Detailed information for compound 1420071

Basic information

Technical information
  • TDR Targets ID: 1420071
  • Name: 1-[3-(2,3-dihydro-1H-inden-5-yloxy)propyl]ben zimidazole
  • MW: 292.375 | Formula: C19H20N2O
  • H donors: 0 H acceptors: 1 LogP: 4.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C(Oc1ccc2c(c1)CCC2)CCn1cnc2c1cccc2
  • InChi: 1S/C19H20N2O/c1-2-8-19-18(7-1)20-14-21(19)11-4-12-22-17-10-9-15-5-3-6-16(15)13-17/h1-2,7-10,13-14H,3-6,11-12H2
  • InChiKey: NWCOFZGRQWJPBX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-(3-indan-5-yloxypropyl)benzimidazole
  • 1-[3-(5-indanyloxy)propyl]benzimidazole
  • 1-[3-(2,3-dihydro-1H-inden-5-yloxy)propyl]-1H-benzimidazole
  • MLS000537337
  • SMR000143775

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0027 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0138 0.1366
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0066 0.0066
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0046 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0175 0.1734
Brugia malayi TAR-binding protein 0.072 0.5188 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0509 0.3636 0.7009
Schistosoma mansoni hypothetical protein 0.0161 0.1073 0.1073
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0225 0.0225
Echinococcus multilocularis transcription factor btf3 0.0042 0.0198 0.0198
Schistosoma mansoni tar DNA-binding protein 0.072 0.5188 0.5188
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0376 0.178
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0225 0.0225
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.013
Schistosoma mansoni ferritin 0.0027 0.0087 0.0087
Mycobacterium leprae conserved hypothetical protein 0.0153 0.1011 1
Brugia malayi RNA binding protein 0.072 0.5188 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0215 0.102
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0087 0.5
Echinococcus granulosus expressed protein 0.0027 0.0087 0.0087
Loa Loa (eye worm) latrophilin receptor protein 2 0.0161 0.1073 0.2068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0041 0.0041
Mycobacterium leprae Probable lipase LipE 0.0153 0.1011 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0225 0.2223
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0103 0.1089
Schistosoma mansoni rab6-interacting 0.0024 0.0062 0.0062
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0939 0.445
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0041 0.0079
Brugia malayi nuclear hormone receptor 0.0021 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.0153 0.1011 0.1948
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0041 0.0079
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0939 0.445
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0098 0.0115
Loa Loa (eye worm) RecQ helicase 0.0022 0.0046 0.0089
Schistosoma mansoni transcription factor btf3 0.0042 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0348 0.245 0.4722
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0138 0.0952
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1057 0.1463
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0098 0.0681
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0041 0.0041
Mycobacterium tuberculosis Probable lipase LipE 0.0153 0.1011 0.1397
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0041 0.0041
Onchocerca volvulus 0.0024 0.0062 0.0062
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0046 0.00000000075347
Giardia lamblia GTOR 0.0046 0.0225 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0089 0.0877
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0098 0.01
Schistosoma mansoni inositol monophosphatase 0.0045 0.0215 0.0215
Schistosoma mansoni DNA polymerase eta 0.0019 0.0027 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0098 0.0681
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0046 0.0089
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.2109 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0198 0.0937
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0198 0.1956
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0225 0.0225
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0199 0.0944
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0261 0.1808 0.1808
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0103 0.0103
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0066 0.0066
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0087 0.0857
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0113 0.0719 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0051 0.0099
Schistosoma mansoni hypothetical protein 0.0113 0.0719 0.0719
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0161 0.1073 0.1073
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0098 0.1014
Schistosoma mansoni hypothetical protein 0.0261 0.1808 0.1808
Echinococcus granulosus flap endonuclease 1 0.0029 0.0103 0.0103
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0041 0.0041
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0046 0.0046
Brugia malayi hypothetical protein 0.0024 0.0062 0.012
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0376 0.3414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0684
Onchocerca volvulus 0.0153 0.1011 0.2842
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0098 0.0462
Schistosoma mansoni rab6-interacting 0.0024 0.0062 0.0062
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.1011 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0153 0.1011 0.1397
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0046 0.0046
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0046 0.0457
Echinococcus multilocularis dna polymerase eta 0.0019 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0041 0.0079
Schistosoma mansoni loxhd1 0.0024 0.0062 0.0062
Brugia malayi hypothetical protein 0.0113 0.0719 0.1386
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0225 0.1065
Leishmania major basic transcription factor 3a, putative 0.0042 0.0198 0.0937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0041 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0041 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0098 0.0462
Brugia malayi Doublecortin family protein 0.0024 0.0062 0.012
Loa Loa (eye worm) hypothetical protein 0.0153 0.1011 0.1948
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0156 0.0739
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0027 0.0053
Echinococcus multilocularis Protein lozenge 0.0061 0.0334 0.0334
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0103 0.0487
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0363 0.0363
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0041 0.0041
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0484 0.3453 0.6656
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0046 0.0219
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0098 0.1014
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0046 0.0272
