Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Caenorhabditis elegans | Protein GLD-1 | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) | Protein Rev | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania donovani | hypothetical protein, conserved | Protein Rev | 116 aa | 95 aa | 26.3 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Leishmania infantum | hypothetical protein, conserved | Protein Rev | 116 aa | 95 aa | 26.3 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0135 | 0.2764 | 0.5 |
Trypanosoma brucei | hypothetical protein | 0.0135 | 0.2764 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0044 | 0.0166 | 0.035 |
Brugia malayi | hypothetical protein | 0.0121 | 0.2369 | 0.2309 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1088 | 0.2291 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2369 | 0.2323 |
Trypanosoma brucei | variant surface glycoprotein (VSG), putative | 0.0135 | 0.2764 | 0.5 |
Loa Loa (eye worm) | tumor suppressor | 0.0388 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0622 | 0.0549 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0044 | 0.0166 | 0.035 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Trypanosoma brucei | calpain, putative | 0.0135 | 0.2764 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0622 | 0.0566 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0622 | 0.0549 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1088 | 0.1018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0188 | 0.4269 | 0.8988 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1088 | 0.1035 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0059 | 0.0125 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0135 | 0.2764 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1088 | 0.2291 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0188 | 0.4269 | 0.8988 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.475 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0188 | 0.4269 | 0.8988 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0188 | 0.4269 | 0.8988 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0188 | 0.4269 | 0.4224 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2369 | 0.2323 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0135 | 0.2764 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1088 | 0.2291 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0135 | 0.2764 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0188 | 0.4269 | 0.8988 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0117 | 0.2251 | 0.4739 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1088 | 0.1018 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.2369 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1054 | 0.1001 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0622 | 0.0566 |
Brugia malayi | Bromodomain containing protein | 0.0147 | 0.3109 | 0.3055 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0078 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0078 | 0.0019 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1088 | 0.1035 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1088 | 0.2291 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1088 | 0.2291 |
Schistosoma mansoni | bromodomain containing protein | 0.0124 | 0.2452 | 0.5162 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.105 | 0.098 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0135 | 0.2764 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0071 | 0.0917 | 0.1932 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1187 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1294 | 0.1242 |
Echinococcus granulosus | geminin | 0.0205 | 0.475 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0135 | 0.2764 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0188 | 0.4269 | 0.8988 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0188 | 0.4269 | 0.4235 |
Trypanosoma brucei | calpain-like protein, putative | 0.0135 | 0.2764 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0188 | 0.4269 | 0.8988 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2869 | 0.2827 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0044 | 0.0166 | 0.035 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0071 | 0.0917 | 0.1932 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1088 | 0.1035 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1088 | 0.1018 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.475 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1088 | 0.2291 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.2369 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0117 | 0.2251 | 0.4739 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1088 | 0.2291 |
Brugia malayi | PHD-finger family protein | 0.0049 | 0.0299 | 0.0223 |
Echinococcus multilocularis | geminin | 0.0205 | 0.475 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.968 uM | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] | ChEMBL. | No reference |
IC50 (binding) | = 17.851 um | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 67.4555 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.