Detailed information for compound 1418041

Basic information

Technical information
  • TDR Targets ID: 1418041
  • Name: prop-2-enyl 2-[furan-2-yl-(methoxycarbonylami no)methyl]-3-oxobutanoate
  • MW: 295.288 | Formula: C14H17NO6
  • H donors: 1 H acceptors: 3 LogP: 1 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOC(=O)C(C(c1ccco1)NC(=O)OC)C(=O)C
  • InChi: 1S/C14H17NO6/c1-4-7-21-13(17)11(9(2)16)12(15-14(18)19-3)10-6-5-8-20-10/h4-6,8,11-12H,1,7H2,2-3H3,(H,15,18)
  • InChiKey: LAYPJHIPFXOLEU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • allyl 2-[2-furyl-(methoxycarbonylamino)methyl]-3-oxo-butanoate
  • 2-[2-furyl-(methoxycarbonylamino)methyl]-3-oxobutanoic acid allyl ester
  • 2-[(carbomethoxyamino)-(2-furyl)methyl]-3-keto-butyric acid allyl ester
  • prop-2-enyl 2-[furan-2-yl-(methoxycarbonylamino)methyl]-3-oxo-butanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.008 0.1458 0.2113
Loa Loa (eye worm) hypothetical protein 0.0073 0.1286 0.1899
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0175 0.0209
Leishmania major importin beta-1 subunit, putative 0.0024 0.0209 0.1623
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1286 1
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0065
Schistosoma mansoni hypothetical protein 0.0176 0.358 0.5261
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0256 0.5511
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0159 0.0185
Loa Loa (eye worm) hypothetical protein 0.0174 0.3534 0.5218
Leishmania major hypothetical protein, conserved 0.0073 0.1286 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1286 0.1858
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1286 0.1899
Entamoeba histolytica hypothetical protein 0.0145 0.2897 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.5323 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1286 1
Echinococcus multilocularis snurportin 1 0.0319 0.6773 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.1458 0.2113
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1286 0.2416
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0175 0.0258
Schistosoma mansoni ap endonuclease 0.0023 0.0175 0.0209
Entamoeba histolytica hypothetical protein 0.0145 0.2897 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.1286 0.1131
Plasmodium vivax importin-beta 2, putative 0.003 0.0335 0.1559
Loa Loa (eye worm) hypothetical protein 0.0038 0.0511 0.0754
Echinococcus granulosus geminin 0.0176 0.358 0.5261
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0256 0.0859
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0175 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.1458 0.2113
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1286 0.1858
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1286 1
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0065
Loa Loa (eye worm) beta-lactamase 0.0073 0.1286 0.1899
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.5031 0.7428
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0159 0.0185
Schistosoma mansoni hypothetical protein 0.0145 0.2897 0.4248
Brugia malayi hypothetical protein 0.0145 0.2897 0.5442
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0175 0.0143
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1286 0.1858
Schistosoma mansoni hypothetical protein 0.008 0.1458 0.2113
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0511 0.0707
Brugia malayi beta-lactamase 0.0073 0.1286 0.2416
Loa Loa (eye worm) hypothetical protein 0.0254 0.5323 0.7859
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0175 0.1361
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0175 0.0059
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0335 0.2601
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.183 0.2665
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.1458 0.2113
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0065
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0209 0.0442
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1286 0.1131
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1286 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1286 0.1899
Loa Loa (eye worm) hypothetical protein 0.0073 0.1286 0.1899
Brugia malayi Latrophilin receptor protein 2 0.008 0.1458 0.2739
Mycobacterium ulcerans hypothetical protein 0.0073 0.1286 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.1458 0.2153
Loa Loa (eye worm) hypothetical protein 0.0073 0.1286 0.1899
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.5031 0.7428
Echinococcus granulosus snurportin 1 0.0319 0.6773 1
Schistosoma mansoni hypothetical protein 0.008 0.1458 0.2113
Mycobacterium tuberculosis Conserved protein 0.0073 0.1286 0.1131
Echinococcus granulosus importin subunit beta 1 0.003 0.0335 0.0445
Schistosoma mansoni hypothetical protein 0.008 0.1458 0.2113
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0209 0.1623
Onchocerca volvulus 0.0073 0.1286 0.5
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1286 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.183 0.2665
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0175 0.0329
Mycobacterium leprae Probable lipase LipE 0.0073 0.1286 0.5
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0511 1
Onchocerca volvulus 0.0073 0.1286 0.5
Mycobacterium ulcerans lipase LipD 0.0073 0.1286 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0159 0.1235
Brugia malayi hypothetical protein 0.0017 0.0048 0.009
Plasmodium falciparum importin beta, putative 0.003 0.0335 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0511 0.3122
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0256 0.1988
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0209 0.0442
Loa Loa (eye worm) hypothetical protein 0.0073 0.1286 0.1899
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0511 0.1285
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0511 0.0707
Schistosoma mansoni ap endonuclease 0.0023 0.0175 0.0209
Mycobacterium tuberculosis Conserved protein 0.0073 0.1286 0.1131
Brugia malayi beta-lactamase family protein 0.0073 0.1286 0.2416