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0041 0.0041
Echinococcus multilocularis RUN 0.0024 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0156 0.1539
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0225 0.0433
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0089 0.0877
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0103 0.0198
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0046 0.0089
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0098 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0198 0.1956
Echinococcus multilocularis tar DNA binding protein 0.072 0.5188 0.5188
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Loa Loa (eye worm) runx1 0.0061 0.0334 0.0644
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0939 0.445
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0027 0.013
Loa Loa (eye worm) hypothetical protein 0.0484 0.3453 0.6656
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0682
Brugia malayi Bromodomain containing protein 0.0081 0.0485 0.0934
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0062 0.0062
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0041 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0153 0.1011 1
Schistosoma mansoni DNA helicase recq1 0.0022 0.0046 0.0046
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0261 0.1808 0.1808
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0153 0.1011 0.1397
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0173 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0138 0.1366
Schistosoma mansoni microtubule-associated protein tau 0.1373 1 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1011 0.1948
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0198 0.1587
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0181 0.1016
Toxoplasma gondii hypothetical protein 0.0049 0.0245 0.2062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0041 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0161 0.1073 0.2068
Loa Loa (eye worm) beta-lactamase 0.0153 0.1011 0.1948
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0041 0.0041
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0046 0.0457
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0153 0.1011 0.1948
Schistosoma mansoni polycystin 1-related 0.0024 0.0062 0.0062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0509 0.3636 0.7009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0103 0.0487
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.012
Onchocerca volvulus 0.0153 0.1011 0.2842
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0138 0.1366
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0268 0.1268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0156 0.1539
Mycobacterium ulcerans lipase LipD 0.0153 0.1011 0.9547
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0041 0.0041
Schistosoma mansoni bromodomain containing protein 0.0068 0.0391 0.0391
Mycobacterium tuberculosis Conserved protein 0.0153 0.1011 0.1397
Brugia malayi nuclear receptor NHR-88 0.0021 0.0041 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0041 0.0079
Schistosoma mansoni ferritin light chain 0.0027 0.0087 0.0087
Brugia malayi Flap endonuclease-1 0.0029 0.0103 0.0198
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0041 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0719 0.0719
Schistosoma mansoni ferritin 0.0027 0.0087 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.1011 0.1011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0376 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.0153 0.1011 0.1948
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0215 0.1752
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0085
Schistosoma mansoni hypothetical protein 0.0161 0.1073 0.1073
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0023 0.0023
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0103 0.3818
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0044 0.5
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0098 0.0681
Toxoplasma gondii ABC1 family protein 0.0153 0.1011 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0161 0.1073 0.1073
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0106 0.105
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0041 0.0079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0153 0.1011 0.9547
Loa Loa (eye worm) hypothetical protein 0.0153 0.1011 0.1948
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.072 0.5188 1
Echinococcus granulosus GPCR family 2 0.0161 0.1073 0.1073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0089 0.0877
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0041 0.0079
Schistosoma mansoni apoferritin-2 0.0027 0.0087 0.0087
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0062 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0181 0.0218
Loa Loa (eye worm) hypothetical protein 0.0046 0.0227 0.0437
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0225 0.1065
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0046 0.0089
Leishmania major hypothetical protein, conserved 0.0153 0.1011 0.4792
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0046 0.0952
Brugia malayi RNA recognition motif domain containing protein 0.072 0.5188 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0225 0.2852
Echinococcus granulosus ferritin 0.0027 0.0087 0.0087
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0198 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0682
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0199 0.0944
Onchocerca volvulus 0.0024 0.0062 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0041 0.0041
Echinococcus multilocularis ferritin 0.0027 0.0087 0.0087
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1011 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0138 0.1366
Schistosoma mansoni lipoxygenase 0.0142 0.0936 0.0936
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0041 0.0041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0098 0.0115
Schistosoma mansoni thyroid hormone receptor 0.0282 0.1962 0.1962
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0376 0.0376
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.2109 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0376 0.338
Loa Loa (eye worm) hypothetical protein 0.0077 0.0451 0.0868
Schistosoma mansoni hypothetical protein 0.0022 0.0051 0.0051
Echinococcus granulosus tumor protein p63 0.0345 0.2425 0.2425
Brugia malayi hypothetical protein 0.0024 0.0062 0.012
Mycobacterium ulcerans esterase/lipase LipP 0.0153 0.1011 0.9547
Brugia malayi beta-lactamase family protein 0.0153 0.1011 0.1948
Trichomonas vaginalis ferritin, putative 0.0027 0.0087 0.086
Mycobacterium tuberculosis Probable lipase LipD 0.0153 0.1011 0.1397
Schistosoma mansoni ferritin 0.0027 0.0087 0.0087
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0376 0.0376
