Detailed information for compound 1419598

Basic information

Technical information
  • TDR Targets ID: 1419598
  • Name: D049-0232
  • MW: 374.371 | Formula: C20H15FN6O
  • H donors: 0 H acceptors: 4 LogP: 3.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)n1ncc2c1ncn1c2nc(n1)COc1ccccc1C
  • InChi: 1S/C20H15FN6O/c1-13-5-2-3-8-17(13)28-11-18-24-20-16-10-23-27(15-7-4-6-14(21)9-15)19(16)22-12-26(20)25-18/h2-10,12H,11H2,1H3
  • InChiKey: OUHJEGMOJSGDPA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NCGC00115128-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei ATP-binding cassette protein, putative 0.0331 0.3509 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0519 0.5938 1
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0165 0.1358 0.0807
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0519 0.5938 0.5938
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0165 0.1358 0.0807
Echinococcus granulosus ATP binding cassette sub family G 0.0331 0.3509 0.3509
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0331 0.3509 0.3509
Schistosoma mansoni multidrug resistance protein 0.0165 0.1358 0.1358
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0519 0.5938 1
Onchocerca volvulus 0.0519 0.5938 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0519 0.5938 0.5938
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0519 0.5938 0.5938
Brugia malayi ABC transporter transmembrane region family protein 0.0165 0.1358 0.128
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0519 0.5938 1
Brugia malayi hypothetical protein 0.0165 0.1358 0.128
Plasmodium vivax multidrug resistance protein 1, putative 0.0519 0.5938 1
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0331 0.3509 0.5125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1709 0.1709
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0165 0.1358 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0519 0.5938 0.5938
Onchocerca volvulus 0.0249 0.2447 0.2558
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0165 0.1358 0.128
Schistosoma mansoni tar DNA-binding protein 0.0729 0.8648 0.8648
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0165 0.1358 0.0259
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0165 0.1358 0.5
Brugia malayi ABC transporter transmembrane region family protein 0.0165 0.1358 0.128
Entamoeba histolytica ABC transporter, putative 0.0331 0.3509 0.4834
Trypanosoma cruzi multidrug resistance protein E, putative 0.0165 0.1358 0.1574
Plasmodium falciparum multidrug resistance protein 2 0.0165 0.1358 0.0807
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.2589 0.2753
Entamoeba histolytica ABC transporter, putative 0.0165 0.1358 0.0259
Entamoeba histolytica P-glycoprotein-2, putative 0.0519 0.5938 1
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0165 0.1358 0.0807
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0165 0.1358 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.2589 0.2753
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0165 0.1358 0.1574
Brugia malayi multidrug resistance protein 3 0.0519 0.5938 0.6759
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.1524 0.1479
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0165 0.1358 0.0807
Loa Loa (eye worm) hypothetical protein 0.0157 0.1247 0.1147
Giardia lamblia Multidrug resistance-associated protein 1 0.0165 0.1358 0.0567
Entamoeba histolytica ATP-binding cassette protein, putative 0.0165 0.1358 0.0259
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0519 0.5938 1
Brugia malayi TAR-binding protein 0.0729 0.8648 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0331 0.3509 1
Echinococcus multilocularis ATP binding cassette sub family B 0.051 0.5816 0.5816
Loa Loa (eye worm) ABC transporter 0.0282 0.2869 0.3087
Echinococcus multilocularis multidrug resistance protein 1 0.0364 0.3925 0.3925
Toxoplasma gondii ABC transporter family protein 0.0165 0.1358 0.0807
Loa Loa (eye worm) hypothetical protein 0.051 0.5816 0.6613
Plasmodium vivax multidrug resistance protein 2, putative 0.0165 0.1358 0.0807
Entamoeba histolytica P-glycoprotein-2 0.0519 0.5938 1
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0165 0.1358 0.0807
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0165 0.1358 0.5
Brugia malayi hypothetical protein 0.0157 0.1247 0.1147
Trypanosoma cruzi ABC transporter, putative 0.0331 0.3509 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0165 0.1358 0.0807
