Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.71 | 0.6547 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4129 | 0.3011 |
Brugia malayi | hypothetical protein | 0.0043 | 0.71 | 0.71 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4129 | 0.3011 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.71 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4129 | 0.4129 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.71 | 0.6547 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.16 | 0.16 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4129 | 0.4129 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.16 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.71 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.16 | 0.16 |
Schistosoma mansoni | lamin | 0.0033 | 0.4129 | 0.3011 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.16 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.71 | 0.6547 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.71 | 0.6547 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.16 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.16 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.16 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.71 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4129 | 0.3011 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4129 | 0.3011 |
Echinococcus granulosus | lamin | 0.0033 | 0.4129 | 0.3011 |
Schistosoma mansoni | lamin | 0.0033 | 0.4129 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4129 | 0.4129 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.5611 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4129 | 0.3011 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4129 | 0.4129 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.5611 | 0.4775 |
Onchocerca volvulus | 0.0033 | 0.4129 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0033 | 0.4129 | 0.3011 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.5611 | 0.4775 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.71 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.16 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3966 | 0.3966 |
Onchocerca volvulus | 0.0033 | 0.4129 | 0.5 | |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.16 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4129 | 0.4129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.