Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 1 | 1 |
Echinococcus multilocularis | nibrin | 0.002 | 0.0264 | 0.0264 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.6486 | 0.6486 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.32 | 0.32 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0599 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0599 | 0.17 |
Onchocerca volvulus | 0.002 | 0.0264 | 0.5 | |
Schistosoma mansoni | topbp1 | 0.002 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0599 | 0.0599 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0599 | 0.0599 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.32 | 0.32 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.32 | 0.32 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1163 | 0.1163 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.2233 | 0.2304 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2165 | 0.2165 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.32 | 0.32 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0599 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.32 | 0.32 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.002 | 0.0264 | 0.5 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.002 | 0.0264 | 0.0264 |
Brugia malayi | RNA binding protein | 0.0067 | 0.32 | 0.32 |
Schistosoma mansoni | DNA ligase IV | 0.002 | 0.0264 | 0.0264 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.2233 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.2233 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.2233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.6486 | 0.6486 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0599 | 0.197 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Echinococcus granulosus | nibrin | 0.002 | 0.0264 | 0.0273 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2165 | 0.2165 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2165 | 0.2165 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.2233 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0032 | 0.0032 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1964 | 1 |
Brugia malayi | topoisomerase | 0.002 | 0.0264 | 0.0264 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0599 | 0.197 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.32 | 0.32 |
Echinococcus granulosus | replication factor c subunit 1 | 0.002 | 0.0264 | 0.0273 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9691 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.32 | 0.32 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0599 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.32 | 0.32 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.002 | 0.0264 | 0.0264 |
Chlamydia trachomatis | DNA ligase | 0.002 | 0.0264 | 0.5 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.002 | 0.0264 | 0.0264 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.32 | 0.32 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.002 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Brugia malayi | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.002 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1163 | 0.1163 |
Brugia malayi | DKFZp564C0469 protein | 0.002 | 0.0264 | 0.0264 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.32 | 0.32 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1964 | 1 |
Treponema pallidum | DNA ligase (lig) | 0.002 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0599 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.2233 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.32 | 0.32 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2165 | 0.2165 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.002 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.6486 | 0.6486 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0599 | 0.17 |
Brugia malayi | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1964 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.32 | 0.3302 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1163 | 0.1163 |
Schistosoma mansoni | topbp1 | 0.002 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0264 | 0.0264 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0029 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.