Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0076 | 0.4815 | 0.4565 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4815 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1286 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3186 | 0.218 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3186 | 0.6617 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4815 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1286 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4815 | 0.405 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1286 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3186 | 0.2858 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1286 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4815 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4815 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4815 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4815 | 0.4565 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4815 | 0.4565 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3186 | 0.6617 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3186 | 0.6617 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3186 | 0.6617 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4815 | 0.405 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4815 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1286 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3186 | 0.6617 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3186 | 0.6617 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3186 | 0.6617 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4815 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4815 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.1286 | 0.0866 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.