malayi TAR-binding protein 0.0136 0.32 0.32
Loa Loa (eye worm) transcription factor SMAD2 0.0394 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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