Loa Loa (eye worm) inositol-1 0.0045 0.0215 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0041 0.0079
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0087 0.0084
Loa Loa (eye worm) hypothetical protein 0.0044 0.0211 0.0408
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0215 0.102
Echinococcus granulosus transcription factor btf3 0.0042 0.0198 0.0198
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0046 0.0129
Brugia malayi Inositol-1 0.0045 0.0215 0.0415
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0975 0.7068 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0376 0.0494
Leishmania major hypothetical protein, conserved 0.0017 0.0009 0.0041
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0215 0.2715
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1011 1
Schistosoma mansoni zinc finger protein 0.0017 0.0009 0.0009
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0215 0.1823
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.1011 0.4792
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0041 0.0041
Echinococcus multilocularis tumor protein p63 0.0345 0.2425 0.2425
Schistosoma mansoni tar DNA-binding protein 0.072 0.5188 0.5188
Leishmania major DNA polymerase kappa, putative 0.0019 0.0027 0.013
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0225 0.1065
Brugia malayi beta-lactamase family protein 0.0153 0.1011 0.1948
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0198 0.1956
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0041 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0225 0.2223
Brugia malayi hypothetical protein 0.0484 0.3453 0.6656
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0103 0.1016
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.0161 0.1073 0.2068
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0198 0.0937
Schistosoma mansoni tar DNA-binding protein 0.072 0.5188 0.5188
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1011 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0113 0.1122
Onchocerca volvulus 0.005 0.0258 0.0637
Entamoeba histolytica hypothetical protein 0.0042 0.0198 0.2462
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0199 0.0944
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0062 0.012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0041 0.0041
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0062 0.0184
Loa Loa (eye worm) RNA binding protein 0.072 0.5188 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0027 0.0027
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0087 0.0084
Trypanosoma brucei unspecified product 0.0019 0.0027 0.013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0012
Echinococcus granulosus RUN 0.0024 0.0062 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1011 0.4792
Mycobacterium tuberculosis Conserved protein 0.0153 0.1011 0.1397
Entamoeba histolytica hypothetical protein 0.0113 0.0719 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0225 0.1065
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0215 1
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0027 0.0053
Mycobacterium ulcerans hypothetical protein 0.0029 0.0098 0.0681
Brugia malayi beta-NAC-like protein 0.0042 0.0198 0.0381
Loa Loa (eye worm) hypothetical protein 0.0509 0.3636 0.7009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0041 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0041 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0027 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0684
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0376 0.338
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.2109 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0027 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Schistosoma mansoni lipoxygenase 0.01 0.062 0.062
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0936 0.0936
Schistosoma mansoni ferritin 0.0027 0.0087 0.0087
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0046 0.0046
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0098 0.1014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0156 0.1539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0684
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0009
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0258 0.0258
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0376 0.338
Schistosoma mansoni flap endonuclease-1 0.0027 0.0082 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0371
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0062 0.116
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0098 0.0188
Brugia malayi Calcitonin receptor-like protein seb-1 0.0509 0.3636 0.7009
Schistosoma mansoni coup transcription factor 0.0021 0.0041 0.0041
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0041 0.0041
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0103 0.0605
Schistosoma mansoni DNA helicase recq5 0.0022 0.0046 0.0046
Brugia malayi Bromodomain containing protein 0.0041 0.0192 0.037
Entamoeba histolytica hypothetical protein 0.0113 0.0719 1
Onchocerca volvulus 0.0029 0.0098 0.0166
Echinococcus multilocularis microtubule associated protein 2 0.1373 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0023 0.0023
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0023 0.0023
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0198 0.157
Schistosoma mansoni hypothetical protein 0.0348 0.245 0.245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0098 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0041 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.013
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0198 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0138 0.1366
Brugia malayi PHD-finger family protein 0.0027 0.0085 0.0164
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0066 0.0066
Echinococcus multilocularis thyroid hormone receptor alpha 0.0282 0.1962 0.1962
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0027 0.013
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0215 0.2129
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0719 0.0719
Schistosoma mansoni inositol monophosphatase 0.0045 0.0215 0.0215
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0062 0.0062
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0027 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.013
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0098 0.0681
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0719 0.0719
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0041 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.1011 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0684
Brugia malayi ecdysteroid receptor 0.0021 0.0041 0.0079
Brugia malayi beta-lactamase 0.0153 0.1011 0.1948
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0363 0.0363
Brugia malayi latrophilin 2 splice variant baaae 0.0348 0.245 0.4722
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0087 0.0577
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0041 0.0079
