Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SCP-2 sterol transfer family protein | 0.0032 | 0.0094 | 0.0094 |
Brugia malayi | sterol carrier protein | 0.0032 | 0.0094 | 0.0094 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0449 | 0.2733 | 0.5 |
Onchocerca volvulus | 0.1598 | 1 | 1 | |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0042 | 0.0153 | 0.0225 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0449 | 0.2733 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0094 | 0.0094 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0449 | 0.2733 | 0.5 |
Mycobacterium ulcerans | dehydratase | 0.0082 | 0.0411 | 0.1202 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0449 | 0.2733 | 1 |
Mycobacterium ulcerans | (3R)-hydroxyacyl-ACP dehydratase subunit HadC | 0.0032 | 0.0095 | 0.0003 |
Onchocerca volvulus | 0.0036 | 0.0114 | 0.0019 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0042 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0411 | 0.0411 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0042 | 0.0153 | 0.0222 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0095 | 0.0003 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.1598 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0042 | 0.0153 | 0.0225 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0082 | 0.0411 | 0.12 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0096 | 0.0096 |
Mycobacterium leprae | conserved hypothetical protein | 0.0449 | 0.2733 | 1 |
Loa Loa (eye worm) | SCP-2 sterol transfer family protein | 0.0032 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0042 | 0.0153 | 0.0153 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0449 | 0.2733 | 1 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0074 | 0.0358 | 0.06 |
Mycobacterium ulcerans | hypothetical protein | 0.0082 | 0.0411 | 0.1202 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0449 | 0.2733 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.1598 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0449 | 0.2733 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0449 | 0.2733 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1598 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | oxidoreductase | 0.0036 | 0.0114 | 0.0114 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0082 | 0.0411 | 0.12 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.1598 | 1 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0449 | 0.2733 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0036 | 0.0114 | 0.0114 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0449 | 0.2733 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0095 | 0.0003 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0449 | 0.2733 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0095 | 0.0003 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0449 | 0.2733 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | (3R)-hydroxyacyl-ACP dehydratase subunit HadA | 0.0032 | 0.0095 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0092 | 0.0092 |
Brugia malayi | maoC like domain containing protein | 0.0082 | 0.0411 | 0.0411 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0095 | 0.0003 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0449 | 0.2733 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.