Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase | 0.0043 | 0.0506 | 0.0506 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0506 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.014 | 0.2522 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0506 | 0.2006 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0497 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0506 | 0.0935 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0506 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0038 | 0.0395 | 0.0731 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0506 | 0.0935 |
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0506 | 0.5 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.014 | 0.2522 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.5412 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.014 | 0.2522 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.014 | 0.2522 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0497 | 1 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0506 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0506 | 0.0506 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.014 | 0.2522 | 1 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.014 | 0.2522 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.014 | 0.2522 | 0.466 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0506 | 0.0935 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0506 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0395 | 0.0395 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0395 | 0.1568 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0506 | 0.0935 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0506 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0506 | 0.0506 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0506 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.014 | 0.2522 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0506 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 1 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.014 | 0.2522 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0506 | 0.0935 |
Trypanosoma brucei | hypothetical protein, conserved | 0.014 | 0.2522 | 1 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0034 | 0.0313 | 0.0952 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0506 | 0.1741 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0506 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0506 | 0.0506 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.014 | 0.2522 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0506 | 0.0935 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.014 | 0.2522 | 1 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0038 | 0.0395 | 0.0731 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0506 | 0.2006 |
Brugia malayi | maoC like domain containing protein | 0.0038 | 0.0395 | 0.0395 |
Mycobacterium ulcerans | dehydratase | 0.0038 | 0.0395 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0506 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0506 | 0.0506 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0506 | 0.2006 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0506 | 0.0935 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0506 | 0.0506 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0506 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0497 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.014 | 0.2522 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.014 | 0.2522 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0506 | 0.0935 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0506 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0506 | 0.0935 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0506 | 0.0935 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0506 | 0.0506 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0506 | 0.0506 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0506 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0506 | 0.0506 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.