Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.0931 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0931 | 0.0931 |
Echinococcus granulosus | tar DNA binding protein | 0.02 | 0.4236 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0303 | 0.0716 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0145 | 0.3022 | 0.7134 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0527 | 0.0527 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.02 | 0.4236 | 0.4236 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.677 | 0.677 |
Schistosoma mansoni | hypothetical protein | 0.0313 | 0.677 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.02 | 0.4236 | 0.4236 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.4236 | 0.6257 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0145 | 0.3022 | 0.7134 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0189 | 0.4005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.3808 | 0.3808 |
Echinococcus multilocularis | GPCR, family 2 | 0.0145 | 0.3022 | 0.7134 |
Brugia malayi | isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.0491 |
Echinococcus granulosus | GPCR family 2 | 0.0145 | 0.3022 | 0.7134 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0931 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0189 | 0.4005 | 0.4005 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3022 | 0.4464 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0459 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.0491 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.4236 | 0.6257 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.0725 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.4005 | 0.4005 |
Echinococcus multilocularis | tar DNA binding protein | 0.02 | 0.4236 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.5271 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0145 | 0.3022 | 0.7134 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.2583 | 0.2583 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.1158 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.2583 | 0.2583 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.3808 | 0.899 |
Loa Loa (eye worm) | TAR-binding protein | 0.02 | 0.4236 | 0.4236 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.3808 | 0.3808 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.4236 | 0.6257 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.4236 | 0.6257 |
Brugia malayi | RNA recognition motif domain containing protein | 0.02 | 0.4236 | 0.4236 |
Brugia malayi | Isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.0491 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.2583 | 0.2583 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0491 | 0.1158 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.0931 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0459 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0931 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0145 | 0.3022 | 0.3022 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0145 | 0.3022 | 0.3022 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0931 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.5271 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0313 | 0.677 | 0.677 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.3808 | 0.899 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0931 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3022 | 0.4464 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.4236 | 0.6257 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0145 | 0.3022 | 0.7134 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3022 | 0.4464 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.0931 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3022 | 0.4464 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.3808 | 0.899 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.1158 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.1158 |
Brugia malayi | TAR-binding protein | 0.02 | 0.4236 | 0.4236 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0303 | 0.0716 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.3808 | 0.3808 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0303 | 0.0448 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0931 | 0.0931 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0145 | 0.3022 | 0.3022 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.0931 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0491 | 0.1158 |
Brugia malayi | RNA binding protein | 0.02 | 0.4236 | 0.4236 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0.0491 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3022 | 0.3022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 7.0795 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.