Detailed information for compound 1420046

Basic information

Technical information
  • TDR Targets ID: 1420046
  • Name: N-[(Z)-1-(4-methoxyphenyl)-3-(3-morpholin-4-y lpropylamino)-3-oxoprop-1-en-2-yl]-4-nitroben zamide
  • MW: 468.502 | Formula: C24H28N4O6
  • H donors: 2 H acceptors: 4 LogP: 2.49 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C(/C(=O)NCCCN1CCOCC1)\NC(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C24H28N4O6/c1-33-21-9-3-18(4-10-21)17-22(24(30)25-11-2-12-27-13-15-34-16-14-27)26-23(29)19-5-7-20(8-6-19)28(31)32/h3-10,17H,2,11-16H2,1H3,(H,25,30)(H,26,29)/b22-17-
  • InChiKey: YDEUUGUBAVCAJO-XLNRJJMWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(Z)-2-(4-methoxyphenyl)-1-(3-morpholinopropylcarbamoyl)vinyl]-4-nitro-benzamide
  • N-[(Z)-2-(4-methoxyphenyl)-1-[(3-morpholinopropylamino)-oxomethyl]vinyl]-4-nitrobenzamide
  • N-[(Z)-1-(4-methoxyphenyl)-3-(3-morpholin-4-ylpropylamino)-3-oxo-prop-1-en-2-yl]-4-nitro-benzamide
  • 6240-37-5
  • BIM-0003324.P001
  • ST5047980
  • BAS 02234292

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens fatty acid synthase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0358 0.04
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0145 0.0163
Leishmania major GTP-binding protein, putative 0.0022 0.0145 0.057
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0547 0.2288
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0612 0.4135
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.001 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.0317 0.3759 0.5
Brugia malayi jmjC domain containing protein 0.0042 0.0396 0.048
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.1462 0.4975
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0522 0.0583
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0358 0.1201
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0068 0.0072
Plasmodium falciparum phd finger protein, putative 0.0033 0.0288 0.5155
Brugia malayi jmjC domain containing protein 0.0011 0.0012 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0146 0.1668 0.1855
Entamoeba histolytica serine/threonine protein kinase, putative 0.0202 0.2352 0.6107
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0303 0.1013
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0119 0.0737
Onchocerca volvulus 0.0668 0.8052 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0358 0.1479
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.023 0.0285
Giardia lamblia PHD finger protein 15 0.0033 0.0288 0.0395
Brugia malayi mbt repeat family protein 0.0052 0.0522 0.0636
Loa Loa (eye worm) hypothetical protein 0.0055 0.0547 0.068
Loa Loa (eye worm) hypothetical protein 0.0214 0.2495 0.3099
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0358 0.1201
Plasmodium vivax importin-beta 2, putative 0.0029 0.024 0.4265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1745 0.1942
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0522 0.0573
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0034 0.0034
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0012 0.0003
Mycobacterium tuberculosis Conserved protein 0.0039 0.0358 0.1201
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.011 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.2352 0.2621
Echinococcus multilocularis dnaJ subfamily B 0.045 0.5378 0.5378
Loa Loa (eye worm) hypothetical protein 0.018 0.2086 0.2591
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0374 0.0374
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0522 0.0648
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.024 0.1574
Onchocerca volvulus 0.0028 0.0224 0.0266
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0308 0.5523
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.3722 0.4622
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0187 0.0383
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.2407 0.269
Onchocerca volvulus 0.0039 0.0358 0.0433
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0039 0.0358 0.1201
Schistosoma mansoni hypothetical protein 0.0068 0.0708 0.0781
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.2763 0.2763
Schistosoma mansoni lamin 0.0029 0.023 0.0246
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0308 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0285 0.3361 0.375
Echinococcus multilocularis GPCR, family 2 0.0068 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0107
Onchocerca volvulus 0.0029 0.023 0.0273
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0176 0.0319
Echinococcus multilocularis musashi 0.0029 0.023 0.023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0214 0.2495 0.3099
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0033 0.0288 0.0311
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0037 0.0471
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0308 0.0382
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.001 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.1745 0.2168
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0308 0.1263
Brugia malayi serine/threonine-protein kinase plk-2 0.0202 0.2352 0.2913
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.2933 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0145 0.0471
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0308 0.1028
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1462 0.1625
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.001 0.0011
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0012 0.0014
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0248 0.0754
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0145 0.249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1745 0.1951
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0353 0.1456
