Detailed information for compound 1422183

Basic information

Technical information
  • TDR Targets ID: 1422183
  • Name: N-methyl-2-[[4-(2-methylpiperidin-1-yl)sulfon ylbenzoyl]amino]-5,6-dihydro-4H-cyclopenta[d] thiophene-3-carboxamide
  • MW: 461.597 | Formula: C22H27N3O4S2
  • H donors: 2 H acceptors: 4 LogP: 3.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1c(NC(=O)c2ccc(cc2)S(=O)(=O)N2CCCCC2C)sc2c1CCC2
  • InChi: 1S/C22H27N3O4S2/c1-14-6-3-4-13-25(14)31(28,29)16-11-9-15(10-12-16)20(26)24-22-19(21(27)23-2)17-7-5-8-18(17)30-22/h9-12,14H,3-8,13H2,1-2H3,(H,23,27)(H,24,26)
  • InChiKey: PTDJKJCZGYQWPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-methyl-2-[[4-[(2-methyl-1-piperidyl)sulfonyl]benzoyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxamide
  • N-methyl-2-[[[4-[(2-methyl-1-piperidinyl)sulfonyl]phenyl]-oxomethyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxamide
  • N-methyl-2-[[4-(2-methylpiperidin-1-yl)sulfonylphenyl]carbonylamino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxamide
  • G839-0081
  • NCGC00134685-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum multidrug resistance-associated protein 2 0.0136 0.2913 0.2749
Echinococcus granulosus multidrug resistance associated protein 1 0.0136 0.2913 0.1398
Trichomonas vaginalis abcb9, putative 0.0427 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0427 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0427 1 1
Schistosoma mansoni smdr1 0.0136 0.2913 0.258
Brugia malayi ABC transporter family protein 0.0136 0.2913 0.2913
Schistosoma mansoni multidrug resistance protein 0.0427 1 1
Entamoeba histolytica multidrug resistance protein, putative 0.0136 0.2913 0.2264
Loa Loa (eye worm) ABC transporter 0.0136 0.2913 0.2749
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0427 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0839 0.0797
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0136 0.2913 0.2749
Entamoeba histolytica P-glycoprotein-1 0.0427 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0427 1 1
Trypanosoma brucei multidrug resistance protein E 0.0136 0.2913 0.3493
Toxoplasma gondii ATP-binding cassette G family transporter ABCG89 0.006 0.1047 0.0841
Schistosoma mansoni tar DNA-binding protein 0.019 0.4218 0.3946
Loa Loa (eye worm) hypothetical protein 0.0427 1 1
Schistosoma mansoni tar DNA-binding protein 0.019 0.4218 0.3946
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.1761 0.1571
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0427 1 1
Schistosoma mansoni multidrug resistance protein 0.0136 0.2913 0.258
Plasmodium vivax ABC transporter B family member 4, putative 0.0136 0.2913 0.2749
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0427 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.0342 0.792 0.7476
Trypanosoma cruzi ABC transporter, putative 0.006 0.1047 0.1068
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0136 0.2913 0.2929
Brugia malayi RE11181p 0.0051 0.0839 0.0839
Trypanosoma cruzi ABC transporter, putative 0.0051 0.0839 0.0797
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0136 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0847 0.0636
Entamoeba histolytica P-glycoprotein-5 0.0427 1 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0136 0.2913 0.1398
Plasmodium falciparum ABC transporter B family member 6, putative 0.0136 0.2913 0.2749
Brugia malayi ABC transporter family protein 0.0136 0.2913 0.2913
Echinococcus granulosus multidrug resistance protein 1 0.0427 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0136 0.2913 0.2749
Entamoeba histolytica P-glycoprotein-2, putative 0.0128 0.2704 0.2036
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0449 0.0449
Brugia malayi RNA binding protein 0.019 0.4218 0.4218
Entamoeba histolytica ATP-binding cassette protein, putative 0.0136 0.2913 0.2264
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Schistosoma mansoni multidrug resistance protein 0.0128 0.2704 0.2361
Echinococcus granulosus multidrug resistance protein 1 0.0427 1 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.2704 0.2536
Echinococcus multilocularis ATP binding cassette sub family B 0.0136 0.2913 0.1398
Brugia malayi ABC transporter family protein 0.0291 0.6671 0.6671
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.26 0.2429
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0419 0.9792 0.9747
Echinococcus multilocularis ATP binding cassette sub family G 0.0342 0.792 0.7476
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.4218 0.4085
Entamoeba histolytica ATP-binding cassette protein, putative 0.0136 0.2913 0.2264
Toxoplasma gondii ABC transporter family protein 0.0136 0.2913 0.2749
