Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase | 0.0543 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0098 | 0.1297 | 0.2993 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0309 | 0.5416 | 0.5416 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0309 | 0.5416 | 0.5416 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.5416 | 0.5416 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0309 | 0.5416 | 0.5416 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.0397 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0543 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.0397 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0397 | 0.0397 |
Mycobacterium ulcerans | glutaminase | 0.0543 | 1 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0098 | 0.1297 | 0.1297 |
Brugia malayi | RNA binding protein | 0.0253 | 0.4333 | 0.4333 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0397 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1297 | 0.1297 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.4333 | 0.4333 |
Schistosoma mansoni | glutaminase | 0.0543 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0211 | 0.351 | 0.351 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.4333 | 0.4333 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.0397 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1297 | 0.1297 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1297 | 0.1297 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0098 | 0.1297 | 0.2993 |
Loa Loa (eye worm) | TAR-binding protein | 0.0253 | 0.4333 | 0.4333 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.169 | 0.169 |
Loa Loa (eye worm) | RNA binding protein | 0.0253 | 0.4333 | 0.4333 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0229 | 0.3871 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0253 | 0.4333 | 0.4333 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.4333 | 0.4333 |
Trichomonas vaginalis | glutaminase, putative | 0.0543 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.4333 | 0.4333 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0098 | 0.1297 | 0.2993 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0098 | 0.1297 | 0.1297 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0098 | 0.1297 | 0.1297 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0098 | 0.1297 | 0.2993 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.351 | 0.351 |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.351 | 0.351 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0253 | 0.4333 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0397 | 1 |
Brugia malayi | hypothetical protein | 0.0033 | 0.004 | 0.004 |
Echinococcus granulosus | tar DNA binding protein | 0.0253 | 0.4333 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.4333 | 0.4333 |
Echinococcus multilocularis | GPCR, family 2 | 0.0098 | 0.1297 | 0.2993 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.0397 | 0.1025 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0253 | 0.4333 | 0.4333 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0229 | 0.3871 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0229 | 0.3871 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0397 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1297 | 0.1297 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0397 | 0.0397 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.169 | 0.169 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.169 | 0.169 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0098 | 0.1297 | 0.2993 |
Leishmania major | hypothetical protein, conserved | 0.0229 | 0.3871 | 1 |
Brugia malayi | TAR-binding protein | 0.0253 | 0.4333 | 0.4333 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 70.7946 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.