Detailed information for compound 1418093

Basic information

Technical information
  • TDR Targets ID: 1418093
  • Name: 1-[(4-methylphenyl)sulfonylmethyl]-1,2-dihydr o-[1,3]thiazolo[3,2-a]benzimidazole
  • MW: 344.451 | Formula: C17H16N2O2S2
  • H donors: 0 H acceptors: 3 LogP: 3.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)CC1CSc2n1c1ccccc1n2
  • InChi: 1S/C17H16N2O2S2/c1-12-6-8-14(9-7-12)23(20,21)11-13-10-22-17-18-15-4-2-3-5-16(15)19(13)17/h2-9,13H,10-11H2,1H3
  • InChiKey: WRNRNAJPWBNTPX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-methylphenyl)sulfonylmethyl]-1,2-dihydrothiazolo[3,2-a]benzimidazole
  • BAS 08317152
  • ChemDiv2_002004
  • MLS000558294
  • SMR000178607
  • 3-(Toluene-4-sulfonylmethyl)-2,3-dihydro-benzo[4,5]imidazo[2,1-b]thiazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 2, group F, member 1 Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131829 All targets in OG5_131829
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Steroid receptor seven-up type 2 Get druggable targets OG5_131829 All targets in OG5_131829
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi ecdysteroid receptor nuclear receptor subfamily 2, group F, member 1 423 aa 354 aa 26.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0088 0.0211
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0088 0.0211
Brugia malayi ecdysteroid receptor 0.0024 0.0088 0.0088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.021 0.2965 0.7153
Schistosoma mansoni intermediate filament proteins 0.0033 0.0214 0.0318
Echinococcus multilocularis lamin dm0 0.0033 0.0214 0.0517
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0361 0.087
Onchocerca volvulus 0.0033 0.0214 0.1068
Schistosoma mansoni tar DNA-binding protein 0.0198 0.279 0.4137
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0088 0.0088
Schistosoma mansoni Smad4 0.0042 0.0361 0.0535
Schistosoma mansoni endoplasmin 0.0039 0.0318 0.0472
Brugia malayi heat shock protein 90 0.0039 0.0318 0.0318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0567 0.1367
Schistosoma mansoni survival motor neuron protein 0.0058 0.0613 0.091
Brugia malayi RNA recognition motif domain containing protein 0.0198 0.279 0.279
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0318 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0361 0.087
Schistosoma mansoni smad1 5 8 and 0.0042 0.0361 0.0535
Echinococcus granulosus endoplasmin 0.0031 0.0194 0.0468
Echinococcus granulosus GPCR family 2 0.021 0.2965 0.7153
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0088 0.013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0088 0.0088
Echinococcus granulosus heat shock protein 90 0.0039 0.0318 0.0768
Echinococcus granulosus lamin 0.0033 0.0214 0.0517
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0361 0.0535
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0662 1 1
Brugia malayi MH1 domain containing protein 0.0042 0.0361 0.0361
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0194 0.2665
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0088 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0088 0.0088
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.021 0.2965 0.2965
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.021 0.2965 0.7153
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0318 0.5
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0088 0.0211
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4145 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 0.279 0.279
Echinococcus multilocularis heat shock protein 90 0.0031 0.0194 0.0468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0567 0.084
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.021 0.2965 0.2965
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0194 0.2665
Loa Loa (eye worm) hypothetical protein 0.0121 0.1595 0.1595
Schistosoma mansoni heat shock protein 0.0039 0.0318 0.0472
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0194 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0616 0.9282 0.9282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0567 0.1367
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0088 0.0211
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0361 0.0361
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0383 0.0569
Entamoeba histolytica hypothetical protein 0.0043 0.0383 0.0527
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0318 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0088 0.0088
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0088 0.0211
Loa Loa (eye worm) Smad1 0.0042 0.0361 0.0361
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Loa Loa (eye worm) RNA binding protein 0.0198 0.279 0.279
Schistosoma mansoni tar DNA-binding protein 0.0198 0.279 0.4137
Loa Loa (eye worm) nuclear factor I 0.0023 0.0069 0.0069
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0501 0.1209
Brugia malayi CHE-14 protein 0.0051 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0051 0.0501 0.0501
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0613 0.0613
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0069
Echinococcus multilocularis heat shock protein 0.0039 0.0318 0.0768
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0318 0.5631
Schistosoma mansoni tar DNA-binding protein 0.0198 0.279 0.4137
Schistosoma mansoni lamin 0.0033 0.0214 0.0318
Onchocerca volvulus 0.0033 0.0214 0.1068
Echinococcus multilocularis lamin 0.0033 0.0214 0.0517
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Schistosoma mansoni hypothetical protein 0.0043 0.0383 0.0569
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Echinococcus multilocularis heat shock protein 90 0.0039 0.0318 0.0768
