Detailed information for compound 1419539

Basic information

Technical information
  • TDR Targets ID: 1419539
  • Name: bicyclo[2.2.2]oct-2-ene-7,8-dicarboxylic acid
  • MW: 196.2 | Formula: C10H12O4
  • H donors: 2 H acceptors: 4 LogP: 0.89 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1C2CCC(C1C(=O)O)C=C2
  • InChi: 1S/C10H12O4/c11-9(12)7-5-1-2-6(4-3-5)8(7)10(13)14/h1-2,5-8H,3-4H2,(H,11,12)(H,13,14)
  • InChiKey: FUBZERMWPMTSEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 28871-80-9
  • CBDivE_008329
  • MLS000530207
  • SMR000135184
  • bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid
  • NSC238002
  • SR-01000644742-1
  • IDI1_015870
  • Maybridge3_004483
  • STK280809
  • Oprea1_705657

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0018 0.0018
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0018 0.0018
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0457 0.0457
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0258 0.0429
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Brugia malayi CHE-14 protein 0.0042 0.0112 0.0112
Leishmania major importin beta-1 subunit, putative 0.0023 0.0028 0.0047
Onchocerca volvulus 0.0021 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.0828 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1144 0.1144
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.0014
Onchocerca volvulus 0.0021 0.0018 0.0019
Echinococcus granulosus casein kinase I delta 0.0082 0.0288 0.0288
Echinococcus granulosus fmrfamide receptor 0.0021 0.0018 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0284 0.0472
Brugia malayi N-terminal motif family protein 0.0187 0.0745 0.0745
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0018 0.0018
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0231
Loa Loa (eye worm) glutathione reductase 0.0048 0.0136 0.0123
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0069 0.0231 0.0231
Echinococcus multilocularis expressed protein 0.0025 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0732 0.3134 0.3134
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.003 0.0049
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0025 0.0037 0.0023
Echinococcus multilocularis casein kinase I alpha 0.0082 0.0288 0.0288
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0136 0.0227
Brugia malayi ORL1-like opioid receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0018 0.0018
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0081 0.028 0.028
Mycobacterium tuberculosis Conserved protein 0.0043 0.0118 0.0118
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0202 0.0811 0.0811
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) TAR-binding protein 0.0387 0.1624 0.1613
Echinococcus granulosus high affinity choline transporter 1 0.0089 0.0317 0.0317
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0104
Brugia malayi G protein-coupled receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0112 0.0098
Trypanosoma cruzi Replication factor A protein 1 0.002 0.0016 0.0027
Brugia malayi Sodium:solute symporter family protein 0.0089 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0098 0.0357 0.0344
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Entamoeba histolytica casein kinase, putative 0.0082 0.0288 0.3421
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.0828 0.1376
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0828 0.8345
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0023
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0068 0.0225 0.0373
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0069 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0619 0.2638 0.2638
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0018 0.0018
Brugia malayi G-protein coupled receptor 0.0021 0.0018 0.0018
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0231
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0231
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0198 0.0198
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0068 0.0225 0.0373
Schistosoma mansoni inositol transporter 0.0349 0.1454 0.1454
Loa Loa (eye worm) hypothetical protein 0.0206 0.0828 0.0815
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0081 0.028 0.0466
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0619 0.2638 0.2638
Schistosoma mansoni hypothetical protein 0.0619 0.2638 0.2638
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.0828 0.0762
Onchocerca volvulus 0.0021 0.0018 0.0019
Echinococcus multilocularis somatostatin receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0069 0.0231 0.0231
Brugia malayi RNA binding protein 0.0387 0.1624 0.1624
Echinococcus granulosus somatostatin receptor 0.0021 0.0018 0.0018
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0072 0.0072
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0018 0.0018
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0089 0.0317 0.0304
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0118 0.0118
Entamoeba histolytica Ran family GTPase 0.0021 0.0019 0.0146
Echinococcus granulosus g protein coupled receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0118 0.119
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0277 0.0277
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0001 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0021 0.0018 0.0019
Toxoplasma gondii casein kinase I 0.0082 0.0288 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0112 0.113
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0218
Leishmania major pyruvate kinase 0.0033 0.0072 0.0119
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.002 0.0016 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0018 0.0018
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.139 0.6016 1
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0166 0.0152
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0277 0.0277
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0025 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0104
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0018 0.0018
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0038 0.0093 0.0369
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0018 0.0018
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0202 0.0811 0.0811
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0112 0.0112
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.0828 0.1376
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0069 0.0231 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Echinococcus multilocularis casein kinase I delta 0.0082 0.0288 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.003 0.003