Plasmodium falciparum ABC transporter B family member 7, putative 0.0165 0.1358 0.0807
Entamoeba histolytica P-glycoprotein 5, putative 0.0519 0.5938 1
Trichomonas vaginalis ABC transporter, putative 0.0519 0.5938 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Schistosoma mansoni ABC transporter 0.0282 0.2869 0.2869
Loa Loa (eye worm) ABC transporter 0.0165 0.1358 0.128
Echinococcus multilocularis ATP binding cassette sub family B 0.0165 0.1358 0.1358
Echinococcus granulosus tar DNA binding protein 0.0729 0.8648 0.8648
Plasmodium falciparum ABC transporter G family member 2 0.0331 0.3509 0.5125
Schistosoma mansoni smdr2 0.0519 0.5938 0.5938
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0519 0.5938 1
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0165 0.1358 0.0807
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1709 0.1709
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0165 0.1358 0.1574
Loa Loa (eye worm) hypothetical protein 0.0156 0.1236 0.1134
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0519 0.5938 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1709 0.1709
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0165 0.1358 0.0807
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0288 0.0288
Plasmodium vivax ABC transporter B family member 4, putative 0.0165 0.1358 0.0807
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.2589 0.2753
Loa Loa (eye worm) TAR-binding protein 0.0729 0.8648 1
Schistosoma mansoni multidrug resistance protein 0.0165 0.1358 0.1358
Brugia malayi ABC transporter family protein 0.0519 0.5938 0.6759
Schistosoma mansoni hypothetical protein 0.0272 0.2747 0.2747
Schistosoma mansoni tar DNA-binding protein 0.0729 0.8648 0.8648
Echinococcus granulosus ATP binding cassette sub family G 0.0331 0.3509 0.3509
Brugia malayi ABC transporter family protein 0.0282 0.2869 0.3087
Brugia malayi MH2 domain containing protein 0.049 0.5554 0.6299
Echinococcus multilocularis ATP binding cassette sub family B 0.0165 0.1358 0.1358
Echinococcus multilocularis multidrug resistance protein 1 0.0519 0.5938 0.5938
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0519 0.5938 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0165 0.1358 0.0259
Loa Loa (eye worm) ABC transporter 0.0165 0.1358 0.128
Echinococcus granulosus ATP binding cassette sub family B 0.0165 0.1358 0.1358
Schistosoma mansoni multidrug resistance protein 0.0165 0.1358 0.1358
Echinococcus granulosus ATP binding cassette sub family B 0.0165 0.1358 0.1358
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0165 0.1358 0.128
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0519 0.5938 0.5938
Brugia malayi ABC transporter family protein 0.0165 0.1358 0.128
Brugia malayi ABC transporter family protein 0.0165 0.1358 0.128
Echinococcus multilocularis ATP binding cassette sub family B 0.0165 0.1358 0.1358
Loa Loa (eye worm) hypothetical protein 0.026 0.2589 0.2753
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0165 0.1358 0.0807
Entamoeba histolytica multidrug resistance protein, putative 0.0165 0.1358 0.0259
Loa Loa (eye worm) RNA binding protein 0.0729 0.8648 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0519 0.5938 0.5938
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0165 0.1358 0.1358
Entamoeba histolytica P-glycoprotein-1 0.0519 0.5938 1
Schistosoma mansoni tar DNA-binding protein 0.0729 0.8648 0.8648
Brugia malayi hypothetical protein 0.0086 0.0341 0.0064
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0519 0.5938 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0165 0.1358 0.0807
Giardia lamblia ABC transporter, putative 0.0165 0.1358 0.0567
Loa Loa (eye worm) hypothetical protein 0.0165 0.1358 0.128
Loa Loa (eye worm) hypothetical protein 0.0165 0.1358 0.128
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.1709 0.17
Entamoeba histolytica ATP-binding cassette protein, putative 0.0165 0.1358 0.0259
Echinococcus granulosus multidrug resistance protein 1 0.0519 0.5938 0.5938
Plasmodium vivax ABC transporter B family member 7, putative 0.0165 0.1358 0.0807
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0331 0.3509 0.5125
Trichomonas vaginalis abcb9, putative 0.0519 0.5938 1
Trypanosoma brucei ABC transporter, putative 0.0331 0.3509 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0519 0.5938 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0288 0.0288
Entamoeba histolytica P-glycoprotein-5 0.0519 0.5938 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1236 0.1134
