Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.1576 | 0.1576 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.1576 | 0.1576 |
Onchocerca volvulus | 0.0047 | 0.1324 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1938 | 0.1938 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2705 | 0.2705 |
Echinococcus multilocularis | caspase 2 | 0.0043 | 0.1139 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0527 | 0.0527 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1938 | 0.1938 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.003 | 0.0527 | 0.0527 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.003 | 0.0527 | 0.0527 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.1576 | 0.1576 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2705 | 0.3094 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.1576 | 0.1576 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1324 | 0.1514 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2705 | 0.3094 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0527 | 0.0602 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2705 | 0.2705 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1938 | 0.1938 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.104 | 0.119 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1938 | 0.1938 |
Echinococcus granulosus | caspase 2 | 0.0043 | 0.1139 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1139 | 0.1139 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1324 | 0.1514 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1576 | 0.1803 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2705 | 0.2705 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2705 | 0.2705 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.1576 | 0.1576 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2705 | 0.2705 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.1576 | 0.1576 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2705 | 0.2705 |
Brugia malayi | Cell death protein 3 precursor | 0.0043 | 0.1139 | 0.1139 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2705 | 0.3094 |
Brugia malayi | hypothetical protein | 0.003 | 0.0527 | 0.0527 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1576 | 0.1803 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.104 | 0.104 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2705 | 0.2705 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1576 | 0.1803 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1324 | 0.1324 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2705 | 0.3094 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0043 | 0.1139 | 0.1303 |
Echinococcus granulosus | geminin | 0.0205 | 0.8743 | 0.8743 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.104 | 0.104 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0043 | 0.1139 | 0.7678 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8743 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8743 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2705 | 0.3094 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8743 | 0.8743 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2705 | 0.2705 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.