Brugia malayi MH2 domain containing protein 0.0124 0.26 0.26
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0427 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0136 0.2913 0.2749
Echinococcus multilocularis ATP binding cassette sub family B 0.0136 0.2913 0.1398
Loa Loa (eye worm) ABC transporter 0.0136 0.2913 0.2749
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.006 0.1047 0.1068
Onchocerca volvulus 0.0427 1 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.26 0.2429
Plasmodium falciparum multidrug resistance-associated protein 1 0.0136 0.2913 0.2749
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0847 0.0847
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0136 0.2913 0.2913
Entamoeba histolytica P-glycoprotein 5, putative 0.0128 0.2704 0.2036
Schistosoma mansoni multidrug resistance protein 0.0136 0.2913 0.258
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0427 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0136 0.2913 0.0416
Schistosoma mansoni tar DNA-binding protein 0.019 0.4218 0.3946
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0427 1 1
Loa Loa (eye worm) ABC transporter 0.0136 0.2913 0.2749
Echinococcus multilocularis ATP binding cassette sub family B 0.0419 0.9792 0.9747
Echinococcus granulosus multidrug resistance protein 1 0.0427 1 1
Schistosoma mansoni multidrug resistance protein 0.0136 0.2913 0.258
Echinococcus granulosus ATP binding cassette sub family G 0.0342 0.792 0.7476
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0136 0.2913 0.2749
Brugia malayi ABC transporter family protein 0.0427 1 1
Plasmodium falciparum multidrug resistance protein 1 0.0427 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0136 0.2913 0.2749
Echinococcus granulosus ATP binding cassette sub family B 0.0136 0.2913 0.1398
Echinococcus multilocularis ATP binding cassette sub family B 0.0136 0.2913 0.1398
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0427 1 1
Leishmania major p-glycoprotein 0.0427 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0342 0.792 0.7872
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0427 1 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1761 0.1373
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0282 0.6462 0.6139
Plasmodium vivax ABC transporter B family member 5, putative 0.0136 0.2913 0.2749
Entamoeba histolytica ATP-binding cassette protein, putative 0.0136 0.2913 0.2264
Plasmodium falciparum multidrug resistance protein 2 0.0136 0.2913 0.2749
Echinococcus granulosus tar DNA binding protein 0.019 0.4218 0.2983
Echinococcus multilocularis multidrug resistance associated protein 1 0.0136 0.2913 0.1398
Trypanosoma brucei ABC transporter, putative 0.0342 0.792 1
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.1047 0.1068
Echinococcus multilocularis tar DNA binding protein 0.019 0.4218 0.2983
Trypanosoma brucei ATP-binding cassette protein, putative 0.0342 0.792 1
Echinococcus multilocularis 0.0136 0.2913 0.1398
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0427 1 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0136 0.2913 0.3493
Entamoeba histolytica P-glyco protein 6, putative 0.0427 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0128 0.2704 0.2704
Toxoplasma gondii ATP-binding cassette G family transporter ABCG87 0.006 0.1047 0.0841
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0427 1 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0128 0.2704 0.2361
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0427 1 1
Loa Loa (eye worm) ABC transporter 0.0291 0.6671 0.6594
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0342 0.792 0.7872
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0427 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0449 0.0229
Echinococcus granulosus ATP binding cassette sub family B 0.0136 0.2913 0.1398
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0136 0.2913 0.3493
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0136 0.2913 0.3493
Giardia lamblia ABC transporter 0.0333 0.7712 1
Trichomonas vaginalis ABC transporter, putative 0.0427 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0136 0.2913 0.2929
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0136 0.2913 0.2749
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0136 0.2913 0.5
Echinococcus multilocularis ATP binding cassette sub family G 0.0342 0.792 0.7476
Loa Loa (eye worm) TAR-binding protein 0.019 0.4218 0.4085
Plasmodium vivax ABC transporter B family member 3, putative 0.0136 0.2913 0.2749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1761 0.1373
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0427 1 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0136 0.2913 0.3493