Echinococcus multilocularis musashi 0.0033 0.0214 0.0517
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0214
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0567 0.1367
Echinococcus multilocularis protein patched 0.0051 0.0501 0.1209
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Echinococcus multilocularis protein dispatched 1 0.0058 0.0613 0.1479
Loa Loa (eye worm) hypothetical protein 0.0148 0.2007 0.2007
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0088 0.0211
Entamoeba histolytica hypothetical protein 0.0043 0.0383 0.0527
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0383 0.0925
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0088 0.0211
Brugia malayi MH2 domain containing protein 0.0616 0.9282 0.9282
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0198 0.279 0.4137
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0318 0.0318
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0133 0.1774 0.4279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0088 0.0088
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0214 0.0214
Schistosoma mansoni patched 1 0.0051 0.0501 0.0743
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0318 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0088 0.0088
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Schistosoma mansoni hypothetical protein 0.0058 0.0613 0.091
Brugia malayi TAR-binding protein 0.0198 0.279 0.279
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0088 0.0211
Loa Loa (eye worm) TAR-binding protein 0.0198 0.279 0.279
Entamoeba histolytica hypothetical protein 0.0043 0.0383 0.0527
Schistosoma mansoni hypothetical protein 0.0049 0.0473 0.0701
Echinococcus multilocularis Smad4 0.0042 0.0361 0.087
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0318 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0088 0.0088
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0119 0.1556 0.1556
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0453 0.6744 0.6744
Schistosoma mansoni hypothetical protein 0.021 0.2965 0.4396
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0088 0.0211
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Brugia malayi Endoplasmin precursor 0.0039 0.0318 0.0318
Brugia malayi Steroid receptor seven-up type 2 0.0133 0.1774 0.1774
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0088 0.0088
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0318 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.021 0.2965 0.7153
Brugia malayi MH2 domain containing protein 0.0042 0.0361 0.0361
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0214 0.0214
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0088 0.013
Brugia malayi MH1 domain containing protein 0.0023 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0043 0.0383 0.0527
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0088 0.0088
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.021 0.2965 0.7153
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1584 0.2349
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0088 0.013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0088 0.0211
Onchocerca volvulus Huntingtin homolog 0.0148 0.2007 1
Brugia malayi Smad1 0.0042 0.0361 0.0361
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0088 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0088 0.0088
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0501 0.0501
Schistosoma mansoni endoplasmin 0.0039 0.0318 0.0472
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0088 0.0437
Echinococcus multilocularis expressed conserved protein 0.0112 0.1444 0.3483
Brugia malayi latrophilin 2 splice variant baaae 0.0453 0.6744 0.6744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0567 0.1367
Echinococcus granulosus intermediate filament protein 0.0033 0.0214 0.0517
Schistosoma mansoni hypothetical protein 0.0049 0.0473 0.0701
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0567 0.0567
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0088 0.013
Schistosoma mansoni smad1 5 8 and 0.0042 0.0361 0.0535
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0088 0.013
Plasmodium vivax endoplasmin, putative 0.0039 0.0318 0.5
Brugia malayi MH1 domain containing protein 0.0042 0.0361 0.0361
Echinococcus multilocularis endoplasmin 0.0031 0.0194 0.0468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0088 0.0088
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0679 0.0679
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0088 0.0437
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0214 0.0214
Echinococcus multilocularis tar DNA binding protein 0.0198 0.279 0.6732
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0088 0.013
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0088 0.0088
Schistosoma mansoni smad1 5 8 and 0.0042 0.0361 0.0535
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0088 0.013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0133 0.1774 0.4279
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0361 0.0361
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Schistosoma mansoni tar DNA-binding protein 0.0198 0.279 0.4137
Onchocerca volvulus 0.0024 0.0088 0.0437
Treponema pallidum heat shock protein 90 0.0031 0.0194 0.5
Echinococcus multilocularis GPCR, family 2 0.021 0.2965 0.7153
Echinococcus multilocularis smad 0.0042 0.0361 0.087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0088 0.0088
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0318 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1556 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0088 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0049 0.0473 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0088