Echinococcus multilocularis geminin 0.0742 0.8948 0.8948
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0358 0.1421
Schistosoma mansoni hypothetical protein 0.0024 0.018 0.019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0358 0.0445
Loa Loa (eye worm) hypothetical protein 0.0057 0.0579 0.0719
Schistosoma mansoni tar DNA-binding protein 0.0285 0.3361 0.375
Schistosoma mansoni inositol monophosphatase 0.0039 0.0353 0.0384
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.001 0.001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0285 0.3361 0.4174
Schistosoma mansoni cpg binding protein 0.0032 0.0267 0.0287
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.1462 0.6198
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.1462 0.1635
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.1745 0.2158
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0237 0.0786
Leishmania major hypothetical protein, conserved 0.0055 0.0547 0.2288
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0012 0.0015
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0308 0.0371
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.043 0.1446
Echinococcus granulosus muscleblind protein 0.018 0.2086 0.2331
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0145 0.057
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0547 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0308 0.1263
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0288 0.0358
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0522 0.0522
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0145 0.0169
Onchocerca volvulus 0.0048 0.0468 0.057
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.001 0.001
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0014 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2352 0.6107
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0285
Echinococcus multilocularis lamin dm0 0.0029 0.023 0.023
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1104 0.2653
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.1668 0.2062
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.1462 0.1462
Echinococcus multilocularis peregrin 0.0033 0.0288 0.0288
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Echinococcus granulosus phd:f box containing protein 0.0011 0.0012 0.0014
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0308 0.0333
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0522 0.0648
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0049 0.0055
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Onchocerca volvulus 0.0039 0.0358 0.0433
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0522 0.0522
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0319 0.3778 0.4216
Brugia malayi TAR-binding protein 0.0285 0.3361 0.4167
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0358 0.1421
Echinococcus multilocularis muscleblind protein 1 0.018 0.2086 0.2086
Brugia malayi mbt repeat family protein 0.0052 0.0522 0.0636
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0068 0.0084
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0248 0.0754
Loa Loa (eye worm) beta-lactamase 0.0039 0.0358 0.0445
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0248 0.0824
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0353 0.0574
Brugia malayi Calcitonin receptor-like protein seb-1 0.0214 0.2495 0.3091
Toxoplasma gondii ABC1 family protein 0.0039 0.0358 0.2387
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.0577 0.0706
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0358 0.039
Echinococcus multilocularis muscleblind protein 0.018 0.2086 0.2086
Brugia malayi hypothetical protein 0.0668 0.8052 1
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0358 0.1201
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.043 0.1855
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0061
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0396 0.0442
Onchocerca volvulus 0.0052 0.0522 0.0636
Schistosoma mansoni cpg binding protein 0.0033 0.0289 0.0312
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1462 0.8107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0015
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0034 0.0038
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0742 0.8948 1
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0448 0.05
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0699 0.0771
Echinococcus multilocularis lamin 0.0029 0.023 0.023
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.018 0.0201
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0468 0.057
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0202 0.2352 0.2921
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.043 0.1855
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0012 0.0014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0358 0.0445
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0353 0.1456
Brugia malayi jmjC domain containing protein 0.0109 0.1215 0.1499
Schistosoma mansoni tar DNA-binding protein 0.0285 0.3361 0.375
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0708 0.0708
Brugia malayi RNA binding protein 0.0285 0.3361 0.4167
Brugia malayi Importin beta-1 subunit 0.0029 0.024 0.0287
Brugia malayi PHD-finger family protein 0.0033 0.0288 0.0346
Schistosoma mansoni importin beta-1 0.0029 0.024 0.0258
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.1775 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1745 0.1745
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2352 0.6107
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0308 0.0308
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.1775 0.6043
Brugia malayi Bromodomain containing protein 0.0033 0.0288 0.0346
Echinococcus granulosus GPCR family 2 0.0068 0.0708 0.0791