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Schistosoma mansoni pyruvate kinase 0.0017 0.0001 0.0001
Trypanosoma cruzi casein kinase, putative 0.0082 0.0288 0.0478
Loa Loa (eye worm) hypothetical protein 0.1338 0.5784 0.5779
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0136 0.0227
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0104
Brugia malayi beta-lactamase 0.0043 0.0118 0.0118
Entamoeba histolytica hypothetical protein 0.0041 0.0106 0.1204
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0025 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0023
Loa Loa (eye worm) prolyl oligopeptidase 0.0202 0.0811 0.0798
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0023
Onchocerca volvulus 0.0021 0.0018 0.0019
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0072 0.0072
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0025 0.0037 0.037
Plasmodium falciparum pyruvate kinase 0.0033 0.0072 0.0119
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Trypanosoma brucei trypanothione reductase 0.0048 0.0136 0.0227
Echinococcus granulosus expressed conserved protein 0.0092 0.0331 0.0331
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0025 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0018 0.0018
Leishmania major DNA polymerase kappa, putative 0.0023 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus multilocularis dna polymerase kappa 0.0023 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0288 0.0288
Toxoplasma gondii exonuclease III APE 0.0023 0.0027 0.0045
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0018 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0164 0.0164
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0081 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Onchocerca volvulus 0.0151 0.0587 0.2667
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0018 0.0004
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0068 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0023
Plasmodium falciparum glutathione reductase 0.0048 0.0136 0.0227
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.1338 0.5784 0.5784
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0094 0.0156
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0025 0.0037 0.0037
Echinococcus granulosus thymidylate synthase 0.0511 0.2164 0.2164
Entamoeba histolytica hypothetical protein 0.0041 0.0106 0.1204
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0072 0.0119
Chlamydia trachomatis dihydrofolate reductase 0.23 1 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0019 0.0032
Onchocerca volvulus 0.0021 0.0018 0.0019
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0118 0.0118
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0511 0.2164 0.2164
Chlamydia trachomatis pyruvate kinase 0.0033 0.0072 0.0072
Brugia malayi Thioredoxin reductase 0.0048 0.0136 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.028 0.028
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0021 0.0018 0.0019
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0025 0.0037 0.0037
Loa Loa (eye worm) MBCTL1 0.0062 0.0198 0.0185
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0018 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis sex peptide receptor 0.0021 0.0018 0.0018
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0166 0.0166
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0025 0.0037 0.0037
Mycobacterium ulcerans thymidylate synthase 0.0511 0.2164 0.2164
Schistosoma mansoni loxhd1 0.002 0.0014 0.0014
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0018 0.0019
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0069 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.0198 0.0185
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0072 0.0119
Plasmodium falciparum importin beta, putative 0.0028 0.0052 0.0086
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0357 0.0357
Schistosoma mansoni amine GPCR 0.0021 0.0018 0.0018
Echinococcus granulosus pyruvate kinase 0.0033 0.0072 0.0072
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.003 0.003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0018 0.0018
Echinococcus granulosus pyruvate kinase 0.0017 0.0001 0.0001
Schistosoma mansoni replication factor A 1 rfa1 0.0042 0.0113 0.0113
Brugia malayi GnHR receptor homolog 0.0021 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.058 0.2467 0.2467
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Echinococcus multilocularis serotonin receptor 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0069 0.0231 0.101
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0018 0.0018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0619 0.2638 0.2638
Plasmodium vivax importin-beta 2, putative 0.0028 0.0052 0.0086
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0166 0.0706
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.23 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.003 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0018 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0027 0.0045
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0072 0.0269
Leishmania major DNA polymerase eta, putative 0.0038 0.0094 0.0156
Leishmania major hypothetical protein, conserved 0.0043 0.0118 0.0196
Echinococcus granulosus g protein coupled receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0277 0.0263
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0018 0.0018
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0231
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0072 0.0058
Brugia malayi Melatonin receptor type 1A 0.0021 0.0018 0.0018
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0219 0.0885 0.0885
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0118 0.0047
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0018 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0619 0.2638 0.2638
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0166 0.0166
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0619 0.2638 0.2638
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0683 0.1136
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0081 0.0283 0.0471
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0118 0.119
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0042 0.0113 0.1136
Echinococcus multilocularis high affinity choline transporter 1 0.0089 0.0317 0.0317
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0277 0.0277
Echinococcus granulosus neuropeptide receptor 0.0021 0.0018 0.0018
Brugia malayi larval opioid receptor 0.0021 0.0018 0.0018
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0152 0.0253