Leishmania major GTP-binding protein, putative 0.0022 0.0159 0.1235
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1286 0.1131
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0511 0.096
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1286 1
Schistosoma mansoni ran 0.0022 0.0159 0.0185
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0175 0.1361
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0175 0.1361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.183 0.2665
Entamoeba histolytica hypothetical protein 0.0145 0.2897 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0175 0.1361
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.2897 0.4248
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0511 0.0707
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0175 0.0209
Loa Loa (eye worm) hypothetical protein 0.0073 0.1286 0.1899
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.183 0.2702
Brugia malayi MH2 domain containing protein 0.0241 0.5031 0.9451
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0175 0.0143
Schistosoma mansoni hypothetical protein 0.0176 0.358 0.5261
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1286 0.5
Trichomonas vaginalis esterase, putative 0.0073 0.1286 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.5323 0.7859
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0209 0.0442
Echinococcus multilocularis GPCR, family 2 0.008 0.1458 0.2113
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1286 1
Schistosoma mansoni hypothetical protein 0.008 0.1458 0.2113
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0034 0.0051
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0175 0.0458
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.3534 0.6639
Loa Loa (eye worm) Smad1 0.0016 0.0034 0.0051
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0159 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0511 0.3122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1286 0.1858
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1286 1
Onchocerca volvulus 0.0073 0.1286 0.5
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0065
Toxoplasma gondii exonuclease III APE 0.0023 0.0175 0.0143
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0159 0.1235
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1286 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.6773 1
Brugia malayi hypothetical protein 0.0026 0.0256 0.048
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0159 0.0299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.5323 1
Schistosoma mansoni hypothetical protein 0.0174 0.3534 0.5193
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.183 0.3438
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.1458 0.2739
Echinococcus multilocularis geminin 0.0176 0.358 0.5261
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0175 0.0143
Loa Loa (eye worm) hypothetical protein 0.003 0.0335 0.0494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.183 0.2665
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0511 0.3971
Toxoplasma gondii ABC1 family protein 0.0073 0.1286 1
Mycobacterium ulcerans beta-lactamase 0.0073 0.1286 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0335 0.0445
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1286 0.1131
Brugia malayi beta-lactamase family protein 0.0073 0.1286 0.2416
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1286 0.1131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.183 0.2665
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0256 0.1988
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0175 0.1361
Brugia malayi Importin beta-1 subunit 0.003 0.0335 0.0629
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0335 0.1559
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0511 0.0707
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0511 0.0707
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0159 0.1235
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0175 0.0917
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0256 0.0859
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0256 0.1988
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0256 0.5511
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1286 0.1131
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1286 0.1131
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1286 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1286 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1286 0.1131
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0511 0.3971
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0034 0.0051
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.2897 0.4248
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0511 0.3971
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.183 0.2665
Schistosoma mansoni ran 0.0022 0.0159 0.0185
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0511 0.3122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.1458 0.2113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0256 0.0378
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0511 0.0707
Entamoeba histolytica hypothetical protein 0.0024 0.0209 0.0182
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0511 0.0707
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0511 0.0707
Schistosoma mansoni hypothetical protein 0.0319 0.6773 1
Schistosoma mansoni importin beta-1 0.003 0.0335 0.0445
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.2897 0.4248
Brugia malayi RNA, U transporter 1 0.0085 0.1561 0.2933
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0335 0.2601
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0511 0.3971
Leishmania major hypothetical protein, conserved 0.0026 0.0256 0.1988
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.183 0.2665
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.1458 0.2153
Brugia malayi Smad1 0.0016 0.0034 0.0065
Entamoeba histolytica hypothetical protein 0.0145 0.2897 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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