Schistosoma mansoni hypothetical protein 0.0068 0.0708 0.0781
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0708 0.0708
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.0271 0.0892
Brugia malayi RNA recognition motif domain containing protein 0.0285 0.3361 0.4167
Plasmodium falciparum importin beta, putative 0.0029 0.024 0.4265
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0308 0.1263
Schistosoma mansoni kinase 0.0103 0.1137 0.1261
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0271 0.0892
Schistosoma mansoni survival motor neuron protein 0.0048 0.0468 0.0513
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.006 0.061 0.0758
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.2352 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.009 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2352 0.6107
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0176 0.0319
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.0271 0.0892
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0308 0.5523
Schistosoma mansoni inositol monophosphatase 0.0039 0.0353 0.0384
Loa Loa (eye worm) fatty acid synthase 0.003 0.0243 0.0302
Trichomonas vaginalis esterase, putative 0.0039 0.0358 0.0589
Brugia malayi hypothetical protein 0.0035 0.0311 0.0375
Echinococcus granulosus snurportin 1 0.0314 0.3722 0.416
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0142 0.0897
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0396 0.0432
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0012 0.0014
Brugia malayi RNA, U transporter 1 0.0084 0.0904 0.1112
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.043 0.1446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.001 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0285 0.3361 0.375
Onchocerca volvulus Alhambra homolog 0.0033 0.0288 0.0346
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.061 0.0747
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0039 0.0358 0.1421
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.1215 0.1358
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0248 0.0754
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0353 0.1456
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0288 0.5155
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.061 0.061
Schistosoma mansoni ran 0.0022 0.0145 0.0152
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0037 0.0471
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0353 0.0574
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0708 0.0791
Echinococcus granulosus geminin 0.0742 0.8948 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0308 0.1263
Echinococcus granulosus lamin dm0 0.0029 0.023 0.0257
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0358 0.1201
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0358 0.0358
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0248 0.0754
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 0.3759 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.001 0.0012
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.061 0.0682
Schistosoma mansoni tar DNA-binding protein 0.0285 0.3361 0.375
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.1215 0.1215
Schistosoma mansoni hypothetical protein 0.0068 0.0708 0.0781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Mycobacterium ulcerans lipase LipD 0.0039 0.0358 0.1421
Brugia malayi CXXC zinc finger family protein 0.0032 0.0267 0.0319
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0014 0.0007
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0066 0.0374
Brugia malayi jmjC domain containing protein 0.0011 0.0012 0.0003
Brugia malayi jmjC domain containing protein 0.0011 0.0012 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0358 0.0433
Loa Loa (eye worm) hypothetical protein 0.0039 0.0358 0.0445
Echinococcus granulosus intermediate filament protein 0.0029 0.023 0.0257
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0288 0.0288
Brugia malayi hypothetical protein 0.0055 0.0547 0.0669
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0358 0.0589
Leishmania major hypothetical protein, conserved 0.0039 0.0358 0.1479
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0202 0.2352 0.2352
Schistosoma mansoni ran 0.0022 0.0145 0.0152
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0029 0.0076
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.2763 0.3088
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.3759 1
Entamoeba histolytica hypothetical protein 0.0024 0.0172 0.0075
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0358 0.1201
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.1775 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0224 0.0266
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.0271 0.0892
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.018 0.018
Loa Loa (eye worm) acyl carrier protein 0.0014 0.005 0.0062
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0014 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.001 0.001
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0176 0.0319
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.001 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.001 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2352 0.6107
Schistosoma mansoni hypothetical protein 0.0742 0.8948 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0358 0.0445
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0358 0.0589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1745 0.1951
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1407 0.1747
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0708 0.0791
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0288 0.0311
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0015