Entamoeba histolytica hypothetical protein 0.0041 0.0106 0.1204
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0357 0.0357
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0027 0.0327
Echinococcus multilocularis pyruvate kinase 0.0033 0.0072 0.0072
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0151 0.0587 0.0574
Brugia malayi GH02984p 0.0089 0.0317 0.0317
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0018 0.0018
Echinococcus granulosus GPCR family 2 0.0619 0.2638 0.2638
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0027 0.0045
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0018 0.0018
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0018 0.0018
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis CK1 family protein kinase 0.0082 0.0288 0.2902
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Trypanosoma cruzi casein kinase, putative 0.0082 0.0288 0.0478
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.003 0.0049
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0258 0.0429
Echinococcus multilocularis expressed conserved protein 0.0092 0.0331 0.0331
Schistosoma mansoni patched 1 0.0042 0.0112 0.0112
Brugia malayi prolyl oligopeptidase family protein 0.0068 0.0225 0.0225
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0018 0.0004
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0025 0.0037 0.0037
Trypanosoma cruzi casein kinase, putative 0.0082 0.0288 0.0478
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0025 0.0037 0.037
Onchocerca volvulus 0.0511 0.2164 1
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0169 0.0169
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0027 0.0273
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0457 0.0388
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0169 0.0169
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0025 0.0037 0.0037
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0828 0.1376
Leishmania major casein kinase, putative 0.0082 0.0288 0.0478
Echinococcus multilocularis geminin 0.0732 0.3134 0.3134
Mycobacterium ulcerans lipase LipD 0.0043 0.0118 0.0118
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0018 0.0018
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0028 0.0253
Brugia malayi RE15519p 0.0021 0.0018 0.0018
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0069 0.0231 0.0218
Loa Loa (eye worm) hypothetical protein 0.0054 0.0166 0.0152
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0511 0.2164 0.2108
Brugia malayi AKH receptor 0.0021 0.0018 0.0018
Brugia malayi G-protein coupled receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0037 0.037
Echinococcus granulosus low density lipoprotein receptor protein 0.0069 0.0231 0.0231
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.003 0.0049
Onchocerca volvulus 0.0025 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0025 0.0037 0.0037
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0032
Schistosoma mansoni GTP-binding protein alpha subunit 0.0025 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0018 0.0004
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.0828 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0025 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0036 0.0087 0.0087
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0001 0.0002
Echinococcus multilocularis thymidylate synthase 0.0511 0.2164 0.2164
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0258 0.0429
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0152 0.0253
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0082 0.0288 0.1275
Onchocerca volvulus 0.0069 0.0231 0.101
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0025 0.0037 0.0037
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0072 0.0119
Loa Loa (eye worm) dihydrofolate reductase 0.23 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0619 0.2638 0.2638
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0404 0.0404
Schistosoma mansoni protein kinase 0.0082 0.0288 0.0288
Echinococcus granulosus dna polymerase kappa 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0027 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0769 0.0769
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0202 0.0811 0.0811
Mycobacterium ulcerans hypothetical protein 0.0043 0.0118 0.0118
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0054 0.0164 0.0151
Brugia malayi isocitrate dehydrogenase 0.0081 0.028 0.028
Brugia malayi hypothetical protein 0.0052 0.0155 0.0155
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0025 0.0037 0.0037
Schistosoma mansoni neuropeptide receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0069 0.0231 0.0231
Echinococcus granulosus allatostatin A receptor 0.0021 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0068 0.0225 0.0373
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0019
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.003 0.0274
Brugia malayi MH2 domain containing protein 0.0239 0.0975 0.0975
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0018 0.0018
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.028 0.0466
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0069 0.0231 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0018 0.0018
Brugia malayi neuropeptide F receptor 0.0021 0.0018 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0284 0.0472
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0021 0.0018 0.0018
Giardia lamblia Phosphoglycerate kinase 0.0206 0.0828 1
Brugia malayi Phosphoglycerate kinase 0.0206 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.058 0.2467 0.2467
Brugia malayi RNA, U transporter 1 0.0081 0.0281 0.0281
Brugia malayi Phosphoglycerate kinase 0.0075 0.0258 0.0258
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0037 0.037
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0018 0.0018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0032
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0025 0.0037 0.0037
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0025 0.0037 0.0037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.003 0.003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0404 0.0404
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0018 0.0018
Brugia malayi CUB domain containing protein 0.0069 0.0231 0.0231
Echinococcus granulosus low density lipoprotein receptor ldl 0.0069 0.0231 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0021 0.0018 0.0019
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0018 0.0018
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.028 0.0466
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0018 0.0018
