Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 10 | Starlite/ChEMBL | No references |
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | hydroxysteroid (17-beta) dehydrogenase 10 | 252 aa | 251 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0024 | 0.0052 | 0.0052 |
Brugia malayi | maoC like domain containing protein | 0.0039 | 0.0314 | 0.0314 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0162 | 0.2535 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0039 | 0.0314 | 0.1054 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.4661 | 0.4661 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0162 | 0.2535 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0162 | 0.2535 | 1 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0039 | 0.0314 | 0.1054 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0162 | 0.2535 | 0.5 |
Onchocerca volvulus | 0.0576 | 1 | 1 | |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.4661 | 0.4661 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0314 | 0.0314 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0071 | 0.0892 | 0.3381 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0162 | 0.2535 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.078 | 0.078 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0576 | 1 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0162 | 0.2535 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0071 | 0.0892 | 0.3381 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0162 | 0.2535 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0162 | 0.2535 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0162 | 0.2535 | 0.5 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0039 | 0.0326 | 0.1151 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0162 | 0.2535 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0162 | 0.2535 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0024 | 0.0052 | 0.0052 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0071 | 0.0892 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0576 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0314 | 0.1054 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0071 | 0.0892 | 0.0892 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0162 | 0.2535 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0162 | 0.2535 | 0.5 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0162 | 0.2535 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0576 | 1 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0576 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0039 | 0.0314 | 0.1054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.