Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4417 | 0.4769 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4087 | 0.4413 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0106 | 0.0114 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0071 | 0.736 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0435 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.9262 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.3667 | 0.2673 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0947 | 0.1287 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0947 | 0.1188 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0071 | 0.736 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0435 | 0.0592 |
Schistosoma mansoni | bromodomain containing protein | 0.0075 | 0.7978 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0947 | 0.1287 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0618 | 0.0667 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3258 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3679 | 0.3972 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3258 | 0.4427 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0618 | 0.0774 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0435 | 0.0546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.