Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | (3R)-hydroxyacyl-ACP dehydratase subunit HadA | 0.0032 | 0.0011 | 0.0003 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0042 | 0.0064 | 0.0198 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0507 | 0.2689 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0036 | 0.0029 | 0.0029 |
Brugia malayi | SCP-2 sterol transfer family protein | 0.0032 | 0.0011 | 0.0011 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0507 | 0.2689 | 1 |
Onchocerca volvulus | 0.1801 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0011 | 0.0003 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0082 | 0.0294 | 0.1055 |
Mycobacterium ulcerans | hypothetical protein | 0.0082 | 0.0294 | 0.1057 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0074 | 0.0246 | 0.0914 |
Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0042 | 0.0064 | 0.0064 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | SCP-2 sterol transfer family protein | 0.0032 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | dehydratase | 0.0082 | 0.0294 | 0.1057 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0011 | 0.0011 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0507 | 0.2689 | 1 |
Mycobacterium ulcerans | (3R)-hydroxyacyl-ACP dehydratase subunit HadC | 0.0032 | 0.0011 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0507 | 0.2689 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.1801 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0011 | 0.0003 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0507 | 0.2689 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.1801 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0011 | 0.0003 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0507 | 0.2689 | 0.5 |
Brugia malayi | maoC like domain containing protein | 0.0082 | 0.0294 | 0.0294 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0011 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0294 | 0.0294 |
Toxoplasma gondii | MaoC family domain-containing protein | 0.005 | 0.0111 | 0.0411 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0507 | 0.2689 | 1 |
Brugia malayi | sterol carrier protein | 0.0032 | 0.0011 | 0.0011 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0042 | 0.0064 | 0.0195 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0507 | 0.2689 | 1 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0082 | 0.0294 | 0.1055 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.1801 | 1 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0507 | 0.2689 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0036 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.1801 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0507 | 0.2689 | 0.5 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0507 | 0.2689 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0042 | 0.0064 | 0.0064 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0507 | 0.2689 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0507 | 0.2689 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0507 | 0.2689 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0042 | 0.0064 | 0.0198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 112.2018 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.