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0014
Echinococcus multilocularis casein kinase I alpha 0.0082 0.0288 0.0288
Onchocerca volvulus 0.0021 0.0018 0.0019
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0025 0.0037 0.0037
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0683 0.1136
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0087 0.0087
Plasmodium vivax casein kinase 1, putative 0.0082 0.0288 0.0478
Brugia malayi beta-lactamase family protein 0.0043 0.0118 0.0118
Echinococcus multilocularis RUN 0.002 0.0014 0.0014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0018 0.0004
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0025 0.0037 0.0037
Brugia malayi Serotonin receptor 0.0021 0.0018 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0081 0.028 0.0267
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0511 0.2164 0.2164
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0014 0.0014
Onchocerca volvulus 0.0054 0.0166 0.0706
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0042 0.0113 0.0113
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0025 0.0037 0.0107
Onchocerca volvulus 0.0069 0.0231 0.101
Schistosoma mansoni amine GPCR 0.0021 0.0018 0.0018
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0028 0.0287
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0619 0.2638 0.2628
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0112 0.0112
Onchocerca volvulus 0.0021 0.0018 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1957 0.8495 0.8493
Brugia malayi prolyl oligopeptidase family protein 0.0202 0.0811 0.0811
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0118 0.0118
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0828 0.1376
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0106 0.0106
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0118 0.0118
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0069 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0023
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0027 0.0045
Echinococcus granulosus hypothetical protein 0.0021 0.0018 0.0018
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0082 0.0288 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0069 0.0231 0.0231
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0404 0.0404
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0277 0.046
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0069 0.0231 0.0231
Mycobacterium tuberculosis Probable oxidoreductase 0.0969 0.4173 0.4173
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0284 0.0472
Echinococcus granulosus Dipeptidyl peptidase 9 0.0068 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.014
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0683 0.1136
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.0014
Schistosoma mansoni opsin-like receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0069 0.0231 0.0231
Trichomonas vaginalis CK1 family protein kinase 0.0082 0.0288 0.2902
Mycobacterium leprae Probable lipase LipE 0.0043 0.0118 0.0047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis low density lipoprotein receptor protein 0.0069 0.0231 0.0231
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0042 0.0113 0.0113
Echinococcus granulosus pyruvate kinase 0.0033 0.0072 0.0072
Mycobacterium tuberculosis Probable reductase 0.0109 0.0404 0.0404
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.003 0.0049
Brugia malayi follicle stimulating hormone receptor 0.025 0.1022 0.1022
Echinococcus multilocularis dihydrofolate reductase 0.23 1 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0037 0.037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0201 0.0335
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0018 0.0018
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.003 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.058 0.2467 0.2467
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0018 0.0018
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0069 0.0231 0.101
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0258 0.0429
Brugia malayi hypothetical protein 0.0081 0.0284 0.0284
Schistosoma mansoni neuropeptide receptor 0.0021 0.0018 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0284 0.0472
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0019 0.0032
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.058 0.2467 0.2467
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.028 0.0466
Echinococcus granulosus dna polymerase eta 0.0054 0.0164 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0992 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1525 0.2534
Loa Loa (eye worm) thymidylate synthase 0.0511 0.2164 0.2154
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.002 0.0016 0.0164
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0118 0.0196
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Trypanosoma brucei Replication factor A protein 1 0.002 0.0016 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0072 0.0721
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0106 0.0106
Echinococcus multilocularis pyruvate kinase 0.0026 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Onchocerca volvulus 0.0021 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0118 0.0104
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0164 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Schistosoma mansoni opsin-like receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.028 0.028
Loa Loa (eye worm) beta-lactamase 0.0043 0.0118 0.0104
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0014 0.0023
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0231
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.0975 0.0963
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.0745 0.3399
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.003 0.0299
Schistosoma mansoni neuropeptide receptor 0.0021 0.0018 0.0018
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0025 0.0037 0.0037
Brugia malayi hypothetical protein 0.0052 0.0157 0.0157
Schistosoma mansoni ran 0.0021 0.0019 0.0019
Schistosoma mansoni myosin xvIII 0.0021 0.0018 0.0018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0032
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0028 0.0287
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0357 0.0357
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0118 0.0118
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis esterase, putative 0.0043 0.0118 0.119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0027 0.0273
Schistosoma mansoni biogenic amine receptor 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0021 0.0018 0.0019