Entamoeba histolytica P-glycoprotein 5, putative 0.0427 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0136 0.2913 0.0286
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0136 0.2913 0.2749
Schistosoma mansoni multidrug resistance protein 0.0427 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.0342 0.792 0.7476
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0427 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0342 0.792 0.7476
Plasmodium vivax ABC transporter B family member 7, putative 0.0136 0.2913 0.2749
Trypanosoma cruzi multidrug resistance protein E, putative 0.0136 0.2913 0.3493
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0136 0.2913 0.2749
Brugia malayi hypothetical protein 0.0136 0.2913 0.2913
Leishmania major ABC-thiol transporter 0.0136 0.2913 0.2749
Entamoeba histolytica P-glycoprotein 6, putative 0.0136 0.2913 0.2264
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0427 1 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0136 0.2913 0.3493
Leishmania major p-glycoprotein e 0.0136 0.2913 0.2749
Loa Loa (eye worm) hypothetical protein 0.0427 1 1
Trypanosoma brucei p-glycoprotein 0.0136 0.2913 0.3493
Echinococcus granulosus multidrug resistance protein 1 0.03 0.6886 0.622
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0427 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Brugia malayi ABC transporter family protein 0.0136 0.2913 0.2913
Plasmodium falciparum ABC transporter B family member 5, putative 0.0136 0.2913 0.2749
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0342 0.792 1
Brugia malayi ABC transporter 0.0128 0.2704 0.2704
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0136 0.2913 0.2913
Plasmodium vivax multidrug resistance protein 1, putative 0.0427 1 1
Plasmodium falciparum ABC transporter B family member 3, putative 0.0136 0.2913 0.2749
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0342 0.792 0.7872
Loa Loa (eye worm) hypothetical protein 0.0128 0.2704 0.2536
Trichomonas vaginalis abcb9, putative 0.0427 1 1
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0136 0.2913 0.258
Giardia lamblia MRP-like ABC transporter 0.0136 0.2913 0.0416
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0136 0.2913 0.2749
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0427 1 1
Echinococcus granulosus multidrug resistance protein 1 0.03 0.6886 0.622
Loa Loa (eye worm) RNA binding protein 0.019 0.4218 0.4085
Trypanosoma cruzi ABC transporter, putative 0.0342 0.792 1
Entamoeba histolytica hypothetical protein 0.0136 0.2913 0.2264
Brugia malayi multidrug resistance related protein 1 0.0136 0.2913 0.2913
Schistosoma mansoni ABC transporter 0.0051 0.0839 0.0408
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Schistosoma mansoni multidrug resistance protein 0.0136 0.2913 0.258
Schistosoma mansoni multidrug resistance protein 0.0427 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0136 0.2913 0.2929
Loa Loa (eye worm) hypothetical protein 0.0136 0.2913 0.2749
Schistosoma mansoni tar DNA-binding protein 0.019 0.4218 0.3946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1761 0.1373
Plasmodium falciparum ABC transporter B family member 7, putative 0.0136 0.2913 0.2749
Toxoplasma gondii ATP-binding cassette G family transporter ABCG107 0.006 0.1047 0.0841
Echinococcus multilocularis ATP binding cassette sub family B 0.0136 0.2913 0.1398
Entamoeba histolytica ATP-binding cassette protein, putative 0.0136 0.2913 0.2264
Schistosoma mansoni tar DNA-binding protein 0.019 0.4218 0.3946
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0136 0.2913 0.2749
Toxoplasma gondii ATP-binding cassette G family transporter ABCG96 0.006 0.1047 0.0841
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0427 1 1
Trypanosoma brucei ABC transporter, putative 0.006 0.1047 0.1068
Loa Loa (eye worm) hypothetical protein 0.0136 0.2913 0.2749
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.006 0.1047 0.1068
Plasmodium vivax ABC transporter B family member 6, putative 0.0136 0.2913 0.2749
Loa Loa (eye worm) multidrug resistance protein 3 0.0427 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0136 0.2913 0.2913
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0847 0.0636
Trichomonas vaginalis ABC transporter, putative 0.0427 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0136 0.2913 0.2749
Echinococcus granulosus ATP binding cassette sub family B 0.0128 0.2704 0.1145
Trypanosoma cruzi ABC transporter, putative 0.0051 0.0839 0.0797
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0427 1 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0136 0.2913 0.3493
Brugia malayi TAR-binding protein 0.019 0.4218 0.4218
