Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.1543 | 1 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0434 | 0.2614 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.1034 | 0.1022 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0015 | 0.5 |
Brugia malayi | maoC like domain containing protein | 0.0082 | 0.0269 | 0.0269 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0044 | 0.0015 | 0.0001 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.0015 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1087 | 0.1075 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0082 | 0.0269 | 0.1031 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0434 | 0.2614 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0434 | 0.2614 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0014 | 0.0014 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.0015 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1087 | 0.1075 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.0852 | 0.0839 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0434 | 0.2614 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1034 | 0.1022 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0015 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1087 | 0.1075 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0015 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0044 | 0.0015 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0044 | 0.0015 | 0.5 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0082 | 0.0269 | 0.1031 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1034 | 0.1022 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0434 | 0.2614 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.0852 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0269 | 0.0269 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0434 | 0.2614 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.0015 | 0.0005 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.1543 | 1 | 1 |
Toxoplasma gondii | MaoC family domain-containing protein | 0.005 | 0.0055 | 0.0154 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0434 | 0.2614 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0434 | 0.2614 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0434 | 0.2614 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0015 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.0015 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0015 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1543 | 1 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.1543 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0044 | 0.0015 | 0.0015 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0073 | 0.0214 | 0.0763 |
Echinococcus granulosus | geminin | 0.0205 | 0.1087 | 0.1075 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0015 | 0.5 |
Onchocerca volvulus | 0.1543 | 1 | 1 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.1034 | 0.1034 |
Entamoeba histolytica | hypothetical protein | 0.0434 | 0.2614 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0015 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0082 | 0.0269 | 0.1031 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0044 | 0.0015 | 0.0001 |
Schistosoma mansoni | alpha glucosidase | 0.0044 | 0.0015 | 0.0001 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0434 | 0.2614 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0044 | 0.0015 | 0.0015 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0434 | 0.2614 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0082 | 0.0269 | 0.1031 |
Mycobacterium leprae | conserved hypothetical protein | 0.0434 | 0.2614 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.1034 | 0.1034 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0434 | 0.2614 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2512 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.