Mycobacterium tuberculosis Hypothetical protein 0.0243 0.0992 0.0992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.058 0.2467 0.2467
Schistosoma mansoni ran 0.0021 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1624 0.1624
Brugia malayi Dihydrofolate reductase 0.23 1 1
Schistosoma mansoni opsin-like receptor 0.0021 0.0018 0.0018
Trypanosoma cruzi casein kinase, putative 0.0082 0.0288 0.0478
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0018 0.0018
Echinococcus granulosus casein kinase I delta 0.0082 0.0288 0.0288
Leishmania major dihydrofolate reductase-thymidylate synthase 0.139 0.6016 1
Leishmania major GTP-binding protein, putative 0.0021 0.0019 0.0032
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1957 0.8495 0.8495
Schistosoma mansoni neuropeptide receptor 0.0021 0.0018 0.0018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0364 0.0364
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1525 0.2534
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0106 0.0106
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0404 0.0404
Mycobacterium ulcerans short chain dehydrogenase 0.0969 0.4173 0.4173
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0072 0.0058
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0087 0.0087
Brugia malayi Calcium binding EGF domain containing protein 0.0069 0.0231 0.0231
Schistosoma mansoni dihydrofolate reductase 0.23 1 1
Schistosoma mansoni high-affinity choline transporter 0.0089 0.0317 0.0317
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.004 0.0103 0.1044
Schistosoma mansoni amine GPCR 0.0021 0.0018 0.0018
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0014
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0094 0.0156
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0089 0.0317 0.0317
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1022 0.101
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0136 0.0123
Toxoplasma gondii thioredoxin reductase 0.0048 0.0136 0.0227
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0069 0.0231 0.0231
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0089 0.0317 0.0527
Echinococcus granulosus importin subunit beta 1 0.0028 0.0052 0.0052
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0014 0.0023
Echinococcus granulosus sex peptide receptor 0.0021 0.0018 0.0018
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0018 0.0018
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0069 0.0231 0.0231
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0349 0.1454 0.1454
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1624 0.1624
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0349 0.1454 0.1454
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0018 0.0018
Brugia malayi neuropeptide F receptor 0.0021 0.0018 0.0018
Treponema pallidum phosphoglycerate kinase 0.0206 0.0828 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.003 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0018 0.0018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0081 0.028 0.028
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0118 0.0118
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0025 0.0037 0.0037
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0136 0.0136
Echinococcus granulosus tar DNA binding protein 0.0387 0.1624 0.1624
Schistosoma mansoni DNA polymerase eta 0.0054 0.0164 0.0164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0027 0.0045
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0202 0.0811 0.3707
Mycobacterium tuberculosis Conserved protein 0.0043 0.0118 0.0118
Echinococcus granulosus expressed protein 0.0025 0.0037 0.0037
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0828 0.1376
Loa Loa (eye worm) latrophilin receptor protein 2 0.0619 0.2638 0.2628
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0042 0.0113 0.0099
Onchocerca volvulus 0.0089 0.0317 0.1411
Onchocerca volvulus 0.0021 0.0018 0.0019
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0027 0.0327
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.0828 0.1376
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0025 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0041 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0105
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0277 0.046
Plasmodium falciparum thioredoxin reductase 0.0048 0.0136 0.0227
Schistosoma mansoni hypothetical protein 0.0732 0.3134 0.3134
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0089 0.0317 0.0317
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0081 0.028 0.0466
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0258 0.0429
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0081 0.028 0.0466
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0014 0.0014
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Schistosoma mansoni GTP-binding protein alpha subunit 0.0025 0.0037 0.0037
Echinococcus granulosus transcription factor Dp 1 0.0046 0.013 0.013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0081 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0037 0.037
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.23 1 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.0828 0.1376
Plasmodium falciparum casein kinase 1 0.0082 0.0288 0.0478
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0069 0.0231 0.0231
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.028 0.0466
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0187 0.0745 0.0732
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0018 0.0018
Echinococcus granulosus basement membrane specific heparan sulfate 0.0069 0.0231 0.0231
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0082 0.0288 0.0478
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0068 0.0225 0.0373
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0018 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0284 0.0472
Schistosoma mansoni lipoxygenase 0.002 0.0014 0.0014
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0018 0.0018
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0018 0.0018
Giardia lamblia DINP protein human, muc B family 0.0023 0.003 0.0359
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0027 0.0027
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0069 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0619 0.2638 0.2638
Onchocerca volvulus 0.0043 0.0118 0.0485
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Entamoeba histolytica hypothetical protein 0.0041 0.0106 0.1204
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.0828 0.1376
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0828 0.1376