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0136 0.2913 0.3493
Leishmania major ATP-binding cassette protein subfamily G, member 2, putative 0.006 0.1047 0.0841
Brugia malayi RNA recognition motif domain containing protein 0.019 0.4218 0.4218
Loa Loa (eye worm) hypothetical protein 0.0419 0.9792 0.9787
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0427 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0136 0.2913 0.0416
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0136 0.2913 0.2264
Plasmodium falciparum ABC transporter B family member 4, putative 0.0136 0.2913 0.2749
Loa Loa (eye worm) hypothetical protein 0.0051 0.0839 0.0628
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0427 1 1
Brugia malayi P-glycoprotein-like protein 0.0136 0.2913 0.2913
Plasmodium vivax multidrug resistance protein 2, putative 0.0136 0.2913 0.2749
Schistosoma mansoni smdr2 0.0427 1 1
Brugia malayi ABC transporter 0.0136 0.2913 0.2913
Trypanosoma brucei ATP-binding cassette protein subfamily G 0.006 0.1047 0.1068
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0342 0.792 0.7822
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0342 0.792 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0427 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0136 0.2913 0.2749
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0136 0.2913 0.2749
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0427 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0427 1 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0427 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0427 1 1
Brugia malayi hypothetical protein 0.0026 0.0225 0.0225
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0136 0.2913 0.3493
Trichomonas vaginalis abcb9, putative 0.0427 1 1
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0136 0.2913 0.2929
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0136 0.2913 0.2749
Entamoeba histolytica ABC transporter, putative 0.0136 0.2913 0.2264
Schistosoma mansoni ABC transporter 0.0291 0.6671 0.6515
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0136 0.2913 0.5
Trichomonas vaginalis ABC transporter, putative 0.0427 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 5, putative 0.006 0.1047 0.0841
Echinococcus multilocularis multidrug resistance associated protein 7 0.0136 0.2913 0.1398
Entamoeba histolytica ABC transporter, putative 0.0342 0.792 0.773
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0136 0.2913 0.2749
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0136 0.2913 1
Plasmodium vivax ABC transporter G family member 2, putative 0.0342 0.792 0.7872
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0136 0.2913 0.2929
Leishmania major pentamidine resistance protein 1 0.0136 0.2913 0.2749
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0136 0.2913 0.2749
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0427 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0847 0.0847
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0136 0.2913 0.2264
Entamoeba histolytica P-glycoprotein-2, putative 0.0427 1 1
Toxoplasma gondii ABC transporter, putative 0.0136 0.2913 0.2749
Echinococcus multilocularis multidrug resistance protein 1 0.03 0.6886 0.622
Leishmania major ATP-binding cassette protein subfamily G, member 1, putative 0.006 0.1047 0.0841
Entamoeba histolytica P-glycoprotein 6, putative 0.0136 0.2913 0.2264
Entamoeba histolytica P-glycoprotein-2 0.0427 1 1
Schistosoma mansoni multidrug resistance protein 0.0136 0.2913 0.258
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.1047 0.1068
Schistosoma mansoni hypothetical protein 0.0282 0.6462 0.6296
Plasmodium falciparum ABC transporter G family member 2 0.0342 0.792 0.7872
Giardia lamblia ABC transporter, putative 0.0136 0.2913 0.0416
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0427 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0427 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.03 0.6886 0.5731
Brugia malayi hypothetical protein 0.0051 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0051 0.0839 0.0628
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0342 0.792 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.1761 0.1761
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0342 0.792 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0136 0.2913 0.2749
Trichomonas vaginalis ABC transporter, putative 0.0427 1 1
Trichomonas vaginalis taga, putative 0.0427 1 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.2913 0.2749
Entamoeba histolytica P-glycoprotein-2 0.0427 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0839 0.0628

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.