Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.035 | 0.3212 | 0.3145 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1042 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0084 | 0.0606 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.033 | 0.3014 | 0.9385 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0084 | 0.0606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1576 | 0.1342 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0084 | 0.0606 | 0.1887 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.033 | 0.3014 | 0.282 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.3014 | 0.4454 |
Brugia malayi | hypothetical protein | 0.005 | 0.027 | 0.0175 |
Brugia malayi | Isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.0515 |
Echinococcus granulosus | tar DNA binding protein | 0.035 | 0.3212 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.035 | 0.3212 | 0.3023 |
Brugia malayi | N-terminal motif family protein | 0.0183 | 0.1576 | 0.1494 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.033 | 0.3014 | 0.9385 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0084 | 0.0606 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.035 | 0.3212 | 0.4746 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.033 | 0.3014 | 0.9385 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0084 | 0.0606 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.033 | 0.3014 | 0.9385 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.1887 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.1887 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.033 | 0.3014 | 0.2946 |
Brugia malayi | Latrophilin receptor protein 2 | 0.033 | 0.3014 | 0.2946 |
Brugia malayi | RNA recognition motif domain containing protein | 0.035 | 0.3212 | 0.3145 |
Echinococcus multilocularis | GPCR, family 2 | 0.033 | 0.3014 | 0.9385 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0183 | 0.1576 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.035 | 0.3212 | 0.4746 |
Schistosoma mansoni | tar DNA-binding protein | 0.035 | 0.3212 | 0.4746 |
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.6767 | 0.6677 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0084 | 0.0606 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0712 | 0.6767 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0084 | 0.0606 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.035 | 0.3212 | 0.4746 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1042 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.0515 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0084 | 0.0606 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0084 | 0.0606 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0712 | 0.6767 | 0.6735 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0084 | 0.0606 | 1 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.3014 | 0.4454 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0084 | 0.0606 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.1887 |
Brugia malayi | TAR-binding protein | 0.035 | 0.3212 | 0.3145 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.3014 | 0.282 |
Loa Loa (eye worm) | hypothetical protein | 0.1042 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.0345 |
Echinococcus multilocularis | tar DNA binding protein | 0.035 | 0.3212 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.1887 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.1887 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0084 | 0.0606 | 0.0896 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.3014 | 0.4454 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.035 | 0.3212 | 0.3023 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.3014 | 0.4454 |
Schistosoma mansoni | tar DNA-binding protein | 0.035 | 0.3212 | 0.4746 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.033 | 0.3014 | 0.9385 |
Loa Loa (eye worm) | TAR-binding protein | 0.035 | 0.3212 | 0.3023 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.