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.061 0.0672
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0012 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0353 0.1456
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.024 0.0976
Onchocerca volvulus Serine\/threonine kinase homolog 0.0202 0.2352 0.2913
Echinococcus multilocularis tar DNA binding protein 0.0285 0.3361 0.3361
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.001 0.001
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.0271 0.1785
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0267 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.001 0.0012
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0145 0.057
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.023 0.0273
Schistosoma mansoni hypothetical protein 0.0314 0.3722 0.4153
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0358 0.0445
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0224 0.0742
Brugia malayi PHD-finger family protein 0.0013 0.0036 0.0032
Brugia malayi beta-lactamase 0.0039 0.0358 0.0433
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0237 0.0786
Brugia malayi isocitrate dehydrogenase 0.0035 0.0308 0.0371
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0522 0.0573
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0044
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.0271 0.0902
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0353 0.0574
Loa Loa (eye worm) intermediate filament protein 0.0029 0.023 0.0285
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0522 0.0636
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.0543 0.0663
Schistosoma mansoni hypothetical protein 0.045 0.5378 0.6006
Brugia malayi intermediate filament protein 0.0029 0.023 0.0273
Loa Loa (eye worm) hypothetical protein 0.0146 0.1668 0.2072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.001 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.001 0.0011
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0248 0.0754
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0358 0.0589
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0288 0.1903
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0012 0.0015
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0012 0.0003
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0248 0.0296
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0396 0.0492
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0358 0.1421
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0288 0.1903
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0547 0.2288
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0172 0.0685
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0172 0.0075
Trypanosoma brucei polo-like protein kinase 0.0202 0.2352 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.2763 0.3431
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0358 0.1479
Loa Loa (eye worm) hypothetical protein 0.018 0.2086 0.2591
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1462 0.8107
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0145 0.057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0358 0.039
Mycobacterium tuberculosis Conserved protein 0.0039 0.0358 0.1201
Loa Loa (eye worm) hypothetical protein 0.0033 0.0288 0.0358
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0308 0.0308
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.001 0.001
Brugia malayi hypothetical protein 0.0236 0.2763 0.3423
Echinococcus granulosus dnaJ subfamily B 0.045 0.5378 0.601
Brugia malayi jmjC domain containing protein 0.0011 0.0012 0.0003
Brugia malayi Muscleblind-like protein 0.018 0.2086 0.2582
Schistosoma mansoni cpg binding protein 0.0033 0.0289 0.0312
Loa Loa (eye worm) hypothetical protein 0.0068 0.0708 0.0879
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0012 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.001 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0448 0.0448
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0202 0.2352 0.2629
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.2407 0.2407
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1462 0.8107
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0145 0.0145
Brugia malayi beta-lactamase family protein 0.0039 0.0358 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0708 0.0868
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1462 0.1625
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0358 0.0589
Echinococcus multilocularis importin subunit beta 1 0.0029 0.024 0.024
Loa Loa (eye worm) MBCTL1 0.006 0.061 0.0758
Echinococcus granulosus FTZ F1 alpha 0.0011 0.001 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0308 0.0308
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0941 0.1042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0172 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1745 0.1745
Echinococcus granulosus cpg binding protein 0.0033 0.0289 0.0322
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.001 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.024 0.0976
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0308 0.1263
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0308 0.0344
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0308 0.2038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0498 0.0619
Brugia malayi AF-10 protein 0.0011 0.0014 0.0005
Brugia malayi Inositol-1 0.0039 0.0353 0.0426
Mycobacterium ulcerans thioesterase 0.0025 0.0187 0.0383
Mycobacterium ulcerans beta-lactamase 0.0039 0.0358 0.1421
Loa Loa (eye worm) TAR-binding protein 0.0285 0.3361 0.4174
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0012 0.0003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0353 0.1387