Plasmodium vivax ABC transporter B family member 3, putative 0.0165 0.1358 0.0807
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0519 0.5938 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0519 0.5938 0.6759
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1709 0.1709
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0272 0.2747 0.3032
Trichomonas vaginalis abcb9, putative 0.0519 0.5938 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0165 0.1358 0.0567
Schistosoma mansoni tar DNA-binding protein 0.0729 0.8648 0.8648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1709 0.1709
Entamoeba histolytica P-glycoprotein 6, putative 0.0165 0.1358 0.0259
Plasmodium falciparum ABC transporter B family member 4, putative 0.0165 0.1358 0.0807
Echinococcus granulosus GPCR family 2 0.0082 0.0288 0.0288
Plasmodium vivax ABC transporter B family member 6, putative 0.0165 0.1358 0.0807
Leishmania major ABC-thiol transporter 0.0165 0.1358 0.0807
Echinococcus granulosus multidrug resistance protein 1 0.0519 0.5938 0.5938
Leishmania major p-glycoprotein e 0.0165 0.1358 0.0807
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0165 0.1358 0.1574
Brugia malayi ABC transporter transmembrane region family protein 0.0156 0.1236 0.1134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0288 0.0288
Trichomonas vaginalis ABC transporter, putative 0.0519 0.5938 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.1524 0.1479
Echinococcus multilocularis ATP binding cassette sub family G 0.0331 0.3509 0.3509
Trichomonas vaginalis abcb9, putative 0.0519 0.5938 1
Loa Loa (eye worm) ABC transporter 0.0165 0.1358 0.128
Entamoeba histolytica P-glyco protein 6, putative 0.0519 0.5938 1
Schistosoma mansoni multidrug resistance protein 0.0165 0.1358 0.1358
Echinococcus granulosus multidrug resistance protein 1 0.0364 0.3925 0.3925
Trichomonas vaginalis taga, putative 0.0519 0.5938 1
Echinococcus granulosus multidrug resistance protein 1 0.0364 0.3925 0.3925
Schistosoma mansoni multidrug resistance protein 0.0165 0.1358 0.1358
Toxoplasma gondii ABC transporter, putative 0.0165 0.1358 0.0807
Echinococcus multilocularis multidrug resistance associated protein 1 0.0165 0.1358 0.1358
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0165 0.1358 0.0807
Trypanosoma brucei p-glycoprotein 0.0165 0.1358 0.1574
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0288 0.0288
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0165 0.1358 0.0807
Trypanosoma brucei multidrug resistance protein E 0.0165 0.1358 0.1574
Trichomonas vaginalis ABC transporter, putative 0.0519 0.5938 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.051 0.5816 0.5816
Brugia malayi ABC transporter 0.0156 0.1236 0.1134
Echinococcus granulosus multidrug resistance associated protein 7 0.0165 0.1358 0.1358
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0729 0.8648 1
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.5554 0.6299
Trichomonas vaginalis ABC transporter, putative 0.0519 0.5938 1
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0165 0.1358 0.1574
Echinococcus granulosus ATP binding cassette sub family B 0.0156 0.1236 0.1236
Schistosoma mansoni multidrug resistance protein 0.0519 0.5938 0.5938
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0519 0.5938 0.5938
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi ABC transporter family protein 0.0165 0.1358 0.128
Echinococcus granulosus ATP binding cassette sub family G 0.0331 0.3509 0.3509
Plasmodium vivax ABC transporter B family member 5, putative 0.0165 0.1358 0.0807
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0519 0.5938 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1709 0.1709
Loa Loa (eye worm) pax transcription factor protein 2 0.0249 0.2447 0.2583
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0331 0.3509 0.5125
Brugia malayi hypothetical protein 0.0134 0.0956 0.0799
Brugia malayi P-glycoprotein-like protein 0.0165 0.1358 0.128
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0165 0.1358 0.1574
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0165 0.1358 0.1574
Entamoeba histolytica ATP-binding cassette protein, putative 0.0165 0.1358 0.0259
Plasmodium falciparum ABC transporter B family member 5, putative 0.0165 0.1358 0.0807
Plasmodium falciparum multidrug resistance protein 1 0.0519 0.5938 1
Plasmodium falciparum ABC transporter B family member 3, putative 0.0165 0.1358 0.0807
Schistosoma mansoni hypothetical protein 0.0082 0.0288 0.0288
