Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.032 | 0.3402 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0832 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.032 | 0.3402 | 0.2131 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0263 | 0.2672 | 0.1261 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.2859 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0284 | 0.294 | 1 |
Leishmania major | hypothetical protein, conserved | 0.029 | 0.3016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.2672 | 0.1261 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0181 | 0.1615 | 0.5492 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.3016 | 0.1671 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0181 | 0.1615 | 0.5492 |
Schistosoma mansoni | tar DNA-binding protein | 0.032 | 0.3402 | 0.4327 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.2672 | 0.3036 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0181 | 0.1615 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.032 | 0.3402 | 0.4327 |
Brugia malayi | RNA recognition motif domain containing protein | 0.032 | 0.3402 | 0.2131 |
Schistosoma mansoni | glutaminase | 0.0284 | 0.294 | 0.3511 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0263 | 0.2672 | 0.1261 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0181 | 0.1615 | 0.5492 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.029 | 0.3016 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.032 | 0.3402 | 0.2131 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.029 | 0.3016 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.2672 | 0.3036 |
Echinococcus multilocularis | GPCR, family 2 | 0.0263 | 0.2672 | 0.7016 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0263 | 0.2672 | 0.7016 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.029 | 0.3016 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.029 | 0.3016 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0284 | 0.294 | 0.1581 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.029 | 0.3016 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.032 | 0.3402 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0284 | 0.294 | 0.1581 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.079 | 0.9453 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.079 | 0.9453 | 0.9348 |
Loa Loa (eye worm) | hypothetical protein | 0.0569 | 0.6608 | 0.5955 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0569 | 0.6608 | 0.5955 |
Schistosoma mansoni | hypothetical protein | 0.0569 | 0.6608 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0181 | 0.1615 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0832 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.2672 | 0.3036 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0181 | 0.1615 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0181 | 0.1615 | 0.5492 |
Echinococcus granulosus | GPCR family 2 | 0.0263 | 0.2672 | 0.7016 |
Brugia malayi | N-terminal motif family protein | 0.079 | 0.9453 | 0.9348 |
Mycobacterium ulcerans | glutaminase | 0.0284 | 0.294 | 1 |
Brugia malayi | RNA binding protein | 0.032 | 0.3402 | 0.2131 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.2672 | 0.3036 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0263 | 0.2672 | 0.1261 |
Schistosoma mansoni | tar DNA-binding protein | 0.032 | 0.3402 | 0.4327 |
Loa Loa (eye worm) | hypothetical protein | 0.0832 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.029 | 0.3016 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.032 | 0.3402 | 0.4327 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0263 | 0.2672 | 0.7016 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0263 | 0.2672 | 0.7016 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0181 | 0.1615 | 0.5492 |
Brugia malayi | hypothetical protein | 0.0187 | 0.1692 | 0.0092 |
Brugia malayi | glutaminase DH11.1 | 0.0284 | 0.294 | 0.1581 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0181 | 0.1615 | 0.5492 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0263 | 0.2672 | 0.7016 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.029 | 0.3016 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.032 | 0.3402 | 0.2131 |
Schistosoma mansoni | tar DNA-binding protein | 0.032 | 0.3402 | 0.4327 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.032 | 0.3402 | 0.2131 |
Brugia malayi | hypothetical protein | 0.029 | 0.3016 | 0.1671 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.5849 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.