Echinococcus multilocularis snurportin 1 0.0314 0.3722 0.3722
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0187 0.0615
Onchocerca volvulus 0.0029 0.023 0.0273
Brugia malayi beta-lactamase family protein 0.0039 0.0358 0.0433
Brugia malayi MH2 domain containing protein 0.0125 0.1407 0.1737
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.0271 0.0902
Loa Loa (eye worm) hypothetical protein 0.0028 0.0223 0.0277
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0547 0.3691
Giardia lamblia Kinase, PLK 0.0202 0.2352 0.6107
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0358 0.6467
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0353 0.0394
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0053
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0187 0.0383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1745 0.1942
Brugia malayi follicle stimulating hormone receptor 0.0251 0.2954 0.3661
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0053
Echinococcus multilocularis cpg binding protein 0.0033 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0048 0.0468 0.0513
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.3759 1
Echinococcus granulosus peregrin 0.0033 0.0288 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2352 0.6107
Leishmania major importin beta-1 subunit, putative 0.0024 0.0172 0.0685
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0012 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1407 0.1747
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0202 0.2352 1
Loa Loa (eye worm) inositol-1 0.0039 0.0353 0.0438
Onchocerca volvulus 0.0032 0.0267 0.0319
Onchocerca volvulus 0.0052 0.052 0.0635
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0353 0.0574
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Mycobacterium leprae Probable lipase LipE 0.0039 0.0358 0.1421
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.2954 0.3668
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0522 0.0583
Loa Loa (eye worm) hypothetical protein 0.0668 0.8052 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.3759 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0358 0.1201
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0132 0.0152
Schistosoma mansoni lamin 0.0029 0.023 0.0246
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.0271 0.0892
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2352 0.6107
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0308 0.2038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0708 0.0868
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0547 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.001 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0358 0.1479
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0145 0.0919
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0181 0.0595
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0248 0.0754
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0547 0.2288
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0722 0.0897
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0353 0.2349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.001 0.0012
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0014 0.0007
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0145 0.249
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.061 0.0682
Loa Loa (eye worm) hypothetical protein 0.0039 0.0358 0.0445
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.061 0.061
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2352 0.6107
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0358 0.0589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1745 0.1942
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.2352 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0248 0.0824
Loa Loa (eye worm) hypothetical protein 0.0029 0.024 0.0299
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0288 0.0322
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0358 0.1201
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.1462 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0224 0.0278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.001 0.001
Echinococcus granulosus lamin 0.0029 0.023 0.0257
Mycobacterium ulcerans polyketide synthase 0.0032 0.0271 0.0892
Schistosoma mansoni hypothetical protein 0.0068 0.0708 0.0781
Loa Loa (eye worm) hypothetical protein 0.0039 0.0358 0.0445
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0214 0.2495 0.3091
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1104 0.2653
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0145 0.0181
Schistosoma mansoni intermediate filament proteins 0.0029 0.023 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.001 0.0012
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0271 0.0902
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0708 0.0879
Echinococcus granulosus tar DNA binding protein 0.0285 0.3361 0.3757
Echinococcus granulosus importin subunit beta 1 0.0029 0.024 0.0269
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0172 0.0075
Onchocerca volvulus 0.0039 0.0358 0.0433
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0396 0.0432
Loa Loa (eye worm) RNA binding protein 0.0285 0.3361 0.4174
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0522 0.0573
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0248 0.0824
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0353 0.5
Mycobacterium ulcerans polyketide synthase 0.003 0.0248 0.0754
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0303 0.1088

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 2.95 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 4.51 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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