Echinococcus multilocularis GPCR, family 2 0.0082 0.0288 0.0288
Entamoeba histolytica hypothetical protein 0.0165 0.1358 0.0259
Brugia malayi RNA recognition motif domain containing protein 0.0729 0.8648 1
Plasmodium falciparum ABC transporter B family member 6, putative 0.0165 0.1358 0.0807
Loa Loa (eye worm) hypothetical protein 0.0165 0.1358 0.128
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0331 0.3509 1
Schistosoma mansoni multidrug resistance protein 0.0156 0.1236 0.1236
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0165 0.1358 0.0807
Schistosoma mansoni smdr1 0.0165 0.1358 0.1358
Echinococcus multilocularis ATP binding cassette sub family G 0.0331 0.3509 0.3509
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0156 0.1236 0.1236
Loa Loa (eye worm) hypothetical protein 0.0519 0.5938 0.6759
Echinococcus granulosus multidrug resistance associated protein 1 0.0165 0.1358 0.1358
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0519 0.5938 1
Loa Loa (eye worm) hypothetical protein 0.0519 0.5938 0.6759
Brugia malayi Pax transcription factor protein 2 0.0249 0.2447 0.2583
Entamoeba histolytica P-glycoprotein-2 0.0519 0.5938 1
Brugia malayi multidrug resistance related protein 1 0.0165 0.1358 0.128
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0519 0.5938 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0519 0.5938 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0165 0.1358 0.1358
Giardia lamblia ABC transporter 0.0322 0.3387 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0519 0.5938 0.5938
Schistosoma mansoni multidrug resistance protein 0.0519 0.5938 0.5938
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0331 0.3509 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0519 0.5938 0.5938
Schistosoma mansoni hypothetical protein 0.0178 0.1524 0.1524
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0364 0.3925 0.5719
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0519 0.5938 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.1709 0.17
Echinococcus multilocularis tar DNA binding protein 0.0729 0.8648 0.8648
Schistosoma mansoni tar DNA-binding protein 0.0729 0.8648 0.8648
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0519 0.5938 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0519 0.5938 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0519 0.5938 0.5
Plasmodium vivax ABC transporter G family member 2, putative 0.0331 0.3509 0.5125
Loa Loa (eye worm) hypothetical protein 0.0134 0.0956 0.0799
Schistosoma mansoni multidrug resistance protein 0.0519 0.5938 0.5938
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0331 0.3509 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0165 0.1358 0.1574
Plasmodium falciparum multidrug resistance-associated protein 1 0.0165 0.1358 0.0807
Echinococcus multilocularis ATP binding cassette sub family B 0.0165 0.1358 0.1358
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0165 0.1358 0.1574
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0165 0.1358 0.0807
Schistosoma mansoni hypothetical protein 0.0082 0.0288 0.0288
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0519 0.5938 0.5938
Schistosoma mansoni hypothetical protein 0.0082 0.0288 0.0288
Echinococcus multilocularis ATP binding cassette sub family G 0.0331 0.3509 0.3509
Leishmania major p-glycoprotein 0.0519 0.5938 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0519 0.5938 0.6759
Entamoeba histolytica P-glycoprotein 6, putative 0.0165 0.1358 0.0259
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0165 0.1358 0.0807
Giardia lamblia MRP-like ABC transporter 0.0165 0.1358 0.0567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1709 0.1709
Brugia malayi ABC transporter 0.0165 0.1358 0.128
Schistosoma mansoni hypothetical protein 0.0082 0.0288 0.0288
Leishmania major pentamidine resistance protein 1 0.0165 0.1358 0.0807
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.5554 0.6299
Plasmodium falciparum multidrug resistance-associated protein 2 0.0165 0.1358 0.0807
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0165 0.1358 0.0807
Echinococcus granulosus multidrug resistance protein 1 0.0519 0.5938 0.5938
Brugia malayi RNA binding protein 0.0729 0.8648 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0519 0.5938 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0519 0.5938 1
Echinococcus multilocularis 0.0165 0.1358 0.1358

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.2512 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.