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0215 0.0215
Echinococcus granulosus bloom syndrome protein 0.0022 0.0046 0.0046
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0156 0.0739
Leishmania major DNA polymerase eta, putative 0.0019 0.0027 0.013
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0098 0.0681
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0113 0.0719 1
Schistosoma mansoni hypothetical protein 0.0161 0.1073 0.1073
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0041 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0138 0.1366
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0161 0.1073 0.1073
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0225 0.0433
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0041 0.0041
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0046 0.0457
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0188
Mycobacterium ulcerans beta-lactamase 0.0153 0.1011 0.9547
Trichomonas vaginalis esterase, putative 0.0153 0.1011 1
Schistosoma mansoni tar DNA-binding protein 0.072 0.5188 0.5188
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0199 0.0944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0156 0.1539
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0153 0.1011 0.1948
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0041 0.0079
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0041 0.0041
Onchocerca volvulus 0.0484 0.3453 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Schistosoma mansoni tar DNA-binding protein 0.072 0.5188 0.5188
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0023 0.0023
Mycobacterium ulcerans hypothetical protein 0.0159 0.1057 1
Trypanosoma brucei ISWI complex protein 0.0017 0.0009 0.0041
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0027 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0087 0.0857
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0215 0.102
Schistosoma mansoni ferritin light chain 0.0027 0.0087 0.0087
Echinococcus multilocularis GPCR, family 2 0.0161 0.1073 0.1073
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0225 0.2852
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0173 0.0173
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0046 0.0219
Schistosoma mansoni lozenge 0.0061 0.0334 0.0334
Onchocerca volvulus 0.0153 0.1011 0.2842
Echinococcus granulosus tar DNA binding protein 0.072 0.5188 0.5188
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0198 0.0937
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0053
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0103 0.0586
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0079
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0044 0.0163
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0225 0.1065
Trypanosoma cruzi ISWI complex protein 0.0017 0.0009 0.0041
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0153 0.1011 0.1397
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0041 0.0079
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0087 0.0577
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Schistosoma mansoni zinc finger protein 0.0021 0.0043 0.0043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0215 0.2129
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0156 0.0739
Loa Loa (eye worm) hypothetical protein 0.0153 0.1011 0.1948
Echinococcus granulosus zinc finger protein 0.0021 0.0043 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0225 0.2223
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0215 0.2129
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.013
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0027 0.0128
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0215 0.102
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0047 0.022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.1011 0.1011
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0098 0.0188
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0215 0.0215
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0041 0.0041
Schistosoma mansoni apoferritin-2 0.0027 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0282 0.1962 0.1962
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0138 0.1366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0682
Echinococcus multilocularis beta LACTamase domain containing family member 0.0153 0.1011 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.005 0.0258 0.0498
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0161 0.1073 0.2068
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0098 0.0681
Trypanosoma cruzi ISWI complex protein 0.0017 0.0009 0.0041
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0198 0.2462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0098 0.0681
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0046 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1011 0.4792
Mycobacterium ulcerans hypothetical protein 0.0153 0.1011 0.9547
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0041 0.0041
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0225 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0041 0.0079
Schistosoma mansoni hypothetical protein 0.0161 0.1073 0.1073
Echinococcus granulosus beta LACTamase domain containing family member 0.0153 0.1011 0.1011
Mycobacterium tuberculosis Probable esterase LipL 0.0153 0.1011 0.1397
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0103 0.0487
Plasmodium falciparum flap endonuclease 1 0.0029 0.0103 0.3814
Mycobacterium tuberculosis Probable hydrolase 0.0153 0.1011 0.1397
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0098 0.0188
Schistosoma mansoni hypothetical protein 0.0024 0.0062 0.0062
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0153 0.1011 0.1397
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0044 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0156 0.1539
Loa Loa (eye worm) TAR-binding protein 0.072 0.5188 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0041 0.0079
Brugia malayi steroid hormone receptor 0.0021 0.0041 0.0079
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0053
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0062 0.0062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0161 0.1073 0.1073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0041 0.0079
Echinococcus multilocularis expressed protein 0.0027 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0041 0.0079
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0376 0.0376
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.2109 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0043 0.0043
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0046 0.0089
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0188

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 7.486 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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