Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0647 | 0.0227 |
Schistosoma mansoni | DNA polymerase eta | 0.0071 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.3114 | 0.2805 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0071 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0071 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.3114 | 0.2805 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0043 | 0.043 | 0.043 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.3114 | 0.2805 |
Leishmania major | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0043 | 0.043 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0647 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0647 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.3114 | 0.2805 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3114 | 0.2805 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0043 | 0.043 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0647 | 0.0227 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0647 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.3114 | 0.2805 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0647 | 0.0227 |
Giardia lamblia | DINP protein human, muc B family | 0.0043 | 0.043 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0071 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0647 | 0.0227 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0071 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3114 | 0.2805 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0647 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0043 | 0.043 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0071 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0043 | 0.043 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0647 | 0.0227 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3114 | 0.2805 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.3114 | 0.2805 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.043 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.