Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3538 | 0.575 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.055 | 0.055 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0371 | 0.0602 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0371 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6548 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.055 | 0.055 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6548 | 0.1027 |
Echinococcus granulosus | geminin | 0.0205 | 0.6153 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6153 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.3538 | 0.3538 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0794 | 0.129 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.3538 | 0.5478 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0371 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0371 | 0.0371 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.6153 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0371 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0794 | 0.0794 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6153 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0794 | 0.0732 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.3538 | 0.3538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3538 | 0.575 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0794 | 0.0794 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.3538 | 0.3538 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0794 | 0.0732 |
Brugia malayi | RNA binding protein | 0.0132 | 0.3538 | 0.3538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3538 | 0.575 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.3538 | 0.3538 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0371 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.055 | 0.055 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0794 | 0.0732 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.055 | 0.055 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.3538 | 0.5478 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.3538 | 0.3538 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0794 | 0.129 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0794 | 0.0732 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6153 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3538 | 0.575 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0794 | 0.129 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0371 | 0.0602 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3538 | 0.575 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.