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0194 0.503
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0194 0.5
Brugia malayi RNA binding protein 0.0198 0.279 0.279
Schistosoma mansoni coup transcription factor 0.0024 0.0088 0.013
Loa Loa (eye worm) hypothetical protein 0.0286 0.4145 0.4145
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0318 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.2348 0.5665
Echinococcus granulosus heat shock protein 90 0.0031 0.0194 0.0468
Loa Loa (eye worm) MH2 domain-containing protein 0.0616 0.9282 0.9282
Schistosoma mansoni hypothetical protein 0.021 0.2965 0.4396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0088 0.0211
Echinococcus granulosus expressed conserved protein 0.0112 0.1444 0.3483
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0088 0.013
Plasmodium falciparum heat shock protein 90 0.0039 0.0318 1
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0318 0.5
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.2348 0.5665
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.021 0.2965 0.2965
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1556 0.1556
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0361 0.087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0088 0.0088
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0318 0.5
Onchocerca volvulus Huntingtin homolog 0.0148 0.2007 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0567 0.084
Brugia malayi steroid hormone receptor 0.0024 0.0088 0.0088
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0501 0.1209
Echinococcus granulosus smad 0.0042 0.0361 0.087
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0088 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0088 0.0088
Brugia malayi MH1 domain containing protein 0.0023 0.0069 0.0069
Brugia malayi nuclear hormone receptor 0.0024 0.0088 0.0088
Brugia malayi hypothetical protein 0.0148 0.2007 0.2007
Brugia malayi hypothetical protein 0.0286 0.4145 0.4145
Schistosoma mansoni heat shock protein 0.0039 0.0318 0.0472
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0318 1
Schistosoma mansoni hypothetical protein 0.0453 0.6744 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0383 0.0925
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0194 0.2665
Echinococcus granulosus lamin dm0 0.0033 0.0214 0.0517
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0194 0.5
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0318 1
Schistosoma mansoni smad 0.0042 0.0361 0.0535
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0088 0.013
Trypanosoma brucei heat shock protein, putative 0.0039 0.0318 0.5
Echinococcus granulosus Smad4 0.0042 0.0361 0.087
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0088 0.0211
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0088 0.0088
Brugia malayi MH2 domain containing protein 0.0042 0.0361 0.0361
Schistosoma mansoni hypothetical protein 0.0049 0.0473 0.0701
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0501 0.1209
Loa Loa (eye worm) endoplasmin 0.0039 0.0318 0.0318
Brugia malayi intermediate filament protein 0.0033 0.0214 0.0214
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1556 0.3753
Loa Loa (eye worm) nuclear hormone receptor 0.012 0.1573 0.1573
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0088 0.013
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1556 0.3753
Brugia malayi Calcitonin receptor-like protein seb-1 0.0662 1 1
Brugia malayi hypothetical protein 0.0043 0.0383 0.0383
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0088 0.0437
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0194 0.503
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Schistosoma mansoni lamin 0.0033 0.0214 0.0318
Onchocerca volvulus 0.0058 0.0613 0.3056
Loa Loa (eye worm) hypothetical protein 0.0148 0.2007 0.2007
Brugia malayi Latrophilin receptor protein 2 0.021 0.2965 0.2965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0501 1
Schistosoma mansoni hypothetical protein 0.021 0.2965 0.4396
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0088 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0088 0.0211
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Brugia malayi nuclear receptor NHR-88 0.0024 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0088 0.0088
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0088 0.0211
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0361 0.087
Echinococcus granulosus heat shock protein 0.0039 0.0318 0.0768
Schistosoma mansoni hypothetical protein 0.021 0.2965 0.4396
Leishmania major heat shock protein 83-1 0.0039 0.0318 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0194 0.0468
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4145 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0567 0.084
Echinococcus granulosus tar DNA binding protein 0.0198 0.279 0.6732

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.52 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
IC50 (functional) 4.214 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 42 um PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ] ChEMBL. No reference
IC50 (functional) > 42 um PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ] ChEMBL. No reference
IC50 (functional) 85.413 uM PubChem BioAssay. Counterscreen for inhibitors of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7308 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2995 uM PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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