Detailed information for compound 1418133

Basic information

Technical information
  • TDR Targets ID: 1418133
  • Name: N-(3-cyanothiophen-2-yl)-2-[4-(2,5-dimethylph enyl)sulfonylpiperazin-1-yl]acetamide
  • MW: 418.533 | Formula: C19H22N4O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccsc1NC(=O)CN1CCN(CC1)S(=O)(=O)c1cc(C)ccc1C
  • InChi: 1S/C19H22N4O3S2/c1-14-3-4-15(2)17(11-14)28(25,26)23-8-6-22(7-9-23)13-18(24)21-19-16(12-20)5-10-27-19/h3-5,10-11H,6-9,13H2,1-2H3,(H,21,24)
  • InChiKey: LKSOXZFPPRSRAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-cyano-2-thienyl)-2-[4-(2,5-dimethylphenyl)sulfonylpiperazin-1-yl]acetamide
  • N-(3-cyano-2-thienyl)-2-[4-(2,5-dimethylphenyl)sulfonyl-1-piperazinyl]acetamide
  • N-(3-cyanothiophen-2-yl)-2-[4-(2,5-dimethylphenyl)sulfonylpiperazin-1-yl]ethanamide
  • MLS000707816
  • SMR000243953
  • T5288366

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi TAR-binding protein 0.0132 0.3203 0.3203
Schistosoma mansoni Smad4 0.0025 0.0182 0.0443
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0182 0.0182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1027 0.2727
Schistosoma mansoni hypothetical protein 0.0051 0.0905 0.2202
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.3203 0.3203
Echinococcus multilocularis GPCR, family 2 0.0051 0.0905 0.2202
Loa Loa (eye worm) transcription factor SMAD2 0.0372 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0994 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0182 0.0443
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0994 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.3203 0.7792
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.4018 0.4018
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1473 0.3585
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0905 0.0905
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0539 1
Brugia malayi MH2 domain containing protein 0.0025 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0161 0.4018 0.4018
Brugia malayi RNA binding protein 0.0132 0.3203 0.3203
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0182 0.0443
Echinococcus granulosus dna polymerase kappa 0.0023 0.0124 0.0328
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0124 0.03
Echinococcus multilocularis tar DNA binding protein 0.0132 0.3203 0.7792
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0994 0.0994
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1027 0.1027
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0124 0.0328
Loa Loa (eye worm) hypothetical protein 0.011 0.2577 0.2577
Schistosoma mansoni tar DNA-binding protein 0.0132 0.3203 0.7792
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0182 0.0483
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.4018 0.4018
Leishmania major DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Schistosoma mansoni jumonji domain containing protein 0.0071 0.1473 0.3585
Echinococcus multilocularis dna polymerase eta 0.0054 0.0994 0.2418
Schistosoma mansoni hypothetical protein 0.0152 0.3765 0.916
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.411 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1027 0.2498
Schistosoma mansoni smad1 5 8 and 0.0025 0.0182 0.0443
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0124 0.5
Brugia malayi MH1 domain containing protein 0.0025 0.0182 0.0182
Brugia malayi MH1 domain containing protein 0.0025 0.0182 0.0182
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1027 0.1027
Loa Loa (eye worm) hypothetical protein 0.0051 0.0905 0.0905
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0124 0.03
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1027 0.2498
Schistosoma mansoni hypothetical protein 0.0051 0.0905 0.2202
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0182 0.0443
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.0994 0.0994
Echinococcus granulosus GPCR family 2 0.0051 0.0905 0.2403
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1027 0.2498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Echinococcus multilocularis Smad4 0.0025 0.0182 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Brugia malayi jmjC domain containing protein 0.0071 0.1473 0.1473
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0124 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0905 0.2403
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0182 0.0483
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0124 0.1243
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Echinococcus multilocularis smad 0.0025 0.0182 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.1473 0.3913
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0124 0.5
Echinococcus granulosus Smad4 0.0025 0.0182 0.0483
Schistosoma mansoni tar DNA-binding protein 0.0132 0.3203 0.7792
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0182 0.0182
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.4018 0.4018
Schistosoma mansoni smad 0.0025 0.0182 0.0443
Schistosoma mansoni DNA polymerase eta 0.0054 0.0994 0.2418
Leishmania major DNA polymerase eta, putative 0.0054 0.0994 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.3203 0.7792
Echinococcus granulosus tar DNA binding protein 0.0132 0.3203 0.8506
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Brugia malayi MH2 domain containing protein 0.0025 0.0182 0.0182
Schistosoma mansoni hypothetical protein 0.011 0.2577 0.6269
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.3765 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0124 0.1243
Echinococcus granulosus smad 0.0025 0.0182 0.0483
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0905 0.2202
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0905 0.2202
Schistosoma mansoni hypothetical protein 0.0051 0.0905 0.2202
Schistosoma mansoni thyroid hormone receptor 0.0164 0.411 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0124 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1027 0.2727
Loa Loa (eye worm) TAR-binding protein 0.0132 0.3203 0.3203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0905 0.0905
Brugia malayi Smad1 0.0025 0.0182 0.0182
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0905 0.2403
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0182 0.0443
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1473 0.3585
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0124 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Schistosoma mansoni thyroid hormone receptor 0.0164 0.411 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.1473 0.3585
Loa Loa (eye worm) RNA binding protein 0.0132 0.3203 0.3203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Brugia malayi jmjC domain containing protein 0.0071 0.1473 0.1473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1027 0.2498
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.3765 0.916
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0124 0.1243
Loa Loa (eye worm) Smad1 0.0025 0.0182 0.0182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0905 0.0905
Schistosoma mansoni hypothetical protein 0.0051 0.0905 0.2202
Leishmania major DNA polymerase eta, putative 0.0038 0.0539 0.5425
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Giardia lamblia DINP protein human, muc B family 0.0023 0.0124 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0124 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1473 0.3585
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0539 0.5425
Schistosoma mansoni smad1 5 8 and 0.0025 0.0182 0.0443
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0124 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.2577 0.2577
Trypanosoma brucei unspecified product 0.0023 0.0124 0.1243
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0124 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0372 1 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.3203 0.7792
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.1473 0.1473
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Echinococcus granulosus dna polymerase eta 0.0054 0.0994 0.2639
Plasmodium vivax JmjC domain containing protein 0.0019 0 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0124 0.03
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0124 0.1243
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0124 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0124 0.1243
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.1473 0.3913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1027 0.2498
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.3203 0.3203

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.