Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0135 | 0.8274 | 0.8274 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.4 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 0.8274 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 0.8274 | 0.8274 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.8274 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.4 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2419 | 0.2923 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0649 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.8274 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2419 | 0.2923 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0649 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2419 | 0.2923 |
Brugia malayi | hypothetical protein | 0.015 | 0.9338 | 0.9338 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2419 | 0.2923 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0649 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.6491 | 0.7845 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2419 | 0.2923 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.2419 | 0.2419 |
Onchocerca volvulus | 0.015 | 0.9338 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.8274 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 0.8274 | 0.8274 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.9338 | 0.9338 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.8274 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0649 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0649 | 0.0649 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.2419 | 0.2923 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0649 | 0.0649 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.2419 | 0.2419 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0649 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4 | 0.4835 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4 | 0.4835 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.2419 | 0.2923 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.4 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 0.8274 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.4 | 0.4835 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0649 | 0.1623 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.4 | 0.4835 |
Brugia malayi | RNA binding protein | 0.0135 | 0.8274 | 0.8274 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.6491 | 0.6491 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0649 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0033 | 0.0033 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 0.8274 | 0.8274 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.2419 | 0.2419 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0649 | 0.1623 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 0.8274 | 0.8274 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.8274 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2419 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.6491 | 0.6491 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2419 | 0.2923 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2419 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2419 | 0.2419 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.