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0014
Onchocerca volvulus 0.0021 0.0018 0.0019
Echinococcus multilocularis pyruvate kinase 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Schistosoma mansoni hypothetical protein 0.0303 0.1255 0.1255
Mycobacterium ulcerans beta-lactamase 0.0043 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Echinococcus granulosus casein kinase I alpha 0.0082 0.0288 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Brugia malayi Doublecortin family protein 0.002 0.0014 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0028 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Mycobacterium ulcerans hypothetical protein 0.0192 0.0769 0.0769
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.139 0.6016 1
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0042 0.0113 0.1136
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.0975 0.0963
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0166 0.0166
Brugia malayi hypothetical protein 0.0041 0.0106 0.0106
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0357 0.4269
Onchocerca volvulus 0.0069 0.0231 0.101
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.058 0.2467 0.2467
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0542 0.0542
Echinococcus multilocularis casein kinase I alpha 0.0082 0.0288 0.0288
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.003 0.0049
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.23 1 1
Onchocerca volvulus 0.0043 0.0118 0.0485
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.003 0.0016
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Schistosoma mansoni ap endonuclease 0.0023 0.0027 0.0027
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0258 0.0429
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1525 0.2534
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0038
Trichomonas vaginalis CK1 family protein kinase 0.0082 0.0288 0.2902
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0025 0.0037 0.0037
Echinococcus granulosus casein kinase I alpha 0.0082 0.0288 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Leishmania major trypanothione reductase 0.0048 0.0136 0.0227
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0025 0.0037 0.0037
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0404 0.0335
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0018 0.0004
Echinococcus multilocularis pyruvate kinase 0.0017 0.0001 0.0001
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0068 0.0225 0.0373
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0018 0.0018
Echinococcus granulosus sodium:glucose cotransporter 0.0349 0.1454 0.1454
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0027 0.0027
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0082 0.0288 0.0274
Brugia malayi replication factor A 73 kDa subunit 0.0042 0.0113 0.0113
Leishmania major replication factor A, 51kDa subunit, putative 0.002 0.0016 0.0027
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0277 0.046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.058 0.2467 0.2457
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.0828 0.1376
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0001 0.0002
Brugia malayi hypothetical protein 0.0025 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0081 0.0284 0.027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Trypanosoma brucei unspecified product 0.0023 0.003 0.0049
Echinococcus granulosus geminin 0.0732 0.3134 0.3134
Schistosoma mansoni polycystin 1-related 0.002 0.0014 0.0014
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0018 0.0018
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0068 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0118 0.0118
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0025 0.0037 0.0037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0277 0.046
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0072 0.0119
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Mycobacterium tuberculosis Conserved protein 0.0043 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Schistosoma mansoni ap endonuclease 0.0023 0.0027 0.0027
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0828 0.8345
Echinococcus granulosus basement membrane specific heparan sulfate 0.0069 0.0231 0.0231
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0166 0.0166
Onchocerca volvulus 0.0081 0.0283 0.1254
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0027 0.0045
Echinococcus multilocularis snurportin 1 0.0303 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0018 0.0018
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0018 0.0018
Echinococcus multilocularis casein kinase i 0.0082 0.0288 0.0288
Onchocerca volvulus 0.0043 0.0118 0.0485
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0118 0.0118
Brugia malayi mbt repeat family protein 0.0054 0.0166 0.0166
Schistosoma mansoni biogenic amine receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.058 0.2467 0.2467
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1624 0.1624
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Brugia malayi hypothetical protein 0.0243 0.0992 0.0992
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0258 0.0429
Brugia malayi Dopamine receptor protein 1 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0018 0.0018
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0277 0.3285
Echinococcus granulosus solute carrier family 5 0.0349 0.1454 0.1454
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0018 0.0018
Brugia malayi casein kinase I 0.0082 0.0288 0.0288
Schistosoma mansoni inositol transporter 0.0349 0.1454 0.1454
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0457 0.0457
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0072 0.0058
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0018 0.0018
Brugia malayi Isocitrate dehydrogenase 0.0081 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0104
Schistosoma mansoni hypothetical protein 0.0069 0.0231 0.0231
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0243 0.0992 0.1649
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0072 0.0119
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0028 0.0014
Giardia lamblia Pyruvate kinase 0.0017 0.0001 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Schistosoma mansoni pyruvate kinase 0.0033 0.0072 0.0072
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0069 0.0231 0.0231
Echinococcus multilocularis tar DNA binding protein 0.0387 0.1624 0.1624
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0231
Brugia malayi hypothetical protein 0.002 0.0014 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1525 0.2534
