Detailed information for compound 1418328

Basic information

Technical information
  • TDR Targets ID: 1418328
  • Name: ethyl 4-[2-[2-(cyclohexanecarbonylamino)acety l]oxyacetyl]-2,5-dimethyl-1H-pyrrole-3-carbox ylate
  • MW: 392.446 | Formula: C20H28N2O6
  • H donors: 2 H acceptors: 4 LogP: 2.76 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(C)[nH]c(c1C(=O)COC(=O)CNC(=O)C1CCCCC1)C
  • InChi: 1S/C20H28N2O6/c1-4-27-20(26)18-13(3)22-12(2)17(18)15(23)11-28-16(24)10-21-19(25)14-8-6-5-7-9-14/h14,22H,4-11H2,1-3H3,(H,21,25)
  • InChiKey: COOPASNGHRCLMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[2-[(cyclohexyl-oxomethyl)amino]-1-oxoethoxy]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
  • 4-[2-[2-(cyclohexanecarbonylamino)acetyl]oxyacetyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
  • ethyl 4-[2-[2-(cyclohexylcarbonylamino)ethanoyloxy]ethanoyl]-2,5-dimethyl-1H-pyrrole-3-carboxylate
  • ZINC04827865
  • T5249629
  • MLS001005411
  • SMR000348704

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0028 0.04 0.1367
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.1751 0.2985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.337 0.4426
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.2927 0.5339
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0449 0.0819
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.5483 0.6214
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0398 0.0726
Trichomonas vaginalis set domain proteins, putative 0.0233 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.2927 1
Brugia malayi glutathione reductase 0.0057 0.1751 0.2018
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.1751 0.1786
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.5483 0.6321
Plasmodium vivax SET domain protein, putative 0.0029 0.0449 0.1533
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.2927 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.2927 0.3182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.337 0.6148
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0246 0.1404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.337 0.6148
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0246 0.084
Echinococcus multilocularis tar DNA binding protein 0.0137 0.5483 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.5865 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.2927 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.1599 0.2916
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.2927 1
Plasmodium vivax glutathione reductase, putative 0.0057 0.1751 0.598
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.04 0.1367
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0 0.5
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.04 0.1367
Brugia malayi Pre-SET motif family protein 0.0029 0.0449 0.0518
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.2927 0.5339
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.1751 0.598
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.5183 0.8837
Leishmania major hypothetical protein, conserved 0.0025 0.0246 0.1404
Leishmania major trypanothione reductase 0.0057 0.1751 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.1599 0.2194
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.1751 0.3193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.337 0.6148
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0246 0.1404
Loa Loa (eye worm) RNA binding protein 0.0137 0.5483 0.6214
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.2927 0.4625
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0449 0.1533
Trypanosoma brucei trypanothione reductase 0.0057 0.1751 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0449 0.0241
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.2927 0.3844
Plasmodium falciparum thioredoxin reductase 0.0057 0.1751 0.598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.337 0.4426
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.2927 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.337 0.3886
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.5865 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.5483 0.7199
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.2927 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.337 0.4426
Loa Loa (eye worm) TAR-binding protein 0.0137 0.5483 0.6214
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.5183 0.8837
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.5183 0.8752
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0449 0.0819
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.1599 0.2726
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0246 0.084
Plasmodium falciparum glutathione reductase 0.0057 0.1751 0.598
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.2927 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.1751 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.1599 0.2726
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0449 0.0589
Brugia malayi RNA binding protein 0.0137 0.5483 0.6321
Brugia malayi Pre-SET motif family protein 0.0205 0.8673 1
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.1599 0.2916
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.2927 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.5183 0.8837
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0449 0.0819
Echinococcus granulosus tar DNA binding protein 0.0137 0.5483 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.5483 0.7199
Brugia malayi TAR-binding protein 0.0137 0.5483 0.6321
Loa Loa (eye worm) glutathione reductase 0.0057 0.1751 0.1786
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.8673 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.2927 1
Brugia malayi Thioredoxin reductase 0.0057 0.1751 0.2018
Brugia malayi hypothetical protein 0.0025 0.0246 0.0283
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.04 0.1367
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.5865 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.2927 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0449 0.0589
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.5183 0.8837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.1751 0.3193
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.5183 0.8837
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.337 0.3708
Schistosoma mansoni tar DNA-binding protein 0.0137 0.5483 0.7199
Mycobacterium tuberculosis Probable reductase 0.013 0.5183 0.8837
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.5865 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0449 0.0589
Schistosoma mansoni tar DNA-binding protein 0.0137 0.5483 0.7199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.337 0.6148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0449 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0246 0.084
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0246 0.1404
Brugia malayi Probable ClpP-like protease 0.0082 0.2927 0.3375
Toxoplasma gondii thioredoxin reductase 0.0057 0.1751 0.598
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0246 0.084
Schistosoma mansoni tar DNA-binding protein 0.0137 0.5483 0.7199

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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