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0018 0.0004
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0025 0.0037 0.037
Loa Loa (eye worm) hypothetical protein 0.0052 0.0155 0.0141
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0018 0.0018
Brugia malayi Importin beta-1 subunit 0.0028 0.0052 0.0052
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0025 0.0037 0.0037
Schistosoma mansoni lipoxygenase 0.0055 0.0169 0.0169
Schistosoma mansoni biogenic amine receptor 0.0021 0.0018 0.0018
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0258 0.0429
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0025 0.0037 0.0037
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0032
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0277 0.0277
Leishmania major hypothetical protein, conserved 0.0081 0.0284 0.0472
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.013 0.013
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0028 0.0047
Echinococcus granulosus sodium:glucose cotransporter 2 0.0349 0.1454 0.1454
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0018 0.0018
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0027 0.0327
Brugia malayi enteropeptidase precursor 0.0069 0.0231 0.0231
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0021 0.0018 0.0019
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Onchocerca volvulus 0.0021 0.0018 0.0019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0081 0.028 0.0466
Brugia malayi basement membrane proteoglycan precursor 0.0069 0.0231 0.0231
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0018 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1624 0.1624
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0404 0.0404
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0018 0.0018
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.028 0.028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.003 0.003
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0018 0.0018
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.0828 0.0828
Toxoplasma gondii ABC1 family protein 0.0043 0.0118 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0018 0.0018
Schistosoma mansoni pyruvate kinase 0.0033 0.0072 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.003 0.0049
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.139 0.6016 1
Schistosoma mansoni sodium/solute symporter 0.0089 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0018 0.0018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0027 0.0027
Brugia malayi Latrophilin receptor protein 2 0.0619 0.2638 0.2638
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) G protein alpha subunit 3 0.0025 0.0037 0.0023
Brugia malayi glutathione reductase 0.0048 0.0136 0.0136
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.026
Brugia malayi hypothetical protein 0.0151 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0104
Echinococcus multilocularis pyruvate kinase 0.0017 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0018 0.0018
Echinococcus granulosus neuropeptide receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0118 0.119
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0198 0.0198
Echinococcus granulosus casein kinase I alpha 0.0082 0.0288 0.0288
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.139 0.6016 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0025 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.1957 0.8495 0.8493
Brugia malayi TAR-binding protein 0.0387 0.1624 0.1624
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0025 0.0037 0.0037
Plasmodium falciparum replication protein A1, large subunit 0.002 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0025 0.0037 0.0037
Trypanosoma cruzi casein kinase, putative 0.0082 0.0288 0.0478
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.003 0.0049
Echinococcus granulosus g protein coupled receptor 0.0021 0.0018 0.0018
Brugia malayi hypothetical protein 0.0021 0.0018 0.0018
Echinococcus multilocularis protein patched 0.0042 0.0112 0.0112
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0166 0.0166
Echinococcus multilocularis isocitrate dehydrogenase 0.0081 0.028 0.028
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0828 0.0828
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0542 0.0542
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0018 0.0018
Giardia lamblia Kinase, CK1 Casein kinase 0.0082 0.0288 0.3478
Giardia lamblia Pyruvate kinase 0.0033 0.0072 0.0864
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Toxoplasma gondii hypothetical protein 0.0059 0.0185 0.0308
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0112 0.0098
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0018 0.0018
Echinococcus granulosus low density lipoprotein receptor ldl 0.0069 0.0231 0.0231
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0072 0.0119
Brugia malayi RNA recognition motif domain containing protein 0.0387 0.1624 0.1624
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0072 0.0721
Echinococcus granulosus snurportin 1 0.0303 0.1255 0.1255
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0068 0.0225 0.0373
Echinococcus multilocularis GPCR, family 2 0.0619 0.2638 0.2638
Echinococcus multilocularis dna polymerase eta 0.0054 0.0164 0.0164
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0072 0.0269
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0198 0.0198
Onchocerca volvulus 0.0069 0.0231 0.101
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0152 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Plasmodium vivax replication protein A1, large subunit, putative 0.002 0.0016 0.0027
Onchocerca volvulus Arrow homolog 0.0069 0.0231 0.101
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.0828 0.0828
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0005
Brugia malayi sulfakinin receptor protein 0.0021 0.0018 0.0018
Brugia malayi G-protein alpha subunit 0.0025 0.0037 0.0037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0027 0.0027
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0072 0.0269
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0105
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0232
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0018 0.0018
Entamoeba histolytica casein kinase 1, putative 0.0082 0.0288 0.3421
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0619 0.2638 0.2638
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0284 0.0472
Brugia malayi Serotonin receptor 0.0021 0.0018 0.0018
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0025 0.0037 0.0037
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0198 0.0198
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.003 0.0049
Echinococcus granulosus sodium:myo inositol cotransporter 0.0349 0.1454 0.1454
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.139 0.6016 1
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0166 0.0166
Echinococcus granulosus serotonin receptor 0.0021 0.0018 0.0018
Brugia malayi hypothetical protein 0.002 0.0014 0.0014
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0025 0.0037 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0027 0.0045
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0018 0.0018
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.058 0.2467 0.2467
Brugia malayi mbt repeat family protein 0.0054 0.0166 0.0166
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0387 0.1624 0.1613
Echinococcus multilocularis casein kinase I delta 0.0082 0.0288 0.0288
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1255 0.1243
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0105
Echinococcus granulosus dihydrofolate reductase 0.23 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0118 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0118 0.0196
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0018 0.0018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0027 0.0027
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0052 0.0086
Plasmodium vivax glutathione reductase, putative 0.0048 0.0136 0.0227
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0164 0.0273
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0112 0.0112
Schistosoma mansoni importin beta-1 0.0028 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0118 0.0118
Loa Loa (eye worm) RNA binding protein 0.0387 0.1624 0.1613
Echinococcus granulosus pyruvate kinase 0.0017 0.0001 0.0001
Trypanosoma brucei casein kinase I, isoform 2 0.0082 0.0288 0.0478
Schistosoma mansoni amine GPCR 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0052 0.0086
Echinococcus granulosus pyruvate kinase 0.0017 0.0001 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.1338 0.5784 0.5784
Brugia malayi Dopamine receptor protein 2 0.0021 0.0018 0.0018
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.0828 0.0828
Onchocerca volvulus 0.0021 0.0018 0.0019
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0069 0.0231 0.101
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0025 0.0037 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0052 0.0086
Brugia malayi Dopamine receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0136 0.0136
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0018 0.0018
Trichomonas vaginalis ran, putative 0.0021 0.0019 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0118 0.0196
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.028 0.0466
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis protein dispatched 1 0.0048 0.0138 0.0138
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0025 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0072 0.0072
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0018 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0018 0.0018
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0198 0.0198
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0025 0.0037 0.037
Brugia malayi putative neuropeptide receptor 0.0021 0.0018 0.0018
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0018 0.0018
Echinococcus granulosus casein kinase i 0.0082 0.0288 0.0288
Onchocerca volvulus 0.0069 0.0231 0.101
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0018 0.0018
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0069 0.0231 0.0218
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0018 0.0004
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0018 0.0018
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0019 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0118 0.119
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0118 0.0196
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0082 0.0288 0.0274
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0027 0.0243
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0025 0.0037 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.1957 0.8495 0.8495
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0018 0.0018
Brugia malayi beta-lactamase family protein 0.0043 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0018 0.0018
Schistosoma mansoni histamine h1 receptor 0.0021 0.0018 0.0018
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0152 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1624 0.1624
Leishmania major DNA polymerase eta, putative 0.0054 0.0164 0.0273
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.0014
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0025 0.0037 0.0037
Echinococcus granulosus orexin receptor type 2 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0089 0.0317 0.0304
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.003 0.0299
Brugia malayi thymidylate synthase 0.0511 0.2164 0.2164
Schistosoma mansoni adenoreceptor 0.0021 0.0018 0.0018
Echinococcus granulosus RUN 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0218
Echinococcus multilocularis solute carrier family 5 0.0349 0.1454 0.1454
Echinococcus multilocularis pyruvate kinase 0.0033 0.0072 0.0072
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0118 0.0118
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.0828 0.0828
Leishmania major pyruvate kinase 0.0033 0.0072 0.0119
Schistosoma mansoni hypothetical protein 0.0335 0.1394 0.1394
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0018 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0118 0.119
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0069 0.0231 0.0218
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.0828 0.0828
Echinococcus multilocularis serotonin receptor 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0284 0.0472
Entamoeba histolytica G protein alpha subunit, putative 0.0025 0.0037 0.036
Brugia malayi casein kinase 1, delta 0.0082 0.0288 0.0288
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0219 0.0885 0.0885
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0025 0.0037 0.0037
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0828 0.0828
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.003 0.0049

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 113.99 um PUBCHEM_BIOASSAY: Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU). Secondary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 11.5701 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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